| Published Application/Species/Dilution | Reference |
|---|
| Chen C, Kim K, Lau L. The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation. Oncogene. 2016;35:1314-23 pubmed publisher |
- western blot; human; fig 1
| Subramaniam S, Ozdener M, Abdoul-Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed |
- western blot; rat; 1:1000; fig 6
| Huo L, Shi W, Chong L, Wang J, Zhang K, Li Y. Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction. Exp Ther Med. 2016;11:57-64 pubmed |
- western blot; mouse; fig 2
| Yu H. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. PLoS ONE. 2016;11:e0156303 pubmed publisher |
- western blot; human; fig 4
| Ang Z, Er J, Tan N, Lu J, Liou Y, Grosse J, et al. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci Rep. 2016;6:34145 pubmed publisher |
- immunohistochemistry; mouse; fig s8
| Hinsenkamp I, Schulz S, Roscher M, Suhr A, Meyer B, Munteanu B, et al. Inhibition of Rho-Associated Kinase 1/2 Attenuates Tumor Growth in Murine Gastric Cancer. Neoplasia. 2016;18:500-11 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Xu Y, Wu D, Zheng W, Yu F, Yang F, Yao Y, et al. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. 2016;7:6146-58 pubmed publisher |
- western blot; mouse; fig 3
| de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher |
- western blot; human; 1:1000; fig 8
| E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher |
- western blot; human; fig 4
| Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed publisher |
- western blot; human; fig s1
| Elder M, Webster S, Williams D, Gaston J, Goodall J. TSLP production by dendritic cells is modulated by IL-1β and components of the endoplasmic reticulum stress response. Eur J Immunol. 2016;46:455-63 pubmed publisher |
| Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, et al. C5a Induces the Synthesis of IL-6 and TNF-α in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways. PLoS ONE. 2016;11:e0161867 pubmed publisher |
| Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;: pubmed |
- western blot; human; 1:1000; fig 5
| Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed |
- western blot; human; 1:1000; fig 7
| Kohler T, Scholz A, Kiachludis D, Hammerschmidt S. Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells. Front Cell Infect Microbiol. 2016;6:48 pubmed publisher |
- western blot; human; fig 7
| Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed publisher |
- western blot; rat; 1:800; fig 6
| Jiao K, Zeng G, Niu L, Yang H, Ren G, Xu X, et al. Activation of α2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint. Sci Rep. 2016;6:30085 pubmed publisher |
- immunocytochemistry; human; fig 7
- western blot; human; fig 7
| Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed publisher |
- western blot; human; fig 6a
| Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed publisher |
- immunohistochemistry - frozen section; mouse; fig 3
| Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed publisher |
| Ren W, Yin J, Chen S, Duan J, Liu G, Li T, et al. Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli -infected piglets. Sci Rep. 2016;6:25640 pubmed publisher |
| Bawadekar M, de Andrea M, Lo Cigno I, Baldanzi G, Caneparo V, Graziani A, et al. The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation. J Interferon Cytokine Res. 2015;35:441-53 pubmed publisher |
| Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher |
- immunocytochemistry; rat; 1:200
- western blot; rat; 1:1000
| Hu J, Li T, Du S, Chen Y, Wang S, Xiong F, et al. The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells. Int J Mol Med. 2015;36:130-8 pubmed publisher |
- western blot; human; 1:1000
| Carvallo L, Lopez L, Che F, Lim J, Eugenin E, Williams D, et al. Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. J Immunol. 2015;194:3246-58 pubmed publisher |
| Kim S, Kim W, Yoon J, Ji J, Morgan M, Cho H, et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. J Invest Dermatol. 2015;135:2021-30 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher |
| Nishioka C, Ikezoe T, Yang J, Yokoyama A. Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells. PLoS ONE. 2015;10:e0125017 pubmed publisher |
- western blot; mouse; fig 6
| Pajaud J, Ribault C, Ben Mosbah I, Rauch C, Henderson C, Bellaud P, et al. Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration. Cell Death Dis. 2015;6:e1598 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Tanaka T, Iino M. Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. Cell Signal. 2015;27:1110-9 pubmed publisher |
- western blot; mouse; 1:1000; fig 10
| Seaberg B, Henslee G, Wang S, Paez-Colasante X, Landreth G, Rimer M. Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions. Mol Cell Biol. 2015;35:1238-53 pubmed publisher |
