Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb | Cell Signaling Technology 4199 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb

catalog :

4199

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

D57A2

reactivity :

human, mouse

application :

western blot, immunoprecipitation

more info or order :

Cell Signaling Technology product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4a	Li D, Liu M, Li Z, Zheng G, Chen A, Zhao L, et al. Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice. Aging Dis. 2021;12:747-763 pubmed publisher
western blot; human; loading ...; fig 2c	Chen Q, Liu X, Wang D, Zheng J, Chen L, Xie Q, et al. Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis. Front Cell Dev Biol. 2021;9:663037 pubmed publisher
western blot; human; loading ...; fig 3f	Wang Q, Gao H, Clark K, Mugisha C, Davis K, Tang J, et al. CARD8 is an inflammasome sensor for HIV-1 protease activity. Science. 2021;371: pubmed publisher
western blot; human; 1:700; loading ...; fig 1c	Jha A, Kumar V, Haque S, Ayasolla K, Saha S, Lan X, et al. Alterations in plasma membrane ion channel structures stimulate NLRP3 inflammasome activation in APOL1 risk milieu. FEBS J. 2019;: pubmed publisher
western blot; human; loading ...; fig 3j	Zhang B, Chen H, Ouyang J, Xie Y, Chen L, Tan Q, et al. SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect. Autophagy. 2019;:1-17 pubmed publisher
western blot; human; 1:1000; loading ...; fig 1c	Thi Tran U, Kitami T. Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition. Commun Biol. 2019;2:2 pubmed publisher
western blot; mouse; loading ...; fig 2a western blot; human; loading ...; fig 2j	Zhang C, Jiang M, Zhou H, Liu W, Wang C, Kang Z, et al. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. J Clin Invest. 2018;128:5399-5412 pubmed publisher
western blot; human; fig 2A	Zhang M, Qi Y, Li H, Cui J, Dai L, Frank J, et al. AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 ? and IL-18. Oncoimmunology. 2016;5:e1160182 pubmed publisher
western blot; human; loading ...; fig 5c western blot; mouse; loading ...; fig 3a	Haque S, Lan X, Wen H, Lederman R, Chawla A, Attia M, et al. HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy. Am J Pathol. 2016;186:347-58 pubmed publisher
western blot; human; loading ...; fig 1d	ViganÃ² E, Diamond C, Spreafico R, Balachander A, Sobota R, Mortellaro A. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015;6:8761 pubmed publisher
	Xie C, Jiang B, Qin L, Tellides G, Kirkiles Smith N, Jane Wit D, et al. Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells. J Clin Invest. 2020;130:3437-3452 pubmed publisher
	Haneklaus M, O Neil J, Clark A, Masters S, O Neill L. The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome. J Biol Chem. 2017;292:6869-6881 pubmed publisher
	Okada M, Matsuzawa A, Yoshimura A, Ichijo H. The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem. 2014;289:32926-36 pubmed publisher
	Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Nakamura M, et al. Serum amyloid A induces NLRP-3-mediated IL-1? secretion in neutrophils. PLoS ONE. 2014;9:e96703 pubmed publisher
	Migita K, Koga T, Satomura K, Izumi M, Torigoshi T, Maeda Y, et al. Serum amyloid A triggers the mosodium urate -mediated mature interleukin-1? production from human synovial fibroblasts. Arthritis Res Ther. 2012;14:R119 pubmed publisher
	Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T. Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity. J Biol Chem. 2011;286:33963-72 pubmed publisher

product information

SKU :

4199S

Product-Name :

Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb

Size :

100 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, (Mk)

Applications :

Immunoprecipitation

Product-Category :

Apoptosis

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

20, 22

Host :

Rabbit

Target :

Casp1 (p20) cleaved

Primary-Protein :

Casp1

Alt-Names :

CASP-1,CASP1,CASP1 nirs variant 1,Caspase-1,Caspase-1 subunit p10,Caspase-1 subunit p20,ICE,IL-1 beta-converting enzyme,IL-1BC,IL1B-convertase,IL1BC,IL1BCE,Interleukin-1 beta convertase,Interleukin-1 beta-converting enzyme,caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase),caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase),interleukin 1-B converting enzyme,interleukin 1-beta convertase,p45

more info or order :

Cell Signaling Technology product webpage