| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; rat; 1:1000; loading ...; fig 3a
| Banerjee S, Mishra S, Xu W, Thompson W, Chowdhury I. Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell. J Ovarian Res. 2022;15:86 pubmed publisher |
- western blot; human; loading ...; fig 6a, 6b, 6c, 6d
| Shu W, Zhu X, Wang K, Cherepanoff S, Conway R, Madigan M, et al. The multi-kinase inhibitor afatinib serves as a novel candidate for the treatment of human uveal melanoma. Cell Oncol (Dordr). 2022;45:601-619 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4c
| Su W, Feng B, Hu L, Guo X, Yu M. MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway. BMC Cancer. 2022;22:602 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Chen Y, Xu J, Pan W, Xu X, Ma X, Chu Y, et al. Galectin-3 enhances trastuzumab resistance by regulating cancer malignancy and stemness in HER2-positive breast cancer cells. Thorac Cancer. 2022;13:1961-1973 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Cao Y, Li Q, Yang Y, Ke Z, Chen S, Li M, et al. Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Front Cardiovasc Med. 2021;8:694219 pubmed publisher |
- immunocytochemistry; mouse; 1:100; loading ...; fig 4g
- western blot; mouse; 1:1000; loading ...; fig 4f
| Kearney A, Norris D, Ghomlaghi M, Kin Lok Wong M, Humphrey S, Carroll L, et al. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. elife. 2021;10: pubmed publisher |
- western blot; human; loading ...; fig 6i
| Getachew A, Abbas N, You K, Yang Z, Hussain M, Huang X, et al. SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury. iScience. 2021;24:102483 pubmed publisher |
- western blot; mouse; loading ...; fig 5h
| Zheng H, Xu W, Zhou W, Yang R, Chen P, Liu T, et al. Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination. Cell Death Dis. 2021;12:497 pubmed publisher |
- western blot; mouse; loading ...; fig 6e, 6f
| Wang X, Zhao Y, Zhou D, Tian Y, Feng G, Lu Z. Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice. Cell Death Dis. 2021;12:212 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5a
| Kusakabe J, Hata K, Miyauchi H, Tajima T, Wang Y, Tamaki I, et al. Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine Models. Cell Mol Gastroenterol Hepatol. 2021;11:1351-1367 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3b, 3c
| Jiang X, Xu Y, Ren H, Jiang J, Wudu M, Wang Q, et al. KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity. Cell Biosci. 2020;10:139 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 5b
| Wu W, Piao H, Wu F, Han Y, An D, Wu Y, et al. Yu Jin Pulvis inhibits carbon tetrachloride-induced liver fibrosis by blocking the MAPK and PI3K/Akt signaling pathways. Am J Transl Res. 2019;11:5998-6006 pubmed |
- western blot; human; loading ...; fig s1f
| Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Fenwick C, Loredo Varela J, Joo V, Pellaton C, Farina A, Rajah N, et al. Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. J Exp Med. 2019;: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3c
| Simond A, Rao T, Zuo D, Zhao J, Muller W. ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor. Oncogene. 2017;36:6059-6066 pubmed publisher |
- western blot; human; fig 4a
| Liu X, Zhou X, Xu H, He Z, Shi X, Wu S. SLC34A2 Regulates the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells Through PTEN/PI3K/AKT Signaling. DNA Cell Biol. 2017;36:775-780 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Cao H, Yu S, Chen D, Jing C, Wang Z, Ma R, et al. Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment. FEBS Open Bio. 2017;7:35-43 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s9a
| Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher |
- western blot; human; loading ...; fig 6d
| Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, et al. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res. 2016;35:190 pubmed |
- western blot; mouse; loading ...; fig 7a
| Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 2
| Chruvattil R, Banerjee S, Nath S, Machhi J, Kharkwal G, Yadav M, et al. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Mol Neurobiol. 2017;54:7483-7496 pubmed publisher |
- western blot; Spodoptera litura; fig 3a
| Shao X, Lai D, Zhang L, Xu H. Induction of Autophagy and Apoptosis via PI3K/AKT/TOR Pathways by Azadirachtin A in Spodoptera litura Cells. Sci Rep. 2016;6:35482 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4f
| Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed publisher |
| Zhang Y, Hu S, Chen Y, Guo M, Wang S. Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway. Int J Mol Med. 2016;38:1055-62 pubmed publisher |
- western blot; mouse; 1:500; fig 6
| Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, et al. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget. 2016;7:45414-45428 pubmed publisher |
- western blot; human; fig 1
| Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher |
- western blot; human; fig 6
| Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed publisher |
- western blot; mouse; fig 6
| Qiu X, Wei R, Li Y, Zhu Q, Xiong C, Chen Y, et al. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016;7:31440-53 pubmed publisher |
- western blot; human; fig 5
| Cornick S, Moreau F, Chadee K. Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin. PLoS Pathog. 2016;12:e1005579 pubmed publisher |
- western blot; human; fig 6
| Osinalde N, Sánchez Quiles V, Blagoev B, Kratchmarova I. Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes. Sci Rep. 2016;6:23530 pubmed publisher |
- western blot; human; fig 4b
| Hung M, Chen Y, Chu P, Shih C, Yu H, Tai W, et al. Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential. Oncogene. 2016;35:4891-902 pubmed publisher |
- western blot; human; loading ...; fig 5e
| Salim H, Zong D, Hååg P, Novak M, Mörk B, Lewensohn R, et al. DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines. BMC Cancer. 2015;15:628 pubmed publisher |
- western blot; human; fig 3
| Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed |
- western blot; human; 1:1000
| Li C, Siragy H. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab. 2015;309:E302-10 pubmed publisher |
- western blot; human; 1:800; fig 5
| Carnesecchi J, Malbouyres M, de Mets R, Balland M, Beauchef G, Vié K, et al. Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS ONE. 2015;10:e0120672 pubmed publisher |
| Younan P, Iampietro M, Nishida A, Ramanathan P, Santos R, Dutta M, et al. Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm. MBio. 2017;8: pubmed publisher |
| Koirala P, Huang J, Ho T, Wu F, Ding X, Mo Y. LncRNA AK023948 is a positive regulator of AKT. Nat Commun. 2017;8:14422 pubmed publisher |
| Pahari S, Khan N, Aqdas M, Negi S, Kaur J, Agrewala J. Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide. Sci Rep. 2016;6:39492 pubmed publisher |
| Chen H, Wu G, Sun Q, Dong Y, Zhao H. Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1?-induced apoptosis via the PI3K/AKT signaling pathway. Am J Transl Res. 2016;8:5108-5117 pubmed |
| Sun P, Wei S, Wei X, Wang J, Zhang Y, Qiao M, et al. Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway. Neural Plast. 2016;2016:4129015 pubmed publisher |
| Lindqvist J, Levy Y, Pati Alam A, Hardeman E, Gregorevic P, Ochala J. Modulating myosin restores muscle function in a mouse model of nemaline myopathy. Ann Neurol. 2016;79:717-725 pubmed publisher |
| Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat Immunol. 2016;17:277-85 pubmed publisher |
| Dooley J, Garcia Perez J, Sreenivasan J, Schlenner S, Vangoitsenhoven R, Papadopoulou A, et al. The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity. Diabetes. 2016;65:53-61 pubmed publisher |
| Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed publisher |
| Duan H, Qu L, Shou C. Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration. Cancer Cell Int. 2014;14:135 pubmed publisher |
| Wellberg E, Rudolph M, Lewis A, Padilla Just N, Jedlicka P, Anderson S. Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis. Breast Cancer Res. 2014;16:481 pubmed publisher |
| Shah K, Tripathy S, Suganthi H, Rudraiah M. Profiling of luteal transcriptome during prostaglandin F2-alpha treatment in buffalo cows: analysis of signaling pathways associated with luteolysis. PLoS ONE. 2014;9:e104127 pubmed publisher |
| Chen T, Wang X, Guo L, Wu M, Duan Z, Lv J, et al. Embryonic Stem Cells Promoting Macrophage Survival and Function are Crucial for Teratoma Development. Front Immunol. 2014;5:275 pubmed publisher |
| Ong Q, Chan E, Lim M, Wong B. Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver. FEBS Open Bio. 2014;4:260-5 pubmed publisher |
| Zhuo B, Wang R, Zhang H, Qin H, Yin Y, Shi Y. Interleukin-24 inhibits cell migration and invasion in the neuroblastoma cell line SH-SY5Y. Oncol Rep. 2013;30:2749-54 pubmed publisher |
| Gao Y, Su P, Wang C, Zhu K, Chen X, Liu S, et al. The role of PTEN in chronic growth hormone-induced hepatic insulin resistance. PLoS ONE. 2013;8:e68105 pubmed publisher |
| Ammann J, Cooke A, Trowsdale J. Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol. 2013;190:5030-6 pubmed publisher |
| Wehler T, Hamdi S, Maderer A, Graf C, Gockel I, Schmidtmann I, et al. Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft--no benefit of combination therapy. Int J Colorectal Dis. 2013;28:385-98 pubmed publisher |
| Jung J, Kim H, Sohn K, Kim M, Lee K. Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene. 2011;30:2264-74 pubmed publisher |
| Ciraolo E, Morello F, Hobbs R, Wolf F, Marone R, Iezzi M, et al. Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Mol Biol Cell. 2010;21:704-11 pubmed publisher |
| Wu M, Katta A, Gadde M, Liu H, Kakarla S, Fannin J, et al. Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS ONE. 2009;4:e6430 pubmed publisher |
