product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
catalog :
4668
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
81E11
reactivity :
hamsters, human, mouse, rat, chicken, bovine, pigs , fruit fly , roundworm
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, reverse phase protein lysate microarray, other
more info or order :
Cell Signaling Technology product webpage
citations: 339
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 3c
Schünke H, Göbel U, Dikic I, Pasparakis M. OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun. 2021;12:5912 pubmed publisher
  • western blot; mouse; 1:1000; fig 4e
Bermúdez Muñoz J, Celaya A, García Mato Á, Muñoz Espín D, Rodriguez de la Rosa L, Serrano M, et al. Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10b
Rossetti G, Ermer J, Stentenbach M, Siira S, Richman T, Milenkovic D, et al. A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv. 2021;7:eabi7514 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Sun H, Ni H, McCracken J, Akakpo J, Fulte S, McKeen T, et al. Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice. Liver Res. 2021;5:79-87 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Rajendran R, Rajendran V, Giraldo Velasquez M, Megalofonou F, Gurski F, Stadelmann C, et al. Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; fig 1c
Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Liu M, Shan M, Zhang Y, Guo Z. Progranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma. J Inflamm Res. 2021;14:3891-3904 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4c
Tan X, Tong L, Li L, Xu J, Xie S, Ji L, et al. Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation. Nat Commun. 2021;12:4853 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3f, 5d
Fan M, Zhang G, Chen W, Qi L, Xie M, Zhang Y, et al. Siglec-15 Promotes Tumor Progression in Osteosarcoma via DUSP1/MAPK Pathway. Front Oncol. 2021;11:710689 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 2a
Nguyen Tran H, Nguyen T, Chen C, Hsu T. Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL-Deficient Kidney Tissue. Cancer Res. 2021;81:5060-5073 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
Ding B, Bao C, Jin L, Xu L, Fan W, Lou W. CASK Silence Overcomes Sorafenib Resistance of Hepatocellular Carcinoma Through Activating Apoptosis and Autophagic Cell Death. Front Oncol. 2021;11:681683 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig 5h
Beaulac H, Gilels F, Zhang J, Jeoung S, White P. Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice. Cell Death Dis. 2021;12:682 pubmed publisher
  • western blot; human; loading ...; fig 5e
Lai W, Zhu W, Xiao C, Li X, Wang Y, Han Y, et al. HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3β/JNK signaling pathway. Cell Death Dis. 2021;12:583 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c
  • western blot; rat; 1:1000; loading ...; fig 3a
Wu Y, Xie L, Hua Y, Xu H, Chen G, Han X, et al. Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. Front Pharmacol. 2021;12:644116 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig s3a
  • western blot; mouse; 1:1000; loading ...; fig 5a
Hao D, Li Y, Shi J, Jiang J. Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway. Mol Med. 2021;27:53 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 8a
Huang W, Liu H, Pan Y, Yang H, Lin J, Zhang H. Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α. J Cardiothorac Surg. 2021;16:127 pubmed publisher
  • western blot; mouse; loading ...; fig ev2c
Pei G, Zyla J, He L, Moura Alves P, Steinle H, Saikali P, et al. Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate. EMBO J. 2021;40:e106272 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Zheng H, Zhang Y, He J, Yang Z, Zhang R, Li L, et al. Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury. Front Immunol. 2021;12:645100 pubmed publisher
  • western blot; human; loading ...; fig 6a
Chen X, Ma W, Yao Y, Zhang Q, Li J, Wu X, et al. Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways. Cell Death Dis. 2021;12:425 pubmed publisher
  • western blot; mouse; fig 3d
Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; loading ...; fig 7a
Liu Y, Nie X, Zhu J, Wang T, Li Y, Wang Q, et al. NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension. J Cell Mol Med. 2021;25:1221-1237 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Crespo M, González Terán B, Nikolic I, Mora A, Folgueira C, Rodriguez E, et al. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 9d
Xiao L, Zhong M, Huang Y, Zhu J, Tang W, Li D, et al. Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways. Aging (Albany NY). 2020;12:21706-21729 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 2b
Xu J, Jiang C, Cai Y, Guo Y, Wang X, Zhang J, et al. Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2020;22:200 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, et al. Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis. Front Immunol. 2020;11:1598 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 10c
Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed publisher
  • western blot; human; loading ...; fig 4a
Lin L, Li Y, Liu M, Li Q, Liu Q, Li R. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging (Albany NY). 2020;12:1685-1703 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig ev1c
Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, et al. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020;12:e11021 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed publisher
  • western blot; human; fig 5a
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 4f
Wang H, Wei Y, Pu Y, Jiang D, Jiang X, Zhang Y, et al. Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity. Sci Signal. 2019;12: pubmed publisher
  • western blot; mouse; loading ...; fig e1a
Majer O, Liu B, Kreuk L, Krogan N, Barton G. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature. 2019;575:366-370 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Zhong B, Shi D, Wu F, Wang S, Hu H, Cheng C, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. Cell Death Dis. 2019;10:687 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 11a
Xu B, Lang L, Li S, Guo J, Wang J, Yang H, et al. Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure. Biomolecules. 2019;9: pubmed publisher
  • western blot; mouse; loading ...; fig 2i
Solis A, Bielecki P, Steach H, Sharma L, Harman C, Yun S, et al. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature. 2019;573:69-74 pubmed publisher
  • western blot; human; loading ...; fig s2i
Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed publisher
  • western blot; human; loading ...; fig 4d
Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, et al. Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. Theranostics. 2019;9:3879-3902 pubmed publisher
  • western blot; human; loading ...; fig 4a
Gu C, Wang L, Zurawski S, Oh S. Signaling Cascade through DC-ASGPR Induces Transcriptionally Active CREB for IL-10 Induction and Immune Regulation. J Immunol. 2019;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d
Udden S, Kwak Y, Godfrey V, Khan M, Khan S, Loof N, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig s2d
Wu J, Ma S, Sandhoff R, Ming Y, Hotz Wagenblatt A, Timmerman V, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019;50:1218-1231.e5 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1f
  • western blot; human; loading ...; fig 1c
