| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; human; 1:50; loading ...; fig 5c
| Wijdeven R, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, et al. Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway. Nat Commun. 2016;7:11808 pubmed publisher |
- western blot; mouse; fig 4
| Ramiscal R, Parish I, Lee Young R, Babon J, Blagih J, Pratama A, et al. Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation. elife. 2015;4: pubmed publisher |
- western blot; swine; fig 4
| Du J, Ge X, Liu Y, Jiang P, Wang Z, Zhang R, et al. Targeting Swine Leukocyte Antigen Class I Molecules for Proteasomal Degradation by the nsp1α Replicase Protein of the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06. J Virol. 2016;90:682-93 pubmed publisher |
- western blot; human; fig 3
| Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, et al. Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells. Nat Commun. 2015;6:7999 pubmed publisher |
- western blot; human; fig 3a
| Drießen S, Berleth N, Friesen O, Löffler A, Böhler P, Hieke N, et al. Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy. Autophagy. 2015;11:1458-70 pubmed publisher |
- western blot; human; fig 2
| Huang J, Cardamone M, JOHNSON H, Neault M, Chan M, Floyd Z, et al. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015;290:19044-54 pubmed publisher |
- western blot; mouse; fig 1
| Cui W, Sun M, Galeva N, Williams T, Azuma Y, Staudinger J. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes. Drug Metab Dispos. 2015;43:1316-25 pubmed publisher |
- western blot; mouse; fig 2c
| Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher |
- western blot; human; fig s1
| Morlé A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed publisher |
| Zhang H, Hu H, Greeley N, Jin J, Matthews A, Ohashi E, et al. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun. 2014;5:5798 pubmed publisher |
| Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed publisher |
- western blot; human; fig 3
| van den Boomen D, Timms R, Grice G, Stagg H, Skødt K, Dougan G, et al. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. Proc Natl Acad Sci U S A. 2014;111:11425-30 pubmed publisher |
| Atsumi S, Nosaka C, Adachi H, Kimura T, Kobayashi Y, Takada H, et al. New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells. BMC Cancer. 2016;16:496 pubmed publisher |
| Bento C, Ashkenazi A, Jimenez Sanchez M, Rubinsztein D. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016;7:11803 pubmed publisher |
| Li W, Yao A, Zhi H, Kaur K, Zhu Y, Jia M, et al. Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila. PLoS Genet. 2016;12:e1006062 pubmed publisher |
| Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed publisher |
| Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci. 2016;17: pubmed publisher |
| Guo H, Wen R, Liu Z, Datla R, Xiao W. Molecular Cloning and Functional Characterization of Two Brachypodium distachyon UBC13 Genes Whose Products Promote K63-Linked Polyubiquitination. Front Plant Sci. 2015;6:1222 pubmed publisher |
| Wolfsperger F, Hogh Binder S, Schittenhelm J, Psaras T, Ritter V, Bornes L, et al. Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms. Cell Death Dis. 2016;7:e2039 pubmed publisher |
| Luo Z, Zhang X, Zeng W, Su J, Yang K, Lu L, et al. TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin. Oncotarget. 2016;7:7179-92 pubmed publisher |
| Breinig M, Klein F, Huber W, Boutros M. A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells. Mol Syst Biol. 2015;11:846 pubmed publisher |
| Zhao J, Zhai B, Gygi S, Goldberg A. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proc Natl Acad Sci U S A. 2015;112:15790-7 pubmed publisher |
| Suzawa M, Miranda D, Ramos K, Ang K, Faivre E, Wilson C, et al. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. elife. 2015;4: pubmed publisher |
| Anzilotti S, Tornincasa M, Gerlini R, Conte A, Brancaccio P, Cuomo O, et al. Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype. Cell Death Dis. 2015;6:e2004 pubmed publisher |
| Wilfinger N, Austin S, Scheiber Mojdehkar B, Berger W, Reipert S, Praschberger M, et al. Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. Oncotarget. 2016;7:1242-61 pubmed publisher |
