product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
IRF-3 (D83B9) Rabbit mAb
catalog :
4302S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation
citations: 17
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig 3
Ma Z, Jacobs S, West J, Stopford C, Zhang Z, Davis Z, et al. Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses. Proc Natl Acad Sci U S A. 2015;112:E4306-15 pubmed publisher
  • western blot; mouse; fig 5
Sim C, Cho Y, Kim B, Baek I, Kim Y, Lee M. 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. Cancer Immunol Immunother. 2016;65:663-75 pubmed publisher
  • western blot; human; fig s10b
Liesche C, Venkatraman L, Aschenbrenner S, Grosse S, Grimm D, Eils R, et al. Death receptor-based enrichment of Cas9-expressing cells. BMC Biotechnol. 2016;16:17 pubmed publisher
  • western blot; human; fig 4
Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher
  • western blot; mouse; fig 1
West A, Khoury-Hanold W, Staron M, Tal M, Pineda C, Lang S, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520:553-7 pubmed publisher
  • western blot; human; fig 5
  • western blot; mouse; fig 5
Majumdar T, Chattopadhyay S, Ozhegov E, Dhar J, Goswami R, Sen G, et al. Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLoS Pathog. 2015;11:e1004779 pubmed publisher
  • western blot; mouse
He L, Zang A, Du M, Ma D, Yuan C, Zhou C, et al. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virol Sin. 2015;30:174-89 pubmed publisher
  • western blot; mouse
Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, et al. Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B. J Biol Chem. 2015;290:1269-80 pubmed publisher
  • western blot; mouse; 1:3000
Lam E, Stein S, Falck-Pedersen E. Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol. 2014;88:974-81 pubmed publisher
  • western blot; human; fig 2
Fork C, Hitzel J, Nichols B, Tikkanen R, Brandes R. Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res Cardiol. 2014;109:439 pubmed publisher
  • western blot; human; 1:1000
Nandi S, Chanda S, Bagchi P, Nayak M, Bhowmick R, Chawla-Sarkar M. MAVS protein is attenuated by rotavirus nonstructural protein 1. PLoS ONE. 2014;9:e92126 pubmed publisher
  • western blot; mouse
Austenaa L, Barozzi I, Chronowska A, Termanini A, Ostuni R, Prosperini E, et al. The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity. 2012;36:572-85 pubmed publisher
Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, et al. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun. 2016;7:11848 pubmed publisher
Blaauboer S, Gabrielle V, Jin L. MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. J Immunol. 2014;192:492-502 pubmed publisher
Muvaffak A, Pan Q, Yan H, Fernandez R, Lim J, Dolinski B, et al. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol Cancer Res. 2014;12:1055-66 pubmed publisher
Manocha G, Mishra R, Sharma N, Kumawat K, Basu A, Singh S. Regulatory role of TRIM21 in the type-I interferon pathway in Japanese encephalitis virus-infected human microglial cells. J Neuroinflammation. 2014;11:24 pubmed publisher
Hu H, Zhang X, Zhang H, Wen G, Zhang Q, Li X, et al. Porcine reproductive and respiratory syndrome virus inhibition of interferon-β transcription by IRF3-independent mechanisms in MARC-145 cells in early infection. Vet Immunol Immunopathol. 2013;156:135-40 pubmed publisher
product information
SKU :
4302S
Product-Name :
IRF-3 (D83B9) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
45-55
Host :
Rabbit
Target :
IRF-3
Primary-Protein :
IRF3
Alt-Names :
IRF-3,IRF3,Interferon regulatory factor 3
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.