product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
NF-κB p65 (C22B4) Rabbit mAb
catalog :
4764
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C22B4
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 149
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; loading ...; fig 1g
Parodi B, Sanna A, Cedola A, Uccelli A, Kerlero de Rosbo N. Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response. Front Immunol. 2021;12:655212 pubmed publisher
  • western blot; human; fig 2a
  • immunocytochemistry; bovine; loading ...; fig 1c
Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4e
Mishra P, Boutej H, Soucy G, Bareil C, Kumar S, Picher Martel V, et al. Transmission of ALS pathogenesis by the cerebrospinal fluid. Acta Neuropathol Commun. 2020;8:65 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6d
Viau A, Baaziz M, Aka A, Mazloum M, Nguyen C, Kuehn E, et al. Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2020;31:1035-1049 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6d
Lindner P, Paul S, Eckstein M, Hampel C, Muenzner J, Erlenbach Wuensch K, et al. EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells. Cell Death Dis. 2020;11:147 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 10a
Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3i
Yue D, Zhao J, Chen H, Guo M, Chen C, Zhou Y, et al. MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation. J Neuroinflammation. 2020;17:28 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Zhang Q, Xiang L, Zaman M, Dong W, He G, Deng G. Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus. Front Immunol. 2019;10:3020 pubmed publisher
  • western blot; human; loading ...; fig 2a
Jobin P, Solis N, Machado Y, Bell P, Kwon N, Kim S, et al. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. J Biol Chem. 2019;294:12866-12879 pubmed publisher
  • western blot; human; loading ...; fig 6f
  • western blot; mouse; loading ...; fig 6b
Mentrup T, Theodorou K, Cabrera Cabrera F, Helbig A, Happ K, Gijbels M, et al. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. J Exp Med. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 9c
Zhou L, Chen X, Lu M, Wu Q, Yuan Q, Hu C, et al. Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria. Kidney Int. 2019;95:830-845 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
  • western blot; human; loading ...; fig 3a
Luong P, Hedl M, Yan J, Zuo T, Fu T, Jiang X, et al. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. elife. 2018;7: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s6a
Cuchet Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, CURTIS J, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018;361:810-813 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
  • western blot; rat; loading ...; fig 7a
Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, et al. Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. Sci Rep. 2018;8:5927 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
Yang L, Shen L, Gao P, Li G, He Y, Wang M, et al. Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms. Oncotarget. 2017;8:92827-92840 pubmed publisher
  • western blot; human; fig 1e
Liu L, Jiang Y, Chahine A, Curtiss E, Steinle J. Epac1 agonist decreased inflammatory proteins in retinal endothelial cells, and loss of Epac1 increased inflammatory proteins in the retinal vasculature of mice. Mol Vis. 2017;23:1-7 pubmed
  • western blot; mouse; loading ...; fig 7c
Xiong X, Liu Y, Mei Y, Peng J, Wang Z, Kong B, et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017;7:41857 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; human; fig 4b
Omsland M, Bruserud Ã, Gjertsen B, Andresen V. Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML). Oncotarget. 2017;8:7946-7963 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 4a
Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5c
  • western blot; mouse; loading ...; fig 5a
Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
  • western blot; mouse; loading ...; fig 6d
Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3c
  • western blot; human; loading ...; fig 4c
Chen R, Xie Y, Zhong X, Fu Y, Huang Y, Zhen Y, et al. Novel chemokine-like activities of histones in tumor metastasis. Oncotarget. 2016;7:61728-61740 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
  • western blot; mouse; fig 4c
Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Song X, Yao Z, Yang J, Zhang Z, Deng Y, Li M, et al. HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways. Oncotarget. 2016;7:33796-808 pubmed publisher
