product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
LC3A (D50G8) XP® Rabbit mAb
catalog :
4599
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D50G8
reactivity :
human, mouse, brown rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 6s2a
Stavoe A, Gopal P, Gubas A, Tooze S, Holzbaur E. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 3b
Merrill N, Schipper J, Karnes J, Kauffman A, Martin K, Mackeigan J. PI3K-C2? knockdown decreases autophagy and maturation of endocytic vesicles. PLoS ONE. 2017;12:e0184909 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 6c
  • western blot; mouse; loading ...; fig 6b
Wu H, Zhao X, Wang F, Jiang Q, Shi L, Gong M, et al. Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication. Front Immunol. 2017;8:117 pubmed publisher
  • western blot; mouse; fig 3D
Kemter E, Frohlich T, Arnold G, Wolf E, Wanke R. Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD). Sci Rep. 2017;7:42970 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6g
Mercado Pimentel M, Igarashi S, Dunn A, Behbahani M, Miller C, Read C, et al. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation. Austin J Med Oncol. 2016;3: pubmed
  • western blot; mouse; fig 6
Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s1a
Chung V, Tan T, Tan M, Wong M, Kuay K, Yang Z, et al. GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. Sci Rep. 2016;6:19943 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Ruiz A, Rockfield S, Taran N, Haller E, Engelman R, Flores I, et al. Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis. Cell Death Dis. 2016;7:e2059 pubmed publisher
  • western blot; mouse; fig 1
Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed publisher
  • western blot; human; fig 6
  • western blot; mouse; fig 6
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
  • western blot; mouse; 1:1000; fig s5
Herranz D, Ambesi Impiombato A, Sudderth J, Sánchez Martín M, Belver L, Tosello V, et al. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med. 2015;21:1182-9 pubmed publisher
  • western blot; human; loading ...; fig 3c, 4a
Yang S, Lin H, Chang V, Chen C, Liu Y, Wang J, et al. Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo. Oncotarget. 2015;6:23857-73 pubmed
  • western blot; human; fig 3
Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, et al. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015;16:838-849 pubmed publisher
  • western blot; dogs; 1:1000; fig 5
Nadeau M, Rico C, Tsoi M, Vivancos M, Filimon S, Paquet M, et al. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer. 2015;15:479 pubmed publisher
  • western blot; human; fig 4
Unni A, Lockwood W, Zejnullahu K, Lee Lin S, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. elife. 2015;4:e06907 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 5
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
  • western blot; human; 1:1000
  • western blot; brown rat; 1:1000
Harris White M, Ferbas K, Johnson M, Eslami P, Poteshkina A, Venkova K, et al. A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies. Neurobiol Dis. 2015;84:60-8 pubmed publisher
  • western blot; human; fig 9
Kommaddi R, Jean Charles P, Shenoy S. Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress. J Biol Chem. 2015;290:8888-903 pubmed publisher
  • western blot; human
Guo W, Liu R, Bhardwaj G, Yang J, Changou C, Ma A, et al. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014;5:e1409 pubmed publisher
  • western blot; mouse
Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana M. RanBP9 overexpression reduces dendritic arbor and spine density. Neuroscience. 2014;265:253-62 pubmed publisher
Ogmundsdóttir M, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, et al. A short isoform of ATG7 fails to lipidate LC3/GABARAP. Sci Rep. 2018;8:14391 pubmed publisher
Pennington S, Klutho P, Xie L, Broadhurst K, Koval O, McCormick M, et al. Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox Biol. 2018;16:401-413 pubmed publisher
Jiang W, Zhang X, Hao J, Shen J, Fang J, Dong W, et al. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells. Sci Rep. 2014;4:7456 pubmed publisher
Bode C, Berlin M, Röstel F, Teichmann B, Gräler M. Evaluating sphingosine and its analogues as potential alternatives for aggressive lymphoma treatment. Cell Physiol Biochem. 2014;34:1686-700 pubmed publisher
Chen W, Zhang L, Zhang K, Zhou B, Kuo M, Hu S, et al. Reciprocal regulation of autophagy and dNTP pools in human cancer cells. Autophagy. 2014;10:1272-84 pubmed publisher
Niebler M, Qian X, Höfler D, Kogosov V, Kaewprag J, Kaufmann A, et al. Post-translational control of IL-1? via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53. PLoS Pathog. 2013;9:e1003536 pubmed publisher
product information
SKU :
4599S
Product-Name :
LC3A (D50G8) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M, R, (Mk, Dg)
Applications :
Flow cytometry
Product-Category :
Autophagy
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
14, 16
Host :
Rabbit
Target :
LC3A
Primary-Protein :
LC3A
Alt-Names :
Autophagy-related protein LC3 A,Autophagy-related ubiquitin-like modifier LC3 A,LC3,LC3A,MAP1 light chain 3-like protein 1,MAP1A/1B light chain 3 A,MAP1A/MAP1B LC3 A,MAP1A/MAP1B light chain 3 A,MAP1ALC3,MAP1BLC3,MAP1LC3A,MLP3A,Microtubule-associated protein 1 light chain 3 alpha,Microtubule-associated proteins 1A/1B light chain 3A,microtubule-associated proteins 1A/1B light chain 3
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.