product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
VDAC (D73D12) Rabbit mAb
catalog :
4661
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D73D12
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, flow cytometry, proximity ligation assay
citations: 42
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 5f
Zhang Y, Hu M, Yang F, Zhang Y, Ma S, Zhang D, et al. Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance. J Mol Med (Berl). 2021;99:1427-1446 pubmed publisher
  • western blot; mouse; loading ...
Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, et al. CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice. Signal Transduct Target Ther. 2021;6:223 pubmed publisher
  • western blot; human; loading ...; fig 3a
Hung C, Lombardo P, Malik N, Brun S, Hellberg K, Van Nostrand J, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021;7: pubmed publisher
  • western blot; mouse; 1:50; loading ...; fig 4a
Hu H, Hone E, Provencher E, Sprowls S, Farooqi I, Corbin D, et al. MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes. Sci Rep. 2020;10:3233 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
  • western blot; rat; fig 1d
Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
  • western blot; human; fig 6a
Nixon C, Mavigner M, Sampey G, Brooks A, Spagnuolo R, Irlbeck D, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020;578:160-165 pubmed publisher
  • western blot; rat; loading ...; fig 3b
  • western blot; human; loading ...; fig 7c
Herring S, Moon H, Rawal P, Chhibber A, Zhao L. Brain clusterin protein isoforms and mitochondrial localization. elife. 2019;8: pubmed publisher
  • flow cytometry; human; loading ...; fig 4c
Høgild M, Gudiksen A, Pilegaard H, Stødkilde Jørgensen H, Pedersen S, Møller N, et al. Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men. Physiol Rep. 2019;7:e14285 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f
Sharma A, Oonthonpan L, Sheldon R, Rauckhorst A, Zhu Z, Tompkins S, et al. Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 4b
Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, et al. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Rep. 2019;27:3587-3601.e4 pubmed publisher
  • western blot; human; loading ...; fig 1b, 3b
Jeppesen D, Fenix A, Franklin J, Higginbotham J, Zhang Q, Zimmerman L, et al. Reassessment of Exosome Composition. Cell. 2019;177:428-445.e18 pubmed publisher
  • western blot; human; loading ...; fig 2h
Riis S, Christensen B, Nellemann B, Møller A, Husted A, Pedersen S, et al. Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. J Appl Physiol (1985). 2019;126:569-577 pubmed publisher
  • western blot; human; loading ...; fig 5c
Møller A, Kampmann U, Hedegaard J, Thorsen K, Nordentoft I, Vendelbo M, et al. Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes. Sci Rep. 2017;7:43775 pubmed publisher
  • western blot; human; loading ...; fig 4a
Musante L, Püttmann L, Kahrizi K, Garshasbi M, Hu H, Stehr H, et al. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. Hum Mutat. 2017;38:621-636 pubmed publisher
  • western blot; human; loading ...; fig 4c
Wolfson R, Chantranupong L, Wyant G, Gu X, Orozco J, Shen K, et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017;543:438-442 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3d
Yao P, Manor U, Petralia R, Brose R, Wu R, Ott C, et al. Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons. Mol Biol Cell. 2017;28:387-395 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 2a
Fischer A, Shabalina I, Mattsson C, Abreu Vieira G, Cannon B, Nedergaard J, et al. UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment. Am J Physiol Endocrinol Metab. 2017;312:E72-E87 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
  • western blot; human; 1:1000; loading ...; fig 2f
Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, et al. Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS. EMBO Mol Med. 2016;8:1421-1437 pubmed publisher
  • immunoprecipitation; human
  • western blot; human; 1:3000; loading ...; fig 8a
Jitobaom K, Tongluan N, Smith D. Involvement of voltage-dependent anion channel (VDAC) in dengue infection. Sci Rep. 2016;6:35753 pubmed publisher
  • western blot; human; loading ...; fig 2d
