product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
EGR1 (15F7) Rabbit mAb
catalog :
4153
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
15F7
reactivity :
human, mouse, rat, cow
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 37
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 2d
Laporte A, Barrott J, Yao R, Poulin N, Brodin B, Jones K, et al. HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma. PLoS ONE. 2017;12:e0169407 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s6c
Kesarwani A, Ramirez O, Gupta A, Yang X, Murthy T, Minella A, et al. Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures. Oncogene. 2017;36:1123-1133 pubmed publisher
  • western blot; human; loading ...; fig 6g
Laporte A, Ji J, Ma L, Nielsen T, Brodin B. Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay. Oncotarget. 2016;7:34384-94 pubmed publisher
  • chromatin immunoprecipitation; human; fig s2
  • western blot; human; 1:1000; fig s2
Wu S, Rupaimoole R, Shen F, Pradeep S, Pecot C, Ivan C, et al. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun. 2016;7:11169 pubmed publisher
  • chromatin immunoprecipitation; human; 1:40; fig 3
Weigel C, Veldwijk M, Oakes C, Seibold P, Slynko A, Liesenfeld D, et al. Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun. 2016;7:10893 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 7
Lee S, Luong R, Johnson D, Cunha G, Rivina L, Gonzalgo M, et al. Androgen signaling is a confounding factor for β-catenin-mediated prostate tumorigenesis. Oncogene. 2016;35:702-14 pubmed publisher
  • chromatin immunoprecipitation; human; fig s3
Ponti D, Bastianelli D, Rosa P, Pacini L, Ibrahim M, Rendina E, et al. The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions. BMC Cell Biol. 2015;16:27 pubmed publisher
  • western blot; human; fig 8a
Sobolewski C, Sanduja S, Blanco F, Hu L, Dixon D. Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. Biomolecules. 2015;5:2035-55 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200
Liu W, Crews F. Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat. Neuroscience. 2015;293:92-108 pubmed publisher
  • western blot; human; fig 5
Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, et al. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep. 2015;5:8428 pubmed publisher
  • western blot; human; fig  3
Dong A, Wodziak D, Lowe A. Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface. J Biol Chem. 2015;290:8016-27 pubmed publisher
  • immunohistochemistry; rat; 1:250
Hoefflin S, Carter D. Neuronal expression of SOX2 is enriched in specific hypothalamic cell groups. J Chem Neuroanat. 2014;61-62:153-60 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:50; fig 4
Pollen A, Nowakowski T, Shuga J, Wang X, Leyrat A, Lui J, et al. Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex. Nat Biotechnol. 2014;32:1053-8 pubmed publisher
Oh J, Wang Y, Chen S, Li P, Du N, Yu Z, et al. Genetic background-dependent role of Egr1 for eyelid development. Proc Natl Acad Sci U S A. 2017;114:E7131-E7139 pubmed publisher
Wodziak D, Dong A, Basin M, Lowe A. Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration. PLoS ONE. 2016;11:e0164968 pubmed publisher
Jiang J, Azevedo Pouly A, Redis R, Lee E, Gusev Y, Allard D, et al. Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma. Oncotarget. 2016;7:53165-53177 pubmed publisher
Luo Y, Jiang Q, Wu J, Qiu J, Zhang W, Mei X, et al. Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer. Oncotarget. 2015;6:22564-74 pubmed
Wu H, Xu F, Yin Y, Da P, You X, Xu H, et al. Salicylate-induced changes in immediate-early genes in the hippocampal CA1 area. Mol Med Rep. 2015;12:1625-30 pubmed publisher
Maeda M, Murakami Y, Watari K, Kuwano M, Izumi H, Ono M. CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines. Lung Cancer. 2015;87:265-71 pubmed publisher
Ponti D, Bellenchi G, Puca R, Bastianelli D, Maroder M, Ragona G, et al. The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS ONE. 2014;9:e96037 pubmed publisher
Onoue K, Nakayama D, Ikegaya Y, Matsuki N, Nomura H. Fear extinction requires Arc/Arg3.1 expression in the basolateral amygdala. Mol Brain. 2014;7:30 pubmed publisher
Hu S, Mei L, Chen J, Huang Z, Wu H. Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat. Eur J Histochem. 2014;58:2294 pubmed publisher
Hodges T, Green M, Simone J, McCormick C. Effects of social context on endocrine function and Zif268 expression in response to an acute stressor in adolescent and adult rats. Int J Dev Neurosci. 2014;35:25-34 pubmed publisher
Guo S, Li Z, Jiang D, Lu Y, Liu Y, Gao L, et al. IRF4 is a novel mediator for neuronal survival in ischaemic stroke. Cell Death Differ. 2014;21:888-903 pubmed publisher
Maroteaux M, Valjent E, Longueville S, Topilko P, Girault J, Herve D. Role of the plasticity-associated transcription factor zif268 in the early phase of instrumental learning. PLoS ONE. 2014;9:e81868 pubmed publisher
Nakamura A, Kobayashi M, Kuraoka M, Yuasa K, Yugeta N, Okada T, et al. Initial pulmonary respiration causes massive diaphragm damage and hyper-CKemia in Duchenne muscular dystrophy dog. Sci Rep. 2013;3:2183 pubmed publisher
Pfeiffer V, Götz R, Xiang C, Camarero G, Braun A, Zhang Y, et al. Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum. PLoS ONE. 2013;8:e58259 pubmed publisher
Dyson O, Walker L, Whitehouse A, Cook P, Akula S. Resveratrol inhibits KSHV reactivation by lowering the levels of cellular EGR-1. PLoS ONE. 2012;7:e33364 pubmed publisher
Kataoka F, Tsuda H, Arao T, Nishimura S, Tanaka H, Nomura H, et al. EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy. Genes Chromosomes Cancer. 2012;51:300-12 pubmed publisher
Hong X, Nelson K, Lemke N, Kalkanis S. Heparanase expression is associated with histone modifications in glioblastoma. Int J Oncol. 2012;40:494-500 pubmed publisher
Cui H, Shao C, Liu Q, Yu W, Fang J, Yu W, et al. Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway. Biochem J. 2011;440:273-82 pubmed publisher
Wells T, Rough K, Carter D. Transcription Mapping of Embryonic Rat Brain Reveals EGR-1 Induction in SOX2 Neural Progenitor Cells. Front Mol Neurosci. 2011;4:6 pubmed publisher
Dussmann P, Pagel J, Vogel S, Magnusson T, Zimmermann R, Wagner E, et al. Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing. BMC Dev Biol. 2011;11:28 pubmed publisher
Besancenot R, Chaligne R, Tonetti C, Pasquier F, Marty C, Lecluse Y, et al. A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation. PLoS Biol. 2010;8: pubmed publisher
Sauer L, Gitenay D, Vo C, Baron V. Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells. Oncogene. 2010;29:2628-37 pubmed publisher
Egerod F, Bartels A, Fristrup N, Borre M, Ørntoft T, Oleksiewicz M, et al. High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. BMC Cancer. 2009;9:385 pubmed publisher
product information
SKU :
4153S
Product-Name :
EGR1 (15F7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, (B)
Applications :
Chromatin Immunoprecipitation
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
75
Host :
Rabbit
Target :
EGR1
Primary-Protein :
EGR1
Alt-Names :
AT225,EGR-1,EGR1,Early growth response protein 1,G0S30,KROX-24,KROX24,NGFI-A,Nerve growth factor-induced protein A,TIS8,Transcription factor ETR103,Transcription factor Zif268,ZIF-268,ZNF225,Zinc finger protein 225,Zinc finger protein Krox-24,early growth response 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.