Li W, Yu X, Zhu C, Wang Z, Zhao Z, Li Y, et al. Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways. Biol Res. 2019;52:10 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Li Z, Tian Y, Qu L, Mao J, Zhong H. AAV-Mig-6 Increase the Efficacy of TAE in VX2 Rabbit Model, Is Associated With JNK Mediated Autophagy. J Cancer. 2019;10:1060-1069 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a, 3c, s3d
Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher
  • western blot; mouse; loading ...; fig 1h
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3c
Duan S, Koziol White C, Jester W, Nycholat C, Macauley M, Panettieri R, et al. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen. J Clin Invest. 2019;129:1387-1401 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y, et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. EBioMedicine. 2019;40:43-55 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2b
Cheng Z, Zhang M, Hu J, Lin J, Feng X, Wang S, et al. Cardiac-specific Mst1 deficiency inhibits ROS-mediated JNK signalling to alleviate Ang II-induced cardiomyocyte apoptosis. J Cell Mol Med. 2019;23:543-555 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2d
Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, et al. Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Nat Commun. 2018;9:4381 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Cao Y, Xu Y, Auchoybur M, Chen W, He S, Qin W, et al. Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages. J Mol Cell Cardiol. 2018;123:1-12 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4a
Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; tbl 1
Roseweir A, Halcrow E, Chichilo S, Powell A, McMillan D, Horgan P, et al. ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer. Br J Cancer. 2018;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Xu Y, Xu J, Ge K, Tian Q, Zhao P, Guo Y. Anti-inflammatory effect of low molecular weight fucoidan from Saccharina japonica on atherosclerosis in apoE-knockout mice. Int J Biol Macromol. 2018;118:365-374 pubmed publisher
  • western blot; human; loading ...; fig 4c
Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Lork M, Kreike M, Staal J, Beyaert R. Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKK?/TBK1 as a Case Study. Front Cell Dev Biol. 2018;6:40 pubmed publisher
  • western blot; human; fig 7a
Toosi B, El Zawily A, Truitt L, Shannon M, Allonby O, Babu M, et al. EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours. Oncogene. 2018;37:4073-4093 pubmed publisher
  • western blot; mouse; fig 3a
Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk U, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018;9:1352 pubmed publisher
  • western blot; human; fig 5a
Morgan E, Wasson C, Hanson L, Kealy D, Pentland I, McGuire V, et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PLoS Pathog. 2018;14:e1006975 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Kou W, Xu X, Ji S, Chen M, Liu D, Wang K, et al. The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice. Biochem Biophys Res Commun. 2018;497:248-255 pubmed publisher
  • western blot; mouse; fig s2d
Shen Q, Zhang Q, Shi Y, Shi Q, Jiang Y, Gu Y, et al. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature. 2018;554:123-127 pubmed publisher
  • western blot; human; 1:1000; fig 3h
Xu S, Zhou Z, Li H, Liu Z, Pan X, Wang F, et al. BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis. J Cell Sci. 2018;131: pubmed publisher
  • western blot; mouse; loading ...; fig s7a
Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, et al. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proc Natl Acad Sci U S A. 2017;114:10737-10742 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Hama T, Nakanishi K, Sato M, Mukaiyama H, Togawa H, Shima Y, et al. Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease. Am J Physiol Renal Physiol. 2017;:ajprenal.00697.2016 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Nishimura S, Mishra Gorur K, Park J, Surovtseva Y, Sebti S, Levchenko A, et al. Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Proc Natl Acad Sci U S A. 2017;114:5503-5508 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, et al. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 2017;8:e2763 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 3f
Yoon C, Cho S, Chang K, Park D, Ryeom S, Yoon S. Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma. Mol Cancer Res. 2017;15:1106-1116 pubmed publisher
  • western blot; mouse; fig 5a
Kaufman D, Papillon J, Larose L, Iwawaki T, Cybulsky A. Deletion of inositol-requiring enzyme-1? in podocytes disrupts glomerular capillary integrity and autophagy. Mol Biol Cell. 2017;28:1636-1651 pubmed publisher
  • western blot; human; 1:1000; fig 4a
Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed publisher
  • western blot; human; loading ...; fig s1a
  • western blot; mouse; fig 4a
Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher
  • western blot; human; fig 3b,3l
Du M, Martin A, HAYS F, Johnson J, FARJO R, Farjo K. Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4. Mol Vis. 2017;23:185-197 pubmed
  • western blot; human; loading ...; fig 4a
Deng H, Fung G, Qiu Y, Wang C, Zhang J, Jin Z, et al. Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection. Front Cell Infect Microbiol. 2017;7:85 pubmed publisher
  • western blot; human; loading ...; fig 1b
Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  • western blot; mouse; loading ...; fig 3
Balmer D, Bapst Wicht L, Pyakurel A, Emery M, Nanchen N, Bochet C, et al. Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis. Front Aging Neurosci. 2017;9:43 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, et al. miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury. Theranostics. 2017;7:664-676 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Dong Q, Fu L, Zhao Y, Tan S, Wang E. Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling. Oncotarget. 2017;8:17059-17069 pubmed publisher
  • western blot; mouse; loading ...; fig s5e
Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Xiong X, Liu Y, Mei Y, Peng J, Wang Z, Kong B, et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017;7:41857 pubmed publisher
  • western blot; mouse; loading ...; fig 2A
  • western blot; human; loading ...; fig 5A
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed publisher
  • western blot; human; loading ...; fig 4a
Yang H, Ju F, Guo X, Ma S, Wang L, Cheng B, et al. RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143. Sci Rep. 2017;7:41738 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2h
Cederquist C, Lentucci C, Martinez Calejman C, Hayashi V, Orofino J, GUERTIN D, et al. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017;6:125-137 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  • western blot; rat; fig 5a
Chen G, Chen J, Yan Z, Li Z, Yu M, Guo W, et al. Maternal diabetes modulates dental epithelial stem cells proliferation and self-renewal in offspring through apurinic/apyrimidinicendonuclease 1-mediated DNA methylation. Sci Rep. 2017;7:40762 pubmed publisher
  • western blot; mouse; loading ...; fig 2d,2h
Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, et al. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res. 2017;27:352-372 pubmed publisher
  • western blot; mouse; fig 5c
Pediaditakis I, Kourgiantaki A, Prousis K, Potamitis C, Xanthopoulos K, Zervou M, et al. BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis. Front Pharmacol. 2016;7:512 pubmed publisher
  • western blot; fruit fly ; 1:2000; loading ...; fig 7c
Tare M, Sarkar A, Bedi S, Kango Singh M, Singh A. Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye. Cell Death Dis. 2016;7:e2566 pubmed publisher
  • western blot; human; loading ...