- western blot; mouse; fig 10B
| Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher |
- western blot; mouse; fig 6c
| Li L, Dong Q, Wang Y, Feng Q, Zhou P, Ou X, et al. Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells. Int J Mol Med. 2015;35:1641-50 pubmed publisher |
| Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, et al. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. Cell Mol Life Sci. 2015;72:3783-801 pubmed publisher |
| Zhuang Y, Nguyen H, Burow M, Zhuo Y, El-Dahr S, Yao X, et al. Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells. Mol Carcinog. 2015;54:1656-67 pubmed publisher |
| Ma Y, Han W, Li J, Hu L, Zhou Y. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36:517-27 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500
| Noda K, Mishina Y, Komatsu Y. Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2015;: pubmed publisher |
- immunohistochemistry; mouse; 1:250; fig 1
| Papaconstantinou J, Wang C, Zhang M, Yang S, DeFord J, Bulavin D, et al. Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells. Aging (Albany NY). 2015;7:718-33 pubmed |
- western blot; human; fig 7
| Okita N, Honda Y, Kishimoto N, Liao W, Azumi E, Hashimoto Y, et al. Supplementation of strontium to a chondrogenic medium promotes chondrogenic differentiation of human dedifferentiated fat cells. Tissue Eng Part A. 2015;21:1695-704 pubmed publisher |
- western blot; mouse; fig 2
| Silva O, Crocetti J, Humphries L, Burkhardt J, Miceli M. Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells. PLoS ONE. 2015;10:e0133353 pubmed publisher |
- western blot; human; fig 4
| Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker-Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed publisher |
- western blot; human; fig 5a
| Rastetter R, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, et al. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 2015;15:638 pubmed publisher |
| Ishaq M, Evans M, Ostrikov K. Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2-ASK1 apoptosis pathways and oxidative stress is mitigated by Srx-Nrf2 anti-oxidant system. Biochim Biophys Acta. 2014;1843:2827-37 pubmed publisher |
| Singel S, Batten K, Cornelius C, Jia G, Fasciani G, Barron S, et al. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res. 2014;16:R28 pubmed publisher |
- western blot; mouse; fig 5
| Matsuyama M, Nomori A, Nakakuni K, Shimono A, Fukushima M. Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy. J Biol Chem. 2014;289:31526-33 pubmed publisher |
- immunocytochemistry; human; 1:800
| Grimsey N, Lin H, Trejo J. Endosomal signaling by protease-activated receptors. Methods Enzymol. 2014;535:389-401 pubmed publisher |
- western blot; human; 1:1000
| Gu H, Mickler E, Cummings O, Sandusky G, Weber D, Gracon A, et al. Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis. FASEB J. 2014;28:4223-34 pubmed publisher |
| Hamada K, Osaka M, Yoshida M. Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium. PLoS ONE. 2014;9:e90502 pubmed publisher |
- western blot; rat; 1:2000
| Hardman S, Hall D, Cabrera A, Hancock C, Thomson D. The effects of age and muscle contraction on AMPK activity and heterotrimer composition. Exp Gerontol. 2014;55:120-8 pubmed publisher |
- western blot; mouse; fig 2
| Luo L, Wall A, Yeo J, Condon N, Norwood S, Schoenwaelder S, et al. Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nat Commun. 2014;5:4407 pubmed publisher |
- western blot; mouse; 1:1000
| Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed publisher |
| Shin J, Le Dour C, Sera F, Iwata S, Homma S, Joseph L, et al. Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus. 2014;5:260-459 pubmed publisher |
| Lemire B, Debigare R, Dubé A, Thériault M, Cote C, Maltais F. MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease. J Appl Physiol (1985). 2012;113:159-66 pubmed publisher |
| Yu G, Lee Y, Cheng C, Wu C, Song J, Gallick G, et al. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res. 2015;13:348-57 pubmed publisher |
| Li C, Lun W, Zhao X, Lei S, Guo Y, Ma J, et al. Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm. 2015;2015:434692 pubmed publisher |
| Chen P, Li J, Huo Y, Lu J, Wan L, Li B, et al. Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis. Peerj. 2015;3:e1518 pubmed publisher |
| Garcia-Manero G, Khoury H, Jabbour E, Lancet J, Winski S, Cable L, et al. A phase I study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes. Clin Cancer Res. 2015;21:985-94 pubmed publisher |
| Martínez-Neri P, López-Rincón G, Mancilla-Jiménez R, Del Toro-Arreola S, Muñoz-Valle J, Fafutis-Morris M, et al. Prolactin modulates cytokine production induced by culture filtrate proteins of M. bovis through different signaling mechanisms in THP1 cells. Cytokine. 2015;71:38-44 pubmed publisher |
