product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
DNMT1 (D63A6) XP® Rabbit mAb
catalog :
5032
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D63A6
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig s7b
Wu S, Xiao Y, Wei J, Xu X, Jin X, Hu X, et al. MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer. J Immunother Cancer. 2021;9: pubmed publisher
  • western blot; human; loading ...; fig 6b
Zhang Y, He L, Huang L, Yao S, Lin N, Li P, et al. Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway. Clin Transl Med. 2021;11:e503 pubmed publisher
  • western blot; human; 1:1000; loading ...
Tacconi C, He Y, Ducoli L, Detmar M. Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells. Angiogenesis. 2020;: pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 2f
Kim K, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, et al. Reprogramming competence of OCT factors is determined by transactivation domains. Sci Adv. 2020;6: pubmed publisher
  • western blot; human; 1:1000; fig 1b
de Cubas A, Dunker W, Zaninovich A, Hongo R, Bhatia A, Panda A, et al. DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer. JCI Insight. 2020;5: pubmed publisher
  • western blot; mouse; loading ...; fig e5e
Lu Z, Zou J, Li S, Topper M, Tao Y, Zhang H, et al. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020;579:284-290 pubmed publisher
  • western blot; human; loading ...; fig 4i
Sin Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, et al. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell. 2019;36:51-67.e7 pubmed publisher
  • western blot; human; fig 1
Lee E, Wang J, Yumoto K, Jung Y, Cackowski F, Decker A, et al. DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis. Neoplasia. 2016;18:553-66 pubmed publisher
  • immunohistochemistry; mouse; fig 6b
  • western blot; mouse; fig 5b
Chang Y, Yang C, Pan S, Chou Y, Chang F, Lai C, et al. DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys. J Clin Invest. 2016;126:721-31 pubmed publisher
  • western blot; rat; 1:2500; fig 6
Götze S, Schumacher E, Kordes C, Häussinger D. Epigenetic Changes during Hepatic Stellate Cell Activation. PLoS ONE. 2015;10:e0128745 pubmed publisher
  • western blot; human
Duvall Noelle N, Karwandyar A, Richmond A, Raman D. LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Oncogene. 2016;35:1122-33 pubmed publisher
  • western blot; human; 1:1000; fig 3
Nakamura K, Nakabayashi K, Htet Aung K, Aizawa K, Hori N, Yamauchi J, et al. DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status. PLoS ONE. 2015;10:e0120545 pubmed publisher
  • western blot; mouse
Geula S, Moshitch Moshkovitz S, Dominissini D, Mansour A, Kol N, Salmon Divon M, et al. Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science. 2015;347:1002-6 pubmed publisher
  • western blot; human
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed publisher
  • western blot; human
Nakamura K, Aizawa K, Nakabayashi K, Kato N, Yamauchi J, Hata K, et al. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. PLoS ONE. 2013;8:e54036 pubmed publisher
Fu X, Wu X, Djekidel M, Zhang Y. Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells. Nat Cell Biol. 2019;: pubmed publisher
Turnbull A, Ioannidis S, Krajewski W, Pinto Fernandez A, Heride C, Martin A, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017;550:481-486 pubmed publisher
Jiang X, Feng Y, Ye L, Li X, Feng J, Zhang M, et al. Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. Stem Cell Reports. 2017;8:290-304 pubmed publisher
Manners M, Ertel A, Tian Y, Ajit S. Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury. Epigenetics Chromatin. 2016;9:23 pubmed publisher
Mei Q, Chen M, Lu X, Li X, Duan F, Wang M, et al. An open-label, single-arm, phase I/II study of lower-dose decitabine based therapy in patients with advanced hepatocellular carcinoma. Oncotarget. 2015;6:16698-711 pubmed
Zhang Y, Andrews G, Wang L. Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP. Nucleic Acids Res. 2012;40:4850-60 pubmed publisher
Zhang Y, Wang L. Nuclear receptor SHP inhibition of Dnmt1 expression via ERR?. FEBS Lett. 2011;585:1269-75 pubmed publisher
product information
SKU :
5032S
Product-Name :
DNMT1 (D63A6) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M, R, Mk, (Hm, B, Dg, GP, Hr)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
200
Host :
Rabbit
Target :
DNMT1
Primary-Protein :
DNMT1
Alt-Names :
AIM,CXXC finger protein 9,CXXC-type zinc finger protein 9,CXXC9,DNA (cytosine-5)-methyltransferase 1,DNA (cytosine-5-)-methyltransferase 1,DNA MTase HsaI,DNA methyltransferase 1,DNA methyltransferase HsaI,DNMT,DNMT1,FLJ16293,M.HsaI,MCMT,MGC104992
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.