| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; fig s5d
| Hamm M, Sohier P, Petit V, Raymond J, Delmas V, Le Coz M, et al. BRN2 is a non-canonical melanoma tumor-suppressor. Nat Commun. 2021;12:3707 pubmed publisher |
- immunohistochemistry; human; 1:200; loading ...; fig s1e
| Zimmer T, Broekaart D, Luinenburg M, Mijnsbergen C, Anink J, Sim N, et al. Balloon cells promote immune system activation in focal cortical dysplasia type 2b. Neuropathol Appl Neurobiol. 2021;47:826-839 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Korotkov A, Sim N, Luinenburg M, Anink J, van Scheppingen J, Zimmer T, et al. MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis. Neuropathol Appl Neurobiol. 2021;47:796-811 pubmed publisher |
- western blot; mouse; 1:1000; loading ...
| Alajati A, D Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, et al. CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo. J Clin Invest. 2020;130:2435-2450 pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:75; loading ...; fig s1d
| Inoue T, Kokubo T, Daino K, Yanagihara H, Watanabe F, Tsuruoka C, et al. Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation-associated renal tumors in Eker rats. Cancer Sci. 2020;111:840-848 pubmed publisher |
- western blot; human; loading ...
| Debruyne D, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. 2019;572:676-680 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| García Aguirre I, Alamillo Iniesta A, Rodríguez Pérez R, Vélez Aguilera G, Amaro Encarnación E, Jiménez Gutiérrez E, et al. Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity. Aging Cell. 2019;18:e13002 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Ip W, Hoshi N, Shouval D, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513-519 pubmed publisher |
- western blot; mouse; loading ...; fig 2e
| Gopinath S. Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor. Skelet Muscle. 2017;7:2 pubmed publisher |
- western blot; rat; loading ...; fig 2b
- western blot; mouse; loading ...; fig 2a
| Jin F, Jiang K, Ji S, Wang L, Ni Z, Huang F, et al. Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex. Hum Mol Genet. 2017;26:407-419 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
| Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 5a
- western blot; human; 1:1000; loading ...; fig 5b
| Wang S, Jiang L, Han Y, Chew S, Ohara Y, Akatsuka S, et al. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016;7:69565-69578 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Pan H, Zhong X, Lee S. Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. BMC Biochem. 2016;17:14 pubmed publisher |
- western blot; mouse; 1:1000; fig s3
| Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Xu K, Wang L, Feng W, Feng Y, Shu H. Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase. Oncogene. 2016;35:5807-5816 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 2
| Nuñez O, Román A, Johnson S, Inoue Y, Hirose M, Casanova Ã, et al. Study of breast cancer incidence in patients of lymphangioleiomyomatosis. Breast Cancer Res Treat. 2016;156:195-201 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1
| Jhaveri K, Teplinsky E, Silvera D, Valeta Magara A, Arju R, Giashuddin S, et al. Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy. Clin Breast Cancer. 2016;16:113-22.e1 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6
| Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed publisher |
- immunohistochemistry; human; fig 5
| Ruiz de Garibay G, Herranz C, Llorente A, Boni J, Serra Musach J, Mateo F, et al. Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness. PLoS ONE. 2015;10:e0132546 pubmed publisher |
| Roffé M, Lupinacci F, Soares L, Hajj G, Martins V. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015;27:1630-42 pubmed publisher |
| Perera Y, Pedroso S, Borras Hidalgo O, Vázquez D, Miranda J, Villareal A, et al. Pharmacologic inhibition of the CK2-mediated phosphorylation of B23/NPM in cancer cells selectively modulates genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis. Mol Cell Biochem. 2015;404:103-12 pubmed publisher |
- western blot; human; 1:1000
| Kato H, Izumi K, Uenoyama A, Shiomi A, Kuo S, Feinberg S. Hypoxia induces an undifferentiated phenotype of oral keratinocytes in vitro. Cells Tissues Organs. 2014;199:393-404 pubmed publisher |
- western blot; human; fig 4
| Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed |
| Lu J, Zavorotinskaya T, Dai Y, Niu X, Castillo J, Sim J, et al. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood. 2013;122:1610-20 pubmed publisher |
| Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, et al. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017;95:817-833.e4 pubmed publisher |
| Sahin K, Cross B, Sahin N, Ciccone K, Suleiman S, Osunkoya A, et al. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch Biochem Biophys. 2015;572:36-9 pubmed publisher |
| Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N. The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells. Mol Cell Endocrinol. 2015;399:1-8 pubmed publisher |
| Vinnikov I, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth L, et al. Hypothalamic miR-103 protects from hyperphagic obesity in mice. J Neurosci. 2014;34:10659-74 pubmed publisher |
| Ferrer I, Mohan P, Chen H, Castellsagué J, Gómez Baldó L, Carmona M, et al. Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling. J Pathol. 2014;233:247-57 pubmed publisher |
| Abid S, Richardson T, Powell H, Jaichander P, Chaudhary J, Chapman K, et al. A-single spermatogonia heterogeneity and cell cycles synchronize with rat seminiferous epithelium stages VIII-IX. Biol Reprod. 2014;90:32 pubmed publisher |
| Rojo F, Domingo L, Sala M, Zazo S, Chamizo C, Menendez S, et al. Gene expression profiling in true interval breast cancer reveals overactivation of the mTOR signaling pathway. Cancer Epidemiol Biomarkers Prev. 2014;23:288-99 pubmed publisher |
| Degen M, Barron P, Natarajan E, Widlund H, Rheinwald J. RSK activation of translation factor eIF4B drives abnormal increases of laminin ?2 and MYC protein during neoplastic progression to squamous cell carcinoma. PLoS ONE. 2013;8:e78979 pubmed publisher |
| Papadakis M, Hadley G, Xilouri M, Hoyte L, Nagel S, McMenamin M, et al. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med. 2013;19:351-7 pubmed publisher |
| Syed F, Sherris D, Paus R, Varmeh S, Singh S, Pandolfi P, et al. Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor. Am J Pathol. 2012;181:1642-58 pubmed publisher |
| Mercier I, Camacho J, Titchen K, Gonzales D, Quann K, Bryant K, et al. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol. 2012;181:278-93 pubmed publisher |
| van Vliet E, Forte G, Holtman L, den Burger J, Sinjewel A, de Vries H, et al. Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia. 2012;53:1254-63 pubmed publisher |
| Degen M, Natarajan E, Barron P, Widlund H, Rheinwald J. MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin ?2 expression in oral dysplasia and squamous cell carcinoma. Am J Pathol. 2012;180:2462-78 pubmed publisher |
| Yoon D, Ryu M, Park Y, Lee H, Lee C, Ryoo B, et al. Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum. Br J Cancer. 2012;106:1039-44 pubmed publisher |
| Goto J, Talos D, Klein P, Qin W, Chekaluk Y, Anderl S, et al. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011;108:E1070-9 pubmed publisher |
| Benedettini E, Sholl L, Peyton M, Reilly J, Ware C, Davis L, et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010;177:415-23 pubmed publisher |
