product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
HSP90 (C45G5) Rabbit mAb
catalog :
4877
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C45G5
reactivity :
human, mouse, rat, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 65
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 4a
Lee Y, Gil E, Jeong I, Kim H, Jang J, Choung Y. Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress. Cells. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3s1-2
Shani O, Raz Y, Monteran L, Scharff Y, Levi Galibov O, Megides O, et al. Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. elife. 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
  • western blot; human; loading ...; fig 3a
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Alajati A, D Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, et al. CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo. J Clin Invest. 2020;130:2435-2450 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8a
Stavoe A, Gopal P, Gubas A, Tooze S, Holzbaur E. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. elife. 2019;8: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s16b
Chaves Pérez A, Yilmaz M, Perna C, de la Rosa S, Djouder N. URI is required to maintain intestinal architecture during ionizing radiation. Science. 2019;364: pubmed publisher
  • western blot; human; loading ...; fig 3e
Jeppesen D, Fenix A, Franklin J, Higginbotham J, Zhang Q, Zimmerman L, et al. Reassessment of Exosome Composition. Cell. 2019;177:428-445.e18 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig s8e
Castel P, Cheng A, Cuevas Navarro A, Everman D, Papageorge A, Simanshu D, et al. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019;363:1226-1230 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4h
Mollaoglu G, Jones A, Wait S, Mukhopadhyay A, Jeong S, Arya R, et al. The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity. 2018;49:764-779.e9 pubmed publisher
  • western blot; mouse; fig 5b
Albrengues J, Shields M, Ng D, Park C, Ambrico A, Poindexter M, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018;361: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1d
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s1d
Huang W, Lin S, Chen H, Chen Y, Chen T, Hsu K, et al. NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation. J Neuroinflammation. 2018;15:140 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Zhang Z, Zi Z, Lee E, Zhao J, Contreras D, South A, et al. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018;24:617-627 pubmed publisher
  • western blot; mouse; 1:1000; fig 2a
Mo Z, Zhao X, Liu H, Hu Q, Chen X, Pham J, et al. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018;9:1007 pubmed publisher
  • western blot; human; loading ...; fig 8d
Taylor J, Cash M, Santostefano K, Nakanishi M, Terada N, Wallet M. CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. J Leukoc Biol. 2018;: pubmed publisher
  • western blot; human; fig 5f
Janes M, Zhang J, Li L, Hansen R, Peters U, Guo X, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018;172:578-589.e17 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, et al. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proc Natl Acad Sci U S A. 2017;114:10737-10742 pubmed publisher
  • western blot; human; 1:1000; fig s7a
Olivares O, Mayers J, Gouirand V, Torrence M, Gicquel T, Borge L, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017;8:16031 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Tan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s5
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, et al. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017;216:2059-2074 pubmed publisher
  • western blot; mouse; fig s2f
Lim J, Ibaseta A, Fischer M, Cancilla B, O Young G, Cristea S, et al. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature. 2017;545:360-364 pubmed publisher
  • western blot; human; loading ...; fig 2c
Zhang X, Spiegelman N, Nelson O, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. elife. 2017;6: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3-s1d
Walker L, Summers D, Sasaki Y, Brace E, Milbrandt J, DiAntonio A. MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2. elife. 2017;6: pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Araujo L, Khim P, Mkhikian H, Mortales C, Demetriou M. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. elife. 2017;6: pubmed publisher
  • western blot; human; fig 6a
Wu L, Zhou B, Oshiro Rapley N, Li M, Paulo J, Webster C, et al. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell. 2016;167:1705-1718.e13 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Wada S, Neinast M, Jang C, Ibrahim Y, Lee G, Babu A, et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 2016;30:2551-2564 pubmed
  • western blot; human; loading ...; fig s2
Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher
  • western blot; human; fig 5
Kim H, Choi M, Inn K, Kim B. Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner. Sci Rep. 2016;6:28896 pubmed publisher
  • western blot; human; loading ...; fig 1a
Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, et al. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget. 2016;7:45414-45428 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:4000; fig st1
  • western blot; human; fig 4
Kaur A, Webster M, Marchbank K, Behera R, Ndoye A, Kugel C, et al. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016;532:250-4 pubmed publisher
  • western blot; pigs ; 1:1000; fig 1
Ganesan S, Reynolds C, Hollinger K, Pearce S, Gabler N, Baumgard L, et al. Twelve hours of heat stress induces inflammatory signaling in porcine skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1288-96 pubmed publisher
  • western blot; human; 1:1000