| Wang C, Zhang L, Li G, Shi Y, Li J, Zhang X, et al. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res. 2014;92:944-54 pubmed publisher |
| Kimura T, Kobayashi S, Hanihara-Tatsuzawa F, Sayama A, Maruyama T, Muta T. Responses of macrophages to the danger signals released from necrotic cells. Int Immunol. 2014;26:697-704 pubmed publisher |
| Gaumann A, Drexler H, Lang S, Stoeltzing O, Diermeier-Daucher S, Buchdunger E, et al. The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®). Int J Oncol. 2014;45:2267-77 pubmed publisher |
| Wang C, Li G, Shi Y, Zhang X, Li J, Wang Z, et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons. J Physiol Biochem. 2014;70:735-47 pubmed publisher |
| Madak-Erdogan Z, Ventrella R, Petry L, Katzenellenbogen B. Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer. Mol Cancer Res. 2014;12:714-27 pubmed publisher |
| Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R. TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin. PLoS ONE. 2014;9:e94801 pubmed publisher |
| Liu J, Lin X, Yang X, Zhou L, He S, Zhuang S, et al. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res. 2014;42:12041-51 pubmed publisher |
| Jacob S, Foster A, Yemelin A, Thines E. Histidine kinases mediate differentiation, stress response, and pathogenicity in Magnaporthe oryzae. Microbiologyopen. 2014;3:668-87 pubmed publisher |
| Birner P, Berghoff A, Dinhof C, Pirker C, Capper D, Schoppmann S, et al. MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases. Arch Dermatol Res. 2014;306:873-84 pubmed publisher |
| Cai W, Liang L, Wang L, Han J, Zhu X, Han H, et al. Inhibition of Notch signaling leads to increased intracellular ROS by up-regulating Nox4 expression in primary HUVECs. Cell Immunol. 2014;287:129-35 pubmed publisher |
| Crocetti J, Silva O, Humphries L, Tibbs M, Miceli M. Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells. J Immunol. 2014;193:2651-60 pubmed publisher |
| Wang C, Li J, Zhang L, Zhang X, Yu S, Liang X, et al. Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-кB signal pathway. Neurochem Int. 2013;63:741-9 pubmed publisher |
| Murata S, Shiragami R, Kosugi C, Tezuka T, Yamazaki M, Hirano A, et al. Antitumor effect of 1, 8-cineole against colon cancer. Oncol Rep. 2013;30:2647-52 pubmed publisher |
| Cochonneau D, Terme M, Michaud A, Dorvillius M, Gautier N, Frikeche J, et al. Cell cycle arrest and apoptosis induced by O-acetyl-GD2-specific monoclonal antibody 8B6 inhibits tumor growth in vitro and in vivo. Cancer Lett. 2013;333:194-204 pubmed publisher |
| Shiragami R, Murata S, Kosugi C, Tezuka T, Yamazaki M, Hirano A, et al. Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. Int J Oncol. 2013;43:431-8 pubmed publisher |
| Liu G, Bi Y, Wang R, Shen B, Zhang Y, Yang H, et al. Kinase AKT1 negatively controls neutrophil recruitment and function in mice. J Immunol. 2013;191:2680-90 pubmed publisher |
| Ammann J, Cooke A, Trowsdale J. Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol. 2013;190:5030-6 pubmed publisher |
| Feige E, Yacov N, Salem Y, Levi I, Mendel I, Propheta-Meiran O, et al. Inhibition of monocyte chemotaxis by VB-201, a small molecule lecinoxoid, hinders atherosclerosis development in ApoE⁻/⁻ mice. Atherosclerosis. 2013;229:430-9 pubmed publisher |
| Yamada J, Jinno S. Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis. J Comp Neurol. 2013;521:1184-201 pubmed publisher |
| Nomura J, Busso N, Ives A, Tsujimoto S, Tamura M, So A, et al. Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK. PLoS ONE. 2013;8:e75527 pubmed publisher |
| Aguilera-Montilla N, Chamorro S, Nieto C, Sanchez-Cabo F, Dopazo A, Fernández-Salguero P, et al. Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells. Blood. 2013;121:e108-17 pubmed publisher |
| Rohani M, DiJulio D, An J, Hacker B, Dale B, Chung W. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes. BMC Immunol. 2010;11:53 pubmed publisher |
| Bruchas M, Schindler A, Shankar H, Messinger D, Miyatake M, Land B, et al. Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. 2011;71:498-511 pubmed publisher |
| Kogai T, Liu Y, Mody K, Shamsian D, Brent G. Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. J Biol Chem. 2012;287:3292-300 pubmed publisher |
| Won A, Garbarino J, Lim W. Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase. Proc Natl Acad Sci U S A. 2011;108:9809-14 pubmed publisher |
| Stavniichuk R, Shevalye H, Hirooka H, Nadler J, Obrosova I. Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. Biochem Pharmacol. 2012;83:932-40 pubmed publisher |
| Stiles J, Amaya C, Pham R, Rowntree R, Lacaze M, Mulne A, et al. Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis. Exp Ther Med. 2012;4:594-604 pubmed |
