IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) | Cell Signaling Technology 4814 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen)

catalog :

4814

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L35A5

reactivity :

human, mouse, rat, bovine, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Cell Signaling Technology product webpage

citations: 212

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:5000; loading ...; fig 2g	Sato K, Sato T, Ohno Oishi M, Ozawa M, Maekawa S, Shiga Y, et al. CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice. Exp Eye Res. 2021;213:108826 pubmed publisher
western blot; mouse; fig 5i	Ma S, Xu H, Huang W, Gao Y, Zhou H, Li X, et al. Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation. Front Physiol. 2021;12:706359 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5a	Wang X, Yung M, Sharma R, Chen F, Poon Y, Lam W, et al. Epigenetic Silencing of miR-33b Promotes Peritoneal Metastases of Ovarian Cancer by Modulating the TAK1/FASN/CPT1A/NF-κB Axis. Cancers (Basel). 2021;13: pubmed publisher
western blot; human; fig s3-1n	Jeong D, Kim H, Kim H, Kang M, Jung H, Oh Y, et al. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. elife. 2021;10: pubmed publisher
western blot; rat; loading ...; fig 3c	Wu Y, Zhang J, Li C, Hu H, Qin B, Wang T, et al. The Activation of ROS/NF-κB/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition. Oxid Med Cell Longev. 2021;2021:8836355 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4c	Frottin F, Pérez Berlanga M, Hartl F, Hipp M. Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model. elife. 2021;10: pubmed publisher
western blot; human; loading ...; fig 7g	Zhang X, Song L, Li L, Zhu B, Huo L, Hu Z, et al. Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy. Signal Transduct Target Ther. 2021;6:235 pubmed publisher
western blot; human; loading ...; fig 5c	Huang S, Luo W, Wu G, Shen Q, Zhuang Z, Yang D, et al. Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells. Aging (Albany NY). 2021;13:14892-14909 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 6b	Zhang F, Wang Y, Liu P, Di P, Li M, Wang C. Puerarin exhibits antiinflammatory properties in gunpowder smog-induced acute lung injury in rats via regulation of the renin-angiotensin system and the NFκB signaling pathway. Exp Ther Med. 2021;22:809 pubmed publisher
western blot; human; loading ...; fig 1a, 4g, 7f western blot; mouse; fig 6a	Chen S, Liu H, Li Z, Tang J, Huang B, Zhi F, et al. Epithelial PBLD attenuates intestinal inflammatory response and improves intestinal barrier function by inhibiting NF-κB signaling. Cell Death Dis. 2021;12:563 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1a	Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
western blot; human; 1:1000; loading ...; fig 4f	Teufel S, Köckemann P, Fabritius C, Wolff L, Bertrand J, Pap T, et al. Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. Cell Death Dis. 2021;12:494 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s10b	Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 7p	Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, et al. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biol. 2021;43:101979 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1b	Huang H, Li N, Li D, Jing D, Liu Z, Xu X, et al. Autophagy Promotes Cigarette Smoke-Initiated and Elastin-Driven Bronchitis-Like Airway Inflammation in Mice. Front Immunol. 2021;12:594330 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2b western blot; mouse; 1:1000; loading ...; fig 2a	Li Q, Xu Q, Tan J, Hu L, Ge C, Xu M. Carminic acid supplementation protects against fructose-induced kidney injury mainly through suppressing inflammation and oxidative stress via improving Nrf-2 signaling. Aging (Albany NY). 2021;13:10326-10353 pubmed publisher
western blot; human; 1:2000	Lopacinski A, Sweatt A, Smolko C, Gray Gaillard E, Borgman C, Shah M, et al. Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Cell Syst. 2021;12:304-323.e13 pubmed publisher
western blot; mouse; loading ...; fig s4a	Li X, Zhang M, Huang X, Liang W, Li G, Lu X, et al. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. 2020;11:6364 pubmed publisher
western blot; mouse; loading ...; fig 5c	Hu Q, Lu Y, Hu F, He S, Xu X, Niu Y, et al. Resistant dextrin reduces obesity and attenuates adipose tissue inflammation in high-fat diet-fed mice. Int J Med Sci. 2020;17:2611-2621 pubmed publisher
western blot; human; 1:1000; loading ...; fig 1a	Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, et al. HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma. Theranostics. 2020;10:10434-10447 pubmed publisher
western blot; mouse; loading ...; fig 8c	Xiong L, Zhao K, Cao Y, Guo H, Pan J, Yang X, et al. Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency. PLoS Biol. 2020;18:e3000731 pubmed publisher
