product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Bcl-2 (D55G8) Rabbit mAb (Human Specific)
catalog :
4223
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D55G8
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation
citations: 29
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5a
Xu Y, Chen X, Pan S, Wang Z, Zhu X. TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer. Cell Death Discov. 2021;7:299 pubmed publisher
  • western blot; human; loading ...; fig 4a
Lassiter R, Merchen T, Fang X, Wang Y. Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation. Front Immunol. 2021;12:671025 pubmed publisher
  • western blot; human; loading ...; fig 3f
Ma X, Zhao T, Yan H, Guo K, Liu Z, Wei L, et al. Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma. Cell Death Dis. 2021;12:544 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 5b
Chen W, Wu C, Chen Y, Guo Y, Qiu L, Liu Z, et al. Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress. Int J Oral Sci. 2021;13:10 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4g
Au C, Furness J, Britt K, Oshchepkova S, Ladumor H, Soo K, et al. Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. elife. 2020;9: pubmed publisher
  • western blot; human; fig 2a
Gu J, Zhang Y, Wang X, Xiang J, Deng S, Wu D, et al. Matrine inhibits the growth of natural killer/T-cell lymphoma cells by modulating CaMKIIγ-c-Myc signaling pathway. BMC Complement Med Ther. 2020;20:214 pubmed publisher
  • western blot; human; loading ...; fig 5a
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Bajpai R, Sharma A, Achreja A, Edgar C, Wei C, Siddiqa A, et al. Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Nat Commun. 2020;11:1228 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Chen Y, Liu Z, Wang Y, Zhuang J, Peng Y, Mo X, et al. FKBP51 induces p53-dependent apoptosis and enhances drug sensitivity of human non-small-cell lung cancer cells. Exp Ther Med. 2020;19:2236-2242 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2f
Wan G, An Y, Tao J, Wang Y, Zhou Q, Yang R, et al. MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway. Biosci Rep. 2020;40: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Tian M, Gong W, Guo J. Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia. Biol Open. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 2c
Hou N, He X, Yang Y, Fu J, Zhang W, Guo Z, et al. TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway. Biomed Res Int. 2019;2019:6712536 pubmed publisher
  • western blot; human; loading ...; fig 4c
Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7a
Gao Y, Zhuang Z, Gao S, Li X, Zhang Z, Ye Z, et al. Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury. Am J Transl Res. 2017;9:887-899 pubmed
  • western blot; human; 1:1000; loading ...; fig 8a
Yokoyama T, Kohn E, Brill E, Lee J. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 2017;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Dong Q, Fu L, Zhao Y, Tan S, Wang E. Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling. Oncotarget. 2017;8:17059-17069 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Cai L, Wang H, Yang Q. CRKL overexpression promotes cell proliferation and inhibits apoptosis in endometrial carcinoma. Oncol Lett. 2017;13:51-56 pubmed publisher
  • western blot; human; loading ...; fig 5
Ren Z, Aerts J, Vandenplas H, Wang J, Gorbenko O, Chen J, et al. Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis. 2016;7:e2560 pubmed publisher
  • western blot; human; 1:3000; loading ...; fig 5a
He X, Liu Z, Xia Y, Xu J, Lv G, Wang L, et al. HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs. Oncotarget. 2017;8:1247-1261 pubmed publisher
  • western blot; human; fig 5
Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed publisher
  • western blot; human; fig 3
Hein A, Post C, Sheinin Y, Lakshmanan I, Natarajan A, Enke C, et al. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016;35:6319-6329 pubmed publisher
  • western blot; human; 1:2000; fig 3
Zhang Y, Zou C, Yang S, Fu J. P120 catenin attenuates the angiotensin II-induced apoptosis of human umbilical vein endothelial cells by suppressing the mitochondrial pathway. Int J Mol Med. 2016;37:623-30 pubmed publisher
  • immunoprecipitation; human; fig 6
  • western blot; human; fig 6
Akahane K, Sanda T, Mansour M, Radimerski T, DeAngelo D, Weinstock D, et al. HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:219-28 pubmed publisher
  • western blot; human
Yoon H, Choi Y, Song J, Do I, Kang S, Ko Y, et al. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PLoS ONE. 2014;9:e88587 pubmed publisher
  • western blot; mouse
Ma T, Galimberti F, Erkmen C, Memoli V, Chinyengetere F, SEMPERE L, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013;12:1545-55 pubmed publisher
Hii L, Lim S, Leong C, Chin S, Tan N, Lai K, et al. The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma. BMC Complement Altern Med. 2019;19:257 pubmed publisher
Pang X, Li R, Shi D, Pan X, Ma C, Zhang G, et al. Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells. Oncol Lett. 2017;14:8028-8034 pubmed publisher
Zhong L, Shu W, Dai W, Gao B, Xiong S. Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction. J Virol. 2017;91: pubmed publisher
Peperzak V, Slinger E, Ter Burg J, Eldering E. Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling. Cell Death Differ. 2017;24:111-119 pubmed publisher
product information
SKU :
4223S
Product-Name :
Bcl-2 (D55G8) Rabbit mAb (Human Specific)
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H
Applications :
Immunoprecipitation
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
26
Host :
Rabbit
Target :
Bcl-2
Primary-Protein :
Bcl-2
Alt-Names :
Apoptosis regulator Bcl-2,B-cell CLL/lymphoma 2,BCL2,Bcl-2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.