| Ratliff E, Mauntz R, Kotzebue R, Gonzalez A, Achal M, Barekat A, et al. Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PLoS ONE. 2015;10:e0132768 pubmed publisher |
| de Almagro M, Goncharov T, Newton K, Vucic D. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination. Cell Death Dis. 2015;6:e1800 pubmed publisher |
| Fajardo V, Bombardier E, McMillan E, TRAN K, Wadsworth B, Gamu D, et al. Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype. Dis Model Mech. 2015;8:999-1009 pubmed publisher |
| del Caño Espinel M, Acebes J, Sanchez D, Ganfornina M. Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy. Mol Neurodegener. 2015;10:11 pubmed publisher |
| Xiong Q, Ãœnal C, Matthias J, Steinert M, Eichinger L. The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions. Open Biol. 2015;5:150008 pubmed publisher |
| Lucibello M, Adanti S, Antelmi E, Dezi D, Ciafrè S, Carcangiu M, et al. Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells. Oncotarget. 2015;6:5275-91 pubmed |
| Mauger O, Klinck R, Chabot B, Muchardt C, Allemand E, Batsché E. Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions. Nucleic Acids Res. 2015;43:1869-82 pubmed publisher |
| Morimoto D, Walinda E, Fukada H, Sou Y, Kageyama S, Hoshino M, et al. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. Nat Commun. 2015;6:6116 pubmed publisher |
| Zhang S, Tang W, Weng S, Liu X, Rao B, Gu J, et al. Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma. Oncotarget. 2014;5:7183-97 pubmed |
| Steg A, Burke M, Amm H, Katre A, Dobbin Z, Jeong D, et al. Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer. Oncotarget. 2014;5:7065-80 pubmed |
| Hauerslev S, Vissing J, Krag T. Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model. PLoS ONE. 2014;9:e100594 pubmed publisher |
| Nakashima A, Kamada S, Tamanoi F, Kikkawa U. Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter. Biol Open. 2014;3:542-52 pubmed publisher |
| Dong S, Zhao J, Wei J, Bowser R, Khoo A, Liu Z, et al. F-box protein complex FBXL19 regulates TGF?1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation. Mol Cancer. 2014;13:76 pubmed publisher |
| Homma T, Ishibashi D, Nakagaki T, Satoh K, Sano K, Atarashi R, et al. Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein. Sci Rep. 2014;4:4504 pubmed publisher |
| Rosenbaek L, Kortenoeven M, Aroankins T, Fenton R. Phosphorylation decreases ubiquitylation of the thiazide-sensitive cotransporter NCC and subsequent clathrin-mediated endocytosis. J Biol Chem. 2014;289:13347-61 pubmed publisher |
| Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, et al. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol. 2014;44:2175-87 pubmed publisher |
| Zhang L, Chen X, Sharma P, Moon M, Sheftel A, Dawood F, et al. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 2014;5:3430 pubmed publisher |
| Nardon C, Schmitt S, Yang H, Zuo J, Fregona D, Dou Q. Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia. PLoS ONE. 2014;9:e84248 pubmed publisher |
| Pagotto A, Caballero O, Volkmar N, Devalle S, Simpson A, Lu X, et al. Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells. PLoS ONE. 2013;8:e83212 pubmed publisher |
| Chen P, Hung J, Hickman T, Coles A, Carey J, Weng Z, et al. Hdac6 regulates Tip60-p400 function in stem cells. elife. 2013;2:e01557 pubmed publisher |
| Liao C, Jeng C, Wang H, Wang S, Wu J. Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway. PLoS ONE. 2013;8:e79350 pubmed publisher |
| Auner H, Moody A, Ward T, Kraus M, Milan E, May P, et al. Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells. PLoS ONE. 2013;8:e74415 pubmed publisher |
| Granese B, Scala I, Spatuzza C, Valentino A, Coletta M, Vacca R, et al. Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome. BMC Med Genomics. 2013;6:24 pubmed publisher |
| Sigismund S, Algisi V, Nappo G, Conte A, Pascolutti R, Cuomo A, et al. Threshold-controlled ubiquitination of the EGFR directs receptor fate. EMBO J. 2013;32:2140-57 pubmed publisher |
| Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, et al. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep. 2013;3:1832 pubmed publisher |
| Hasenauer S, Malinger D, Koschut D, Pace G, Matzke A, von Au A, et al. Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins. PLoS ONE. 2013;8:e62357 pubmed publisher |
