| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 3b
| Yang M, Li C, Zhu S, Cao L, Kroemer G, Zeh H, et al. TFAM is a novel mediator of immunogenic cancer cell death. Oncoimmunology. 2018;7:e1431086 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Bogenberger J, Whatcott C, Hansen N, Delman D, Shi C, Kim W, et al. Combined venetoclax and alvocidib in acute myeloid leukemia. Oncotarget. 2017;8:107206-107222 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher |
- western blot; human; loading ...; fig 1f
| Rada M, Vasileva E, Lezina L, Marouco D, Antonov A, Macip S, et al. Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene. 2017;36:922-932 pubmed publisher |
- western blot; human; loading ...; fig 5f
| Horn T, Ferretti S, Ebel N, Tam A, Ho S, Harbinski F, et al. High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. Cancer Res. 2016;76:6950-6963 pubmed |
- western blot; human; loading ...; fig 5b,5c,6b,6c,6d
| Pomares H, Palmeri C, Iglesias Serret D, Moncunill Massaguer C, Saura Esteller J, Núñez Vázquez S, et al. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget. 2016;7:64987-65000 pubmed publisher |
- western blot; human; loading ...; fig 4b, 4d
| Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher |
- western blot; human; 1:500; loading ...; fig s6d
| Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18:897-909 pubmed publisher |
- western blot; human; fig 2
| Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed publisher |
- western blot; mouse; 1:2000; fig s1a
- western blot; human; 1:2000; loading ...; fig s1a
| Hornsveld M, Tenhagen M, van de Ven R, Smits A, van Triest M, van Amersfoort M, et al. Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer. Cell Death Differ. 2016;23:1483-92 pubmed publisher |
- western blot; human; fig 1
| Gilormini M, Malesys C, Armandy E, Manas P, Guy J, Magne N, et al. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget. 2016;7:16731-44 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Moncunill Massaguer C, Saura Esteller J, Pérez Perarnau A, Palmeri C, Núñez Vázquez S, Cosialls A, et al. A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 2015;6:41750-65 pubmed publisher |
- western blot; human; fig 3
| Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Lauková J, KozubÃk A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher |
- western blot; human; loading ...; fig st2
| Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed publisher |
- western blot; human; fig 1
| Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS ONE. 2015;10:e0132767 pubmed publisher |
- western blot; human; fig 4
| Heinemann A, Cullinane C, De Paoli Iseppi R, Wilmott J, Gunatilake D, Madore J, et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. 2015;6:21507-21 pubmed |
- western blot; human; fig 5
| Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed publisher |
- western blot; human; fig 2
| Vogel C, Smit M, Maddalo G, Possik P, Sparidans R, van der Burg S, et al. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell Melanoma Res. 2015;28:307-17 pubmed publisher |
| Seeßle J, Liebisch G, Schmitz G, Stremmel W, Chamulitrat W. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochim Biophys Acta. 2015;1851:549-65 pubmed publisher |
- western blot; human; 1:1000; tbl 1
| Vega Naredo I, Cunha Oliveira T, Serafim T, Sardao V, Oliveira P. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Methods Mol Biol. 2015;1241:163-80 pubmed publisher |
- western blot; human; fig 3c
| Harashima N, Minami T, Uemura H, Harada M. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer. 2014;13:217 pubmed publisher |
| Singh K, Shukla P, Quan A, Desjardins J, Lovren F, Pan Y, et al. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem. 2012;287:6604-14 pubmed publisher |
| Peperzak V, Slinger E, Ter Burg J, Eldering E. Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling. Cell Death Differ. 2017;24:111-119 pubmed publisher |
| Li N, Richard S. Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor. Nucleic Acids Res. 2016;44:8726-8741 pubmed |
| Lupini L, Pepe F, Ferracin M, Braconi C, Callegari E, Pagotto S, et al. Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma. Oncotarget. 2016;7:31361-71 pubmed publisher |