western blot; rat; 1:500; loading ...; fig 1h	Chen J, Zhang M, Zhang S, Wu J, Xue S. Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-κB pathway and targeting SIRT1. BMC Cardiovasc Disord. 2020;20:240 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4b, s12b	von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 5a	Yan S, Ding H, Peng J, Wang X, Pang C, Wei J, et al. Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro. Biosci Rep. 2020;40: pubmed publisher
western blot; human; fig s1a	Chen M, Zhao Z, Meng Q, Liang P, Su Z, Wu Y, et al. TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy. Adv Sci (Weinh). 2020;7:1901261 pubmed publisher
western blot; human; loading ...; fig 2a	Jobin P, Solis N, Machado Y, Bell P, Rai S, Kwon N, et al. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage. J Biol Chem. 2020;295:2186-2202 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s3b, s4e	Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
western blot; human; loading ...; fig 2a	Gehring T, Erdmann T, Rahm M, Graß C, Flatley A, O Neill T, et al. MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Cell Rep. 2019;29:873-888.e10 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3b	Jin Y, Li Y, Wang X, Yang Y. Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways. Cancer Cell Int. 2019;19:220 pubmed publisher
western blot; human; loading ...; fig 2b	Yang M, Chen P, Liu J, Zhu S, Kroemer G, Klionsky D, et al. Clockophagy is a novel selective autophagy process favoring ferroptosis. Sci Adv. 2019;5:eaaw2238 pubmed publisher
western blot; human; loading ...; fig 2a	Jobin P, Solis N, Machado Y, Bell P, Kwon N, Kim S, et al. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. J Biol Chem. 2019;294:12866-12879 pubmed publisher
western blot; human; loading ...; fig 6a, 6b	Tordjman J, Majumder M, Amiri M, Hasan A, Hess D, Lala P. Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells. BMC Cancer. 2019;19:561 pubmed publisher
western blot; mouse; loading ...; fig 5g	Liu Y, Li R, Chen X, Zhi Y, Deng R, Zhou E, et al. Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway. MBio. 2019;10: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6c	Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, et al. Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. Nat Commun. 2019;10:1801 pubmed publisher
western blot; human; loading ...; fig 3a	Oda H, Beck D, Kuehn H, Sampaio Moura N, Hoffmann P, Ibarra M, et al. Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC. Front Immunol. 2019;10:479 pubmed publisher
western blot; human; loading ...; fig e3d, e5f	Liu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisher
western blot; human; loading ...; fig 3d	Vickman R, Yang J, Lanman N, Cresswell G, Zheng F, Zhang C, et al. Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer. Mol Cancer Res. 2019;17:1253-1263 pubmed publisher
western blot; human; loading ...; fig 4j	Liu P, Shah R, Li Y, Arora A, Ung P, Raman R, et al. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol. 2019;21:203-213 pubmed publisher
western blot; mouse; loading ...; fig 4b	Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
western blot; mouse; loading ...; fig 1f	Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
western blot; human; fig 2c	Xiao N, Li H, Yu W, Gu C, Fang H, Peng Y, et al. SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation. FASEB J. 2019;33:163-174 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2b	Seeholzer T, Kurz S, Schlauderer F, Woods S, Gehring T, Widmann S, et al. BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Front Immunol. 2018;9:2695 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3g	Zhang X, Zhang M, Wang C. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Biochem Biophys Res Commun. 2018;506:137-144 pubmed publisher
western blot; human; 1:1000; loading ...	Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2h	Polivka L, Hadj Rabia S, Bal E, Leclerc Mercier S, Madrange M, Hamel Y, et al. Epithelial barrier dysfunction in Desmoglein-1 deficiency. J Allergy Clin Immunol. 2018;: pubmed publisher
western blot; mouse; loading ...; fig 6h	Xi J, Huang Q, Wang L, Ma X, Deng Q, Kumar M, et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018;37:3151-3165 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6c	Liu F, Dai M, Xu Q, Zhu X, Zhou Y, Jiang S, et al. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis. Oncogene. 2018;37:2394-2409 pubmed publisher
western blot; human; loading ...; fig 3b	Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, et al. MAVS activates TBK1 and IKK? through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017;13:e1006720 pubmed publisher
western blot; human; fig 1c	Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher
