product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PHD-2/Egln1 (D31E11) Rabbit mAb
catalog :
4835
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D31E11
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; fig s10a
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2j
Li L, Kang H, Zhang Q, D Agati V, Al Awqati Q, Lin F. FoxO3 activation in hypoxic tubules prevents chronic kidney disease. J Clin Invest. 2019;129:2374-2389 pubmed publisher
  • western blot; mouse; fig 3a
Zheng X, Zhai B, Koivunen P, Shin S, Lu G, Liu J, et al. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014;28:1429-44 pubmed publisher
  • western blot; mouse; 1:1000
Cheng S, Xing W, Pourteymoor S, Mohan S. Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development. J Bone Miner Res. 2014;29:2276-86 pubmed publisher
Lee G, Won H, Lee Y, Choi J, Oh T, Jang J, et al. Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation. Sci Rep. 2016;6:18928 pubmed publisher
Tadakawa M, Takeda T, Li B, Tsuiji K, Yaegashi N. The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells. Mol Cell Endocrinol. 2015;399:1-8 pubmed publisher
Song D, Li L, Arsenault P, Tan Q, Bigham A, Heaton Johnson K, et al. Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing. J Biol Chem. 2014;289:14656-65 pubmed publisher
Zhdanov A, Dmitriev R, Papkovsky D. Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. Biosci Rep. 2012;32:587-95 pubmed publisher
Koivunen P, Lee S, Duncan C, Lopez G, Lu G, Ramkissoon S, et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012;483:484-8 pubmed publisher
product information
SKU :
4835S
Product-Name :
PHD-2/Egln1 (D31E11) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
50
Host :
Rabbit
Target :
PHD-2 (Egln1)
Primary-Protein :
EGLN1
Alt-Names :
C1orf12,DKFZp761F179,ECYT3,EGLN1,Egl nine homolog 1,HIF prolyl hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HIFPH2,HPH-2,HPH2,Hypoxia-inducible factor prolyl hydroxylase 2,PHD2,Prolyl hydroxylase domain-containing protein 2,SM-20,SM20,ZMYND6,egl nine homolog 1 (C. elegans),egl nine-like protein 1,zinc finger MYND domain-containing protein 6
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.