product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-p38 MAPK (Thr180/Tyr182) (12F8) Rabbit mAb
catalog :
4631S
quantity :
200 ul
price :
274 USD
clonality :
monoclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 30
Published Application/Species/DilutionReference
  • western blot; mouse; 1:1000; fig s6
Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed publisher
  • western blot; mouse; fig 4c
Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher
  • western blot; rat
Wang Y, Xiao X, Li N, Yang D, Xing Y, Huo R, et al. Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen-mediated protection against cardiac hypertrophy. Br J Pharmacol. 2015;172:5586-95 pubmed publisher
  • western blot; human; fig 1
Meena J, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, et al. Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion. EMBO J. 2015;34:1371-84 pubmed publisher
  • western blot; human; fig 2
Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed publisher
  • western blot; mouse
Kim S, Ka S, Lee Y, Park B, Fei X, Jung J, et al. The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: role of AMP-activated protein kinase α activation. PLoS ONE. 2015;10:e0117120 pubmed publisher
  • western blot; rat; fig S3
Simard E, Söllradl T, Maltais J, Boucher J, D'Orléans-Juste P, Grandbois M. Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS ONE. 2015;10:e0128881 pubmed publisher
  • western blot; human; 1:1000
Wang S, Awad K, Elinoff J, Dougherty E, Ferreyra G, Wang J, et al. G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY. J Biol Chem. 2015;290:19544-57 pubmed publisher
  • western blot; human
Hu J, Cheng Y, Li Y, Jin Z, Pan Y, Liu G, et al. microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer. 2014;50:2336-50 pubmed publisher
  • western blot; human
Cazanave S, Wang X, Zhou H, Rahmani M, Grant S, Durrant D, et al. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death Differ. 2014;21:1303-12 pubmed publisher
  • western blot; human
Jilg C, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, et al. PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. Oncotarget. 2014;5:12646-64 pubmed
  • western blot; mouse
Zhao X, Zhu L, Chang Q, Jiang C, You Y, Luo T, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem. 2014;289:30052-62 pubmed publisher
  • immunohistochemistry; chicken; 1:400
Fischer A, Zelinka C, Gallina D, Scott M, Todd L. Reactive microglia and macrophage facilitate the formation of Müller glia-derived retinal progenitors. Glia. 2014;62:1608-28 pubmed publisher
  • western blot; human
  • western blot; mouse
Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed publisher
  • western blot; human
Hauerslev S, Sveen M, Vissing J, Krag T. Protein turnover and cellular stress in mildly and severely affected muscles from patients with limb girdle muscular dystrophy type 2I. PLoS ONE. 2013;8:e66929 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Maeda Y, Fukushima K, Omichi R, Kariya S, Nishizaki K. Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. PLoS ONE. 2013;8:e58775 pubmed publisher
  • western blot; rat
Lu Q, Harris V, Sun X, Hou Y, Black S. Ca²⁺/calmodulin-dependent protein kinase II contributes to hypoxic ischemic cell death in neonatal hippocampal slice cultures. PLoS ONE. 2013;8:e70750 pubmed publisher
  • western blot; human; 1:500
Krishna S, Luan C, Mishra R, Xu L, Scheidt K, Anderson W, et al. A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4. PLoS ONE. 2013;8:e81504 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed publisher
Lee J, Kim Y, Song I, Ha S, Kim Y, Baek N, et al. Cyanidin-3-glucoside isolated from mulberry fruit protects pancreatic β-cells against oxidative stress-induced apoptosis. Int J Mol Med. 2015;35:405-12 pubmed publisher
Bueno-Silva B, Kawamoto D, Ando-Suguimoto E, Alencar S, Rosalen P, Mayer M. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS ONE. 2015;10:e0144954 pubmed publisher
Rickard D, Sehon C, Kasparcova V, Kallal L, Haile P, Zeng X, et al. Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway. PLoS ONE. 2014;9:e96737 pubmed publisher
Börgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S. Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem. 2014;289:13-27 pubmed publisher
Zhou H, Guo W, Zhao Y, Wang Y, Zha R, Ding J, et al. MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer. Cancer Sci. 2014;105:956-65 pubmed publisher
Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, et al. Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PLoS ONE. 2013;8:e72252 pubmed publisher
Rickard D, Sehon C, Kasparcova V, Kallal L, Zeng X, Montoute M, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS ONE. 2013;8:e69619 pubmed publisher
Amako Y, Iglói Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, et al. Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis. J Biol Chem. 2013;288:24753-63 pubmed publisher
Cao Y, Xia D, Qi S, Du J, Ma P, Wang S, et al. Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways. Cell Prolif. 2013;46:447-56 pubmed publisher
Miyaji M, Kortum R, Surana R, Li W, Woolard K, Simpson R, et al. Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proc Natl Acad Sci U S A. 2009;106:14502-7 pubmed publisher
Handra-Luca A, Lesty C, Hammel P, Sauvanet A, Rebours V, Martin A, et al. Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma. Pancreas. 2012;41:416-21 pubmed publisher
product information
SKU :
4631S
Product-Name :
Phospho-p38 MAPK (Thr180/Tyr182) (12F8) Rabbit mAb
Size :
200 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, Dm, (Hm, Mi, Z)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
43
Host :
Rabbit
Target :
p38-alpha MAPK (Thr180/Tyr182) phosphate/p38-beta MAPK (Thr188/Tyr190) phosphate/p38-delta MAPK (Thr180/Tyr182) phosphate/p38-gamma MAPK (Thr183/Tyr185) phosphate
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.