product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
IκBα (44D4) Rabbit mAb
catalog :
4812S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation
citations: 19
Published Application/Species/DilutionReference
  • western blot; mouse; fig 2b
Liu H, Shi H, Huang F, Peterson K, Wu H, Lan Y, et al. Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway. Sci Rep. 2016;6:19137 pubmed publisher
  • western blot; human
Zhuang C, Sheng C, Shin W, Wu Y, Li J, Yao J, et al. A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways. Oncotarget. 2014;5:10830-9 pubmed
  • western blot; rat
Tse K, Chow K, Leung W, Wong Y, Wise H. Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways. Neuroscience. 2014;267:241-51 pubmed publisher
  • western blot; human; 1:1000
Leidner J, Voogdt C, Niedenthal R, Moller P, Marienfeld U, Marienfeld R. SUMOylation attenuates the transcriptional activity of the NF-κB subunit RelB. J Cell Biochem. 2014;115:1430-40 pubmed publisher
  • western blot; mouse
Carlson T, Pellerin A, Djuretic I, Trivigno C, Koralov S, Rao A, et al. Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation. J Immunol. 2014;192:2167-76 pubmed publisher
  • western blot; mouse; 1:1000
Niu F, Yao H, Zhang W, Sutliff R, Buch S. Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci. 2014;34:11812-25 pubmed publisher
Yan X, Cen Y, Wang Q. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression. Sci Rep. 2016;6:28915 pubmed publisher
Li X, Jiang J, Shi S, Bligh S, Li Y, Jiang Y, et al. A RG-II type polysaccharide purified from Aconitum coreanum alleviates lipopolysaccharide-induced inflammation by inhibiting the NF-κB signal pathway. PLoS ONE. 2014;9:e99697 pubmed publisher
Burcham G, Cresswell G, Snyder P, Chen L, Liu X, Crist S, et al. Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis. Am J Pathol. 2014;184:3176-91 pubmed publisher
Fraser B, Maranchuk R, Foley E. A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB. Front Immunol. 2014;5:322 pubmed publisher
Anderson I, Low J, Weston S, Weinberger M, Zhyvoloup A, Labokha A, et al. Heat shock protein 90 controls HIV-1 reactivation from latency. Proc Natl Acad Sci U S A. 2014;111:E1528-37 pubmed publisher
Knights A, Fucíková J, Pasam A, Koernig S, Cebon J. Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy. Cancer Immunol Immunother. 2013;62:321-35 pubmed publisher
Yu X, Guo C, Yi H, Qian J, Fisher P, Subjeck J, et al. A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity. Cancer Res. 2013;73:2093-103 pubmed publisher
Antognelli C, Mezzasoma L, Fettucciari K, Mearini E, Talesa V. Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells. Prostate. 2013;73:121-32 pubmed publisher
Hu W, Jin L, Jiang C, Long G, Scolyer R, Wu Q, et al. AEBP1 upregulation confers acquired resistance to BRAF (V600E) inhibition in melanoma. Cell Death Dis. 2013;4:e914 pubmed publisher
Dai P, Jeong S, Yu Y, Leng T, Wu W, Xie L, et al. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol. 2009;182:3450-60 pubmed publisher
Xie S, Li J, Wang J, Wu Q, Yang P, Hsu H, et al. IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16. J Immunol. 2010;184:2289-96 pubmed publisher
Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, et al. Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation. EMBO J. 2012;31:3856-70 pubmed publisher
Palkowitsch L, Marienfeld U, Brunner C, Eitelhuber A, Krappmann D, Marienfeld R. The Ca2+-dependent phosphatase calcineurin controls the formation of the Carma1-Bcl10-Malt1 complex during T cell receptor-induced NF-kappaB activation. J Biol Chem. 2011;286:7522-34 pubmed publisher
product information
SKU :
4812S
Product-Name :
IκBα (44D4) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Mi
Applications :
Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
39
Host :
Rabbit
Target :
IkB-a
Primary-Protein :
IkB-alpha
Alt-Names :
I-kappa-B-alpha,IKBA,IkB-alpha,IkappaBalpha,MAD-3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,nuclear factor of kappa light chain gene enhancer in B-cells,nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.