| Feng F, Zhang Y, Kothari V, Evans J, Jackson W, Chen W, et al. MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner. Neoplasia. 2016;18:213-22 pubmed publisher |
| Bajpai R, Matulis S, Wei C, Nooka A, Von Hollen H, Lonial S, et al. Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax. Oncogene. 2016;35:3955-64 pubmed publisher |
| GarcÃa Ãlvaro M, Addante A, Roncero C, Fernández M, Fabregat I, Sánchez A, et al. BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation. Int J Mol Sci. 2015;16:20431-48 pubmed publisher |
| Kim R, Kang M, Kim T, Yang P, Bae S, Williams D, et al. Regulation of p53 during senescence in normal human keratinocytes. Aging Cell. 2015;14:838-46 pubmed publisher |
| Akita S, Hattori N, Masuda T, Horimasu Y, Nakashima T, Iwamoto H, et al. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer Sci. 2015;106:921-8 pubmed publisher |
| Frik M, Martinez A, Elie B, Gonzalo O, Ramírez de Mingo D, Sanaú M, et al. In vitro and in vivo evaluation of water-soluble iminophosphorane ruthenium(II) compounds. A potential chemotherapeutic agent for triple negative breast cancer. J Med Chem. 2014;57:9995-10012 pubmed publisher |
| Mungamuri S, Wang S, Manfredi J, Gu W, Aaronson S. Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Oncogene. 2015;34:2461-70 pubmed publisher |
| Zhu Y, Zhou Y, Shi J. Post-slippage multinucleation renders cytotoxic variation in anti-mitotic drugs that target the microtubules or mitotic spindle. Cell Cycle. 2014;13:1756-64 pubmed publisher |
| Kaindl U, Morak M, Portsmouth C, Mecklenbräuker A, Kauer M, Zeginigg M, et al. Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia. Leukemia. 2014;28:600-8 pubmed publisher |
| Meijer A, Kruyt F, van der Zee A, Hollema H, Le P, Ten Hoor K, et al. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. Br J Cancer. 2013;109:2685-95 pubmed publisher |
| Zinn R, Gardner E, Dobromilskaya I, Murphy S, Marchionni L, Hann C, et al. Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Mol Cancer. 2013;12:16 pubmed publisher |
| Silden E, Hjelle S, Wergeland L, Sulen A, Andresen V, Bourdon J, et al. Expression of TP53 isoforms p53? or p53? enhances chemosensitivity in TP53(null) cell lines. PLoS ONE. 2013;8:e56276 pubmed publisher |
| Ifeadi V, Garnett Benson C. Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PLoS ONE. 2012;7:e31762 pubmed publisher |
| Stauber R, Knauer S, Habtemichael N, Bier C, Unruhe B, Weisheit S, et al. A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer. Oncotarget. 2012;3:31-43 pubmed |
| Zagorodna O, Martin S, Rutkowski D, Kuwana T, Spitz D, Knudson C. 2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Oncogene. 2012;31:2738-49 pubmed publisher |
| Ozata D, Caramuta S, Velazquez Fernandez D, Akçakaya P, Xie H, Höög A, et al. The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. Endocr Relat Cancer. 2011;18:643-55 pubmed publisher |
| Hart J, Vogt P. Phosphorylation of AKT: a mutational analysis. Oncotarget. 2011;2:467-76 pubmed |
| Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, et al. Novel nucleolar pathway connecting intracellular energy status with p53 activation. J Biol Chem. 2011;286:20861-9 pubmed publisher |
| Brekman A, Singh K, Polotskaia A, Kundu N, Bargonetti J. A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation. Breast Cancer Res. 2011;13:R3 pubmed publisher |
| Coureuil M, Ugolin N, Tavernier M, Chevillard S, Barroca V, Fouchet P, et al. Puma and Trail/Dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors. PLoS ONE. 2010;5:e12134 pubmed publisher |
| Zall H, Weber A, Besch R, Zantl N, Hacker G. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1. Mol Cancer. 2010;9:164 pubmed publisher |
| de Bruijn M, Raats D, Hoogwater F, van Houdt W, Cameron K, Medema J, et al. Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. Br J Cancer. 2010;102:1254-64 pubmed publisher |
| Cheung M, Pei J, Pei Y, Jhanwar S, Pass H, Testa J. The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival. Oncogene. 2010;29:1633-40 pubmed publisher |
| Ulasov I, Sonabend A, Nandi S, Khramtsov A, Han Y, Lesniak M. Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. Br J Cancer. 2009;100:1154-64 pubmed publisher |