  • western blot; human; loading ...; fig 1c
Lin A, Wang G, Zhao H, Zhang Y, Han Q, Zhang C, et al. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. Oncoimmunology. 2016;5:e1074376 pubmed
  • immunocytochemistry; mouse; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 5b
Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, et al. Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway. Drug Des Devel Ther. 2016;10:851-9 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  • western blot; rat; fig 3
Hong M, Nam K, Kim K, Kim S, Kim I. The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016;21:485-97 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3a
  • western blot; human; loading ...; fig 2b
Lu S, Natarajan S, Mott J, Kharbanda K, Harrison Findik D. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway. PLoS ONE. 2016;11:e0147474 pubmed publisher
  • western blot; human
Theendakara V, Peters Libeu C, Spilman P, Poksay K, Bredesen D, Rao R. Direct Transcriptional Effects of Apolipoprotein E. J Neurosci. 2016;36:685-700 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 6
  • immunocytochemistry; mouse; 1:200; fig 2
  • western blot; mouse; 1:1000; fig 2
Wu H, Shi L, Wang Q, Cheng L, Zhao X, Chen Q, et al. Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells. Sci Rep. 2016;6:19507 pubmed publisher
  • western blot; human; loading ...; fig s1
Klein T, Fung S, Renner F, Blank M, Dufour A, Kang S, et al. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nat Commun. 2015;6:8777 pubmed publisher
  • western blot; human; fig 1
Liu C, Zheng L, Wang H, Ran X, Liu H, Sun X. The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice. Cell Death Dis. 2015;6:e1929 pubmed publisher
  • western blot; mouse
He L, Zang A, Du M, Ma D, Yuan C, Zhou C, et al. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virol Sin. 2015;30:174-89 pubmed publisher
  • western blot; mouse; fig 1
Wang Y, Lian Q, Yang B, Yan S, Zhou H, He L, et al. TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLoS Pathog. 2015;11:e1005012 pubmed publisher
  • western blot; human; 1:5000; fig 4
Dille S, Kleinschnitz E, Kontchou C, Nölke T, Häcker G. In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport. Infect Immun. 2015;83:3268-80 pubmed publisher
  • western blot; mouse; 1:1000; fig  6
Revuelta López E, Cal R, Herraiz Martínez A, De Gonzalo Calvo D, Nasarre L, Roura S, et al. Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes. J Mol Cell Cardiol. 2015;85:25-36 pubmed publisher
  • western blot; human
Katanov C, Lerrer S, Liubomirski Y, Leider Trejo L, Meshel T, Bar J, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-? and the NF-?B pathway. Stem Cell Res Ther. 2015;6:87 pubmed publisher
  • western blot; mouse; 1:3000
Parodi B, Rossi S, Morando S, Cordano C, Bragoni A, Motta C, et al. Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS. Acta Neuropathol. 2015;130:279-95 pubmed publisher
  • western blot; mouse
Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3
Xu H, Cho S, Bang M, Bae C, Choi Y, Li Y, et al. FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol. 2015;46:2309-16 pubmed publisher
  • western blot; mouse; fig 10A
Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher
  • western blot; mouse; 1:2000; fig 5c
Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, et al. Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. EMBO Mol Med. 2015;7:240-58 pubmed publisher
  • western blot; rat
Yang D, Sun Y, Bhaumik S, Li Y, Baumann J, Lin X, et al. Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci. 2014;34:16467-81 pubmed publisher
  • western blot; mouse; 1:1000
Huang L, Zhang S, Zhang P, Zhang X, Zhu L, Chen K, et al. Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation. J Am Heart Assoc. 2014;3:e001309 pubmed publisher
  • western blot; human; 1:1000; fig 7
Lu H, Clauser K, Tam W, Fröse J, Ye X, Eaton E, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16:1105-17 pubmed publisher
  • western blot; human
Tang J, Shen L, Yang Q, Zhang C. Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition. Cell Prolif. 2014;47:427-34 pubmed publisher
  • western blot; rat; 1:1000
Yang L, Kan E, Lu J, Wu C, Ling E. Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro. J Neuroinflammation. 2014;11:148 pubmed publisher
  • western blot; mouse
Bartuzi P, Wijshake T, Dekker D, Fedoseienko A, Kloosterhuis N, Youssef S, et al. A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta. 2014;1842:2257-65 pubmed publisher
  • western blot; human; fig 3, 4, 5