Zou P, Liu L, Zheng L, Payne K, Manjili M, Idowu M, et al. Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment. Oxid Med Cell Longev. 2016;2016:4085727 pubmed
  • western blot; human; fig 7
Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
  • proximity ligation assay; mouse; 1:500; fig 4
Hall A, Burke N, Dongworth R, Kalkhoran S, Dyson A, Vicencio J, et al. Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction. Cell Death Dis. 2016;7:e2238 pubmed publisher
  • western blot; mouse; 1:5000; fig s2
Beck S, Guo L, Phensy A, Tian J, Wang L, Tandon N, et al. Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nat Commun. 2016;7:11483 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2e
  • western blot; human; loading ...; fig 2e
Swiader A, Nahapetyan H, Faccini J, D Angelo R, Mucher E, Elbaz M, et al. Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Oncotarget. 2016;7:28821-35 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Gray L, Rauckhorst A, Taylor E. A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity. J Biol Chem. 2016;291:7409-17 pubmed publisher
  • western blot; rat; 1:1000; fig 8
Lesmana R, Sinha R, Singh B, Zhou J, Ohba K, Wu Y, et al. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology. 2016;157:23-38 pubmed publisher
  • western blot; mouse; fig 6
  • western blot; rat; fig 3
Sabirzhanov B, Stoica B, Zhao Z, Loane D, Wu J, Dorsey S, et al. miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016;23:654-68 pubmed publisher
  • western blot; mouse; 1:1000; fig s2
Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, et al. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model. PLoS ONE. 2015;10:e0132451 pubmed publisher
  • western blot; mouse; 1:200; fig 8
Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, et al. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS ONE. 2015;10:e0127942 pubmed publisher
  • western blot; mouse; 1:10000
Stauch K, Purnell P, Fox H. Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability. J Proteome Res. 2014;13:2620-36 pubmed publisher
  • western blot; rat
Smith I, Godinez G, Singh B, McCaughey K, Alcantara R, Gururaja T, et al. Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction. FASEB J. 2014;28:2790-803 pubmed publisher
Ruiz M, Bodhicharla R, Ståhlman M, Svensk E, Busayavalasa K, Palmgren H, et al. Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity. elife. 2019;8: pubmed publisher
Rushing A, Rushing B, Hoang K, Sanders S, Peloponese J, Polakowski N, et al. HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. PLoS Pathog. 2019;15:e1007922 pubmed publisher
Remacle A, Hullugundi S, Dolkas J, Angert M, Cieplak P, Scott D, et al. Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism. Biochem J. 2018;475:2355-2376 pubmed publisher
Feng L, Vujicic S, Dietrich M, Litbarg N, Setty S, Antoni A, et al. Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis. J Biol Chem. 2018;293:10245-10263 pubmed publisher
Wang L, Scott I, Zhu L, Wu K, Han K, Chen Y, et al. GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis. Nat Commun. 2017;8:523 pubmed publisher
Banks C, Rodriguez N, Gashler K, Pandya R, Mortenson J, Whited M, et al. Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol. 2017;37: pubmed publisher
El Zowalaty A, Li R, Zheng Y, Lydon J, DeMayo F, Ye X. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology. 2017;158:2168-2178 pubmed publisher
Tang M, Vranas M, Krahn A, Pundlik S, Trempe J, Fon E. Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation. Nat Commun. 2017;8:14697 pubmed publisher
Sharp W, Fang Y, Han M, Zhang H, Hong Z, Banathy A, et al. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014;28:316-26 pubmed publisher
Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, et al. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. J Biol Chem. 2012;287:1054-65 pubmed publisher
product information
SKU :
4661S
Product-Name :
VDAC (D73D12) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
32
Host :
Rabbit
Target :
VDAC1
Primary-Protein :
VDAC1
Alt-Names :
MGC111064,Outer mitochondrial membrane protein porin 1,PORIN,PORIN-31-HL,Plasmalemmal porin,Porin 31HL,Porin 31HM,VDAC,VDAC-1,VDAC1,Voltage-dependent anion-selective channel protein 1,hVDAC1,voltage-dependent anion channel 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.