Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; human; 1:2000; loading ...; fig 2b
- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5d
| Feng W, Cao Z, Lim P, Zhao H, Luo H, Mao N, et al. Rapid interrogation of cancer cell of origin through CRISPR editing. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3c
| Lin G, Li J, Cai J, Zhang H, Xin Q, Wang N, et al. RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway. J Cancer. 2021;12:6715-6726 pubmed publisher
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- western blot; mouse; fig 1a
| Eritja N, Navaridas R, Ruiz Mitjana A, Vidal Sabanés M, Egea J, Encinas M, et al. Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation. Cancers (Basel). 2021;13: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4e
| Passman A, Strauss R, McSpadden S, Finch Edmondson M, Andrewartha N, Woo K, et al. Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model. Cancers (Basel). 2021;13: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 5e
| Zhu X, Peng S, Wang L, Chen X, Feng C, Liu Y, et al. Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer. Cell Death Dis. 2021;12:918 pubmed publisher
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- western blot; thale cress; fig 5c
| Minton D, Elliehausen C, Javors M, Santangello K, Konopka A. Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis. Arthritis Res Ther. 2021;23:253 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4a
| Li R, Hao Y, Wang Q, Meng Y, Wu K, Liu C, et al. ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation. Cell Death Dis. 2021;12:911 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 2e
| Jung S, Kim D, Choi Y, Kim S, Park H, Lee H, et al. Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. Sci Rep. 2021;11:19667 pubmed publisher
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- western blot; mouse; loading ...; fig s7d
| Nickl B, Qadri F, Bader M. Anti-inflammatory role of Gpnmb in adipose tissue of mice. Sci Rep. 2021;11:19614 pubmed publisher
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- western blot; mouse; loading ...; fig s7d
| Mesquita F, Abrami L, Sergeeva O, Turelli P, Qing E, Kunz B, et al. S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity. Dev Cell. 2021;56:2790-2807.e8 pubmed publisher
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- western blot; human; loading ...; fig 7b
| Zhao Y, Sun J, Li Y, Zhou X, Zhai W, Wu Y, et al. Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway. Acta Pharm Sin B. 2021;11:2835-2849 pubmed publisher
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- western blot; human; loading ...; fig 9a
| Li K, Wu R, Zhou M, Tong H, Luo K. Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system. Sci Adv. 2021;7:eabg7265 pubmed publisher
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- western blot; mouse; fig 9b
| Liu C, Chen G, Chen Y, Dang Y, Nie G, Wu D, et al. Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway. Front Pharmacol. 2021;12:724670 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3a
| Rossetti G, Ermer J, Stentenbach M, Siira S, Richman T, Milenkovic D, et al. A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv. 2021;7:eabi7514 pubmed publisher
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- western blot; rat; loading ...; fig 6b
| Hu S, Liu D, Li C, Xu Y, Hu K, Cui L, et al. Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NF-κB signaling pathway. Sci Rep. 2021;11:18824 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3b
| Langdon C, Gadek K, Garcia M, Evans M, Reed K, Bush M, et al. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun. 2021;12:5520 pubmed publisher
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- western blot; mouse; loading ...; fig 5b
| Liu Y, Li Y, Huang S, Li Y, Xia J, Jia J, et al. Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways. Aging (Albany NY). 2021;13:21155-21190 pubmed publisher
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- western blot; mouse; loading ...; fig 7a
| Rajendran R, Rajendran V, Giraldo Velasquez M, Megalofonou F, Gurski F, Stadelmann C, et al. Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE. Int J Mol Sci. 2021;22: pubmed publisher
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- immunohistochemistry; mouse; 1:100; loading ...; fig 2g
| Machida Y, Imai T. Different properties of mammary carcinogenesis induced by two chemical carcinogens, DMBA and PhIP, in heterozygous BALB/c Trp53 knockout mice. Oncol Lett. 2021;22:738 pubmed publisher
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- western blot; human; loading ...; fig 6a, 6b
| Wang C, Yang Z, Xu E, Shen X, Wang X, Li Z, et al. Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway. Clin Transl Med. 2021;11:e522 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 6b
| Chen Q, Fan K, Chen X, Xie X, Huang L, Song G, et al. Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling. J Cell Mol Med. 2021;25:9378-9389 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 2b
| De Velasco M, Kura Y, Ando N, Sako N, Banno E, Fujita K, et al. Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. Cancers (Basel). 2021;13: pubmed publisher
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- western blot; human; 1:1000; fig 1d
| Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
