| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; zebrafish ; 1:200; loading ...; fig 2s2f
| Ye Z, Su Z, Xie S, Liu Y, Wang Y, Xu X, et al. Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration. elife. 2020;9: pubmed publisher |
- western blot knockout validation; mouse; loading ...; fig 1a
| Lu L, Finegold M, Johnson R. Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration. Exp Mol Med. 2018;50:e423 pubmed publisher |
- western blot; human; loading ...; fig s5e
- western blot; mouse; loading ...; fig 4f
| Kumar B, Adebayo A, Prasad M, Capitano M, Wang R, Bhat Nakshatri P, et al. Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity. Sci Adv. 2022;8:eabh3375 pubmed publisher |
- western blot; human; loading ...; fig 4g
| Zhang Y, He L, Huang L, Yao S, Lin N, Li P, et al. Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway. Clin Transl Med. 2021;11:e503 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5c
| Roper N, Velez M, Chiappori A, Kim Y, Wei J, Sindiri S, et al. Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer. Nat Commun. 2021;12:3880 pubmed publisher |
- immunocytochemistry; mouse; 1:100; loading ...; fig 4g
| Leach J, Vlahov N, Tsantoulis P, Ridgway R, Flanagan D, Gilroy K, et al. Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nat Commun. 2021;12:3464 pubmed publisher |
- western blot; mouse; 1:50; loading ...; fig 3a
| Barthet V, Brucoli M, Ladds M, Nössing C, Kiourtis C, Baudot A, et al. Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Sci Adv. 2021;7: pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 7d
| Carter P, Schnell U, Chaney C, TONG B, Pan X, ye J, et al. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021;131: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a, 6b
| Hu Z, Chen Y, Huang M, Tu J, Tu S, Pan Y, et al. PLG inhibits Hippo signaling pathway through SRC in the hepatitis B virus-induced hepatocellular-carcinoma progression. Am J Transl Res. 2021;13:515-531 pubmed |
- immunocytochemistry; mouse; 1:200; loading ...; fig 7c
- western blot; mouse; 1:200; loading ...; fig 7h
| Chen F, Liu X, Chen Y, Liu J, Lu H, Wang W, et al. Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells. EBioMedicine. 2020;52:102618 pubmed publisher |
- western blot; human; loading ...; fig 7b
| Kim J, Berrios C, Kim M, SCHADE A, Adelmant G, Yeerna H, et al. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. elife. 2020;9: pubmed publisher |
- western blot; human; loading ...; fig 4b
| Fusco P, Parisatto B, Rampazzo E, Persano L, Frasson C, Di Meglio A, et al. Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours. BMC Cancer. 2019;19:970 pubmed publisher |
- western blot; human; loading ...; fig 3b
| Zhou L, Wang Q, Zhang H, Li Y, Xie S, Xu M. YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine. Biomolecules. 2019;9: pubmed publisher |
- immunohistochemistry; zebrafish ; 1:400; loading ...; fig 1s1c
| Fillatre J, Fauny J, Fels J, Li C, Goll M, Thisse C, et al. TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish. elife. 2019;8: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6c
| Gao C, Chen G, Zhang D, Zhang J, Kuan S, Hu W, et al. PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654. Cell Mol Gastroenterol Hepatol. 2019;8:561-578 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3a
| Rong X, Han Q, Lin X, Kremerskothen J, Wang E. FRMPD1 activates the Hippo pathway via interaction with WWC3 to suppress the proliferation and invasiveness of lung cancer cells. Cancer Manag Res. 2019;11:3395-3410 pubmed publisher |
- western blot; human; fig 8a
| Miller C, Lou H, Simpson C, van de Kooij B, Ha B, Fisher O, et al. Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. PLoS Biol. 2019;17:e2006540 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2f
| Rivera Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, et al. YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma. Cell Death Dis. 2018;9:1108 pubmed publisher |
- western blot; human; 1:1000; fig 4a
| Ho L, Skiba N, Ullmer C, Rao P. Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2018;59:1969-1984 pubmed publisher |
- western blot; human; 1:500; fig 3b
| Zheng X, Dong Q, Zhang X, Han Q, Han X, Han Y, et al. The coiled-coil domain of oncogene RASSF 7 inhibits hippo signaling and promotes non-small cell lung cancer. Oncotarget. 2017;8:78734-78748 pubmed publisher |
- western blot; human; fig 1b
| van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al. Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet. 2017;49:1261-1266 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4b
| Hadden W, Young J, Holle A, McFetridge M, Kim D, Wijesinghe P, et al. Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels. Proc Natl Acad Sci U S A. 2017;114:5647-5652 pubmed publisher |
- immunocytochemistry; human; 1:150; loading ...; fig 4k
- western blot; human; 1:1000; loading ...; fig s5d
| Nardone G, Oliver De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, et al. YAP regulates cell mechanics by controlling focal adhesion assembly. Nat Commun. 2017;8:15321 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 2n
| Watanabe Y, Miyasaka K, Kubo A, Kida Y, Nakagawa O, Hirate Y, et al. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 2017;7:46135 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4e
| Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher |
- western blot; human; loading ...; fig 2g
| Heidary Arash E, Shiban A, Song S, Attisano L. MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. EMBO Rep. 2017;18:420-436 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...