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 8a
Su J, Zhou H, Liu X, Nilsson J, Fredrikson G, Zhao M. oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca2+ /K+ channel flow. J Cell Mol Med. 2017;21:929-940 pubmed publisher
  • western blot; mouse; loading ...; fig 5i
Bodrikov V, Pauschert A, Kochlamazashvili G, Stuermer C. Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. Exp Neurol. 2017;289:31-45 pubmed publisher
  • western blot; human; loading ...; fig 3a
Hess N, Jiang S, Li X, Guan Y, Tapping R. TLR10 Is a B Cell Intrinsic Suppressor of Adaptive Immune Responses. J Immunol. 2017;198:699-707 pubmed publisher
  • western blot; human; loading ...; fig 7e
Natarajan S, Muthukrishnan E, Khalimonchuk O, Mott J, Becker D. Evidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress. J Cell Biochem. 2017;118:1678-1688 pubmed publisher
  • western blot; mouse; loading ...; fig s3h, s4a
Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s5d
Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Choi Y, Shembade N, Parvatiyar K, Balachandran S, Harhaj E. TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 2a
Yue G, Xie S, Lee J, Kwok H, Gao S, Nian Y, et al. New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment. Sci Rep. 2016;6:35263 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Huai W, Song H, Yu Z, Wang W, Han L, Sakamoto T, et al. Mint3 potentiates TLR3/4- and RIG-I-induced IFN-? expression and antiviral immune responses. Proc Natl Acad Sci U S A. 2016;113:11925-11930 pubmed
  • western blot; human; loading ...; fig 4a
Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed
  • western blot; human; loading ...; fig 4c
Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6d
Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed publisher
  • western blot; human; 1:100; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; mouse; fig 3
Vernia S, Edwards Y, Han M, Cavanagh Kyros J, Barrett T, Kim J, et al. An alternative splicing program promotes adipose tissue thermogenesis. elife. 2016;5: pubmed publisher
  • western blot; mouse; loading ...; fig s5b, s6b
Janowski A, Colegio O, Hornick E, McNiff J, Martin M, Badovinac V, et al. NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest. 2016;126:3917-3928 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Cao Y, Wang X, Xu C, Gao Z, Zhou H, Wang Y, et al. 4-HPR impairs bladder cancer cell migration and invasion by interfering with the Wnt5a/JNK and Wnt5a/MMP-2 signaling pathways. Oncol Lett. 2016;12:1833-1839 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 5a
Zhang K, Cai H, Gao S, Yang G, Deng H, Xu G, et al. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals. Oncotarget. 2016;7:69436-69449 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Ando Y, Oku T, Tsuji T. Platelet Supernatant Suppresses LPS-Induced Nitric Oxide Production from Macrophages Accompanied by Inhibition of NF-?B Signaling and Increased Arginase-1 Expression. PLoS ONE. 2016;11:e0162208 pubmed publisher
  • western blot; rat; fig 5
Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, et al. C5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways. PLoS ONE. 2016;11:e0161867 pubmed publisher
  • western blot; human; fig 4a
Cheng G, Gao F, Sun X, Bi H, Zhu Y. Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP?2/9 production via the p38 MAPK signaling pathway. Mol Med Rep. 2016;14:3199-205 pubmed publisher
  • western blot; human; fig 1
Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; roundworm ; fig s3a
Shikuma N, Antoshechkin I, Medeiros J, Pilhofer M, Newman D. Stepwise metamorphosis of the tubeworm Hydroides elegans is mediated by a bacterial inducer and MAPK signaling. Proc Natl Acad Sci U S A. 2016;113:10097-102 pubmed publisher
  • western blot; rat; loading ...; fig 3a
Ruess D, Probst M, Marjanovic G, Wittel U, Hopt U, Keck T, et al. HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0161233 pubmed publisher
  • western blot; mouse; fig 7d
Ramo K, Sugamura K, Craige S, Keaney J, Davis R. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. elife. 2016;5: pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • western blot; human; loading ...; fig 6a
Shen P, Chen M, He M, Chen L, Song Y, Xiao P, et al. Inhibition of ER?/ERK/P62 cascades induces "autophagic switch" in the estrogen receptor-positive breast cancer cells exposed to gemcitabine. Oncotarget. 2016;7:48501-48516 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4e
  • western blot; human; loading ...; fig 4c
Xiao B, Chen D, Luo S, Hao W, Jing F, Liu T, et al. Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling. Oncotarget. 2016;7:50057-50073 pubmed publisher
  • western blot; human; fig 1
Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  • western blot; mouse; fig 2
Zhao W, Li A, Feng X, Hou T, Liu K, Liu B, et al. Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue. Cell Signal. 2016;28:1401-11 pubmed publisher
  • western blot; human; fig 2
Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen F, Frankowski K, et al. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016;12:1460-71 pubmed publisher
  • western blot; mouse; 1:2000; fig 1a
Desrochers L, Bordeleau F, Reinhart King C, Cerione R, Antonyak M. Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation. Nat Commun. 2016;7:11958 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher
  • western blot; human; fig 2
Leonard S, Kinsella G, Benetti E, Findlay J. Regulating the effects of GPR21, a novel target for type 2 diabetes. Sci Rep. 2016;6:27002 pubmed publisher
  • western blot; mouse; 1:1000; fig s5
Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed publisher
  • western blot; mouse; fig 2
Yu H. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. PLoS ONE. 2016;11:e0156303 pubmed publisher
  • western blot; mouse; fig 3
de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:50; fig 3
  • western blot; rat; 1:1000; fig 5
Pei H, Jiang T, Liu G, Li Z, Luo K, An J, et al. The Effect of Minimally Invasive Hematoma Aspiration on the JNK Signal Transduction Pathway after Experimental Intracerebral Hemorrhage in Rats. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Song X, Yao Z, Yang J, Zhang Z, Deng Y, Li M, et al. HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways. Oncotarget. 2016;7:33796-808 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Hu L, Tan J, Yang X, Tan H, Xu X, You M, et al. Polysaccharide Extracted from Laminaria japonica Delays Intrinsic Skin Aging in Mice. Evid Based Complement Alternat Med. 2016;2016:5137386 pubmed publisher
  • western blot; human; loading ...; fig 4g
Wang Y, Cao J, Fan Y, Xie Y, Xu Z, Yin Z, et al. Artemisinin inhibits monocyte adhesion to HUVECs through the NF-?B and MAPK pathways in vitro. Int J Mol Med. 2016;37:1567-75 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 3
Kim B, Silverman S, Liu Y, Wordinger R, Pang I, Clark A. In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells. Mol Neurodegener. 2016;11:30 pubmed publisher
  • western blot; rat; fig 6
Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M. An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid ? Precursor Protein Signaling. J Biol Chem. 2016;291:12282-93 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed publisher
