| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; loading ...; fig s13a
| Wolpaw A, Grossmann L, Dessau J, Dong M, Aaron B, Brafford P, et al. Epigenetic state determines inflammatory sensing in neuroblastoma. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher |
- western blot knockout validation; human; loading ...; fig 4b
| Iampietro M, Younan P, Nishida A, Dutta M, Lubaki N, Santos R, et al. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. PLoS Pathog. 2017;13:e1006397 pubmed publisher |
- western blot knockout validation; human; loading ...; fig 3a
| Bao M, Wang Y, Liu Y, Shi P, Lu H, Sha W, et al. NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells. J Exp Med. 2016;213:2383-2398 pubmed |
- western blot; mouse; loading ...; fig 6a, 6c
| Wang F, Li M, Zhang A, Li H, Jiang C, Guo J. PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction. J Immunol Res. 2022;2022:7685796 pubmed publisher |
- western blot; mouse; 1:1000; fig 3d, s1c
| Liu W, Zhou H, Wang H, Zhang Q, Zhang R, Willard B, et al. IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice. Nat Commun. 2022;13:2748 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6b
| Hong J, Zhang M, He Y, Jin Y, He Q, Zhang Y, et al. Qinghao-Biejia Herb Pair Alleviates Pristane-Induced Lupus-Like Disease and Associated Renal and Aortic Lesions in ApoE-/- Mice. Front Pharmacol. 2022;13:897669 pubmed publisher |
- western blot; rat; fig 6a
| Sun W, Byon C, Kim D, Choi H, Park J, Joo S, et al. Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88. Front Pharmacol. 2021;12:708575 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4e
| Hu Y, Li C, Wang X, Chen W, Qian Y, Dai X. TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage. Front Cell Dev Biol. 2021;9:693342 pubmed publisher |
- western blot; mouse; fig 3b
| Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; human; loading ...; fig s3d
| Iannucci A, Caneparo V, Raviola S, Debernardi I, Colangelo D, Miggiano R, et al. Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding. PLoS Pathog. 2020;16:e1008811 pubmed publisher |
- western blot; mouse; loading ...; fig e2a
| Zhou H, Wang H, Yu M, Schugar R, Qian W, Tang F, et al. IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes. Nat Immunol. 2020;21:1219-1231 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2b, s2b
| Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 7a, 7d
| Liu M, Yin L, Li W, Hu J, Wang H, Ye B, et al. C1q/TNF-related protein-9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction. J Cell Physiol. 2019;234:18731-18747 pubmed publisher |
- western blot; human; loading ...; fig s5c
| Skjesol A, Yurchenko M, Bösl K, Gravastrand C, Nilsen K, Grøvdal L, et al. The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 2019;15:e1007684 pubmed publisher |
- western blot; human; loading ...; fig 4f
| Liu P, Shah R, Li Y, Arora A, Ung P, Raman R, et al. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol. 2019;21:203-213 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Bi E, Li R, Bover L, Li H, Su P, Ma X, et al. E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs. J Clin Invest. 2018;128:4821-4831 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3b
| Han F, Xia X, Dou M, Wang Y, Xue W, Ding X, et al. Arctigenin: A two-edged sword in ischemia/reperfusion induced acute kidney injury. Biomed Pharmacother. 2018;103:1127-1136 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 8b
| Lu Y, Kim N, Jiang Y, Zhang H, Zheng D, Zhu F, et al. Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. Br J Pharmacol. 2018;175:1085-1099 pubmed publisher |
- western blot; mouse; fig 6b
| Naik S, Padhi A, Ganguli G, Sengupta S, Pati S, Das D, et al. Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway. Infect Immun. 2017;85: pubmed publisher |
- western blot; human; loading ...; fig 6a
| Franz S, Rennert P, Woznik M, Grützke J, Lüdde A, Arriero Pais E, et al. Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes. J Virol. 2017;91: pubmed publisher |
- immunoprecipitation; human; fig 1b
- western blot; human; fig 1b
| Du M, Martin A, HAYS F, Johnson J, FARJO R, Farjo K. Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4. Mol Vis. 2017;23:185-197 pubmed |
- immunoprecipitation; human; loading ...; fig 2f
- immunocytochemistry; human; loading ...; fig 2c
