product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Tom20 (D8T4N) Rabbit mAb
catalog :
42406
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D8T4N
reactivity :
human, mouse, rat, chicken, pigs
application :
western blot, immunocytochemistry
citations: 19
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig 6e
Scagliola A, Miluzio A, Ventura G, Oliveto S, Cordiglieri C, Manfrini N, et al. Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma. Nat Commun. 2021;12:4878 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig s1c
Matsui H, Ito J, Matsui N, Uechi T, Onodera O, Kakita A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nat Commun. 2021;12:3101 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6f
  • western blot; mouse; 1:1000; loading ...; fig 4e
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  • western blot; human; fig s5e
Sünderhauf A, Raschdorf A, Hicken M, Schlichting H, Fetzer F, Brethack A, et al. GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells. Front Oncol. 2020;10:575854 pubmed publisher
  • western blot; pigs ; 1:1000; loading ...; fig 4b
Cao H, Krueger E, Chen J, Drizyte Miller K, Schulz M, McNiven M. The anti-viral dynamin family member MxB participates in mitochondrial integrity. Nat Commun. 2020;11:1048 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
  • western blot; rat; 1:1000; loading ...; fig 1d
Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
  • immunocytochemistry; chicken; 1:500; fig 4b
Wang J, Ba G, Han Y, Ming S, Wang M, Fu P, et al. Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens. Int J Biol Macromol. 2020;146:497-507 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 3h
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • western blot; human; loading ...; fig 6e
van Heesch S, Witte F, Schneider Lunitz V, Schulz J, Adami E, Faber A, et al. The Translational Landscape of the Human Heart. Cell. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Sanin D, Matsushita M, Klein Geltink R, Grzes K, van Teijlingen Bakker N, Corrado M, et al. Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2. Immunity. 2018;49:1021-1033.e6 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2b
  • western blot; mouse; 1:1000; loading ...; fig 3e
Sodero A, Rodríguez Silva M, Salio C, Sassoè Pognetto M, Chambers J. Sab is differentially expressed in the brain and affects neuronal activity. Brain Res. 2017;1670:76-85 pubmed publisher
  • western blot; mouse; loading ...; fig 8c
Upadhyay M, Agarwal S, Bhadauriya P, Ganesh S. Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol Dis. 2017;100:39-51 pubmed publisher
  • western blot; human; fig 1
Jung J, Ravi S, Lee D, McFadden K, Kamradt M, Toussaint L, et al. NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion. Curr Biol. 2016;26:3288-3302 pubmed publisher
Busch J, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, et al. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep. 2019;29:1728-1738.e9 pubmed publisher
Bowling J, Skolfield M, Riley W, Nolin A, Wolf L, Nelson D. Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway. BMC Mol Cell Biol. 2019;20:33 pubmed publisher
Yu M, Nguyen N, Huang Y, Lin D, Fujimoto T, Molkentine J, et al. Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer. JCI Insight. 2019;5: pubmed publisher
Yasunaga K, Ito T, Miki M, Ueda K, Fujiyama T, Tachibana Y, et al. Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy. Biomed Res Int. 2018;2018:8719397 pubmed publisher
Anderson G, Wardell S, Cakir M, Yip C, Ahn Y, Ali M, et al. Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. Nat Commun. 2018;9:1677 pubmed publisher
Wang L, Scott I, Zhu L, Wu K, Han K, Chen Y, et al. GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis. Nat Commun. 2017;8:523 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.