| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; mouse; fig 6e
- immunocytochemistry; human; loading ...; fig 2e
| Kannan A, Bhatia K, Branzei D, Gangwani L. Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy. Nucleic Acids Res. 2018;46:8326-8346 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- immunohistochemistry; human; 1:300; loading ...; fig 4h
| Collin G, Huna A, Warnier M, Flaman J, Bernard D. Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence. Cell Death Dis. 2018;9:259 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig st6
| Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 5c
| Nagano T, Nakashima A, Onishi K, Kawai K, Awai Y, Kinugasa M, et al. Proline dehydrogenase promotes senescence through the generation of reactive oxygen species. J Cell Sci. 2017;130:1413-1420 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4a
| Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman S, et al. Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis. Immunity. 2016;45:903-916 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4b
- western blot; human; loading ...; fig s1e
| Bridges K, Chen X, Liu H, Rock C, Buchholz T, Shumway S, et al. MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Oncotarget. 2016;7:71660-71672 pubmed publisher |
- immunocytochemistry; human; fig 2
| Nelson D, Jaber Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016;17:158 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 1a
| Hewitt G, Carroll B, Sarallah R, Correia Melo C, Ogrodnik M, Nelson G, et al. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 2016;12:1917-1930 pubmed |
- western blot; human; fig 2
| Yalon M, Tuval Kochen L, Castel D, Moshe I, Mazal I, Cohen O, et al. Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. PLoS ONE. 2016;11:e0155711 pubmed publisher |
- reverse phase protein lysate microarray; mouse; fig s1.b,c
| Gruosso T, Mieulet V, Cardon M, Bourachot B, Kieffer Y, Devun F, et al. Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med. 2016;8:527-49 pubmed publisher |
- immunocytochemistry; human; 1:200; fig 4
| Soo Lee N, Jin Chung H, Kim H, Yun Lee S, Ji J, Seo Y, et al. TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage. Nat Commun. 2016;7:10463 pubmed publisher |
- western blot; human; fig 3
| Choi Y, Meghani K, Brault M, Leclerc L, He Y, Day T, et al. Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016;14:429-439 pubmed publisher |
- immunocytochemistry; human; fig 4a
| Pellegrini C, Columbaro M, Capanni C, D Apice M, Cavallo C, Murdocca M, et al. All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Oncotarget. 2015;6:29914-28 pubmed publisher |
- immunocytochemistry; human
| Bouley J, Saad L, Grall R, Schellenbauer A, Biard D, Paget V, et al. A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines. Oncotarget. 2015;6:27980-8000 pubmed publisher |
- immunocytochemistry; mouse; fig s4
| Ip L, Poulogiannis G, Viciano F, Sasaki J, Kofuji S, Spanswick V, et al. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015;6:10548-62 pubmed |
- immunocytochemistry; human; fig 1
| Warren D, Tajsic T, Porter L, Minaisah R, Cobb A, Jacob A, et al. Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing. Cell Death Differ. 2015;22:1540-50 pubmed publisher |
- immunocytochemistry; mouse
- western blot; mouse
| Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:350
| Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging (Albany NY). 2014;6:496-510 pubmed |
- immunocytochemistry; mouse; 1:200; fig s3
| Schröder Heurich B, Wieland B, Lavin M, Schindler D, Dork T. Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB J. 2014;28:1331-41 pubmed publisher |
- immunocytochemistry; human; 1:100
| Dai C, Sun F, Zhu C, Hu X. Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors. PLoS ONE. 2013;8:e63054 pubmed publisher |
| Guirouilh Barbat J, Gelot C, Xie A, Dardillac E, Scully R, Lopez B. 53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks. PLoS Genet. 2016;12:e1006230 pubmed publisher |
| Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher |
| Tiwana G, Prevo R, Buffa F, Yu S, Ebner D, Howarth A, et al. Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen. Oncotarget. 2015;6:5978-89 pubmed |
| Sone K, Piao L, Nakakido M, Ueda K, Jenuwein T, Nakamura Y, et al. Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nat Commun. 2014;5:5691 pubmed publisher |
| Manguan García C, Pintado Berninches L, Carrillo J, Machado Pinilla R, Sastre L, Perez Quilis C, et al. Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. PLoS ONE. 2014;9:e101424 pubmed publisher |
| Park J, Tougeron D, Huang S, Okamoto K, Sinicrope F. Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. PLoS ONE. 2014;9:e100819 pubmed publisher |
| Zhou Y, Caron P, Legube G, Paull T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res. 2014;42:e19 pubmed publisher |
| Chen Z, Jaafar L, Agyekum D, Xiao H, Wade M, Kumaran R, et al. Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic Acids Res. 2013;41:e182 pubmed publisher |
| Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson D, Rai T, et al. Lysosome-mediated processing of chromatin in senescence. J Cell Biol. 2013;202:129-43 pubmed publisher |
| Starke S, Meinke P, Camozzi D, Mattioli E, Pfaeffle R, Siekmeyer M, et al. Progeroid laminopathy with restrictive dermopathy-like features caused by an isodisomic LMNA mutation p.R435C. Aging (Albany NY). 2013;5:445-59 pubmed |
| Hsu J, Lin T, Tsai R. Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1. J Cell Biol. 2012;197:613-24 pubmed publisher |
| Hewitt G, Jurk D, Marques F, Correia Melo C, Hardy T, Gackowska A, et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun. 2012;3:708 pubmed publisher |
| Olsen B, Wang S, Svenstrup T, Chen B, Guerra B. Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage. BMC Mol Biol. 2012;13:7 pubmed publisher |
| Hudson R, Yi M, Esposito D, Watkins S, Hurwitz A, Yfantis H, et al. MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. Nucleic Acids Res. 2012;40:3689-703 pubmed publisher |
| Nikitin P, Yan C, Forte E, Bocedi A, Tourigny J, White R, et al. An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell Host Microbe. 2010;8:510-22 pubmed publisher |
| Christmann M, Tomicic M, Aasland D, Berdelle N, Kaina B. Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage. Nucleic Acids Res. 2010;38:6418-32 pubmed publisher |
| Lee J, Goodarzi A, Jeggo P, Paull T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 2010;29:574-85 pubmed publisher |
