product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Ezh2 Antibody
catalog :
4905
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, chromatin immunoprecipitation
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1f
Wang J, Cheng P, Pavlyukov M, Yu H, Zhang Z, Kim S, et al. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017;127:3075-3089 pubmed publisher
  • western blot; human; loading ...; fig 7a
Li X, Dai X, Wan L, Inuzuka H, Sun L, North B. Smurf1 regulation of DAB2IP controls cell proliferation and migration. Oncotarget. 2016;7:26057-69 pubmed publisher
  • western blot; human; fig 4
Cai L, Wang Z, Liu D. Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression. Tumour Biol. 2016;37:6359-69 pubmed publisher
  • western blot; human; fig 2
Lee S, Roh Y, Kim S, Lee J, Seol S, Lee H, et al. Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer. Clin Cancer Res. 2015;21:5391-403 pubmed publisher
  • immunoprecipitation; human
Liu C, Li S, Dai X, Ma J, Wan J, Jiang H, et al. PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex. Nucleic Acids Res. 2015;43:6270-84 pubmed publisher
  • western blot; human; fig 2c
Dai X, North B, Inuzuka H. Negative regulation of DAB2IP by Akt and SCFFbw7 pathways. Oncotarget. 2014;5:3307-15 pubmed
  • western blot; human
van der Linden M, Willekes M, van Roon E, Seslija L, Schneider P, Pieters R, et al. MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL. Cell Cycle. 2014;13:834-44 pubmed publisher
Endoh M, Endo T, Shinga J, Hayashi K, Farcas A, Ma K, et al. PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. elife. 2017;6: pubmed publisher
Ryland K, Svoboda L, Vesely E, McIntyre J, Zhang L, Martens J, et al. Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene. 2015;34:4591-600 pubmed publisher
Li Q, Wang H, Chepelev I, Zhu Q, Wei G, Zhao K, et al. Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. PLoS Genet. 2014;10:e1004524 pubmed publisher
Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell S, Doxaki C, et al. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. PLoS Pathog. 2014;10:e1004136 pubmed publisher
Ekman M, Bhattachariya A, Dahan D, Uvelius B, Albinsson S, Swärd K. Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. PLoS ONE. 2013;8:e82308 pubmed publisher
Wan X, Zhao Y, Fan X, Cai H, Zhang Y, Chen M, et al. Molecular prognostic prediction for locally advanced nasopharyngeal carcinoma by support vector machine integrated approach. PLoS ONE. 2012;7:e31989 pubmed publisher
Mandal M, Powers S, Maienschein Cline M, Bartom E, Hamel K, Kee B, et al. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat Immunol. 2011;12:1212-20 pubmed publisher
Wu S, Zhang Y. Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability. J Biol Chem. 2011;286:28511-9 pubmed publisher
Pancione M, Sabatino L, Fucci A, Carafa V, Nebbioso A, Forte N, et al. Epigenetic silencing of peroxisome proliferator-activated receptor ? is a biomarker for colorectal cancer progression and adverse patients' outcome. PLoS ONE. 2010;5:e14229 pubmed publisher
Cao P, Deng Z, Wan M, Huang W, Cramer S, Xu J, et al. MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Mol Cancer. 2010;9:108 pubmed publisher
Szulwach K, Li X, Smrt R, Li Y, Luo Y, Lin L, et al. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol. 2010;189:127-41 pubmed publisher
Kwon M, Kim S, Choi Y, Jung H, Balch C, Kim S, et al. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis. 2010;31:974-83 pubmed publisher
Wang G, Song J, Wang Z, Dormann H, Casadio F, Li H, et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 2009;459:847-51 pubmed publisher
O Hagan H, Mohammad H, Baylin S. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet. 2008;4:e1000155 pubmed publisher
product information
SKU :
4905S
Product-Name :
Ezh2 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Pg
Applications :
Chromatin Immunoprecipitation
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
98
Host :
Rabbit
Target :
EZH2
Primary-Protein :
EZH2
Alt-Names :
ENX-1,ENX1,EZH1,EZH2,Enhancer of zeste homolog 2,Histone-lysine N-methyltransferase EZH2,KMT6,KMT6A,Lysine N-methyltransferase 6,MGC9169,enhancer of zeste 2,enhancer of zeste homolog 2 (Drosophila)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.