product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-HSL (Ser660) Antibody
catalog :
4126
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000
Lemecha M, Chalise J, Takamuku Y, Zhang G, Yamakawa T, Larson G, et al. Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia. Mol Metab. 2022;66:101612 pubmed publisher
  • western blot; mouse; 1:1000; fig 4c
Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, et al. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s1e
Cui X, Jing J, Wu R, Cao Q, Li F, Li K, et al. Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue. Nat Commun. 2021;12:5362 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Wang S, Cao Q, Cui X, Jing J, Li F, Shi H, et al. Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice. Biomolecules. 2021;11: pubmed publisher
  • western blot; mouse; 1:1000; fig 3e
Gómez Valadés A, Pozo M, Varela L, Boudjadja M, Ramirez S, Chivite I, et al. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis. Cell Metab. 2021;: pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, et al. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. J Nutr Biochem. 2021;95:108761 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4a
Wu T, Liu Q, Li Y, Li H, Chen L, Yang X, et al. Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway. J Exp Med. 2021;218: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1d, 1e
Hundahl C, Kotzbeck P, Burm H, Christiansen S, Torz L, Helge A, et al. Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis. Mol Metab. 2021;47:101174 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan A, et al. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019;10:1546 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y, et al. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019;668:310-317 pubmed publisher
  • western blot; mouse; fig 5c
Markussen L, Winther S, Wicksteed B, Hansen J. GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep. 2018;8:3469 pubmed publisher
  • western blot; human; loading ...; fig 1a
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, et al. Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer. Oncol Lett. 2018;15:1357-1361 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Kuo T, Chen T, Lee R, Nguyen N, Broughton A, Zhang D, et al. Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. Diabetes. 2017;66:1601-1610 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Xiao N, Yang L, Yang Y, Liu L, Li J, Liu B, et al. Ginsenoside Rg5 Inhibits Succinate-Associated Lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance. Front Pharmacol. 2017;8:43 pubmed publisher
  • western blot; human; fig 3
Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
  • western blot; human; loading ...; fig 4f
Rittig N, Bach E, Thomsen H, Pedersen S, Nielsen T, Jørgensen J, et al. Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial. PLoS ONE. 2016;11:e0162167 pubmed publisher
  • western blot; mouse; fig 4
Zhao W, Li A, Feng X, Hou T, Liu K, Liu B, et al. Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue. Cell Signal. 2016;28:1401-11 pubmed publisher
  • western blot; mouse; fig 3
Park J, Xu X, Cho S, Hur K, Lee M, Kersten S, et al. CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. Sci Rep. 2016;6:27938 pubmed publisher
  • western blot; mouse; 1:20,000; fig s5
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, et al. ASK1 signalling regulates brown and beige adipocyte function. Nat Commun. 2016;7:11158 pubmed publisher
Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, et al. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. Proc Natl Acad Sci U S A. 2017;114:E9474-E9482 pubmed publisher
Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher
Duszka K, Picard A, Ellero Simatos S, Chen J, Defernez M, Paramalingam E, et al. Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction. Sci Rep. 2016;6:36937 pubmed publisher
product information
SKU :
4126L
Product-Name :
Phospho-HSL (Ser660) Antibody
Size :
300 ul
Price-(USD) :
658 USD
Species-x-Reactivity :
M, R
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
81, 83
Host :
Rabbit
Target :
HSL (Ser951) phosphate
Primary-Protein :
HSL
Alt-Names :
HSL,Hormone-sensitive lipase,LHS,LIPE,LIPS,hormone-sensitive lipase testicular isoform,lipase, hormone-sensitive
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.