product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
HSF1 Antibody
catalog :
4356
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, pig
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, western blot knockout validation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; fig 1
Jiang Q, Zhang Z, Li S, Wang Z, Ma Y, Hu Y. Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen‑transformed MEF cells. Mol Med Rep. 2015;12:6517-26 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Liu D, Wu L, Wu Y, Wei X, Wang W, Zhang S, et al. Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. Aging (Albany NY). 2019;11:8982-8997 pubmed publisher
  • western blot; mouse; 1:100; loading ...; fig 6a
López Erauskin J, Tadokoro T, Baughn M, Myers B, McAlonis Downes M, Chillon Marinas C, et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018;100:816-830.e7 pubmed publisher
  • western blot; mouse; loading ...; fig 2h
  • western blot; human; loading ...; fig 5c, 5d
Qiao A, Jin X, Pang J, Moskophidis D, Mivechi N. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017;216:723-741 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 2a
  • western blot; human; 1:400; loading ...; fig s1c
Goenka A, Sengupta S, Pandey R, Parihar R, Mohanta G, Mukerji M, et al. Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression. J Cell Sci. 2016;129:3541-3552 pubmed
  • western blot; pig; 1:1000; fig 1
Ganesan S, Reynolds C, Hollinger K, Pearce S, Gabler N, Baumgard L, et al. Twelve hours of heat stress induces inflammatory signaling in porcine skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1288-96 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 4
Liu D, Liu X, Wu Y, Wang W, Ma X, Liu H. Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter. Int J Mol Sci. 2016;17: pubmed publisher
  • immunocytochemistry; human; 1:500
Schraivogel D, Schindler S, Danner J, Kremmer E, Pfaff J, Hannus S, et al. Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels. Nucleic Acids Res. 2015;43:7447-61 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Lee J, Lee Y, Lim J, Byun H, Park I, Kim G, et al. Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness. J Biol Chem. 2015;290:21421-31 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Zeng X, Wang H, Bai F, Zhou X, Li S, Ren L, et al. Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol. 2015;172:4303-18 pubmed publisher
  • chromatin immunoprecipitation; human; fig 8
  • western blot; human; fig 8
Luan Q, Jin L, Jiang C, Tay K, Lai F, Liu X, et al. RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy. Autophagy. 2015;11:975-94 pubmed publisher
  • western blot; human; fig 3
Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed publisher
  • western blot; human; fig 5
Baraz R, Cisterne A, Saunders P, Hewson J, Thien M, Weiss J, et al. mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death. PLoS ONE. 2014;9:e102494 pubmed publisher
  • chromatin immunoprecipitation; human
Chen Y, Chen J, Yu J, Yang G, Temple E, Harbinski F, et al. Identification of mixed lineage leukemia 1(MLL1) protein as a coactivator of heat shock factor 1(HSF1) protein in response to heat shock protein 90 (HSP90) inhibition. J Biol Chem. 2014;289:18914-27 pubmed publisher
Kourtis N, Moubarak R, Aranda Orgilles B, Lui K, Aydin I, Trimarchi T, et al. FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. Nat Cell Biol. 2015;17:322-332 pubmed publisher
Peng B, Zhang X, Cao F, Wang Y, Xu L, Cao L, et al. Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells. BMC Cancer. 2014;14:146 pubmed publisher
Filone C, Caballero I, Dower K, Mendillo M, Cowley G, Santagata S, et al. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog. 2014;10:e1003904 pubmed publisher
Carpenter R, Paw I, Dewhirst M, Lo H. Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Oncogene. 2015;34:546-57 pubmed publisher
Schulz R, Streller F, Scheel A, Ruschoff J, Reinert M, Dobbelstein M, et al. HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer. Cell Death Dis. 2014;5:e980 pubmed publisher
Abu Farha M, Tiss A, Abubaker J, Khadir A, Al Ghimlas F, Al Khairi I, et al. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. PLoS ONE. 2013;8:e75342 pubmed publisher
Shu X, Geng H, Li L, Ying J, Ma C, Wang Y, et al. The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/?-catenin signaling and is frequently silenced in multiple tumors. PLoS ONE. 2011;6:e27346 pubmed publisher
Shibata T, Kimura Y, Mukai A, Mori H, Ito S, Asaka Y, et al. Transthiocarbamoylation of proteins by thiolated isothiocyanates. J Biol Chem. 2011;286:42150-61 pubmed publisher
product information
SKU :
4356P
Product-Name :
HSF1 Antibody
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Chromatin Immunoprecipitation
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
82
Host :
Rabbit
Target :
HSF1
Primary-Protein :
HSF1
Alt-Names :
HSF 1,HSF1,HSTF 1,HSTF1,Heat shock factor protein 1,Heat shock transcription factor 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.