Liu X, Xiao Z, Han L, Zhang J, Lee S, Wang W, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18:431-42 pubmed publisher
  • western blot; human; 1:1000; fig 7
Scheckel C, Drapeau E, Frias M, Park C, Fak J, Zucker Scharff I, et al. Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. elife. 2016;5: pubmed publisher
  • western blot; human; fig s1b
Belian E, Noseda M, Abreu Paiva M, Leja T, Sampson R, Schneider M. Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. PLoS ONE. 2015;10:e0125384 pubmed publisher
  • western blot; human; fig s4
Min K, Liggett J, Silva G, Wu W, Wang R, Shen R, et al. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Oncogene. 2016;35:377-88 pubmed publisher
  • western blot; human; fig 5
Hirakawa H, Fujisawa H, Masaoka A, Noguchi M, Hirayama R, Takahashi M, et al. The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells. Cancer Med. 2015;4:426-36 pubmed publisher
  • western blot; human; fig 5
Baraz R, Cisterne A, Saunders P, Hewson J, Thien M, Weiss J, et al. mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death. PLoS ONE. 2014;9:e102494 pubmed publisher
  • western blot; human
Trinh A, Kim S, Chang H, Mastrocola A, Tibbetts R. Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. J Biol Chem. 2013;288:23765-75 pubmed publisher
Kremer D, Nelson B, Lin L, Yarosz E, Halbrook C, Kerk S, et al. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun. 2021;12:4860 pubmed publisher
Lee Y, Ho S, Graves J, Xiao Y, Huang S, Lin W. CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019;21:134 pubmed publisher
Greenberg R, Long H, Swigut T, Wysocka J. Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome. Cell. 2019;178:1421-1436.e24 pubmed publisher
Rigogliuso G, Biniossek M, Goodier J, Mayer B, Pereira G, Schilling O, et al. A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins. Mob DNA. 2019;10:36 pubmed publisher
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher
Sun Y, Bandi M, Lofton T, Smith M, Bristow C, Carugo A, et al. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019;26:469-482.e5 pubmed publisher
Salvatierra J, Diaz Bustamante M, Meixiong J, Tierney E, Dong X, Bosmans F. A disease mutation reveals a role for NaV1.9 in acute itch. J Clin Invest. 2018;128:5434-5447 pubmed publisher
Yien Y, Shi J, Chen C, Cheung J, Grillo A, Shrestha R, et al. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018;293:19797-19811 pubmed publisher
López Erauskin J, Tadokoro T, Baughn M, Myers B, McAlonis Downes M, Chillon Marinas C, et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018;100:816-830.e7 pubmed publisher
Kalogeropulou A, Zhao J, Bolliger M, Memou A, Narasimha S, Molitor T, et al. P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Biochem J. 2018;475:1271-1293 pubmed publisher
Krysiak J, Unger A, Beckendorf L, Hamdani N, von Frieling Salewsky M, Redfield M, et al. Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. Nat Commun. 2018;9:262 pubmed publisher
Liu N, Lee C, Swigut T, Grow E, Gu B, Bassik M, et al. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Nature. 2017;: pubmed publisher
Gomes L, Menck C, Cuervo A. Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy. 2017;13:928-940 pubmed publisher
Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
Ditsworth D, Maldonado M, McAlonis Downes M, Sun S, Seelman A, Drenner K, et al. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017;133:907-922 pubmed publisher
Uo T, Dvinge H, Sprenger C, Bradley R, Nelson P, Plymate S. Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain. Oncogene. 2017;36:1440-1450 pubmed publisher
Grandl G, Müller S, Moest H, Moser C, Wollscheid B, Wolfrum C. Depot specific differences in the adipogenic potential of precursors are mediated by collagenous extracellular matrix and Flotillin 2 dependent signaling. Mol Metab. 2016;5:937-947 pubmed publisher
Hsieh J, Koseki M, Molusky M, Yakushiji E, Ichi I, Westerterp M, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016;535:303-7 pubmed publisher
Liang H, Esposito A, De S, Ber S, Collin P, Surana U, et al. Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing. Nat Commun. 2014;5:4048 pubmed publisher
Kim H, Abd Elmageed Z, Davis C, El Bahrawy A, Naura A, Ekaidi I, et al. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37. Mol Med. 2014;20:270-9 pubmed publisher
Chaudhury A, Kongchan N, Gengler J, Mohanty V, Christiansen A, Fachini J, et al. A piggyBac-based reporter system for scalable in vitro and in vivo analysis of 3' untranslated region-mediated gene regulation. Nucleic Acids Res. 2014;42:e86 pubmed publisher
Colin S, Darne B, Kadi A, Ferry A, Favier M, Lesaffre C, et al. The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3?-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients. J Pharmacol Exp Ther. 2014;349:107-17 pubmed publisher
Gerdts J, Summers D, Sasaki Y, DiAntonio A, Milbrandt J. Sarm1-mediated axon degeneration requires both SAM and TIR interactions. J Neurosci. 2013;33:13569-80 pubmed publisher
Sundin T, Peffley D, Hentosh P. Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. Mol Cell Biochem. 2013;375:97-104 pubmed publisher
Liu X, Ko S, Xu Y, Fattah E, Xiang Q, Jagannath C, et al. Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem. 2012;287:19687-98 pubmed publisher
Venkataramani V, Thiele K, Behnes C, Wulf G, Thelen P, Opitz L, et al. Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells. Am J Pathol. 2012;180:1636-52 pubmed publisher
product information
SKU :
4877S
Product-Name :
HSP90 (C45G5) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, (B)
Applications :
Flow cytometry
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
90
Host :
Rabbit
Target :
HSP90A/HSP90B
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.