product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Histone H3 (D1H2) XP® Rabbit mAb
catalog :
4499S
quantity :
100 ul
price :
260 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat, cow, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry
citations: 37
Published Application/Species/DilutionReference
  • western blot; human; 1:1000; fig s4c
Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, et al. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. 2016;7:12237 pubmed publisher
  • western blot; human; fig 8
Khanom R, Nguyen C, Kayamori K, Zhao X, Morita K, Miki Y, et al. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS ONE. 2016;11:e0161163 pubmed publisher
  • western blot; human; 1:2000; fig s4
Wang J, Hu K, Guo J, Cheng F, Lv J, Jiang W, et al. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nat Commun. 2016;7:11363 pubmed publisher
  • western blot; human; fig 5
Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, et al. Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget. 2016;7:24483-94 pubmed publisher
  • western blot; human; tbl 1
Richarson A, Scott D, Zagnitko O, Aza-Blanc P, Chang C, Russler-Germain D. Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation. elife. 2016;5: pubmed publisher
  • western blot; human; 1:1000; fig 3
Wu T, Li Y, Liu B, Zhang S, Wu L, Zhu X, et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS ONE. 2016;11:e0149361 pubmed publisher
  • western blot; rat; 1:1000; fig 1
Wei J, Xiong Z, Lee J, Cheng J, Duffney L, Matas E, et al. Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress. J Neurosci. 2016;36:2119-30 pubmed publisher
  • western blot; mouse; fig 2
  • western blot; rat; fig 10
Song J, Sun Y, Peluso I, Zeng Y, Yu X, Lu J, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016;: pubmed
  • western blot; mouse; 1:2000; fig 1
Lee E, Kim S, Cho K. Reconstituted High-Density Lipoprotein Containing Human Growth Hormone-1 Shows Potent Tissue Regeneration Activity with Enhancement of Anti-Oxidant and Anti-Atherosclerotic Activities. Rejuvenation Res. 2015;18:245-56 pubmed publisher
  • immunocytochemistry; human
Luense S, Denner P, Fernandez-Montalvan A, Hartung I, Husemann M, Stresemann C, et al. Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors. J Biomol Screen. 2015;20:190-201 pubmed publisher
  • western blot; human; fig 7
Bardhan K, Paschall A, Yang D, Chen M, Simon P, Bhutia Y, et al. IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer. Cancer Immunol Res. 2015;3:795-805 pubmed publisher
  • western blot; mouse; 1:2000; fig 4
Meyer S, Krebs S, Thirion C, Blum H, Krause S, Pfaffl M. Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells. PLoS ONE. 2015;10:e0139520 pubmed publisher
  • western blot; rat; 1:25000
Wang W, Visavadiya N, Pandya J, Nelson P, Sullivan P, Springer J. Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury. Exp Neurol. 2015;265:84-93 pubmed publisher
  • western blot; human; fig 1
Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed publisher
  • western blot; human
Poirier J, Gardner E, Connis N, Moreira A, de Stanchina E, Hann C, et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene. 2015;34:5869-78 pubmed publisher
  • western blot; human; 1:1000
Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed publisher
  • western blot; human
Quan J, Adelmant G, Marto J, Look A, Yusufzai T. The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. PLoS ONE. 2014;9:e108066 pubmed publisher
  • western blot; human
Hast B, Cloer E, Goldfarb D, Li H, Siesser P, Yan F, et al. Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res. 2014;74:808-17 pubmed publisher
  • western blot; human
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed publisher
  • western blot; human; 1:5000; fig s1
Wanet A, Remacle N, Najar M, Sokal E, Arnould T, Najimi M, et al. Mitochondrial remodeling in hepatic differentiation and dedifferentiation. Int J Biochem Cell Biol. 2014;54:174-85 pubmed publisher
  • immunocytochemistry; human
Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, et al. TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells. FEBS Lett. 2014;588:4334-41 pubmed publisher
  • western blot; human; 1:5000
Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed publisher
  • western blot; mouse
Zeng Z, Shen L, Li X, Luo T, Wei X, Zhang J, et al. Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis. Clin Sci (Lond). 2014;127:435-48 pubmed publisher
  • western blot; human
Ulanet D, Couto K, Jha A, Choe S, Wang A, Woo H, et al. Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition. PLoS ONE. 2014;9:e115144 pubmed publisher
  • immunocytochemistry; human; 1:200
Copeland A, Altamura L, Van Deusen N, Schmaljohn C. Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene. J Virol. 2013;87:11659-69 pubmed publisher
Eggert E, Hillig R, Koehr S, Stöckigt D, Weiske J, Barak N, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016;59:4578-600 pubmed publisher
Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, et al. Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon. Mol Cell Biol. 2016;36:1297-309 pubmed publisher
Blaauboer S, Gabrielle V, Jin L. MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. J Immunol. 2014;192:492-502 pubmed publisher
Liu N, Li X, Huang H, Zhao C, Liao S, Yang C, et al. Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth. Oncotarget. 2014;5:5453-71 pubmed
Kapoor A, Forman M, Arav-Boger R. Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication. PLoS ONE. 2014;9:e92704 pubmed publisher
Hendriks I, D'Souza R, Yang B, Verlaan-de Vries M, Mann M, Vertegaal A. Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol. 2014;21:927-36 pubmed publisher
Gormally M, Dexheimer T, Marsico G, Sanders D, Lowe C, Matak-Vinkovic D, et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014;5:5165 pubmed publisher
Kawakami T, He J, Morita H, Yokoyama K, Kaji H, Tanaka C, et al. Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells. PLoS ONE. 2014;9:e84704 pubmed publisher
Ramsey J, Kettyle L, Sharpe D, Mulgrew N, Dickson G, Bijl J, et al. Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia. Stem Cells. 2013;31:1434-45 pubmed publisher
Wang H, Cheng F, Woan K, Sahakian E, Merino O, Rock-Klotz J, et al. Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10. J Immunol. 2011;186:3986-96 pubmed publisher
Liu Y, He M, Sun X, Peng K, Zhao L. Alteration of nuclear protein profiling for NIH-3T3 cells exposed to H₂O₂. Cell Biochem Funct. 2010;28:578-84 pubmed publisher
Song N, Ding Y, Zhuo W, He T, Fu Z, Chen Y, et al. The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells. Angiogenesis. 2012;15:697-711 pubmed publisher
product information
SKU :
4499S
Product-Name :
Histone H3 (D1H2) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M, R, Mk, (Hm, C, Dm, X, Z, B)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
17
Host :
Rabbit
Target :
H3
Primary-Protein :
H3
Alt-Names :
H3 histone family, member A,H3/A,H31,H3FA,H3FB,H3FC,H3FD,H3FF,H3FH,H3FI,H3FJ,H3FK,H3FL,HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J,Histone H3.1,Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l,histone 1, H3a,histone cluster 1, H3a
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.