product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
NF-κB2 p100/p52 Antibody
catalog :
4882
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, chromatin immunoprecipitation, western blot knockout validation
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:500; fig s3h
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
  • western blot; human; loading ...; fig 3c
Liu J, Hideshima T, Xing L, Wang S, Zhou W, Samur M, et al. ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Sci Adv. 2021;7: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10b
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
  • western blot; mouse; loading ...; fig e7c
Lu Z, Zou J, Li S, Topper M, Tao Y, Zhang H, et al. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020;579:284-290 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, Kawakami E, Mutoh M, et al. Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity. Nat Commun. 2020;11:234 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Beug S, Cheung H, Sanda T, St Jean M, Beauregard C, Mamady H, et al. The transcription factor SP3 drives TNF-α expression in response to Smac mimetics. Sci Signal. 2019;12: pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Hakuno D, Kimura M, Ito S, Satoh J, Nakashima Y, Horie T, et al. Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction. Sci Rep. 2018;8:16749 pubmed publisher
  • western blot; human; loading ...; fig s8f
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018;361:290-295 pubmed publisher
  • western blot; mouse; loading ...; fig 4f
Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
  • western blot; mouse; fig 6c
Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher
  • western blot; mouse; loading ...; fig 1k
Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Guicciardi M, Krishnan A, Bronk S, Hirsova P, Griffith T, Gores G. Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice. Cell Death Dis. 2017;8:e2535 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Hammers D, Sleeper M, Forbes S, Coker C, Jirousek M, Zimmer M, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016;1:e90341 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s5f
Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; mouse; loading ...; fig s5d, s6d
Janowski A, Colegio O, Hornick E, McNiff J, Martin M, Badovinac V, et al. NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest. 2016;126:3917-3928 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3d
  • western blot; human; 1:1000; fig 1a
Manghera M, Ferguson Parry J, Lin R, Douville R. NF-?B and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5' Long Terminal Repeat. J Virol. 2016;90:9338-49 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Zhou Y, Xu H, Ding Y, Lu Q, Zou M, Song P. AMPK?1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget. 2016;7:53654-53667 pubmed publisher
  • western blot; mouse; fig s8
  • western blot; human; fig s2
Duran C, Lee D, Jung J, Ravi S, Pogue C, Toussaint L, et al. NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-?B pathway. Oncogenesis. 2016;5:e231 pubmed publisher
  • western blot; mouse; fig 5e
Levit Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity P, Rajewsky K, et al. Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function. J Immunol. 2016;196:2348-60 pubmed publisher
Majorini M, Manenti G, Mano M, De Cecco L, Conti A, Pinciroli P, et al. cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells. Cell Death Differ. 2018;25:2147-2164 pubmed publisher
Choi M, Maruyama T, Chun C, Park Y. Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of I?B?. Arthritis Rheumatol. 2018;70:1440-1449 pubmed publisher
Tanwar S, Dhar A, Varanasi V, Mukherjee T, Boppana R, Basak S, et al. Mediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase. Sci Rep. 2017;7:46029 pubmed publisher
Poulos M, Ramalingam P, Gutkin M, Kleppe M, Ginsberg M, Crowley M, et al. Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis. Nat Commun. 2016;7:13829 pubmed publisher
Armstrong C, Galisteo R, Brown S, Winkles J. TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion. Oncotarget. 2016;7:81474-81492 pubmed publisher
Chen X, Nie Y, Xiao H, Bian Z, Scarzello A, Song N, et al. TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis. Sci Rep. 2016;6:32834 pubmed publisher
Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed publisher
Xu J, Wang Y, Hua X, Xu J, Tian Z, Jin H, et al. Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NF?B2 (p100). Oncotarget. 2016;7:34112-30 pubmed publisher
Yadava R, Foff E, Yu Q, Gladman J, Zheng T, Mahadevan M. TWEAK Regulates Muscle Functions in a Mouse Model of RNA Toxicity. PLoS ONE. 2016;11:e0150192 pubmed publisher
Zhan Y, Wei Y, Chen P, Zhang H, Liu D, Zhang J, et al. Expression, purification and biological characterization of the extracellular domain of CD40 from Pichia pastoris. BMC Biotechnol. 2016;16:8 pubmed publisher
Wang Y, Xu J, Gao G, Li J, Huang H, Jin H, et al. Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. Oncogene. 2016;35:4080-90 pubmed publisher
product information
SKU :
4882P
Product-Name :
NF-κB2 p100/p52 Antibody
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
52 (mature). 120 (precursor).
Host :
Rabbit
Target :
NFkB2 p100/p52
Primary-Protein :
NFkB-p100
Alt-Names :
DNA-binding factor KBF2,H2TF1,LYT-10,LYT10,Lymphocyte translocation chromosome 10 protein,NFKB2,Nuclear factor NF-kappa-B p100 subunit,Nuclear factor NF-kappa-B p52 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2,Oncogene Lyt-10,nuclear factor of kappa light chain gene enhancer in B-cells 2,nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100),p52
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.