Kobayashi T, Masoumi K, Massoumi R. Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells. Oncogene. 2015;34:2251-60 pubmed publisher
  • western blot; human
Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol. 2014;592:1873-86 pubmed publisher
  • western blot; rat; 1:2000
Zhang Q, Pan Y, Wang R, Kang L, Xue Q, Wang X, et al. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. J Nutr Biochem. 2014;25:420-8 pubmed publisher
  • western blot; human; fig 6D
Bohonowych J, Hance M, Nolan K, DEFEE M, Parsons C, Isaacs J. Extracellular Hsp90 mediates an NF-?B dependent inflammatory stromal program: implications for the prostate tumor microenvironment. Prostate. 2014;74:395-407 pubmed publisher
  • ELISA; human
Lee W, Ku S, Min B, Lee S, Jee J, Kim J, et al. Vascular barrier protective effects of pellitorine in LPS-induced inflammation in vitro and in vivo. Fitoterapia. 2014;92:177-87 pubmed publisher
  • western blot; mouse
Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse
Tan C, Tan E, Luo B, Huang C, Loo J, Choong C, et al. SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via activation of iNOS. J Am Heart Assoc. 2013;2:e000269 pubmed publisher
  • immunocytochemistry; mouse; 1:200
  • western blot; mouse; 1:1000
Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, et al. Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells. Mol Cell Endocrinol. 2013;372:73-85 pubmed publisher
  • western blot; mouse
Dai J, Shen D, Bian Z, Zhou H, Gan H, Zong J, et al. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PLoS ONE. 2013;8:e53412 pubmed publisher
  • immunohistochemistry; rat
Pranski E, Dalal N, Sanford C, Herskowitz J, Gearing M, Lazo C, et al. RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-?B signaling in dopaminergic cells. Neurobiol Dis. 2013;54:264-79 pubmed publisher
  • immunocytochemistry; human
Newman A, Scholefield C, Kemp A, Newman M, McIver E, Kamal A, et al. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE. 2012;7:e50672 pubmed publisher
  • western blot; human; 1:1000; fig s2
Wu L, Shao L, An N, Wang J, Pazhanisamy S, Feng W, et al. IKK? regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS ONE. 2011;6:e18447 pubmed publisher
Seo J, Jin M, Chang Y. Anti-inflammatory effect of Salsola komarovii extract with dissociated glucocorticoid activity. BMC Complement Med Ther. 2020;20:176 pubmed publisher
Wang H, Fu L, Cheng C, Gao R, Lin M, Su H, et al. Inhibition of LPS-Induced Oxidative Damages and Potential Anti-Inflammatory Effects of Phyllanthus emblica Extract via Down-Regulating NF-κB, COX-2, and iNOS in RAW 264.7 Cells. Antioxidants (Basel). 2019;8: pubmed publisher
Kim J, Yoon J, Nikapitiya C, Kim T, Uddin M, Lee H, et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus. Cell Rep. 2019;27:2105-2118.e5 pubmed publisher
Shaverdashvili K, Padlo J, Weinblatt D, Jia Y, Jiang W, Rao D, et al. KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. PLoS ONE. 2019;14:e0215746 pubmed publisher
Stempel M, Chan B, Juranic Lisnic V, Krmpotic A, Hartung J, Paludan S, et al. The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection. EMBO J. 2019;38: pubmed publisher
Serresi M, Siteur B, Hulsman D, Company C, Schmitt M, Lieftink C, et al. Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities. J Exp Med. 2018;215:3115-3135 pubmed publisher
Yan N, Wen D, Zhao Y, Xu S. Epimedium sagittatum inhibits TLR4/MD-2 mediated NF-κB signaling pathway with anti-inflammatory activity. BMC Complement Altern Med. 2018;18:303 pubmed publisher
Albarrán Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, et al. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018;215:2655-2672 pubmed publisher
Travers J, Rochman M, Miracle C, Habel J, Brusilovsky M, Caldwell J, et al. Chromatin regulates IL-33 release and extracellular cytokine activity. Nat Commun. 2018;9:3244 pubmed publisher
De Nardo D, Balka K, Cardona Gloria Y, Rao V, Latz E, Masters S. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018;293:15195-15207 pubmed publisher
Hunt D, Drake L, Drake J. Murine macrophage TLR2-FcγR synergy via FcγR licensing of IL-6 cytokine mRNA ribosome binding and translation. PLoS ONE. 2018;13:e0200764 pubmed publisher
Li Q, Dai C, Xue R, Wang P, Chen L, Han Y, et al. S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4-ERK1/2 Signaling. Front Immunol. 2018;9:388 pubmed publisher
Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, et al. Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated. Toxins (Basel). 2018;10: pubmed publisher