  • western blot; human; 1:1000; fig 4
Martínez M, Ubeda A, Moreno J, Trillo M. Power Frequency Magnetic Fields Affect the p38 MAPK-Mediated Regulation of NB69 Cell Proliferation Implication of Free Radicals. Int J Mol Sci. 2016;17:510 pubmed publisher
  • western blot; human; fig 1
Phelps Polirer K, Abt M, Smith D, Yeh E. Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer. PLoS ONE. 2016;11:e0153025 pubmed publisher
  • western blot; human; loading ...; fig 1b
Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
  • western blot; human; fig 3
Huang W, Zhao H, Dong H, Wu Y, Yao L, Zou F, et al. High-mobility group box 1 impairs airway epithelial barrier function through the activation of the RAGE/ERK pathway. Int J Mol Med. 2016;37:1189-98 pubmed publisher
  • western blot; human; loading ...; fig 2a
Jiang S, Li X, Hess N, Guan Y, Tapping R. TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling. J Immunol. 2016;196:3834-41 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Chen S, Wang C, Yeo S, Liang C, Okamoto T, Sun S, et al. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes Dev. 2016;30:856-69 pubmed publisher
  • western blot; pigs ; 1:1000; fig 2
Ganesan S, Reynolds C, Hollinger K, Pearce S, Gabler N, Baumgard L, et al. Twelve hours of heat stress induces inflammatory signaling in porcine skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1288-96 pubmed publisher
  • western blot; human; 1:750; fig s4
Federspiel J, Codreanu S, Palubinsky A, Winland A, Betanzos C, McLaughlin B, et al. Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress. Mol Cell Proteomics. 2016;15:1947-61 pubmed publisher
  • western blot; hamsters; loading ...; fig 3a
Gao Z, Zhang H, Hu F, Yang L, Yang X, Zhu Y, et al. Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan. Cell Signal. 2016;28:652-62 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Du K, Farhood A, Jaeschke H. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017;91:761-773 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Yu C, Tang L, Liang C, Chen X, Song S, Ding X, et al. Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  • western blot; human; 1:1000; fig 5
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed
  • western blot; rat; 1:1000; fig 5
Shinde V, Kotla P, Strang C, Gorbatyuk M. Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa. Cell Death Dis. 2016;7:e2085 pubmed publisher
  • western blot; human; fig 4
Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
Ito T, Itakura J, Takahashi S, Sato M, Mino M, Fushimi S, et al. Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia. Crit Care Med. 2016;44:e530-43 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Chen P, Li J, Huo Y, Lu J, Wan L, Li B, et al. Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis. Peerj. 2015;3:e1518 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Ishibashi T, Yaguchi A, Terada K, Ueno Yokohata H, Tomita O, Iijima K, et al. Ph-like ALL-related novel fusion kinase ATF7IP-PDGFRB exhibits high sensitivity to tyrosine kinase inhibitors in murine cells. Exp Hematol. 2016;44:177-88.e5 pubmed publisher
  • western blot; human; 1:1000; fig s2a
Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed publisher
  • western blot; mouse; 1:1000; fig s7
Franco Villanueva A, Wandosell F, Antón I. Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities. Brain Behav. 2015;5:e00359 pubmed publisher
  • western blot; human; 1:500; fig 3
Wu Y, Ai X, Liu F, Liang H, Zhang B, Chen X. c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma. Mol Med Rep. 2016;13:1345-52 pubmed publisher
  • western blot; human; loading ...; fig 2b, 2c
Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher
  • western blot; rat; 1:1000; fig 5a
Li W, Wei S, Liu C, Song M, Wu H, Yang Y. Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling. Int J Mol Med. 2016;37:63-73 pubmed publisher
  • western blot; rat
Rizvi F, Mathur A, Krishna S, Siddiqi M, Kakkar P. Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes. Redox Biol. 2015;6:587-598 pubmed publisher
  • western blot; human; fig 1
Dumas A, Lê Bury G, Marie Anaïs F, Herit F, Mazzolini J, Guilbert T, et al. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J Cell Biol. 2015;211:359-72 pubmed publisher
  • western blot; human; 1:1000; fig 4
Chauhan S, Ahmed Z, Bradfute S, Arko Mensah J, Mandell M, Won Choi S, et al. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015;6:8620 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4a
Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed publisher
  • western blot; human; 1:1000; fig 6
Qiu H, Liu B, Liu W, Liu S. Interleukin-27 enhances TNF-α-mediated activation of human coronary artery endothelial cells. Mol Cell Biochem. 2016;411:1-10 pubmed publisher
  • western blot; human; 1:1000; fig 7
Zhou X, Tao Y, Liang C, Zhang Y, Li H, Chen Q. BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype. Int J Mol Sci. 2015;16:20344-59 pubmed publisher
  • western blot; mouse
Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015;10:e0136952 pubmed publisher
  • western blot; mouse; fig s5
Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, et al. Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature. 2015;525:389-393 pubmed publisher
  • western blot; rat; fig S3
Simard E, Söllradl T, Maltais J, Boucher J, D Orléans Juste P, Grandbois M. Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS ONE. 2015;10:e0128881 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Fisher O, Deng H, Liu D, Zhang Y, Wei R, Deng Y, et al. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015;6:7937 pubmed publisher
  • western blot; human; fig 5
Zhang X, Wang X, Wu T, Li B, Liu T, Wang R, et al. Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. Sci Rep. 2015;5:12579 pubmed publisher
  • western blot; mouse; fig 6
Ito A, Hong C, Rong X, Zhu X, Tarling E, Hedde P, et al. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. elife. 2015;4:e08009 pubmed publisher
  • immunohistochemistry; human; 1:25; fig 1
Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, et al. JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J. 2015;34:2162-81 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Noda K, Mishina Y, Komatsu Y. Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2016;415:306-313 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Chang C, Lin C, Lu C, Martel J, Ko Y, Ojcius D, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015;6:7489 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Wu P, Yen J, Kou M, Wu M. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS ONE. 2015;10:e0130599 pubmed publisher
  • western blot; human; fig 6
Unni A, Lockwood W, Zejnullahu K, Lee Lin S, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. elife. 2015;4:e06907 pubmed publisher
  • western blot; human; loading ...; fig 4
Sun L, Xu C, Chen G, Yu M, Yang S, Qiu Y, et al. A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway. Int J Biol Sci. 2015;11:664-71 pubmed publisher
  • western blot; human; 1:1000; fig s5a
Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher
  • western blot; human; fig s1
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