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- western blot; human; 1:1000; fig 1c
| Tang X, Li G, Shi L, Su F, Qian M, Liu Z, et al. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. Nat Commun. 2021;12:5058 pubmed publisher
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- immunohistochemistry - paraffin section; zebrafish ; 1:100; loading ...; fig 4e
| Luo J, Lu C, Feng M, Dai L, Wang M, Qiu Y, et al. Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. J Exp Clin Cancer Res. 2021;40:262 pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig 6d
| Reynoso S, Castillo V, Katkar G, López Sánchez I, Taheri S, Espinoza C, et al. GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility. elife. 2021;10: pubmed publisher
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- western blot; human; loading ...; fig 5b
| Kareddula A, Medina D, Petrosky W, Dolfi S, Tereshchenko I, Walton K, et al. The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype. Ther Adv Urol. 2021;13:17562872211022462 pubmed publisher
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- immunohistochemistry - free floating section; mouse; 1:200; fig 4a
- western blot; mouse; 1:2000; fig 3b
| Ceccarelli M, D Andrea G, Micheli L, Gentile G, Cavallaro S, Merlino G, et al. Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/-/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611. Front Oncol. 2021;11:692053 pubmed publisher
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- western blot; mouse; 1:1000; fig 2e
| Vinsland E, Baskaran P, Mihaylov S, Hobbs C, Wood H, Bouybayoune I, et al. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Sci Rep. 2021;11:16299 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 6d
| Xu X, Lei Y, Chen L, Zhou H, Liu H, Jiang J, et al. Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J Exp Clin Cancer Res. 2021;40:253 pubmed publisher
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- western blot; mouse; 1:500; loading ...
| Herranz C, Mateo F, Baiges A, Ruiz de Garibay G, Junza A, Johnson S, et al. Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis. EMBO Mol Med. 2021;13:e13929 pubmed publisher
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- western blot; human; 1:500-1:1000; loading ...; fig s1a
- western blot; mouse; 1:500-1:1000; loading ...; fig 1a
| Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1g
- western blot; human; 1:1000; loading ...; fig 1f, 4j
| Jiang Q, Zheng N, Bu L, Zhang X, Zhang X, Wu Y, et al. SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions. Mol Cancer. 2021;20:100 pubmed publisher
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- western blot; human; loading ...; fig 1f
| Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed publisher
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- western blot; human; loading ...; fig 7b, s7a
| Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher
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- western blot; rat; 1:500; loading ...; fig 3a
| Meng L, Zhang Y, Li D, Shang X, Hao X, Chen X, et al. TIMP3 attenuates cerebral ischemia/reperfusion-induced apoptosis and oxidative stress in neurocytes by regulating the AKT pathway. Exp Ther Med. 2021;22:973 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 2b
| Laliotis G, Chavdoula E, Paraskevopoulou M, Kaba A, La Ferlita A, Singh S, et al. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nat Commun. 2021;12:4624 pubmed publisher
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- western blot; human; fig 10a
| Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
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- western blot; mouse; 1:2000; loading ...; fig 2a
| Matsuzawa T, Morita M, Shimane A, Otsuka R, Mei Y, Irie F, et al. Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis. J Biol Chem. 2021;:101006 pubmed publisher
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- western blot; mouse; 1:1000
| Jiao L, Eickhoff R, Egners A, Jumpertz S, Roth J, Erdem M, et al. Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. J Pathol. 2021;255:270-284 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:100; fig 3f
| Shen C, Hsieh C, Jiang K, Lin C, Chiang N, Li T, et al. AUY922 induces retinal toxicity through attenuating TRPM1. J Biomed Sci. 2021;28:55 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1c
- western blot; human; 1:1000; loading ...; fig 1h, 3g, 4a
| Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, et al. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Adv Sci (Weinh). 2021;8:e2004303 pubmed publisher
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- western blot; mouse; 1:3000; loading ...; fig 3a
| Xu L, Zhang X, Xin Y, Ma J, Yang C, Zhang X, et al. Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. Cell Death Dis. 2021;12:710 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig s2a
| Liu H, Zang P, Lee I, Anderson B, Christiani A, Strait Bodey L, et al. Growth hormone secretagogue receptor-1a mediates ghrelin's effects on attenuating tumour-induced loss of muscle strength but not muscle mass. J Cachexia Sarcopenia Muscle. 2021;12:1280-1295 pubmed publisher
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- western blot; mouse; loading ...; fig 8d