- western blot; human; loading ...; fig 2f
| Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, et al. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell. 2017;168:789-800.e10 pubmed publisher |
- western blot; human; loading ...; fig 3f
| Mondello P, Derenzini E, Asgari Z, Philip J, Brea E, SESHAN V, et al. Dual inhibition of histone deacetylases and phosphoinositide 3-kinase enhances therapeutic activity against B cell lymphoma. Oncotarget. 2017;8:14017-14028 pubmed publisher |
- western blot; mouse; fig 1
- western blot; human; fig 1
| Boro M, Singh V, Balaji K. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci Rep. 2016;6:37695 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Wang Y, Hu C, Li J, You X, Gao F. Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation. Oncotarget. 2016;7:38451-38466 pubmed publisher |
- western blot; human; fig 6
| Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed publisher |
| Ulbrich F, Kaufmann K, Roesslein M, Wellner F, Auwärter V, Kempf J, et al. Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4. PLoS ONE. 2015;10:e0143887 pubmed publisher |
- western blot; domestic rabbit
| De S, Zhou H, DeSantis D, Croniger C, Li X, Stark G. Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal. Proc Natl Acad Sci U S A. 2015;112:9680-5 pubmed publisher |
- western blot; mouse; fig 11
| Ito A, Hong C, Rong X, Zhu X, Tarling E, Hedde P, et al. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. elife. 2015;4:e08009 pubmed publisher |
| Chattergoon M, Latanich R, Quinn J, Winter M, Buckheit R, Blankson J, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10:e1004082 pubmed publisher |
- western blot; rat; 1:1000
| Jayakumar A, Tong X, Curtis K, Ruiz Cordero R, Abreu M, Norenberg M. Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy. J Neurochem. 2014;128:890-903 pubmed publisher |
| Kim Y, Lee S, Kim S, Jang H, Hwang I, Jin S, et al. Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Nat Chem Biol. 2019;15:907-916 pubmed publisher |
| Briard B, Karki R, Malireddi R, Bhattacharya A, Place D, Mavuluri J, et al. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2019;4:316-327 pubmed publisher |
| Dong D, Zhou H, Na S, Niedra R, Peng Y, Wang H, et al. GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. PLoS ONE. 2018;13:e0205303 pubmed publisher |
| Laustsen A, Bak R, Krapp C, Kjær L, Egedahl J, Petersen C, et al. Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nat Commun. 2018;9:3525 pubmed publisher |
| Johnson J, Lucas S, Amon L, Skelton S, Nazitto R, Carbonetti S, et al. Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host Microbe. 2018;23:366-381.e9 pubmed publisher |
| Gunasekaran M, Sharma M, Hachem R, Bremner R, Smith M, Mohanakumar T. Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection. J Immunol. 2018;200:2535-2541 pubmed publisher |
| Chauhan A. Fc?RIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells. J Immunol. 2017;198:4596-4606 pubmed publisher |
| Wang X, Gao Y, Song J, Tang C, Wang M, Que L, et al. The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation. Br J Pharmacol. 2017;174:1841-1856 pubmed publisher |
| Lee B, Miyata M, Lim J, Li J. Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88. Proc Natl Acad Sci U S A. 2016;113:E165-71 pubmed publisher |
| Hirata B, Banin R, Dornellas A, de Andrade I, Zemdegs J, Caperuto L, et al. Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats. Mediators Inflamm. 2015;2015:419106 pubmed publisher |
| Avbelj M, Wolz O, Fekonja O, BenÄina M, RepiÄ M, Mavri J, et al. Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization. Blood. 2014;124:3896-904 pubmed publisher |
| Abdi J, Mutis T, Garssen J, Redegeld F. Toll-like receptor (TLR)-1/2 triggering of multiple myeloma cells modulates their adhesion to bone marrow stromal cells and enhances bortezomib-induced apoptosis. PLoS ONE. 2014;9:e96608 pubmed publisher |
| Zhao M, Chen Y, Chen X, Dong X, Zhou J, Wang H, et al. Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Toxicol Lett. 2014;224:201-8 pubmed publisher |
| Piao W, Vogel S, Toshchakov V. Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivo. J Immunol. 2013;190:2263-72 pubmed publisher |
| Geraghty P, Dabo A, D ARMIENTO J. TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem. 2011;286:30211-8 pubmed publisher |