  • immunocytochemistry; rat; 1:200
  • western blot; rat; 1:1000
Hu J, Li T, Du S, Chen Y, Wang S, Xiong F, et al. The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells. Int J Mol Med. 2015;36:130-8 pubmed publisher
  • western blot; human; fig 5
Peiris Pagès M, Sotgia F, Lisanti M. Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells. Oncotarget. 2015;6:10728-45 pubmed
  • western blot; human; 1:1000; fig 4
Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey M, et al. The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Front Microbiol. 2015;6:280 pubmed publisher
  • western blot; human; fig 5
Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed publisher
  • western blot; human; fig f4
Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed
  • western blot; human; 1:1000; loading ...; fig 9
Chuang W, Su C, Lin P, Lin C, Chen Y. Sann-Joong-Kuey-Jian-Tang induces autophagy in HepG2 cells via regulation of the phosphoinositide-3 kinase/Akt/mammalian target of rapamycin and p38 mitogen-activated protein kinase pathways. Mol Med Rep. 2015;12:1677-84 pubmed publisher
  • western blot; rat; loading ...; fig 7b
  • western blot; mouse; loading ...; fig 3d
  • western blot; human; loading ...; fig 1b
Pilar Valdecantos M, Prieto Hontoria P, Pardo V, Módol T, Santamaría B, Weber M, et al. Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. Free Radic Biol Med. 2015;84:263-278 pubmed publisher
  • western blot; mouse
Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher
  • western blot; mouse
Williams J, Ni H, Haynes A, Manley S, Li Y, Jaeschke H, et al. Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice. J Biol Chem. 2015;290:10934-46 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6
  • western blot; human; 1:1000; loading ...; fig 2
Yang Y, Deng Q, Feng X, Sun J. Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice. Mol Med Rep. 2015;12:746-52 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
Wei Z, Yu D, Bi Y, Cao Y. A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury. Mol Med Rep. 2015;12:63-70 pubmed publisher
  • western blot; human; 1:1000; fig 4
He P, Jiang S, Ma M, Wang Y, Li R, Fang F, et al. Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling. Mol Med Rep. 2015;12:503-9 pubmed publisher
  • western blot; human
Lee J, Chung L, Chen Y, Feng T, Chen W, Juang H. Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells. Cancer Lett. 2015;360:310-8 pubmed publisher
  • western blot; human; loading ...; fig s2b
Sanjurjo L, Amézaga N, Aran G, Naranjo Gómez M, Arias L, Armengol C, et al. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses. Autophagy. 2015;11:487-502 pubmed publisher
  • western blot; human; fig 2
Santhana Kumar K, Tripolitsioti D, Ma M, Grählert J, Egli K, Fiaschetti G, et al. The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus. 2015;4:19 pubmed publisher
  • western blot; human
Seeßle J, Liebisch G, Schmitz G, Stremmel W, Chamulitrat W. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochim Biophys Acta. 2015;1851:549-65 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
De Luca A, Rotili D, Carpanese D, Lenoci A, Calderan L, Scimeca M, et al. A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts. Oncotarget. 2015;6:4126-43 pubmed
  • western blot; human
Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed publisher
  • western blot; mouse; fig 2
Arruda A, Pers B, Parlakgül G, Güney E, Inouye K, Hotamisligil G. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014;20:1427-35 pubmed publisher
  • western blot; human
Blaabjerg L, Christensen G, Matsumoto M, van der Meulen T, Huising M, Billestrup N, et al. CRFR1 activation protects against cytokine-induced β-cell death. J Mol Endocrinol. 2014;53:417-27 pubmed publisher
  • western blot; rat
Wang Y, Xiao X, Li N, Yang D, Xing Y, Huo R, et al. Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen-mediated protection against cardiac hypertrophy. Br J Pharmacol. 2015;172:5586-95 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; mouse; fig 5
Matsuyama M, Nomori A, Nakakuni K, Shimono A, Fukushima M. Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy. J Biol Chem. 2014;289:31526-33 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Bertin S, Lozano Ruiz B, Bachiller V, García Martínez I, Herdman S, Zapater P, et al. Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol. 2015;8:505-15 pubmed publisher
  • western blot; human
Tobar N, Toyos M, Urra C, Méndez N, Arancibia R, Smith P, et al. c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer. 2014;14:640 pubmed publisher
  • western blot; mouse; fig 6
Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, et al. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun. 2014;5:4657 pubmed publisher
  • western blot; human
Bailon E, Ugarte Berzal E, Amigo Jiménez I, Van den Steen P, Opdenakker G, Garcia Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed publisher
  • western blot; human; loading ...; fig 6a
Wang F, Cai M, Mai S, Chen J, Bai H, Li Y, et al. Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression. Oncotarget. 2014;5:6716-33 pubmed
  • western blot; pigs ; 1:500
Zhang S, Ren M, Zeng X, He P, Ma X, Qiao S. Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino Acids. 2014;46:2633-42 pubmed publisher
  • western blot; mouse
Gonzalez Rodriguez A, Reibert B, Amann T, Constien R, Rondinone C, Valverde A. In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice. Dis Model Mech. 2014;7:1093-100 pubmed publisher
  • western blot; rat; 1:1000
Huang L, Zhu G, Deng Y, Jiang W, Fang M, Chen C, et al. Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-? and IL-1?-induced Na-K-Cl Cotransporter up-regulation. J Neuroinflammation. 2014;11:102 pubmed publisher
  • western blot; human
Chien P, Hsieh H, Chi P, Yang C. PAR1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes. Br J Pharmacol. 2014;171:4504-19 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250
Fernandes K, Harder J, JOHN S, Shrager P, Libby R. DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury. Neurobiol Dis. 2014;69:108-16 pubmed publisher
  • western blot; mouse
Gonzalez Rodriguez A, Mayoral R, Agra N, Valdecantos M, Pardo V, Miquilena Colina M, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5:e1179 pubmed publisher
  • western blot; human; fig 5
Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, et al. DNA damage induces the accumulation of Tiam1 by blocking ?-TrCP-dependent degradation. J Biol Chem. 2014;289:15482-94 pubmed publisher
  • western blot; human
Liu B, Cao Y, Huizinga T, Hafler D, Toes R. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014;44:2121-9 pubmed publisher
  • western blot; human; 1:1000
Losa D, Köhler T, Bellec J, Dudez T, Crespin S, Bacchetta M, et al. Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner. J Immunol. 2014;192:4804-12 pubmed publisher
  • western blot; rat
Codeluppi S, Fernández Zafra T, Sandor K, Kjell J, Liu Q, Abrams M, et al. Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling. PLoS ONE. 2014;9:e92649 pubmed publisher
  • western blot; human
Singel S, Batten K, Cornelius C, Jia G, Fasciani G, Barron S, et al. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res. 2014;16:R28 pubmed publisher