| Sun M, Ouzounian M, de Couto G, Chen M, Yan R, Fukuoka M, et al. Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways. J Am Heart Assoc. 2013;2:e000191 pubmed publisher |
| Thakral D, Coman M, Bandyopadhyay A, Martin S, Riley J, Kavathas P. The human CD8? M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties. PLoS ONE. 2013;8:e59374 pubmed publisher |
| Wen W, Peng C, Kim M, Ho Jeong C, Zhu F, Yao K, et al. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene. 2014;33:421-8 pubmed publisher |
| Xiong X, Hao Y, Sun K, Li J, Li X, Mishra B, et al. The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol. 2012;10:e1001440 pubmed publisher |
| Ido Kitamura Y, Sasaki T, Kobayashi M, Kim H, Lee Y, Kikuchi O, et al. Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation. PLoS ONE. 2012;7:e47231 pubmed publisher |
| Oh Y, Franck W, Han S, Shows A, Gokce E, Muddiman D, et al. Polyubiquitin is required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae. PLoS ONE. 2012;7:e42868 pubmed publisher |
| Niimi A, Chambers A, Downs J, Lehmann A. A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Res. 2012;40:7393-403 pubmed publisher |
| Thelen M, Damme M, Daμμe M, Schweizer M, Hagel C, Wong A, et al. Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis. PLoS ONE. 2012;7:e35493 pubmed publisher |
| Gregory J, Barros T, Meehan S, Dobson C, Luheshi L. The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila. PLoS ONE. 2012;7:e31899 pubmed publisher |
| Li S, Chen Y, Shi Q, Yue T, Wang B, Jiang J. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol. 2012;10:e1001239 pubmed publisher |
| Li X, Lu Y, Liang K, Hsu J, Albarracin C, Mills G, et al. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 2012;31:4372-83 pubmed publisher |
| Da Silva Ferrada E, Torres Ramos M, Aillet F, Campagna M, Matute C, Rivas C, et al. Role of monoubiquitylation on the control of I?B? degradation and NF-?B activity. PLoS ONE. 2011;6:e25397 pubmed publisher |
| Charbonney E, Speight P, Masszi A, Nakano H, Kapus A. ?-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol Biol Cell. 2011;22:4472-85 pubmed publisher |
| Zhou F, Zhang L, van Laar T, van Dam H, Ten Dijke P. GSK3? inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011;22:3533-40 pubmed publisher |
| Islam A, Turner E, Menzel J, Malo M, Harkness T. Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast. Cell Div. 2011;6:13 pubmed publisher |
| Hsieh M, Chen R. Cdc48 and cofactors Npl4-Ufd1 are important for G1 progression during heat stress by maintaining cell wall integrity in Saccharomyces cerevisiae. PLoS ONE. 2011;6:e18988 pubmed publisher |
| Waithe D, Ferron L, Page K, Chaggar K, Dolphin A. Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation. J Biol Chem. 2011;286:9598-611 pubmed publisher |
| Durrington H, Upton P, Hoer S, Boname J, Dunmore B, Yang J, et al. Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II. J Biol Chem. 2010;285:37641-9 pubmed publisher |
| Seidel K, den Dunnen W, Schultz C, Paulson H, Frank S, de Vos R, et al. Axonal inclusions in spinocerebellar ataxia type 3. Acta Neuropathol. 2010;120:449-60 pubmed publisher |
| Hooper C, Puttamadappa S, Loring Z, Shekhtman A, Bakowska J. Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets. BMC Biol. 2010;8:72 pubmed publisher |
| Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, et al. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010;17:488-98 pubmed publisher |
| Pinato S, Scandiuzzi C, Arnaudo N, Citterio E, Gaudino G, Penengo L. RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX. BMC Mol Biol. 2009;10:55 pubmed publisher |
| van der Kemp P, de Padula M, Burguiere Slezak G, Ulrich H, Boiteux S. PCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 2009;37:2549-59 pubmed publisher |
| An J, Yang D, Xu Q, Zhang S, Huo Y, Shang Z, et al. DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein. Mol Cancer. 2008;7:32 pubmed publisher |
| Davies A, Huttner D, Daigaku Y, Chen S, Ulrich H. Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a. Mol Cell. 2008;29:625-36 pubmed publisher |
| Gupta Rossi N, Six E, LeBail O, Logeat F, Chastagner P, Olry A, et al. Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol. 2004;166:73-83 pubmed |
