| Published Application/Species/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; fig s3
| Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 2
| Nunez O, Roman A, Johnson S, Inoue Y, Hirose M, Casanova A, et al. Study of breast cancer incidence in patients of lymphangioleiomyomatosis. Breast Cancer Res Treat. 2016;156:195-201 pubmed publisher |
| Perera Y, Pedroso S, Borras-Hidalgo O, Vázquez D, Miranda J, Villareal A, et al. Pharmacologic inhibition of the CK2-mediated phosphorylation of B23/NPM in cancer cells selectively modulates genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis. Mol Cell Biochem. 2015;404:103-12 pubmed publisher |
| Roffe M, Lupinacci F, Soares L, Hajj G, Martins V. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015;27:1630-42 pubmed publisher |
- western blot; human; fig 4
| Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed |
- western blot; human; 1:1000
| Kato H, Izumi K, Uenoyama A, Shiomi A, Kuo S, Feinberg S. Hypoxia induces an undifferentiated phenotype of oral keratinocytes in vitro. Cells Tissues Organs. 2014;199:393-404 pubmed publisher |
| Lu J, Zavorotinskaya T, Dai Y, Niu X, Castillo J, Sim J, et al. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood. 2013;122:1610-20 pubmed publisher |
| Sahin K, Cross B, Sahin N, Ciccone K, Suleiman S, Osunkoya A, et al. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch Biochem Biophys. 2015;572:36-9 pubmed publisher |
| Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N. The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells. Mol Cell Endocrinol. 2015;399:1-8 pubmed publisher |
| Rojo F, Domingo L, Sala M, Zazo S, Chamizo C, Menendez S, et al. Gene expression profiling in true interval breast cancer reveals overactivation of the mTOR signaling pathway. Cancer Epidemiol Biomarkers Prev. 2014;23:288-99 pubmed publisher |
| Vinnikov I, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth L, et al. Hypothalamic miR-103 protects from hyperphagic obesity in mice. J Neurosci. 2014;34:10659-74 pubmed publisher |
| Ferrer I, Mohan P, Chen H, Castellsagué J, Gómez-Baldó L, Carmona M, et al. Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling. J Pathol. 2014;233:247-57 pubmed publisher |
| Abid S, Richardson T, Powell H, Jaichander P, Chaudhary J, Chapman K, et al. A-single spermatogonia heterogeneity and cell cycles synchronize with rat seminiferous epithelium stages VIII-IX. Biol Reprod. 2014;90:32 pubmed publisher |
| Papadakis M, Hadley G, Xilouri M, Hoyte L, Nagel S, McMenamin M, et al. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med. 2013;19:351-7 pubmed publisher |
| Degen M, Barron P, Natarajan E, Widlund H, Rheinwald J. RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma. PLoS ONE. 2013;8:e78979 pubmed publisher |
| van Vliet E, Forte G, Holtman L, den Burger J, Sinjewel A, de Vries H, et al. Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia. 2012;53:1254-63 pubmed publisher |
| Syed F, Sherris D, Paus R, Varmeh S, Singh S, Pandolfi P, et al. Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor. Am J Pathol. 2012;181:1642-58 pubmed publisher |
| Mercier I, Camacho J, Titchen K, Gonzales D, Quann K, Bryant K, et al. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol. 2012;181:278-93 pubmed publisher |
| Degen M, Natarajan E, Barron P, Widlund H, Rheinwald J. MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin γ2 expression in oral dysplasia and squamous cell carcinoma. Am J Pathol. 2012;180:2462-78 pubmed publisher |
| Yoon D, Ryu M, Park Y, Lee H, Lee C, Ryoo B, et al. Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum. Br J Cancer. 2012;106:1039-44 pubmed publisher |
| Benedettini E, Sholl L, Peyton M, Reilly J, Ware C, Davis L, et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010;177:415-23 pubmed publisher |
| Goto J, Talos D, Klein P, Qin W, Chekaluk Y, Anderl S, et al. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011;108:E1070-9 pubmed publisher |