  • western blot; bovine; 1:1000; fig 4b
Ma M, Baumgartner M. Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton. PLoS Pathog. 2014;10:e1004003 pubmed publisher
  • immunohistochemistry - free floating section; mouse; fig 5
Stancu I, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, et al. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB J. 2014;28:2620-31 pubmed publisher
  • western blot; rat
Qian H, Shi J, Fan T, Lv J, Chen S, Song C, et al. Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats. World J Gastroenterol. 2014;20:1822-32 pubmed publisher
  • western blot; rat; 1:1000
Borkham Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-? signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher
  • western blot; mouse; 1:1000
Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed publisher
  • western blot; mouse; fig 5
Cagnet S, Faraldo M, Kreft M, Sonnenberg A, Raymond K, Glukhova M. Signaling events mediated by ?3?1 integrin are essential for mammary tumorigenesis. Oncogene. 2014;33:4286-95 pubmed publisher
  • western blot; mouse; 1:200
Bittner S, Ruck T, Schuhmann M, Herrmann A, Moha Ou Maati H, Bobak N, et al. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med. 2013;19:1161-5 pubmed publisher
  • western blot; human
Liang H, Hussey S, Sanchez Avila A, Tantiwong P, Musi N. Effect of lipopolysaccharide on inflammation and insulin action in human muscle. PLoS ONE. 2013;8:e63983 pubmed publisher
  • western blot; mouse
  • western blot; human
Mobasher M, Gonzalez Rodriguez A, Santamaria B, Ramos S, Martin M, Goya L, et al. Protein tyrosine phosphatase 1B modulates GSK3?/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death Dis. 2013;4:e626 pubmed publisher
  • western blot; mouse
Dai J, Shen D, Bian Z, Zhou H, Gan H, Zong J, et al. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PLoS ONE. 2013;8:e53412 pubmed publisher
  • western blot; chicken
  • western blot; human
Moreno Garcia M, Sommer K, Rincón Arano H, Brault M, Ninomiya Tsuji J, Matesic L, et al. Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-?B activation. Mol Cell Biol. 2013;33:1149-63 pubmed publisher
  • western blot; mouse; 1:1 000
Xu X, Wang Q, Long Y, Zhang R, Wei X, Xing M, et al. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Res. 2013;23:131-41 pubmed publisher
  • western blot; mouse; 1:1000
Okami N, Narasimhan P, Yoshioka H, Sakata H, Kim G, Jung J, et al. Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase. J Cereb Blood Flow Metab. 2013;33:106-14 pubmed publisher
  • western blot; human
Lemire B, Debigare R, Dubé A, Thériault M, Cote C, Maltais F. MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease. J Appl Physiol (1985). 2012;113:159-66 pubmed publisher
Morgan E, Scarth J, Patterson M, Wasson C, Hemingway G, Barba Moreno D, et al. E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer. Cell Death Differ. 2021;28:1669-1687 pubmed publisher
Gehring T, Erdmann T, Rahm M, Graß C, Flatley A, O Neill T, et al. MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Cell Rep. 2019;29:873-888.e10 pubmed publisher
Kashyap A, Fernandez Rodriguez L, Zhao Y, Monaco G, Trefny M, Yoshida N, et al. GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Cell Rep. 2019;28:3367-3380.e8 pubmed publisher
White S, Avantaggiati M, Nemazanyy I, Di Poto C, Yang Y, Pende M, et al. YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Dev Cell. 2019;49:425-443.e9 pubmed publisher
Ma F, Chang X, Wang G, Zhou H, Ma Z, Lin H, et al. Streptococcus Suis Serotype 2 Stimulates Neutrophil Extracellular Traps Formation via Activation of p38 MAPK and ERK1/2. Front Immunol. 2018;9:2854 pubmed publisher
Stefanoska K, Bertz J, Volkerling A, van der Hoven J, Ittner L, Ittner A. Neuronal MAP kinase p38? inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour. Sci Rep. 2018;8:14296 pubmed publisher
Insua Rodríguez J, Pein M, Hongu T, Meier J, Descot A, Lowy C, et al. Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis. EMBO Mol Med. 2018;10: pubmed publisher
Huck O, You J, Han X, Cai B, PANEK J, Amar S. Reduction of Articular and Systemic Inflammation by Kava-241 in a Porphyromonas gingivalis-Induced Arthritis Murine Model. Infect Immun. 2018;86: pubmed publisher
Lei F, Jin L, Liu X, Lai F, Yan X, Farrelly M, et al. RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors. Cell Death Dis. 2018;9:679 pubmed publisher
Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka E, Yamaguchi T, et al. High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages. Sci Rep. 2018;8:6736 pubmed publisher
Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, et al. Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated. Toxins (Basel). 2018;10: pubmed publisher
Shimobayashi M, Albert V, Woelnerhanssen B, Frei I, Weissenberger D, Meyer Gerspach A, et al. Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018;128:1538-1550 pubmed publisher
Rossi M, Zhu L, McMillin S, Pydi S, Jain S, Wang L, et al. Hepatic Gi signaling regulates whole-body glucose homeostasis. J Clin Invest. 2018;128:746-759 pubmed publisher
Jing H, Zhang X, Wisner S, Chen X, Spiegelman N, Linder M, et al. SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. elife. 2017;6: pubmed publisher
Chen L, Liu C, Gao J, Xie Z, Chan L, Keating D, et al. Inhibition of Miro1 disturbs mitophagy and pancreatic ?-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes. Oncotarget. 2017;8:90693-90705 pubmed publisher
Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, et al. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. 2017;127:4449-4461 pubmed publisher
Kong F, Liu Z, Jain V, Shima K, Suzuki T, Muglia L, et al. Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. J Immunol. 2017;199:3654-3667 pubmed publisher
Perdiz D, Lorin S, Leroy Gori I, Poüs C. Stress-induced hyperacetylation of microtubule enhances mitochondrial fission and modulates the phosphorylation of Drp1 at 616Ser. Cell Signal. 2017;39:32-43 pubmed publisher
Sheng X, You Q, Zhu H, Chang Z, Li Q, Wang H, et al. Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLoS Pathog. 2017;13:e1006534 pubmed publisher
Satterfield L, Shuck R, Kurenbekova L, Allen Rhoades W, Edwards D, Huang S, et al. miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. Int J Cancer. 2017;141:2062-2075 pubmed publisher
Rattanasinchai C, Llewellyn B, Conrad S, Gallo K. MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells. Oncogenesis. 2017;6:e345 pubmed publisher
Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed publisher
Wang L, Chen X, Du Z, Li G, Chen M, Chen X, et al. Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics. J Exp Clin Cancer Res. 2017;36:47 pubmed publisher
Liao X, Feng B, Zhang D, Liu P, Zhou X, Li R, et al. The Sirt6 gene: Does it play a role in tooth development?. PLoS ONE. 2017;12:e0174255 pubmed publisher
Ocaña G, Perez L, Guindon L, Deffit S, Evans Molina C, Thurmond D, et al. Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90?. Immunology. 2017;151:198-210 pubmed publisher
Pryce B, Al Zahrani K, Dufresne S, Belkina N, Labrèche C, Patino Lopez G, et al. Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017;7:3 pubmed publisher
