| Published Application/Species/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; mouse; fig 6
- western blot; mouse; fig 3
| Ren S, Luo Y, Chen H, Warburton D, Lam H, Wang L, et al. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016;186:3261-3272 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield P, et al. Neuronal human BACE1 knockin induces systemic diabetes in mice. Diabetologia. 2016;59:1513-23 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 5
| Pan D, Jiang C, Ma Z, Blonska M, You M, Lin X. MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression. Oncogene. 2016;35:919-28 pubmed publisher |
- western blot; mouse; fig 1
| Cherepkova M, Sineva G, Pospelov V. Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway. Cell Death Dis. 2016;7:e2050 pubmed publisher |
- western blot; human; 1:200; fig 4
| Du R, Liu Z, Hou X, Fu G, An N, Wang L. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. Mol Med Rep. 2016;13:5045-52 pubmed publisher |
- western blot; human; fig 2
| Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher |
- immunohistochemistry; mouse; fig 3c
| Nakazawa M, Eisinger-Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher |
- immunocytochemistry; rat; fig 6
- western blot; rat; fig 6
| Ren J, Li J, Liu X, Feng Y, Gui Y, Yang J, et al. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling. Sci Rep. 2016;6:23968 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:400; fig 4
| Hakim S, Dyson J, Feeney S, Davies E, Sriratana A, Koenig M, et al. Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 2016;: pubmed |
- immunohistochemistry - frozen section; mouse; fig 1
- western blot; mouse; 1:1000; fig 1
| Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151 pubmed publisher |
- flow cytometry; mouse; fig 5
| Apostolidis S, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed publisher |
- western blot; mouse; 1:2000; fig 7
| Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed publisher |
| Rao E, Zhang Y, Zhu G, Hao J, Persson X, Egilmez N, et al. Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death. Oncotarget. 2015;6:7944-58 pubmed |
- western blot; mouse; fig 5
| Nikonova A, Deneka A, Eckman L, Kopp M, Hensley H, Egleston B, et al. Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease. Front Oncol. 2015;5:228 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:50
| Chandler R, Damrauer J, Raab J, Schisler J, Wilkerson M, Didion J, et al. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun. 2015;6:6118 pubmed publisher |
| Isoyama S, Kajiwara G, Tamaki N, Okamura M, Yoshimi H, Nakamura N, et al. Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474. Cancer Sci. 2015;106:171-8 pubmed publisher |
| Maliqueo M, Sundstrom Poromaa I, Vanky E, Fornes R, Benrick A, Akerud H, et al. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692-700 pubmed publisher |
- western blot; human; fig s2
| Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed publisher |
- western blot; mouse; 1:6000; fig 3
| Li S, TANG J, Chen J, Zhang P, Wang T, Chen T, et al. Regulation of bone formation by baicalein via the mTORC1 pathway. Drug Des Devel Ther. 2015;9:5169-83 pubmed publisher |
- western blot; mouse; fig 7d
| Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher |
| Williams J, Ni H, Haynes A, Manley S, Li Y, Jaeschke H, et al. Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice. J Biol Chem. 2015;290:10934-46 pubmed publisher |
- western blot; human; 1:1000; fig 2e,4c,7c
| Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61 pubmed publisher |
- western blot; human; 1:2000
| López de Figueroa P, Lotz M, Blanco F, Caramés B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67:966-76 pubmed publisher |
- western blot; mouse; fig 6
| Feng D, Youn D, Zhao X, Gao Y, Quinn W, Xiaoli A, et al. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS ONE. 2015;10:e0126240 pubmed publisher |
- western blot; mouse; fig 2
| Boj S, Hwang C, Baker L, Chio I, Engle D, Corbo V, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160:324-38 pubmed publisher |
- western blot; human; fig 4a
| Li X, Cui P, Jiang H, Guo Y, Pishdari B, Hu M, et al. Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action. Am J Transl Res. 2015;7:574-86 pubmed |
- western blot; mouse; 1:1000; fig s2
| Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen P, Viero G, et al. eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. Nat Commun. 2015;6:8261 pubmed publisher |
- western blot; mouse; 1:2000
| Dahlhoff M, Schafer M, Muzumdar S, Rose C, Schneider M. ERBB3 is required for tumor promotion in a mouse model of skin carcinogenesis. Mol Oncol. 2015;9:1825-33 pubmed publisher |
- western blot; human; fig 4
| Wang J, Ma L, Tang X, Zhang X, Qiao Y, Shi Y, et al. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. 2015;6:24075-91 pubmed |
- western blot; mouse; 1:1000
| Smithline Z, Nikonova A, Hensley H, Cai K, Egleston B, Proia D, et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS ONE. 2014;9:e114403 pubmed publisher |
| Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, et al. VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res. 2014;16:R53 pubmed publisher |
- western blot; mouse; 1:1000
| Barns M, Gondro C, Tellam R, Radley-Crabb H, Grounds M, Shavlakadze T. Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice. Int J Biochem Cell Biol. 2014;53:174-85 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 1
| Furgason J, Li W, Milholland B, Cross E, Li Y, McPherson C, et al. Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation. Mutagenesis. 2014;29:341-50 pubmed publisher |
- western blot; mouse; fig 7
| Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-33 pubmed publisher |
| McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization. Eur J Immunol. 2014;44:1137-42 pubmed publisher |
| Andre F, O'Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G, et al. Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 2014;15:580-91 pubmed publisher |
| Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed publisher |
| Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli R, et al. Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res. 2010;13:571-9 pubmed publisher |
| Engelman J, Chen L, Tan X, Crosby K, Guimaraes A, Upadhyay R, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008;14:1351-6 pubmed |
| Thomé C, Dos Santos G, Ferreira G, Scheucher P, Izumi C, Leopoldino A, et al. Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity. Mol Cell Proteomics. 2012;11:1898-912 pubmed publisher |
