Published Application/Species/Sample/Dilution | Reference |
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- western blot; mouse; 1:1000; loading ...; fig 3d
| Nagpal A, Redvers R, Ling X, Ayton S, Fuentes M, Tavancheh E, et al. Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis. Breast Cancer Res. 2019;21:94 pubmed publisher
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- western blot; human; 1:10,000; loading ...; fig 7a
| Carretero Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menéndez González J, Gay C, et al. GIPC proteins negatively modulate Plexind1 signaling during vascular development. elife. 2019;8: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3a, 3c, s3d
| Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig s6a
| Cuchet Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, CURTIS J, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018;361:810-813 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig s4a
| Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
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- western blot; human; loading ...; fig s2f
| Muhar M, Ebert A, Neumann T, Umkehrer C, Jude J, Wieshofer C, et al. SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis. Science. 2018;360:800-805 pubmed publisher
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- immunohistochemistry; zebrafish ; 1:500; loading ...; fig e9a
| Escamilla C, Filonova I, Walker A, Xuan Z, Holehonnur R, Espinosa F, et al. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017;551:227-231 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 2c
- western blot; human; fig 1c
| Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan X, et al. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017;8:9251-9266 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 5b
| Ferland D, Darios E, Neubig R, Sjögren B, Truong N, Torres R, et al. Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol. 2017;88:30-41 pubmed publisher
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- western blot; mouse; loading ...; fig 5a
| Yang P, Schmit B, Fu C, Desart K, Oh S, Berceli S, et al. Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events. Sci Rep. 2016;6:35444 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 4b
| Wang Y, Han G, Guo B, Huang J. Hyaluronan oligosaccharides promote diabetic wound healing by increasing angiogenesis. Pharmacol Rep. 2016;68:1126-1132 pubmed publisher
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- western blot; mouse; loading ...; fig 4b
| Luessen D, Hinshaw T, Sun H, Howlett A, MARRS G, McCool B, et al. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. 2016;110:297-307 pubmed publisher
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- western blot; mouse; loading ...; fig 2f
- western blot; human; loading ...; fig 2f
| Hernandez Rapp J, Rainone S, Goupil C, Dorval V, Smith P, Saint Pierre M, et al. microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. Sci Rep. 2016;6:30953 pubmed publisher
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- western blot; human; 1:1000; fig 6
| Anta B, Pérez RodrÃguez A, Castro J, GarcÃa DomÃnguez C, Ibiza S, MartÃnez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed publisher
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- immunocytochemistry; human; 1:100; loading ...; fig 4b
| Dai H, Chen H, Liu W, You Y, Tan J, Yang A, et al. Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study. J Cancer Res Clin Oncol. 2016;142:2107-17 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig s3c
| Xiang N, Liu J, Liao Y, Huang Y, Wu Z, Bai Z, et al. Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway. Sci Rep. 2016;6:27583 pubmed publisher
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- western blot; human; loading ...; fig 7b
| Kunze M, Benz F, Brauß T, Lampe S, Weigand J, Braun J, et al. sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism. Biochim Biophys Acta. 2016;1859:848-59 pubmed publisher
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- immunohistochemistry - free floating section; zebrafish ; fig 3
| Filosa A, Barker A, Dal Maschio M, Baier H. Feeding State Modulates Behavioral Choice and Processing of Prey Stimuli in the Zebrafish Tectum. Neuron. 2016;90:596-608 pubmed publisher
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- western blot; human; loading ...; fig 5a
| Wolczyk D, Zaremba Czogalla M, Hryniewicz Jankowska A, Tabola R, Grabowski K, Sikorski A, et al. TNF-? promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts. Cell Oncol (Dordr). 2016;39:353-63 pubmed publisher
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| Haven B, Heilig E, Donham C, Settles M, Vasilevsky N, Owen K. Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. elife. 2016;5: pubmed publisher
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- western blot; rat; 1:1000; fig 4
| Vincent K, Cornea V, Jong Y, Laferriere A, Kumar N, Mickeviciute A, et al. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016;7:10604 pubmed publisher
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- western blot; human; 1:2000; fig 1e
| Eichel K, Jullié D, von Zastrow M. β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation. Nat Cell Biol. 2016;18:303-10 pubmed publisher
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- western blot; human; 1:800; fig s2
| Skieterska K, Rondou P, Lintermans B, Van Craenenbroeck K. KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant. PLoS ONE. 2015;10:e0145654 pubmed publisher
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- western blot; mouse; fig 1
| Diersch S, Wirth M, Schneeweis C, Jörs S, Geisler F, Siveke J, et al. Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene. 2016;35:3880-6 pubmed publisher
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- western blot; rat; 1:1000; fig 5
| Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed publisher
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- western blot; mouse; 1:3000
| Tang Y, Ye M, Du Y, Qiu X, Lv X, Yang W, et al. EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus. Neuroscience. 2015;304:109-21 pubmed publisher
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- western blot; mouse; fig s1
| Gierut J, Lyons J, Shah M, Genetti C, Breault D, Haigis K. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015;15:165-71 pubmed publisher
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- western blot; human; fig 3
| Shen Y, Zeng L, Novosyadlyy R, Forest A, Zhu A, Korytko A, et al. A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation. MAbs. 2015;7:931-45 pubmed publisher
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| Ramirez U, Nikonova A, Liu H, Pecherskaya A, Lawrence S, Serebriiskii I, et al. Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC Cancer. 2015;15:436 pubmed publisher