| Ramjee V, Li D, Manderfield L, Liu F, Engleka K, Aghajanian H, et al. Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction. J Clin Invest. 2017;127:899-911 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 7a
| Price A, Huang E, Sebastiano V, Dunn A. A semi-interpenetrating network of polyacrylamide and recombinant basement membrane allows pluripotent cell culture in a soft, ligand-rich microenvironment. Biomaterials. 2017;121:179-192 pubmed publisher |
- western blot; human; loading ...; fig s4a
| Nguyen H, Kugler J, Cohen S. DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. PLoS ONE. 2017;12:e0169587 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 2b
- western blot; mouse; 1:500; loading ...; fig 3a
- western blot; human; 1:500; loading ...; fig 3b
| Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed publisher |
- western blot; zebrafish ; 1:200; loading ...; fig 5a
| Mayrhofer M, Gourain V, Reischl M, Affaticati P, Jenett A, Joly J, et al. A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. Dis Model Mech. 2017;10:15-28 pubmed publisher |
- western blot; human; loading ...; fig s1e
- western blot; mouse; loading ...; fig 1a
| Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1g
- western blot; human; 1:1000; loading ...; fig 4a
| Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed publisher |
- immunohistochemistry; mouse; 1:500; loading ...; fig 3b
- western blot; mouse; 1:3000; loading ...; fig 3a
- western blot; human; 1:3000; loading ...; fig 4c
| Zhang Q, Zhang Y, Parsels J, Lohse I, Lawrence T, Pasca di Magliano M, et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia. 2016;18:666-673 pubmed publisher |
- western blot; human; 1:100; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 5B
- western blot; human; fig 5A
- immunohistochemistry - paraffin section; mouse; 1:100; fig 4E
| Georgescu M, Gagea M, Cote G. NHERF1/EBP50 Suppresses Wnt-?-Catenin Pathway-Driven Intestinal Neoplasia. Neoplasia. 2016;18:512-23 pubmed publisher |
- western blot; human; fig 2
- western blot; mouse; fig 2
| Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:400; loading ...; fig 4e
- western blot; rat; loading ...; fig 4c
| Ruess D, Probst M, Marjanovic G, Wittel U, Hopt U, Keck T, et al. HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0161233 pubmed publisher |
- immunohistochemistry; mouse; 1:200; fig 2
- western blot; mouse; 1:1000; fig 4
| Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed publisher |
- western blot; human; loading ...; fig 1c
- western blot; mouse; fig 5a
| Feng X, Liu P, Zhou X, Li M, Li F, Wang Z, et al. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016;291:18947-58 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100; fig s10
| Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher |
- immunocytochemistry; human; 1:200; fig 2
| Qiao Y, Qian Y, Wang J, Tang X. Melanoma cell adhesion molecule stimulates yes-associated protein transcription by enhancing CREB activity via c-Jun/c-Fos in hepatocellular carcinoma cells. Oncol Lett. 2016;11:3702-3708 pubmed |
- immunohistochemistry; mouse; fig 2
| Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:1000; fig 5
| Lodge E, Russell J, Patist A, Francis West P, Andoniadou C. Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development. Front Physiol. 2016;7:114 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500; fig 2
| Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, et al. Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway. J Pathol. 2016;239:97-108 pubmed publisher |
- western blot; human; fig s6
| Hoa L, Kulaberoglu Y, Gundogdu R, Cook D, Mavis M, Gomez M, et al. The characterisation of LATS2 kinase regulation in Hippo-YAP signalling. Cell Signal. 2016;28:488-497 pubmed publisher |
- western blot; human; fig 3
| Liu X, Li H, Rajurkar M, Li Q, Cotton J, Ou J, et al. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016;14:1169-1180 pubmed publisher |
- western blot; human; fig 3
| Couderc C, Boin A, Fuhrmann L, Vincent Salomon A, Mandati V, Kieffer Y, et al. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. Neoplasia. 2016;18:10-24 pubmed publisher |
- immunocytochemistry; human; fig 2
- western blot; human; fig 3
| Dai X, Zhuang L, Wang D, Zhou T, Chang L, Gai R, et al. Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget. 2016;7:6933-47 pubmed publisher |
- western blot; human; fig 7
- western blot; mouse; fig 4
| Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, et al. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016;113:E71-80 pubmed publisher |
- immunoprecipitation; human; fig 4
- western blot; human; fig 2
| Kim M, Kim M, Park S, Lee C, Lim D. Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016;17:64-78 pubmed publisher |
| Hsu P, Miao J, Wang Y, Zhang W, Yang Y, Wang C, et al. Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma. J Cell Mol Med. 2018;22:3139-3148 pubmed publisher |
| Jeong S, Kim H, Kim M, Lee J, Lee J, Kim J, et al. Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. J Clin Invest. 2018;128:1010-1025 pubmed publisher |
| Huang Y, Yang C, Wei P, Huynh T, Whang Peng J, Meng T, et al. Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways. J Hematol Oncol. 2017;10:60 pubmed publisher |
| Loforese G, Malinka T, Keogh A, Baier F, Simillion C, Montani M, et al. Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. EMBO Mol Med. 2017;9:46-60 pubmed publisher |
| Sun D, Li X, He Y, Li W, Wang Y, Wang H, et al. YAP1 enhances cell proliferation, migration, and invasion of gastric cancer in vitro and in vivo. Oncotarget. 2016;7:81062-81076 pubmed publisher |
| Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed publisher |
| Nokin M, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, et al. Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. elife. 2016;5: pubmed publisher |
| Laquaglia M, Grijalva J, Mueller K, Perez Atayde A, Kim H, Sadri Vakili G, et al. YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma. Sci Rep. 2016;6:30238 pubmed publisher |
| Seo E, Kim W, Hur J, Kim H, Nam S, Choi A, et al. The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis. Sci Rep. 2016;6:31931 pubmed publisher |
| Poitelon Y, Lopez Anido C, Catignas K, Berti C, Palmisano M, Williamson C, et al. YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nat Neurosci. 2016;19:879-87 pubmed publisher |
| Nelson N, Clark G. Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling. Oncotarget. 2016;7:33821-31 pubmed publisher |
| Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, et al. Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. PLoS Genet. 2016;12:e1005894 pubmed publisher |
