product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Sox2 (L1D6A2) Mouse mAb
catalog :
4900
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
L1D6A2
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4b
Sun X, He Z, Guo L, Wang C, Lin C, Ye L, et al. ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer. J Exp Clin Cancer Res. 2021;40:149 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1b
Morales Garcia J, Calleja Conde J, Lopez Moreno J, Alonso Gil S, Sanz Sancristobal M, Riba J, et al. N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo. Transl Psychiatry. 2020;10:331 pubmed publisher
  • immunocytochemistry; rat; 1:100; loading ...; fig 1d
Torres Mejía E, Trumbach D, Kleeberger C, Dornseifer U, Orschmann T, Bäcker T, et al. Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis. Sci Rep. 2020;10:1984 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2a
Kon E, Calvo Jiménez E, Cossard A, Na Y, Cooper J, Jossin Y. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4a
Koch K, Hartmann R, Schröter F, Suwala A, Maciaczyk D, Krüger A, et al. Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget. 2016;7:73414-73431 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 2a
Magown P, Brownstone R, Rafuse V. Tumor prevention facilitates delayed transplant of stem cell-derived motoneurons. Ann Clin Transl Neurol. 2016;3:637-49 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 2
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed publisher
  • immunocytochemistry; mouse; 1:50; fig s4
Langer D, Martianov I, Alpern D, Rhinn M, Keime C, Dolle P, et al. Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Nat Commun. 2016;7:11063 pubmed publisher
  • western blot; human; fig 7
Ananthula S, Sinha A, El Gassim M, Batth S, Marshall G, Gardner L, et al. Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget. 2016;7:20869-89 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 1
Joseph J, van Roosmalen I, Busschers E, Tomar T, Conroy S, Eggens Meijer E, et al. Serum-Induced Differentiation of Glioblastoma Neurospheres Leads to Enhanced Migration/Invasion Capacity That Is Associated with Increased MMP9. PLoS ONE. 2015;10:e0145393 pubmed publisher
  • immunocytochemistry; human; 1:100
Costabile V, Duraturo F, Delrio P, Rega D, Pace U, Liccardo R, et al. Lithium chloride induces mesenchymal‑to‑epithelial reverting transition in primary colon cancer cell cultures. Int J Oncol. 2015;46:1913-23 pubmed publisher
  • immunohistochemistry; rat; 1:100
Hoefflin S, Carter D. Neuronal expression of SOX2 is enriched in specific hypothalamic cell groups. J Chem Neuroanat. 2014;61-62:153-60 pubmed publisher
  • western blot; human
Jia D, Yang W, Li L, Liu H, Tan Y, Ooi S, et al. β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ. 2015;22:298-310 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Ma M, Czepiel M, Krause T, Schafer K, Boddeke E, Copray S. Generation of induced pluripotent stem cells from hair follicle bulge neural crest stem cells. Cell Reprogram. 2014;16:307-13 pubmed publisher
  • immunocytochemistry; mouse
Martianov I, Cler E, Duluc I, Vicaire S, Philipps M, Freund J, et al. TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3. PLoS ONE. 2014;9:e87365 pubmed publisher
Sharma A, Cao E, Kumar V, Zhang X, Leong H, Wong A, et al. Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy. Nat Commun. 2018;9:4931 pubmed publisher
Wu C, Jiang X, Wang X, Liu X, Li X, Yang B, et al. Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. J Virol. 2018;92: pubmed publisher
Schaefer T, Wang H, Mir P, Konantz M, Pereboom T, Paczulla A, et al. Molecular and functional interactions between AKT and SOX2 in breast carcinoma. Oncotarget. 2015;6:43540-56 pubmed publisher
Velazquez F, Prucca C, Etienne O, D Astolfo D, Silvestre D, Boussin F, et al. Brain development is impaired in c-fos -/- mice. Oncotarget. 2015;6:16883-901 pubmed
Hofacer R, Deng M, Ward C, Joseph B, Hughes E, Jiang C, et al. Cell age-specific vulnerability of neurons to anesthetic toxicity. Ann Neurol. 2013;73:695-704 pubmed publisher
Wells T, Rough K, Carter D. Transcription Mapping of Embryonic Rat Brain Reveals EGR-1 Induction in SOX2 Neural Progenitor Cells. Front Mol Neurosci. 2011;4:6 pubmed publisher
product information
SKU :
4900S
Product-Name :
Sox2 (L1D6A2) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, (R, B, Dg, Hr)
Applications :
Flow cytometry
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
35
Host :
Mouse
Target :
Sox2
Primary-Protein :
SOX2
Alt-Names :
ANOP3,MCOPS3,MGC2413,SOX2,SRY (sex determining region Y)-box 2,SRY-related HMG-box gene 2,Transcription factor SOX-2,transcription factor SOX2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.