product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
β-TrCP (D13F10) Rabbit mAb
catalog :
4394S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 12
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig 5
Yi Y, Kang H, Bae E, Oh S, Seong Y, Bae I. β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells. Exp Mol Med. 2015;47:e143 pubmed publisher
  • western blot (knockdown validation); human; 1:1000; fig s5
Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, et al. Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat Commun. 2015;6:6156 pubmed publisher
  • western blot; human; 1:500; fig 2
Pagan J, Marzio A, Jones M, Saraf A, Jallepalli P, Florens L, et al. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol. 2015;17:31-43 pubmed publisher
  • western blot; human
  • immunoprecipitation; human
Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher
  • western blot; human
Kim T, Siesser P, Rossman K, Goldfarb D, Mackinnon K, Yan F, et al. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol. 2015;35:167-81 pubmed publisher
  • western blot; human; fig 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
  • western blot; human
Ma L, Pan Q, Sun F, Yu Y, Wang J. Cluster of differentiation 166 (CD166) regulates cluster of differentiation (CD44) via NF-κB in liver cancer cell line Bel-7402. Biochem Biophys Res Commun. 2014;451:334-8 pubmed publisher
  • western blot; human; fig 1
  • immunoprecipitation; human; fig 1
Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, et al. DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation. J Biol Chem. 2014;289:15482-94 pubmed publisher
  • western blot; human
  • immunocytochemistry; human
Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, et al. TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells. FEBS Lett. 2014;588:4334-41 pubmed publisher
Shi M, Cho H, Inn K, Yang A, Zhao Z, Liang Q, et al. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014;5:4820 pubmed publisher
Wu X, Fukushima H, North B, Nagaoka Y, Nagashima K, Deng F, et al. SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination. Oncotarget. 2014;5:4211-21 pubmed
Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, et al. β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation. Mol Cell Biol. 2012;32:3990-4000 pubmed publisher
product information
SKU :
4394S
Product-Name :
β-TrCP (D13F10) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Ubiquitin and Ubiquitin-like proteins
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
62
Host :
Rabbit
Target :
beta-Trcp
Primary-Protein :
BTRC
Alt-Names :
BETA-TRCP,BTRC,BTRCP,E3RSIkappaB,F-box and WD repeats protein beta-TrCP,F-box/WD repeat-containing protein 1A,FBW1A,FBXW1,FBXW1A,FWD1,MGC4643,bTrCP1,beta-TrCP1,beta-transducin repeat containing,betaTrCP,pIkappaBalpha-E3 receptor subunit
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.