product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-ATM (Ser1981) (10H11.E12) Mouse mAb
catalog :
4526S
quantity :
100 ul
price :
274 USD
clonality :
monoclonal
host :
mouse
antigen modification :
phosphorylated
clone name :
10H11.E12

The same clone is also sold as:
reactivity :
human, mouse, rat, pig
application :
western blot, immunocytochemistry
more info or order :
Cell Signaling Technology product webpage
citations: 22
Published Application/Species/DilutionReference
  • western blot; human; 1:500; fig s6
Harley M, Murina O, Leitch A, Higgs M, Bicknell L, Yigit G, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet. 2016;48:36-43 pubmed publisher
  • immunocytochemistry; human; fig 4
Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
  • western blot; human; fig 5
Neumann J, Yang Y, Kohler R, Giaisi M, Witzens-Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed publisher
  • western blot; human; fig 3
Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, et al. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0132052 pubmed publisher
  • western blot; pig; fig 2
Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher
  • immunocytochemistry; mouse; fig 3
  • western blot; mouse; 1:1000; fig 3
Boersma V, Moatti N, Segura-Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-40 pubmed publisher
  • western blot; rat; fig s8
Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, et al. Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis. Sci Rep. 2015;5:13737 pubmed publisher
  • western blot; human; fig 5
Batenburg N, Thompson E, Hendrickson E, Zhu X. Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation. EMBO J. 2015;34:1399-416 pubmed publisher
  • western blot; mouse; 1:3000; fig 3
Rein K, Yanez D, Terré B, Palenzuela L, Aivio S, Wei K, et al. EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res. 2015;43:7371-87 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; 1:1000
Penicud K, Behrens A. DMAP1 is an essential regulator of ATM activity and function. Oncogene. 2014;33:525-31 pubmed publisher
  • western blot; human; 1:1000
  • immunocytochemistry; human; 1:50
Nikitin P, Price A, McFadden K, Yan C, Luftig M. Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. PLoS ONE. 2014;9:e87299 pubmed publisher
  • western blot; human
Osterman M, Kathawa D, Liu D, Guo H, Zhang C, Li M, et al. Elevated DNA damage response in pancreatic cancer. Histochem Cell Biol. 2014;142:713-20 pubmed publisher
  • western blot; mouse; fig 5
Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon C, Zhang H, et al. Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism. PLoS ONE. 2012;7:e41094 pubmed publisher
  • western blot; human
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. Nucleic Acids Res. 2013;41:900-11 pubmed publisher
  • western blot; human
Sappino A, Buser R, Seguin Q, Fernet M, Lesne L, Gumy-Pause F, et al. The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage. Oncogenesis. 2012;1:e7 pubmed publisher
Singh R, Shankar B, Sainis K. TGF-β1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells. Cell Signal. 2014;26:1604-15 pubmed publisher
Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison B, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014;289:7109-20 pubmed publisher
Ogara M, Belluscio L, de la Fuente V, Berardino B, Sonzogni S, Byk L, et al. CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions. Biochim Biophys Acta. 2014;1843:1309-24 pubmed publisher
Zhu H, Yue J, Pan Z, Wu H, Cheng Y, Lu H, et al. Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining. PLoS ONE. 2010;5:e12055 pubmed publisher
Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed publisher
Hawkes W, Printsev I, Alkan Z. Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells. J Cell Biochem. 2012;113:61-9 pubmed publisher
Zhang L, Chen H, Gong M, Gong F. The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation. Front Oncol. 2013;3:7 pubmed publisher
product information
SKU :
4526S
Product-Name :
Phospho-ATM (Ser1981) (10H11.E12) Mouse mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H
Applications :
Western blot
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
350
Host :
Mouse
Target :
ATM (Ser1981) phosphate
Primary-Protein :
ATM
Alt-Names :
A-T mutated,AT mutated,AT1,ATA,ATC,ATD,ATDC,ATE,ATM,Ataxia telangiectasia mutated,DKFZp781A0353,MGC74674,Serine-protein kinase ATM,TEL1,TEL1, telomere maintenance 1, homolog,TELO1,ataxia telangiectasia mutated (includes complementation groups A, C and D),human phosphatidylinositol 3-kinase homolog
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.