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- western blot; human; 1:1000; fig 1b
| Janes K. An analysis of critical factors for quantitative immunoblotting. Sci Signal. 2015;8:rs2 pubmed publisher
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- western blot; human; fig s9
| Westcott J, Prechtl A, Maine E, Dang T, Esparza M, Sun H, et al. An epigenetically distinct breast cancer cell subpopulation promotes collective invasion. J Clin Invest. 2015;125:1927-43 pubmed publisher
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- western blot; mouse; 1:4000; fig 4
| Orr A, Hsiao E, Wang M, Ho K, Kim D, Wang X, et al. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015;18:423-34 pubmed publisher
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| Guo W, Liu R, Bhardwaj G, Yang J, Changou C, Ma A, et al. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014;5:e1409 pubmed publisher
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- western blot; mouse; 1:1000
| Yu B, Chang J, Liu Y, Li J, Kevork K, Al Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-?B. Nat Med. 2014;20:1009-17 pubmed publisher
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- western blot; human; loading ...; fig 6b
| Wang F, Cai M, Mai S, Chen J, Bai H, Li Y, et al. Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression. Oncotarget. 2014;5:6716-33 pubmed
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| Sperrhacke M, Fischer J, Wu Z, Klünder S, Sedlacek R, Schroeder J, et al. SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. J Invest Dermatol. 2014;134:1645-1654 pubmed publisher
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| Yabuta C, Yano F, Fujii A, Shearer T, Azuma M. Galectin-3 enhances epithelial cell adhesion and wound healing in rat cornea. Ophthalmic Res. 2014;51:96-103 pubmed publisher
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- western blot; human; 1:1000
| Wang Z, Ren Z, Hu Z, Hu X, Zhang H, Wu H, et al. Angiotensin-II induces phosphorylation of ERK1/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic dissection formation. J Mol Histol. 2014;45:401-12 pubmed publisher
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| Mórotz G, Glennon E, Greig J, Lau D, Bhembre N, Mattedi F, et al. Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. Acta Neuropathol Commun. 2019;7:200 pubmed publisher
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| Shimell J, Shah B, Cain S, Thouta S, Kuhlmann N, Tatarnikov I, et al. The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation. Cell Rep. 2019;29:2422-2437.e8 pubmed publisher
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| Yankaskas C, Thompson K, Paul C, Vitolo M, Mistriotis P, Mahendra A, et al. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat Biomed Eng. 2019;3:452-465 pubmed publisher
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| Beránek V, Reinkemeier C, Zhang M, Liang A, Kym G, Chin J. Genetically Encoded Protein Phosphorylation in Mammalian Cells. Cell Chem Biol. 2018;25:1067-1074.e5 pubmed publisher
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| Du W, Ni L, Liu B, Wei Y, Lv Y, Qiang S, et al. Upregulation of SALL4 by EGFR activation regulates the stemness of CD44-positive lung cancer. Oncogenesis. 2018;7:36 pubmed publisher
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| Yan S, Um S, Peek V, Stephens J, Zeng W, Konicek B, et al. MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping. Invest New Drugs. 2018;36:536-544 pubmed publisher
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| Meijer B, Jang S, Guerrera I, Chhuon C, Lipecka J, Reisacher C, et al. Threonine eliminylation by bacterial phosphothreonine lyases rapidly causes cross-linking of mitogen-activated protein kinase (MAPK) in live cells. J Biol Chem. 2017;292:7784-7794 pubmed publisher
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| Hudson G, Flannigan K, Erickson S, Vicentini F, Zamponi A, Hirota C, et al. Constitutive androstane receptor regulates the intestinal mucosal response to injury. Br J Pharmacol. 2017;174:1857-1871 pubmed publisher
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| Sasaki R, Devhare P, Steele R, Ray R, Ray R. Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells. Hepatology. 2017;66:746-757 pubmed publisher
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| Agabiti S, Li J, Wiemer A. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. Cell Death Dis. 2017;8:e2678 pubmed publisher
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| Koirala P, Huang J, Ho T, Wu F, Ding X, Mo Y. LncRNA AK023948 is a positive regulator of AKT. Nat Commun. 2017;8:14422 pubmed publisher
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| Houslay K, Christian F, MacLeod R, Adams D, Houslay M, Baillie G. Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochem J. 2017;474:597-609 pubmed publisher
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| Zhong G, Li Y, Li H, Sun W, Cao D, Li J, et al. Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle. Front Physiol. 2016;7:274 pubmed publisher
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| Filippi S, Barnes C, Kirk P, Kudo T, Kunida K, McMahon S, et al. Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling. Cell Rep. 2016;15:2524-35 pubmed publisher
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| Sharma V, Young L, Cavadas M, Owen K. Registered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. elife. 2016;5: pubmed publisher
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| Ko H, Park B, Choi S, Kang H, Kim A, Kim H, et al. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J. 2016;57:761-8 pubmed publisher
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| Randlett O, Wee C, Naumann E, Nnaemeka O, Schoppik D, Fitzgerald J, et al. Whole-brain activity mapping onto a zebrafish brain atlas. Nat Methods. 2015;12:1039-46 pubmed
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| Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, et al. Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model. PLoS ONE. 2015;10:e0142786 pubmed publisher
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| Guo D, Zhang H, Tan S, Gu Y. Nifedipine promotes the proliferation and migration of breast cancer cells. PLoS ONE. 2014;9:e113649 pubmed publisher
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| Micel L, Tentler J, Tan A, Selby H, Brunkow K, Robertson K, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015;14:317-25 pubmed publisher
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| Kawashima I, Umehara T, Noma N, Kawai T, Shitanaka M, Richards J, et al. Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation. Mol Endocrinol. 2014;28:706-21 pubmed publisher
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