product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Caspase-8 (D35G2) Rabbit mAb
catalog :
4790
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
D35G2
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2a
Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher
  • western blot; human; 1:1000; fig 5e
Lang M, Jenkins S, Balzano P, Owoyele A, Patel A, Bamezai A. Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4+ T-cell lines. Immun Inflamm Dis. 2017;5:448-460 pubmed publisher
  • western blot; mouse; fig 4
Lin J, Kumari S, Kim C, Van T, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124-128 pubmed publisher
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; human; loading ...; fig 1c
Seifert L, Werba G, Tiwari S, Giao Ly N, Alothman S, Alqunaibit D, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532:245-9 pubmed publisher
  • western blot; human; fig 7
Oh Y, Yue P, Wang D, Tong J, Chen Z, Khuri F, et al. Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling. Oncotarget. 2015;6:41324-38 pubmed publisher
  • western blot; rat; 1:1000
Wang Y, Li Q, Wei X, Xu J, Chen Q, Song S, et al. Targeted knockout of TNF-? by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats. Mol Med Rep. 2015;12:4389-4395 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed publisher
  • western blot; mouse; fig 4c
Deutsch M, Graffeo C, Rokosh R, Pansari M, Ochi A, Levie E, et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 2015;6:e1759 pubmed publisher
  • immunocytochemistry; human
  • western blot; rat
Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher
  • western blot; mouse; 1:1000
ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, et al. Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress. Mol Biol Cell. 2015;26:1947-56 pubmed publisher
  • western blot; human; 1:2000; fig 6
  • western blot; mouse; 1:2000; fig 1
Pooya S, Liu X, Kumar V, Anderson J, Imai F, Zhang W, et al. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nat Commun. 2014;5:4993 pubmed publisher
  • western blot; human; 1:500
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed publisher
  • western blot; human; 1:1000
Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher
Brown A, Winter J, Gapinske M, Tague N, Woods W, Perez Pinera P. Multiplexed and tunable transcriptional activation by promoter insertion using nuclease-assisted vector integration. Nucleic Acids Res. 2019;47:e67 pubmed publisher
Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed publisher
He G, Günther C, Thonn V, Yu Y, Martini E, Buchen B, et al. Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med. 2017;214:1655-1662 pubmed publisher
Roy P, Mukherjee T, Chatterjee B, Vijayaragavan B, Banoth B, Basak S. Non-canonical NF?B mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NF?B pathway. Oncogene. 2017;36:1417-1429 pubmed publisher
Zhao J, Mou Y, Bernstock J, Klimanis D, Wang S, Spatz M, et al. Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0140772 pubmed publisher
Pourbakhsh H, Taghiabadi E, Abnous K, Hariri A, Hosseini S, Hosseinzadeh H. Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci. 2014;17:1020-31 pubmed
Kim J, Bae J. MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis. PLoS ONE. 2013;8:e79626 pubmed publisher
Taghiabadi E, Imenshahidi M, Abnous K, Mosafa F, Sankian M, Memar B, et al. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evid Based Complement Alternat Med. 2012;2012:352091 pubmed publisher
Tamayev R, Akpan N, Arancio O, Troy C, D ADAMIO L. Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection. Mol Neurodegener. 2012;7:60 pubmed publisher
Pritchard J, Gilbert L, Meacham C, Ricks J, Jiang H, Lauffenburger D, et al. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Res. 2011;71:5850-8 pubmed publisher
product information
SKU :
4790S
Product-Name :
Caspase-8 (D35G2) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, (Mk, Pg)
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
10, 57
Host :
Rabbit
Target :
Casp8
Primary-Protein :
Casp8
Alt-Names :
ALPS2B,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,CASP-8,CASP8,Caspase-8,Caspase-8 subunit p10,Caspase-8 subunit p18,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,FLJ17672,ICE-like apoptotic protease 5,MACH,MACH-alpha-1/2/3 protein,MACH-beta-1/2/3/4 protein,MCH5,MGC78473,MORT1-associated ced-3 homolog,caspase 8, apoptosis-related cysteine peptidase,caspase 8, apoptosis-related cysteine protease
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.