western blot; human; 1:1000; loading ...; fig s13b	Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, et al. The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nat Commun. 2017;8:15426 pubmed publisher
western blot; human; loading ...; fig 3d	Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher
western blot; human; loading ...; fig 2b	Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-ÎºB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
western blot; human; loading ...; fig 1a,1b,1f	Zhang C, Jiang H, Wang P, Liu H, Sun X. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017;7:44708 pubmed publisher
western blot; human; loading ...; fig 1b	Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
flow cytometry; mouse; fig 2a western blot; mouse; fig 5a	Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFÎºB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher
western blot; mouse; loading ...; fig 5b	Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
western blot; mouse; loading ...; fig 7c	Xiong X, Liu Y, Mei Y, Peng J, Wang Z, Kong B, et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017;7:41857 pubmed publisher
western blot; human; loading ...; fig 6a	Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, et al. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Sci Rep. 2017;7:41434 pubmed publisher
western blot; human; fig s4a	Günster R, Matthews S, Holden D, Thurston T. SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages. Infect Immun. 2017;85: pubmed publisher
western blot; mouse; loading ...; fig s1a	Niu X, Pi S, Baral S, Xia Y, He Q, Li Y, et al. P2Y12 Promotes Migration of Vascular Smooth Muscle Cells Through Cofilin Dephosphorylation During Atherogenesis. Arterioscler Thromb Vasc Biol. 2017;37:515-524 pubmed publisher
western blot; mouse; loading ...; fig 1a	Hammers D, Sleeper M, Forbes S, Coker C, Jirousek M, Zimmer M, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016;1:e90341 pubmed publisher
western blot; mouse; loading ...; fig 6d	Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
western blot; human; 1:500; loading ...; fig 5e	Shahriari K, Shen F, Worrede Mahdi A, Liu Q, Gong Y, Garcia F, et al. Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Oncogene. 2017;36:2846-2856 pubmed publisher
western blot; mouse; loading ...; fig 1b	Siegmund D, Kums J, Ehrenschwender M, Wajant H. Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis. 2016;7:e2375 pubmed publisher
western blot; human; fig 6c	LÃ³pez de Maturana R, Lang V, Zubiarrain A, Sousa A, VÃ¡zquez N, Gorostidi A, et al. Mutations in LRRK2 impair NF-ÎºB pathway in iPSC-derived neurons. J Neuroinflammation. 2016;13:295 pubmed
western blot; human; loading ...; fig 2a	Lin T, Cheng C, Su H, Huang N, Chen J, Kang H, et al. Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus. Front Immunol. 2016;7:440 pubmed
western blot; mouse; fig 4G	Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, et al. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016;126:4497-4515 pubmed publisher
western blot; human; fig 3e	van Haren S, Dowling D, Foppen W, Christensen D, Andersen P, Reed S, et al. Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016;197:4413-4424 pubmed
western blot; mouse; 1:1000; loading ...; fig s5e	Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
western blot; pigs ; loading ...; fig 1a	Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 9a	He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
western blot; mouse; loading ...; fig 4	Figueroa González G, García Castillo V, Coronel Hernández J, López Urrutia E, León Cabrera S, Arias Romero L, et al. Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer. J Cancer. 2016;7:1632-1644 pubmed
western blot; human; loading ...; fig 2a	Joo D, Tang Y, Blonska M, Jin J, Zhao X, Lin X. Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31. Mol Cell Biol. 2016;36:3010-3018 pubmed
western blot; mouse; 1:1000; loading ...; fig 2a	Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
western blot; mouse; loading ...; fig 5a	Ando Y, Oku T, Tsuji T. Platelet Supernatant Suppresses LPS-Induced Nitric Oxide Production from Macrophages Accompanied by Inhibition of NF-?B Signaling and Increased Arginase-1 Expression. PLoS ONE. 2016;11:e0162208 pubmed publisher
western blot; human; loading ...; fig 4b	de Jong M, Liu Z, Chen D, Alto N. Shigella flexneri suppresses NF-?B activation by inhibiting linear ubiquitin chain ligation. Nat Microbiol. 2016;1:16084 pubmed publisher
western blot; human; loading ...; fig s7d	Scott D, Rhee D, Duda D, Kelsall I, Olszewski J, Paulo J, et al. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Cell. 2016;166:1198-1214.e24 pubmed publisher
western blot; human; fig 1	Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
