product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PLK1 (208G4) Rabbit mAb
catalog :
4513
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
208G4
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig s1e
Yan C, Saleh N, Yang J, Nebhan C, Vilgelm A, Reddy E, et al. Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. Mol Cancer. 2021;20:85 pubmed publisher
  • western blot; human; loading ...; fig 5e
Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, et al. SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth. Adv Sci (Weinh). 2021;8:e2004846 pubmed publisher
  • western blot; human
Xue J, Zhao Y, Aronowitz J, Mai T, Vides A, Qeriqi B, et al. Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition. Nature. 2020;577:421-425 pubmed publisher
  • western blot; human; loading ...; fig 9a
Littler S, Sloss O, Geary B, Pierce A, Whetton A, Taylor S. Oncogenic MYC amplifies mitotic perturbations. Open Biol. 2019;9:190136 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
Maachani U, Shankavaram U, Kramp T, Tofilon P, Camphausen K, Tandle A. FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells. Oncotarget. 2016;7:77365-77377 pubmed publisher
  • western blot; human; loading ...; fig 5a
Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed publisher
  • western blot; human; loading ...; fig 4c
Bouhlal H, Ouled Haddou H, Debuysscher V, Singh A, Ossart C, Reignier A, et al. RB/PLK1-dependent induced pathway by SLAMF3 expression inhibits mitosis and control hepatocarcinoma cell proliferation. Oncotarget. 2016;7:9832-43 pubmed publisher
  • immunohistochemistry; human; fig 4
Eriksson P, Aine M, Veerla S, Liedberg F, Sjödahl G, Höglund M. Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems. BMC Med Genomics. 2015;8:25 pubmed publisher
  • western blot; human
Choi M, Kim W, Cheon M, Lee C, Kim J. Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells. Cancer Lett. 2015;357:591-601 pubmed publisher
Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Sci Rep. 2019;9:19704 pubmed publisher
Isfort I, Cyra M, Elges S, Kailayangiri S, Altvater B, Rossig C, et al. SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma. Clin Cancer Res. 2019;25:3718-3731 pubmed publisher
Merrick D, Edwards M, Franklin W, Sugita M, Keith R, Miller Y, et al. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018;78:4971-4983 pubmed publisher
Tanaka N, Patel A, Tang L, Silver N, Lindemann A, Takahashi H, et al. Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation. Clin Cancer Res. 2017;23:6541-6554 pubmed publisher
Gutteridge R, Singh C, Ndiaye M, Ahmad N. Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma. Cancer Lett. 2017;394:13-21 pubmed publisher
Petrelli A, Carollo R, Cargnelutti M, Iovino F, Callari M, Cimino D, et al. By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy. Oncotarget. 2015;6:2315-30 pubmed
da Silva E, Jamur M, Oliver C. Mast cell function: a new vision of an old cell. J Histochem Cytochem. 2014;62:698-738 pubmed publisher
Banerjee S, Zagórska A, Deak M, Campbell D, Prescott A, Alessi D. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase. Biochem J. 2014;461:233-45 pubmed publisher
Ferrer I, Mohan P, Chen H, Castellsagué J, Gómez Baldó L, Carmona M, et al. Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling. J Pathol. 2014;233:247-57 pubmed publisher
Yen C, Hsiao C, Chen W, Wen Y, Lin Y, Chang T, et al. Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. Oncotarget. 2014;5:716-25 pubmed
Hartsink Segers S, Exalto C, Allen M, Williamson D, Clifford S, Horstmann M, et al. Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. Haematologica. 2013;98:1539-46 pubmed publisher
Benhenda S, Ducroux A, Rivi re L, Sobhian B, Ward M, Dion S, et al. Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription. J Virol. 2013;87:4360-71 pubmed publisher
Watt S, Pourreyron C, Purdie K, Hogan C, Cole C, Foster N, et al. Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma. Oncogene. 2011;30:4666-77 pubmed publisher
Hashimoto T, Kikkawa U, Kamada S. Contribution of caspase(s) to the cell cycle regulation at mitotic phase. PLoS ONE. 2011;6:e18449 pubmed publisher
Hendrickson D, Hogan D, McCullough H, Myers J, Herschlag D, Ferrell J, et al. Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol. 2009;7:e1000238 pubmed publisher
product information
SKU :
4513P
Product-Name :
PLK1 (208G4) Rabbit mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, R, Mk
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
62
Host :
Rabbit
Target :
PLK1
Primary-Protein :
PLK1
Alt-Names :
PLK,PLK-1,PLK1,Polo-like kinase 1,STPK13,Serine/threonine-protein kinase 13,Serine/threonine-protein kinase PLK1,cell cycle regulated protein kinase,polo (Drosophia)-like kinase,polo like kinase,polo-like kinase 1 (Drosophila)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.