product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (Biotinylated)
catalog :
4093
clonality :
monoclonal
host :
rabbit
conjugate :
biotin
antigen modification :
phosphorylated
clone name :
D3A7
reactivity :
human, mouse, rat, cow
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
citations: 56
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4j
  • western blot; mouse; fig 5f
Zhang H, Song Y, Yang H, Liu Z, Gao L, Liang X, et al. Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018;37:2456-2468 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; human; fig 3
Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, et al. Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Sci Rep. 2016;6:29588 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Hammoud A, Kirstein N, Mournetas V, Darracq A, Broc S, Blanchard C, et al. Murine Embryonic Stem Cell Plasticity Is Regulated through Klf5 and Maintained by Metalloproteinase MMP1 and Hypoxia. PLoS ONE. 2016;11:e0146281 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
Aparicio Domingo P, Romera Hernandez M, Karrich J, Cornelissen F, Papazian N, Lindenbergh Kortleve D, et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. J Exp Med. 2015;212:1783-91 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Binder Gallimidi A, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein A, et al. Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6:22613-23 pubmed
  • immunohistochemistry; human; 1:50; loading ...; fig 1c
Choi E, Byeon S, Kim S, Lee H, Kwon H, Ahn H, et al. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PLoS ONE. 2015;10:e0130839 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 6
Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, et al. Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. Gastric Cancer. 2015;18:774-83 pubmed publisher
de Masson A, Bouaziz J, Le Buanec H, Robin M, O Meara A, Parquet N, et al. CD24(hi)CD27⁺ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. Blood. 2015;125:1830-9 pubmed publisher
Milner J, Vogel T, Forbes L, Ma C, Stray Pedersen A, Niemela J, et al. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 2015;125:591-9 pubmed publisher
Das L, Rosenjack J, Au L, Galle P, Hansen M, Cathcart M, et al. Hyper-inflammation and skin destruction mediated by rosiglitazone activation of macrophages in IL-6 deficiency. J Invest Dermatol. 2015;135:389-399 pubmed publisher
Park J, Kim M, Kang S, Jannasch A, Cooper B, Patterson J, et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol. 2015;8:80-93 pubmed publisher
Kim J, Sohn B, Lee H, Kim S, Yoo J, Park Y, et al. Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation. PLoS Med. 2014;11:e1001770 pubmed publisher
Wang X, Lin G, Lin Z, Chen Y, Chen Y, Zhang J, et al. Association of pSTAT3-VEGF signaling pathway with peritumoral edema in newly diagnosed glioblastoma: an immunohistochemical study. Int J Clin Exp Pathol. 2014;7:6133-40 pubmed
Yoshida R, Nakayama H, Nagata M, Hirosue A, Tanaka T, Kawahara K, et al. Overexpression of nucleostemin contributes to an advanced malignant phenotype and a poor prognosis in oral squamous cell carcinoma. Br J Cancer. 2014;111:2308-15 pubmed publisher
Wang S, Chen X, Tang M. MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2. Oncol Rep. 2014;32:2824-30 pubmed publisher
Rosich L, Montraveta A, Xargay Torrent S, López Guerra M, Roldán J, Aymerich M, et al. Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma. Oncotarget. 2014;5:6788-800 pubmed
Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, et al. A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene. Jpn J Clin Oncol. 2014;44:963-8 pubmed publisher
Mano Y, Aishima S, Kubo Y, Tanaka Y, Motomura T, Toshima T, et al. Correlation between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma. Am J Clin Pathol. 2014;142:391-7 pubmed publisher
Vinnikov I, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth L, et al. Hypothalamic miR-103 protects from hyperphagic obesity in mice. J Neurosci. 2014;34:10659-74 pubmed publisher
Saito Y, Yukawa A, Matozaki M, Mikami H, Yamagami T, Yamagishi N, et al. Nmi interacts with Hsp105? and enhances the Hsp105?-mediated Hsp70 expression. Exp Cell Res. 2014;327:163-70 pubmed publisher
Ekyalongo R, Mukohara T, Funakoshi Y, Tomioka H, Kataoka Y, Shimono Y, et al. TYRO3 as a potential therapeutic target in breast cancer. Anticancer Res. 2014;34:3337-45 pubmed
Pelosi M, De Rossi M, Barberi L, Musaro A. IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity. Biomed Res Int. 2014;2014:206026 pubmed publisher
Deng J, Yuan S, Pennati A, Murphy J, Wu J, Lawson D, et al. Engineered fusokine GIFT4 licenses the ability of B cells to trigger a tumoricidal T-cell response. Cancer Res. 2014;74:4133-44 pubmed publisher
Folgiero V, Goffredo B, Filippini P, Masetti R, Bonanno G, Caruso R, et al. Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia. Oncotarget. 2014;5:2052-64 pubmed
Briggs D, Lockie S, Benzler J, Wu Q, Stark R, Reichenbach A, et al. Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice. Endocrinology. 2014;155:2411-22 pubmed publisher
Liu B, Cao Y, Huizinga T, Hafler D, Toes R. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014;44:2121-9 pubmed publisher
Lin G, Yang L, Wang X, Chen Y, Tang W, Chen L, et al. STAT3 Tyr705 phosphorylation affects clinical outcome in patients with newly diagnosed supratentorial glioblastoma. Med Oncol. 2014;31:924 pubmed publisher
Alnaeeli M, Raaka B, Gavrilova O, Teng R, Chanturiya T, Noguchi C. Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity. Diabetes. 2014;63:2415-31 pubmed publisher
Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, et al. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. J Leukoc Biol. 2014;95:853-66 pubmed publisher
Liu B, Stoop J, Huizinga T, Toes R. IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-?B pathway in human B cells to boost antibody production. J Immunol. 2013;191:4086-94 pubmed publisher
Aftimos P, Wiedig M, Langouo Fontsa M, Awada A, Ghanem G, Journe F. Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: a rationale to combine targeted drugs based on protein expression inhibition profiles. Int J Oncol. 2013;43:919-26 pubmed publisher
Specht S, Isse K, Nozaki I, Lunz J, Demetris A. SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis. Clin Exp Metastasis. 2013;30:877-90 pubmed publisher
Zhang H, Yea K, Xie J, Ruiz D, Wilson I, Lerner R. Selecting agonists from single cells infected with combinatorial antibody libraries. Chem Biol. 2013;20:734-41 pubmed publisher
Levidou G, Siakantaris M, Papadaki T, Papadavid E, Vassilakopoulos T, Angelopoulou M, et al. A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides. J Am Acad Dermatol. 2013;69:375-84 pubmed publisher
Sadighi Akha A, Theriot C, Erb Downward J, McDermott A, Falkowski N, Tyra H, et al. Acute infection of mice with Clostridium difficile leads to eIF2? phosphorylation and pro-survival signalling as part of the mucosal inflammatory response. Immunology. 2013;140:111-22 pubmed publisher
Naraoka T, Ishibashi Y, Tsuda E, Yamamoto Y, Kusumi T, Kakizaki I, et al. Time-dependent gene expression and immunohistochemical analysis of the injured anterior cruciate ligament. Bone Joint Res. 2012;1:238-44 pubmed publisher
Rajala H, Eldfors S, Kuusanmäki H, van Adrichem A, Olson T, Lagström S, et al. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood. 2013;121:4541-50 pubmed publisher
Lupberger J, Duong F, Fofana I, Zona L, Xiao F, Thumann C, et al. Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha. Hepatology. 2013;58:1225-35 pubmed publisher
Mano Y, Aishima S, Fujita N, Tanaka Y, Kubo Y, Motomura T, et al. Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma. Pathobiology. 2013;80:146-54 pubmed publisher
Espinoza J, Takami A, Trung L, Kato S, Nakao S. Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells. PLoS ONE. 2012;7:e51306 pubmed publisher
Komohara Y, Horlad H, Ohnishi K, Fujiwara Y, Bai B, Nakagawa T, et al. Importance of direct macrophage-tumor cell interaction on progression of human glioma. Cancer Sci. 2012;103:2165-72 pubmed publisher
Sevilla L, Latorre V, Sanchis A, Perez P. Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation. J Invest Dermatol. 2013;133:361-70 pubmed publisher
Hyndman B, Gujral T, Krieger J, Cockburn J, Mulligan L. Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease. Hum Mutat. 2013;34:132-42 pubmed publisher
Diermeier Daucher S, Ortmann O, Buchholz S, Brockhoff G. Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012;4:614-22 pubmed publisher
Yanaihara N, Anglesio M, Ochiai K, Hirata Y, Saito M, Nagata C, et al. Cytokine gene expression signature in ovarian clear cell carcinoma. Int J Oncol. 2012;41:1094-100 pubmed publisher
Lo J, Patel V, Wang Z, Levasseur J, Kaufman S, Penninger J, et al. Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol. 2013;98:109-22 pubmed publisher
Morandi F, Prigione I, Airoldi I. Human TCR??+ T cells represent a novel target for IL-27 activity. Eur J Immunol. 2012;42:1547-52 pubmed publisher
Kraus M, Wang Y, Aleksandrowicz D, Bachman E, Szewczak A, Walker D, et al. Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera. PLoS ONE. 2012;7:e37207 pubmed publisher
KASS D, Yu G, Loh K, Savir A, Borczuk A, Kahloon R, et al. Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury. Am J Pathol. 2012;180:1963-78 pubmed publisher
de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould H. Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS ONE. 2012;7:e32967 pubmed publisher
Teng S, Hsu W, Chiu C, Wong M, Chang S. Overexpression of P-glycoprotein, STAT3, phospho-STAT3 and KIT in spontaneous canine cutaneous mast cell tumours before and after prednisolone treatment. Vet J. 2012;193:551-6 pubmed publisher
Zorzoli A, Di Carlo E, Cocco C, Ognio E, Ribatti D, Ferretti E, et al. Interleukin-27 inhibits the growth of pediatric acute myeloid leukemia in NOD/SCID/Il2rg-/- mice. Clin Cancer Res. 2012;18:1630-40 pubmed publisher
Ciccia F, Accardo Palumbo A, Alessandro R, Rizzo A, Principe S, Peralta S, et al. Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. Arthritis Rheum. 2012;64:1869-78 pubmed publisher
Li S, Wang N, Brodt P. Metastatic cells can escape the proapoptotic effects of TNF-? through increased autocrine IL-6/STAT3 signaling. Cancer Res. 2012;72:865-75 pubmed publisher
Jensen T, Schmidt H, Møller H, Donskov F, Høyer M, Sjoegren P, et al. Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma. Cancer. 2012;118:2476-85 pubmed publisher
Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs. 2012;30:1352-60 pubmed publisher
product information
SKU :
4093S
Product-Name :
Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (Biotinylated)
Size :
100 ul
Price-(USD) :
321 USD
Species-x-Reactivity :
H, M, R, Mk, (Hm, B, Pg, Hr)
Applications :
Western blot
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
79, 86
Host :
Rabbit
Target :
STAT3 (Tyr705) phosphate
Primary-Protein :
STAT3
Alt-Names :
APRF,Acute-phase response factor,DNA-binding protein APRF,FLJ20882,HIES,MGC16063,STAT3,Signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 (acute-phase response factor)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.