Qin M, Zhang J, Xu C, Peng P, Tan L, Liu S, et al. Knockdown of NIK and IKK?-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-?? Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK. PLoS ONE. 2017;12:e0170595 pubmed publisher
Lordén G, Sanjuán García I, de Pablo N, Meana C, Alvarez Miguel I, Pérez García M, et al. Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. J Exp Med. 2017;214:511-528 pubmed publisher
Chen X, Tzekov R, Su M, Hong H, Min W, Han A, et al. Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. PLoS ONE. 2016;11:e0166386 pubmed publisher
Zhu G, Huang Q, Huang Y, Zheng W, Hua J, Yang S, et al. Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-κB/JNK pathways in colorectal cancer. Oncotarget. 2016;7:73711-73724 pubmed publisher
Xiao C, Fu L, Yan C, Shou F, Liu Q, Li L, et al. SPAG9 is overexpressed in osteosarcoma, and regulates cell proliferation and invasion through regulation of JunD. Oncol Lett. 2016;12:2674-2679 pubmed
Joseph J, Ametepe E, Haribabu N, Agbayani G, Krishnan L, Blais A, et al. Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium. Nat Commun. 2016;7:12748 pubmed publisher
McLaughlin C, Nechipurenko I, Liu N, Broihier H. A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons. J Cell Biol. 2016;214:459-74 pubmed publisher
Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, et al. CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer. Oncotarget. 2016;7:47637-47649 pubmed publisher
Zhang H, Li L, Wang Y, Dong F, Chen X, Liu F, et al. NF-?B signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. Int J Mol Med. 2016;38:417-22 pubmed publisher
Xiang S, Zeng Y, Xiong B, Qin Y, Huang X, Jiang Y, et al. Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells. J Inflamm (Lond). 2016;13:19 pubmed publisher
Wang X, Mazurkiewicz M, Hillert E, Olofsson M, Pierrou S, Hillertz P, et al. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep. 2016;6:26979 pubmed publisher
Li M, Wang J, Fang Y, Gong S, Li M, Wu M, et al. microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production. Sci Rep. 2016;6:23351 pubmed publisher
Liu X, Zhang C, Lu C, Lin S, Wu J, Wang Z. A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun. 2016;7:10879 pubmed publisher
Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, et al. Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model. PLoS ONE. 2015;10:e0142786 pubmed publisher
Wu Y, Zhou J, Wang H, Wu Y, Gao Q, Wang L, et al. The activation of p38 MAPK limits the abnormal proliferation of vascular smooth muscle cells induced by high sodium concentrations. Int J Mol Med. 2016;37:74-82 pubmed publisher
Van Rossom S, Op de Beeck K, Hristovska V, Winderickx J, Van Camp G. The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways. Front Cell Neurosci. 2015;9:231 pubmed publisher
Hou J, Ma J, Yu K, Li W, Cheng C, Bao L, et al. Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells. BMC Genomics. 2015;16:435 pubmed publisher
Li J, Xiang S, Zhang Q, Wu J, Tang Q, Zhou J, et al. Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C. J Exp Clin Cancer Res. 2015;34:46 pubmed publisher
Wang Z, Xiong F, Xie X, Chen D, Pan J, Cheng L. Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrol. 2015;16:44 pubmed publisher
Li X, Lao Y, Zhang H, Wang X, Tan H, Lin Z, et al. The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation. BMC Cancer. 2015;15:254 pubmed publisher
Boeddeker S, Baston Buest D, Fehm T, Kruessel J, Hess A. Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli. PLoS ONE. 2015;10:e0121103 pubmed publisher
Li C, Lun W, Zhao X, Lei S, Guo Y, Ma J, et al. Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm. 2015;2015:434692 pubmed publisher
Bozic I, Savic D, Laketa D, Bjelobaba I, Milenkovic I, Pekovic S, et al. Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS ONE. 2015;10:e0118372 pubmed publisher
Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, et al. Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells. PLoS ONE. 2014;9:e114791 pubmed publisher
Sayedyahossein S, Xu S, Rudkouskaya A, McGavin M, McCormick J, Dagnino L. Staphylococcus aureus keratinocyte invasion is mediated by integrin-linked kinase and Rac1. FASEB J. 2015;29:711-23 pubmed publisher
Kao C, Chao A, Tsai C, Chuang W, Huang W, Chen G, et al. Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation. Cell Death Dis. 2014;5:e1510 pubmed publisher
Liu J, Lin X, Yang X, Zhou L, He S, Zhuang S, et al. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res. 2014;42:12041-51 pubmed publisher
Yu G, Lee Y, Cheng C, Wu C, Song J, Gallick G, et al. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res. 2015;13:348-57 pubmed publisher
Wang L, Chiou S, Shen Y, Yen F, Ding H, Wu M. Anti-inflammatory effect and mechanism of the green fruit extract of Solanum integrifolium Poir. Biomed Res Int. 2014;2014:953873 pubmed publisher
Luo X, Tai W, Sun L, Qiu Q, Xia Z, Chung S, et al. Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice. PLoS ONE. 2014;9:e104860 pubmed publisher
Kimura T, Kobayashi S, Hanihara Tatsuzawa F, Sayama A, Maruyama T, Muta T. Responses of macrophages to the danger signals released from necrotic cells. Int Immunol. 2014;26:697-704 pubmed publisher
Mori K, Kitazawa R, Kondo T, Mori M, Hamada Y, Nishida M, et al. Diabetic osteopenia by decreased ?-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene. PLoS ONE. 2014;9:e102797 pubmed publisher
George S, Vishwamitra D, Manshouri R, Shi P, Amin H. The ALK inhibitor ASP3026 eradicates NPM-ALK? T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014;5:5750-63 pubmed
Pavese J, Ogden I, Voll E, Huang X, Xu L, Jovanovic B, et al. Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. PLoS ONE. 2014;9:e102289 pubmed publisher
Chen J, Li L, Su J, Li B, Chen T, Wong Y. Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin. PLoS ONE. 2014;9:e101277 pubmed publisher
Li Z, Park H, Shi Z, Li Z, Pham C, Du Y, et al. Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. Oncotarget. 2014;5:3197-209 pubmed
Chen W, Zhang L, Zhang K, Zhou B, Kuo M, Hu S, et al. Reciprocal regulation of autophagy and dNTP pools in human cancer cells. Autophagy. 2014;10:1272-84 pubmed publisher
Zhou H, Guo W, Zhao Y, Wang Y, Zha R, Ding J, et al. MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer. Cancer Sci. 2014;105:956-65 pubmed publisher
Guo Y, Riley K, Iwasaki A, Steitz J. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. Mol Cell. 2014;54:67-79 pubmed publisher
Kutsukake M, Matsutani T, Tamura K, Matsuda A, Kobayashi M, Tachikawa E, et al. Pioglitazone attenuates lung injury by modulating adipose inflammation. J Surg Res. 2014;189:295-303 pubmed publisher
Zhang K, Duan L, Ong Q, Lin Z, Varman P, Sung K, et al. Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. PLoS ONE. 2014;9:e92917 pubmed publisher
Wang J, Jia Z, Zhang C, Sun M, Wang W, Chen P, et al. miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2. RNA Biol. 2014;11:339-50 pubmed publisher
Ting C, Huang H, Huang T, Wu C, Chen J. The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS. Biomaterials. 2014;35:3627-40 pubmed publisher
Leventaki V, Drakos E, Karanikou M, Psatha K, Lin P, Schlette E, et al. c-JUN N-terminal kinase (JNK) is activated and contributes to tumor cell proliferation in classical Hodgkin lymphoma. Hum Pathol. 2014;45:565-72 pubmed publisher
