Aurora A/AIK (1G4) Rabbit mAb | Cell Signaling Technology 4718 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Aurora A/AIK (1G4) Rabbit mAb

catalog :

4718

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

1G4

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:500; loading ...; fig 4h, s5m	Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed publisher
western blot; human; 1:500; loading ...; fig 1b	Umstead M, Xiong J, Qi Q, Du Y, Fu H. Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling. Oncotarget. 2017;8:28359-28372 pubmed publisher
western blot; human; 1:1000; loading ...; fig s6a	Tagal V, Wei S, Zhang W, Brekken R, Posner B, Peyton M, et al. SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers. Nat Commun. 2017;8:14098 pubmed publisher
immunocytochemistry; human; loading ...; fig 3	Schneider M, Christopoulos P, Muley T, Warth A, Klingmueller U, Thomas M, et al. AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients. Int J Oncol. 2017;50:365-372 pubmed publisher
western blot; human; 1:200; fig st1	Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
western blot; human; fig 2	Qi D, Wang Q, Yu M, Lan R, Li S, Lu F. Mitotic phosphorylation of SOX2 mediated by Aurora kinase A is critical for the stem-cell like cell maintenance in PA-1 cells. Cell Cycle. 2016;15:2009-18 pubmed publisher
western blot; human; fig 3	Dos Santos E, Carneiro Lobo T, Aoki M, Levantini E, BassÃ¨res D. Aurora kinase targeting in lung cancer reduces KRAS-induced transformation. Mol Cancer. 2016;15:12 pubmed publisher
western blot; human; 1:1000; fig s11	Aviner R, Shenoy A, Elroy Stein O, Geiger T. Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis. PLoS Genet. 2015;11:e1005554 pubmed publisher
western blot; human; fig 6	Qi D, Wang Q, Li H, Zhang T, Lan R, Kwong D, et al. SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells. Mol Biosyst. 2015;11:3059-67 pubmed publisher
western blot; human	Choi M, Kim W, Cheon M, Lee C, Kim J. Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells. Cancer Lett. 2015;357:591-601 pubmed publisher
western blot; mouse	McGinnis L, Pelech S, Kinsey W. Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev. 2014;81:928-45 pubmed publisher
	Schmukler E, Wolfson E, Elazar Z, Kloog Y, Pinkas Kramarski R. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PLoS ONE. 2017;12:e0171351 pubmed publisher
	Wang Y, Begley M, Li Q, Huang H, Lako A, Eck M, et al. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proc Natl Acad Sci U S A. 2016;113:9810-5 pubmed publisher
	Ohta S, Wood L, Toramoto I, Yagyu K, Fukagawa T, Earnshaw W. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol Biol Cell. 2015;26:1225-37 pubmed publisher
	Su Y, Pan S, Li Z, Li L, Wu X, Hao P, et al. Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach. Sci Rep. 2015;5:7724 pubmed publisher
	Hill R, Kuijper S, Lindsey J, Petrie K, Schwalbe E, Barker K, et al. Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer Cell. 2015;27:72-84 pubmed publisher
	Yang H, Lawrence H, Kazi A, Gevariya H, Patel R, Luo Y, et al. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation. Oncotarget. 2014;5:2947-61 pubmed
	Ma M, Robinson P, Chircop M. Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation. PLoS ONE. 2013;8:e68387 pubmed publisher
	Wang L, Wang M, Wang S, Qi T, Guo L, Li J, et al. Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage. PLoS ONE. 2013;8:e60179 pubmed publisher
	Hendrickson D, Hogan D, McCullough H, Myers J, Herschlag D, Ferrell J, et al. Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol. 2009;7:e1000238 pubmed publisher

product information

SKU :

4718P

Product-Name :

Aurora A/AIK (1G4) Rabbit mAb

Size :

40 ul

Price-(USD) :

123 USD

Species-x-Reactivity :

H, Mk

Applications :

Immunofluorescence (Immunocytochemistry)

Product-Category :

Cell Cycle / Checkpoint Control

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

Aurora A

Primary-Protein :

AurA

Alt-Names :

AIK,ARK-1,ARK1,AURA,AURKA,AURORA2,Aurora A,Aurora kinase A,Aurora-related kinase 1,Aurora/IPL1-related kinase 1,BTAK,Breast tumor-amplified kinase,IPL1-related kinase,MGC34538,STK15,STK6,STK7,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A,aurora/IPL1-like kinase,breast-tumor-amplified kinase,hARK1,serine/threonine kinase 6,serine/threonine protein kinase 15

more info or order :

Cell Signaling Technology product webpage