western blot; human; 1:1000; loading ...; fig s8c	Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 9b	Ta M, Schwensen K, Liuwantara D, Huso D, Watnick T, Rangan G. Constitutive renal Rel/nuclear factor-?B expression in Lewis polycystic kidney disease rats. World J Nephrol. 2016;5:339-57 pubmed publisher
western blot; human; loading ...; fig 3b	Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-?B pathway in a transcription-independent manner. Nucleic Acids Res. 2016;44:7331-49 pubmed publisher
western blot; human; fig 6	Kim H, Choi M, Inn K, Kim B. Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner. Sci Rep. 2016;6:28896 pubmed publisher
western blot; mouse; fig 1	Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
western blot; human; loading ...; fig 4a	Wang Y, Cao J, Fan Y, Xie Y, Xu Z, Yin Z, et al. Artemisinin inhibits monocyte adhesion to HUVECs through the NF-?B and MAPK pathways in vitro. Int J Mol Med. 2016;37:1567-75 pubmed publisher
western blot; mouse; fig 6 immunohistochemistry - paraffin section; human; fig 7	Rebolleda N, Losada Fernandez I, Perez Chacon G, Castejon R, Rosado S, Morado M, et al. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS ONE. 2016;11:e0154159 pubmed publisher
western blot; mouse; 1:1000; fig 6	Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
western blot; human; fig 5	BÃ¶hringer M, Pohlers S, Schulze S, Albrecht Eckardt D, Piegsa J, Weber M, et al. Candida albicans infection leads to barrier breakdown and a MAPK/NF-ÎºB mediated stress response in the intestinal epithelial cell line C2BBe1. Cell Microbiol. 2016;18:889-904 pubmed publisher
western blot; human; loading ...; fig 5b	Zheng M, Turton K, Zhu F, Li Y, Grindle K, Annis D, et al. A mix of S and Î”S variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture. Oncogenesis. 2016;4:e184 pubmed publisher
western blot; human; 1:1000; fig s2d	Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed publisher
western blot; mouse; fig 5	Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, et al. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep. 2015;5:18588 pubmed publisher
western blot; human; 1:1000; fig s6	Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015;6:8755 pubmed publisher
western blot; human; fig 3	Qin W, Li C, Zheng W, Guo Q, Zhang Y, Kang M, et al. Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget. 2015;6:39839-54 pubmed publisher
western blot; human; fig 2	Liu C, Zheng L, Wang H, Ran X, Liu H, Sun X. The RCAN1 inhibits NF-ÎºB and suppresses lymphoma growth in mice. Cell Death Dis. 2015;6:e1929 pubmed publisher
western blot; mouse; loading ...; fig 2c	Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, et al. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016;23:358-68 pubmed publisher
western blot; mouse; 1:1000; fig 1	Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher
western blot; human; 1:1000; fig 6	Qiu H, Liu B, Liu W, Liu S. Interleukin-27 enhances TNF-Î±-mediated activation of human coronary artery endothelial cells. Mol Cell Biochem. 2016;411:1-10 pubmed publisher
western blot; mouse; fig 3 immunohistochemistry - paraffin section; human; fig 1 western blot; human; fig 2	Crivellaro S, Panuzzo C, CarrÃ G, Volpengo A, Crasto F, Gottardi E, et al. Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IÎºBÎ± mediated p53 nuclear exclusion. Oncotarget. 2015;6:25217-25 pubmed publisher
western blot; mouse; fig 3	Gurt I, Artsi H, Cohen Kfir E, Hamdani G, Ben Shalom G, Feinstein B, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS ONE. 2015;10:e0134391 pubmed publisher
western blot; human; loading ...; fig 3b	Shatz M, Shats I, Menendez D, Resnick M. p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget. 2015;6:16963-80 pubmed
immunocytochemistry; human; fig 3b	Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed publisher
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immunohistochemistry; human; 1:50; loading ...; fig 5g	Piao H, Yuan Y, Wang M, Sun Y, Liang H, Ma L. ?-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014;16:245-54 pubmed publisher
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product information

SKU :

4814P

Product-Name :

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen)

Size :

40 ul

Price-(USD) :

123 USD

Species-x-Reactivity :

H, M, R, Mk, B, Pg, GP

Applications :

Flow cytometry

Product-Category :

Immunology and Inflammation

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Mouse

Target :

IkB-a

Primary-Protein :

IkB-alpha

Alt-Names :

I-kappa-B-alpha,IKBA,IkB-alpha,IkappaBalpha,MAD-3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,nuclear factor of kappa light chain gene enhancer in B-cells,nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

more info or order :

Cell Signaling Technology product webpage