product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p44/42 MAPK (Erk1/2) (L34F12) Mouse mAb
catalog :
4696S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry
citations: 19
Published Application/Species/DilutionReference
  • western blot; mouse; 1:3000
Tang Y, Ye M, Du Y, Qiu X, Lv X, Yang W, et al. EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus. Neuroscience. 2015;304:109-21 pubmed publisher
  • western blot; human
Ramirez U, Nikonova A, Liu H, Pecherskaya A, Lawrence S, Serebriiskii I, et al. Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC Cancer. 2015;15:436 pubmed publisher
  • western blot; mouse; 1:1000
Yu B, Chang J, Liu Y, Li J, Kevork K, Al-Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB. Nat Med. 2014;20:1009-17 pubmed publisher
  • western blot; human
Sperrhacke M, Fischer J, Wu Z, Klünder S, Sedlacek R, Schroeder J, et al. SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. J Invest Dermatol. 2014;134:1645-54 pubmed publisher
  • western blot; rat; 1:500
Yabuta C, Yano F, Fujii A, Shearer T, Azuma M. Galectin-3 enhances epithelial cell adhesion and wound healing in rat cornea. Ophthalmic Res. 2014;51:96-103 pubmed publisher
  • western blot; human
Guo W, Liu R, Bhardwaj G, Yang J, Changou C, Ma A, et al. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014;5:e1409 pubmed publisher
  • western blot; human; 1:1000
Wang Z, Ren Z, Hu Z, Hu X, Zhang H, Wu H, et al. Angiotensin-II induces phosphorylation of ERK1/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic dissection formation. J Mol Histol. 2014;45:401-12 pubmed publisher
Ko H, Park B, Choi S, Kang H, Kim A, Kim H, et al. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J. 2016;57:761-8 pubmed publisher
Zhong G, Li Y, Li H, Sun W, Cao D, Li J, et al. Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle. Front Physiol. 2016;7:274 pubmed publisher
Skieterska K, Rondou P, Lintermans B, Van Craenenbroeck K. KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant. PLoS ONE. 2015;10:e0145654 pubmed publisher
Micel L, Tentler J, Tan A, Selby H, Brunkow K, Robertson K, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015;14:317-25 pubmed publisher
Wu A, Dalvi P, Lu X, Yang M, Riddick D, Matthews J, et al. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol. 2013;83:377-88 pubmed publisher
Rao S, Liu X, Freedman B, Behrens E. Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells. J Biol Chem. 2013;288:12448-58 pubmed publisher
Wu Q, Chambliss K, Lee W, Yuhanna I, Mineo C, Shaul P. Point mutations in the ERα Gαi binding domain segregate nonnuclear from nuclear receptor function. Mol Endocrinol. 2013;27:2-11 pubmed publisher
Morigi M, Buelli S, Zanchi C, Longaretti L, Macconi D, Benigni A, et al. Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling. Am J Pathol. 2006;169:1965-75 pubmed
Areshkov P, Avdieiev S, Balynska O, LeRoith D, Kavsan V. Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation. Int J Biol Sci. 2012;8:39-48 pubmed
Satoh T, Smith A, Sarde A, Lu H, Mian S, Mian S, et al. B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease. PLoS ONE. 2012;7:e33891 pubmed publisher
Wong V, Chen H, Ko J, Chan K, Chan Y, Law S, et al. Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype. Int J Cancer. 2012;130:83-95 pubmed publisher
Adhikary S, Kocieda V, Yen J, Tuma R, Ganea D. Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression. Blood. 2012;120:3741-9 pubmed publisher
product information
SKU :
4696S
Product-Name :
p44/42 MAPK (Erk1/2) (L34F12) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, Mi, Z, Pg
Applications :
Flow cytometry
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
42, 44
Host :
Mouse
Target :
ERK1/ERK2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.