Gunasekaran M, Sharma M, Hachem R, Bremner R, Smith M, Mohanakumar T. Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection. J Immunol. 2018;200:2535-2541 pubmed publisher
Ooki A, Begum A, Marchionni L, Vandenbussche C, Mao S, Kates M, et al. Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018;143:113-126 pubmed publisher
Rao S, Sigl V, Wimmer R, Novatchkova M, Jais A, Wagner G, et al. RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes Dev. 2017;31:2099-2112 pubmed publisher
Edwards R, Luis P, Varuzza P, Joseph A, Presley S, Chaturvedi R, et al. The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. J Biol Chem. 2017;292:21243-21252 pubmed publisher
Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, et al. Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling. Infect Immun. 2017;85: pubmed publisher
Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, et al. Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis. Immunology. 2018;153:71-83 pubmed publisher
Badran Y, Dedeoglu F, Leyva Castillo J, Bainter W, Ohsumi T, Bousvaros A, et al. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017;214:1937-1947 pubmed publisher
Giusto M, Barberi L, Di Sario F, Rizzuto E, Nicoletti C, Ascenzi F, et al. Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis. Physiol Rep. 2017;5: pubmed publisher
Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
Tan J, Tedrow J, Nouraie M, Dutta J, Miller D, Li X, et al. Loss of Twist1 in the Mesenchymal Compartment Promotes Increased Fibrosis in Experimental Lung Injury by Enhanced Expression of CXCL12. J Immunol. 2017;198:2269-2285 pubmed publisher
Chan T, Hsu C, Pai V, Liao W, Huang S, Tan K, et al. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells. J Exp Med. 2016;213:2967-2988 pubmed
Li T, Jin K, Zhu D, Li L, Mao Z, Wu B, et al. Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure. Oncotarget. 2016;7:78872-78882 pubmed publisher
Li Z, Chen Z, Zhang T, Wei C, Shi W. TGF-? and NF-?B signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response. Aging (Albany NY). 2016;8:2337-2354 pubmed publisher
Xiang S, Zeng Y, Xiong B, Qin Y, Huang X, Jiang Y, et al. Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells. J Inflamm (Lond). 2016;13:19 pubmed publisher
Lee A, Jung Y, Thanh T, Lee S, Kim W, Kang K, et al. Paricalcitol attenuates lipopolysaccharide-induced myocardial inflammation by regulating the NF-κB signaling pathway. Int J Mol Med. 2016;37:1023-9 pubmed publisher
Price L, Shao D, Meng C, Perros F, Garfield B, Zhu J, et al. Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells. Respir Res. 2015;16:114 pubmed publisher
Hou J, Ma J, Yu K, Li W, Cheng C, Bao L, et al. Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells. BMC Genomics. 2015;16:435 pubmed publisher
Zheng N, Wang D, Ming H, Zhang H, Yu X. BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R. BMC Nephrol. 2015;16:72 pubmed publisher
Sharma N, Verma R, Kumawat K, Basu A, Singh S. miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells. J Neuroinflammation. 2015;12:30 pubmed publisher
Li C, Lun W, Zhao X, Lei S, Guo Y, Ma J, et al. Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm. 2015;2015:434692 pubmed publisher
Yuan K, Yu H, Feng W, Chong P, Yang T, Xue C, et al. Bifidobacterium infantis has a beneficial effect on 5-fluorouracil-induced intestinal mucositis in rats. Benef Microbes. 2015;6:113-8 pubmed publisher
Yue Y, Wang Y, Li D, Song Z, Jiao H, Lin H. A central role for the mammalian target of rapamycin in LPS-induced anorexia in mice. J Endocrinol. 2015;224:37-47 pubmed publisher
Zhang X, Shi Y, Weng Y, Lai Q, Luo T, Zhao J, et al. The truncate mutation of Notch2 enhances cell proliferation through activating the NF-κB signal pathway in the diffuse large B-cell lymphomas. PLoS ONE. 2014;9:e108747 pubmed publisher
Abdi J, Garssen J, Faber J, Redegeld F. Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells. J Nutr Biochem. 2014;25:1254-62 pubmed publisher
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product information
SKU :
4764S
Product-Name :
NF-κB p65 (C22B4) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, B, (Dg)
Applications :
Flow cytometry
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
65
Host :
Rabbit
Target :
NFkB-p65
Primary-Protein :
NFkB-p65
Alt-Names :
MGC131774,NFKB3,Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3,RELA,TF65,Transcription factor p65,p65,v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)),v-rel reticuloendotheliosis viral oncogene homolog A (avian),v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.