De Nardo D, Labzin L, Kono H, Seki R, Schmidt S, Beyer M, et al. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol. 2014;15:152-60 pubmed publisher
El Gazzar A, Cai X, Reeves R, Dai Z, Caballero Benítez A, McDonald D, et al. Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells. Oncogene. 2014;33:4932-40 pubmed publisher
Nomura J, Busso N, Ives A, Tsujimoto S, Tamura M, So A, et al. Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK. PLoS ONE. 2013;8:e75527 pubmed publisher
Zhuo B, Wang R, Zhang H, Qin H, Yin Y, Shi Y. Interleukin-24 inhibits cell migration and invasion in the neuroblastoma cell line SH-SY5Y. Oncol Rep. 2013;30:2749-54 pubmed publisher
Cao L, Cao Y, Xu C, Edvinsson L. Altered endothelin receptor expression and affinity in spontaneously hypertensive rat cerebral and coronary arteries. PLoS ONE. 2013;8:e73761 pubmed publisher
Davidson R, Jupp O, de Ferrars R, Kay C, Culley K, Norton R, et al. Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis Rheum. 2013;65:3130-40 pubmed publisher
Cao Y, Xia D, Qi S, Du J, Ma P, Wang S, et al. Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways. Cell Prolif. 2013;46:447-56 pubmed publisher
Marker D, Tremblay M, Puccini J, Barbieri J, Gantz Marker M, Loweth C, et al. The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. J Neurosci. 2013;33:9998-10010 pubmed publisher
Nori S, Rocco M, Florenzano F, Ciotti M, Aloe L, Manni L. Increased nerve growth factor signaling in sensory neurons of early diabetic rats is corrected by electroacupuncture. Evid Based Complement Alternat Med. 2013;2013:652735 pubmed publisher
Cheng W, Chiao M, Liang Y, Yang Y, Shen C, Yang C. Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity. Mol Biol Rep. 2013;40:5315-26 pubmed publisher
Tezuka Y, Okada M, Tada Y, Yamauchi J, Nishigori H, Sanbe A. Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation. PLoS ONE. 2013;8:e61649 pubmed publisher
Chen D, Wang W, Qin J, Wang M, Murugesan S, Nadkarni D, et al. Identification of the ZAK-MKK4-JNK-TGF? signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ. Curr Cancer Drug Targets. 2013;13:651-60 pubmed
Guo W, Zhang Y, Zhang L, Huang B, Tao F, Chen W, et al. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin. Autophagy. 2013;9:996-1008 pubmed publisher
Pal M, Wunderlich C, Spohn G, Brönneke H, Schmidt Supprian M, Wunderlich F. Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice. PLoS ONE. 2013;8:e54247 pubmed publisher
Lu J, Bian Z, Zhang R, Zhang Y, Liu C, Yan L, et al. Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Basic Res Cardiol. 2013;108:326 pubmed publisher
Yoshikawa N, Shimizu N, Maruyama T, Sano M, Matsuhashi T, Fukuda K, et al. Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice. PLoS ONE. 2012;7:e52522 pubmed publisher
Garcia Garcia F, Mullol J, Perez Gonzalez M, Pujols L, Alobid I, Roca Ferrer J, et al. Signal transduction pathways (MAPKs, NF-?B, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance. PLoS ONE. 2012;7:e51281 pubmed publisher
Stiles J, Amaya C, Pham R, Rowntree R, Lacaze M, Mulne A, et al. Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis. Exp Ther Med. 2012;4:594-604 pubmed
Mufson E, He B, Nadeem M, Perez S, Counts S, Leurgans S, et al. Hippocampal proNGF signaling pathways and ?-amyloid levels in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 2012;71:1018-29 pubmed publisher
Saporta M, Shy B, Patzkó A, Bai Y, Pennuto M, Ferri C, et al. MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B. Brain. 2012;135:2032-47 pubmed publisher
Lu N, Liu J, Liu J, Zhang C, Jiang F, Wu H, et al. Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha. PLoS ONE. 2012;7:e35722 pubmed publisher
Wang L, Kou M, Weng C, Hu L, Wang Y, Wu M. Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-?B, and MAPK pathways. Arch Toxicol. 2012;86:879-96 pubmed publisher
Cao L, Zhang Y, Cao Y, Edvinsson L, Xu C. Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS ONE. 2012;7:e33008 pubmed publisher
Spindler S, Li R, Dhahbi J, Yamakawa A, Sauer F. Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. PLoS ONE. 2012;7:e29782 pubmed publisher
Soberanes S, Gonzalez A, Urich D, Chiarella S, Radigan K, Osornio Vargas A, et al. Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Sci Rep. 2012;2:275 pubmed publisher
Lan R, Geng H, Polichnowski A, Singha P, Saikumar P, McEwen D, et al. PTEN loss defines a TGF-?-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol. 2012;302:F1210-23 pubmed publisher
Prosperi J, Khramtsov A, Khramtsova G, Goss K. Apc mutation enhances PyMT-induced mammary tumorigenesis. PLoS ONE. 2011;6:e29339 pubmed publisher
Su J, Yen J, Li S, Weng C, Lin M, Ho C, et al. 3',4'-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radic Biol Med. 2012;52:126-41 pubmed publisher
Zhou H, Shen D, Bian Z, Zong J, Deng W, Zhang Y, et al. Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload. PLoS ONE. 2011;6:e26744 pubmed publisher
Cui H, Shao C, Liu Q, Yu W, Fang J, Yu W, et al. Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway. Biochem J. 2011;440:273-82 pubmed publisher
Zode G, Sethi A, Brun Zinkernagel A, Chang I, Clark A, Wordinger R. Transforming growth factor-?2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway. Mol Vis. 2011;17:1745-58 pubmed
Kim K, Singh R, Strongin R, Moore R, Brard L, Lange T. Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation. PLoS ONE. 2011;6:e19049 pubmed publisher
Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-? feedforward signaling. Cell. 2011;145:92-103 pubmed publisher
Stieler J, Bullmann T, Kohl F, Tøien Ø, Brückner M, Hartig W, et al. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS ONE. 2011;6:e14530 pubmed publisher
Xu B, Gerin I, Miao H, Vu Phan D, Johnson C, Xu R, et al. Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. PLoS ONE. 2010;5:e14199 pubmed publisher
Nakou M, Bertsias G, Stagakis I, Centola M, Tassiulas I, Hatziapostolou M, et al. Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus. PLoS ONE. 2010;5:e13351 pubmed publisher
Hsieh C, Kuro O M, Rosenblatt K, Brobey R, Papaconstantinou J. The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY). 2010;2:597-611 pubmed
Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M, Posas F. The p38 SAPK is recruited to chromatin via its interaction with transcription factors. J Biol Chem. 2010;285:31819-28 pubmed publisher
Yang P, An H, Liu X, Wen M, Zheng Y, Rui Y, et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol. 2010;11:487-94 pubmed publisher
product information
SKU :
4668S
Product-Name :
Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Dm, Sc
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
46, 54
Host :
Rabbit
Target :
SAPK/JNK1 (Thr183/Tyr185) phosphate
Primary-Protein :
JNK1
Alt-Names :
JNK,JNK-46,JNK1,JNK1 alpha protein kinase,JNK1 beta protein kinase,JNK1A2,JNK21B1/2,JUN N-terminal kinase,MAP kinase 8,MAPK 8,MAPK8,MK08,Mitogen-activated protein kinase 8,PRKM8,SAPK1,Stress-activated protein kinase 1,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1,mitogen-activated protein kinase 8 isoform JNK1 alpha1,mitogen-activated protein kinase 8 isoform JNK1 beta2,protein kinase JNK1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.