| Wang W, Lu G, Liu H, Xiong Z, Leung H, Cao R, et al. Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3. Adv Sci (Weinh). 2021;:e2100849 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1a
| Saltykova I, Elahi A, Pitale P, Gorbatyuk O, Athar M, Gorbatyuk M. Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration. Cell Death Dis. 2021;12:664 pubmed publisher
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- immunohistochemistry; mouse; loading ...; fig 1h
| Wang Q, Tao C, Hannan A, Yoon S, Min X, Peregrin J, et al. Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling. Sci Adv. 2021;7: pubmed publisher
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- western blot; human; 1:3000; loading ...; fig 3a
| Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, et al. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Clin Transl Med. 2021;11:e454 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 7a
| Guix F, Capitán A, Casadomé Perales Á, Palomares Perez I, López Del Castillo I, Miguel V, et al. Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup. Life Sci Alliance. 2021;4: pubmed publisher
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- western blot; rat; loading ...; fig 6a
| Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, et al. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell Death Dis. 2021;12:642 pubmed publisher
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- western blot; mouse; loading ...; fig 6c
| Zhang B, Lapenta K, Wang Q, Nam J, Chung D, Robert M, et al. Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. J Biol Chem. 2021;297:100887 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 7c
| Beckmann D, Römer Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, et al. Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. Nat Commun. 2021;12:3624 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3c
| Wu Q, Tian A, Li B, Leduc M, Forveille S, Hamley P, et al. IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. J Immunother Cancer. 2021;9: pubmed publisher
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- western blot; human; loading ...; fig 1b
| Tian L, Chen C, Guo Y, Zhang F, Mi J, Feng Q, et al. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer. Neoplasia. 2021;23:643-652 pubmed publisher
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- western blot; human; loading ...; fig 6a, 8d
| Zhu J, Cai T, Zhou J, Du W, Zeng Y, Liu T, et al. CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer. J Exp Clin Cancer Res. 2021;40:192 pubmed publisher
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- western blot; human; 1:3000; loading ...; fig 1a, 1b
| Yin S, Liu L, Brobbey C, PALANISAMY V, Ball L, Olsen S, et al. PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021;12:3444 pubmed publisher
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- immunohistochemistry; mouse; 1:200; loading ...; fig 3c
- western blot; human; fig 1c
| Wang J, Zhang Y, Xiao Y, Yuan X, Li P, Wang X, et al. Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Am J Cancer Res. 2021;11:2005-2024 pubmed
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- western blot; human; loading ...; fig 4c, 4h
| Qin X, Li J, Wang S, Lv J, Luan F, Liu Y, et al. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics. 2021;11:6950-6965 pubmed publisher
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- western blot; human; 1:1000; fig 6h
| Li H, Zhao S, Shen L, Wang P, Liu S, Ma Y, et al. E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer. Aging (Albany NY). 2021;13:13626-13643 pubmed publisher
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- western blot; rat; loading ...; fig 6a
| Chen Y, Chen Y, Jiang X, Shi M, Yang Z, Chen Z, et al. Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo. J Inflamm Res. 2021;14:2207-2223 pubmed publisher
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- western blot; human; fig 6c
| Schwiebs A, Faqar Uz Zaman F, Herrero San Juan M, Radeke H. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. Int J Mol Sci. 2021;22: pubmed publisher
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- western blot; human; loading ...; fig 5e
| Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, et al. SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth. Adv Sci (Weinh). 2021;8:e2004846 pubmed publisher
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- western blot; mouse; loading ...; fig s2a
| Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed publisher
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- western blot; human; 1:1500; fig 3e
| Kulkarni N, O Neill A, Dokoshi T, Luo E, Wong G, Gallo R. Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors. J Biol Chem. 2021;297:100828 pubmed publisher
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- western blot; human; fig 4d
| Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, et al. Targeting fibroblast growth factor receptors to combat aggressive ependymoma. Acta Neuropathol. 2021;142:339-360 pubmed publisher
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- western blot; mouse; 1:2000; loading ...; fig 5e
| Li L, Yang L, Yang F, Zhao X, Xue S, Gong F. Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice. J Inflamm Res. 2021;14:1959-1971 pubmed publisher
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- western blot; mouse; 1:2000; loading ...; fig 1i
| Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, et al. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021;131: pubmed publisher
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- western blot; mouse; loading ...; fig 4c
| Kamm D, Pyles K, Sharpe M, Healy L, Colca J, McCommis K. Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. J Biol Chem. 2021;296:100807 pubmed publisher
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- western blot; human; loading ...; fig 3e
| Lei S, Zhang B, Huang L, Zheng Z, Xie S, Shen L, et al. SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA. Cell Death Discov. 2021;7:117 pubmed publisher
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- western blot; human; loading ...; fig 5c
| Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, et al. DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021;11:6355-6369 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4e
| Cao C, Zhang Y, Cheng J, Wu F, Niu X, Hu X, et al. β-Arrestin2 Inhibits the Apoptosis and Facilitates the Proliferation of Fibroblast-like Synoviocytes in Diffuse-type Tenosynovial Giant Cell Tumor. Cancer Genomics Proteomics. 2021;18:461-470 pubmed publisher
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- western blot; mouse; loading ...; fig 5h
| Zheng H, Xu W, Zhou W, Yang R, Chen P, Liu T, et al. Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination. Cell Death Dis. 2021;12:497 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 7b
| Li Q, Liu M, Sun Y, Jin T, Zhu P, Wan X, et al. SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress. J Exp Clin Cancer Res. 2021;40:168 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3a
| Al Zahrani K, Abou Hamad J, Pascoal J, Labrèche C, Garland B, Sabourin L. AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer. Breast Cancer Res. 2021;23:55 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 1a
| Luo L, Zhang Z, Qiu N, Ling L, Jia X, Song Y, et al. Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer. Nat Commun. 2021;12:2699 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3d
| Kaneko K, Lin H, Fu Y, Saha P, De la Puente Gomez A, Xu Y, et al. Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021;6: pubmed publisher
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- immunohistochemistry; mouse; 1:100; loading ...; fig s6a
- western blot; mouse; 1:1000; loading ...; fig 4b
| Tien J, Chugh S, Goodrum A, Cheng Y, Mannan R, Zhang Y, et al. AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3e
| Yang C, Liu Q, Chen Y, Wang X, Ran Z, Fang F, et al. Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve. Commun Biol. 2021;4:534 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4b
| Xu Y, Pan S, Chen H, Qian H, Wang Z, Zhu X. MEX3A suppresses proliferation and EMT via inhibiting Akt signaling pathway in cervical cancer. Am J Cancer Res. 2021;11:1446-1462 pubmed
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- western blot; human; 1:1000; fig 4h
| Pan Z, Wang B, Hou D, You R, Wang X, Xie W, et al. METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia. FEBS Open Bio. 2021;11:1659-1672 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 4
- immunoprecipitation; human; loading ...; fig 3a, 3b
- western blot; human; 1:1000; loading ...; fig 3a, 3b
| Zhang J, Hu J, Li W, Zhang C, Su P, Wang Y, et al. Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer. Front Oncol. 2021;11:608570 pubmed publisher
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- western blot; mouse; 1:2000; loading ...; fig s5d
| Wang S, Li S, Li Y, Jiang Q, Li X, Wang Y, et al. Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation. Stem Cell Reports. 2021;16:1290-1301 pubmed publisher
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- western blot; mouse; 1:100; loading ...; fig 4e
| Rupert J, Narasimhan A, Jengelley D, Jiang Y, Liu J, Au E, et al. Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia. J Exp Med. 2021;218: pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 6b
| Gao S, Gao L, Wang S, Shi X, Yue C, Wei S, et al. ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021;9:618987 pubmed publisher
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- western blot; mouse; loading ...; fig 6b, 7a
- western blot; human; loading ...; fig 4a
| Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, et al. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021;296:100624 pubmed publisher
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- western blot; mouse; fig 2a
| Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021;22: pubmed publisher
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- immunohistochemistry; mouse; fig 7e
| Meng L, Coleman V, Zhao Y, Ost M, Voigt A, Bunschoten A, et al. Pseudo-Starvation Driven Energy Expenditure Negatively Affects Ovarian Follicle Development. Int J Mol Sci. 2021;22: pubmed publisher
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- western blot; human; loading ...; fig 6c
| Moore K, Fulmer D, Guo L, Koren N, Glover J, Moore R, et al. PDGFRα: Expression and Function during Mitral Valve Morphogenesis. J Cardiovasc Dev Dis. 2021;8: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s9b
| Shi L, Magee P, Fassan M, Sahoo S, Leong H, LEE D, et al. A KRAS-responsive long non-coding RNA controls microRNA processing. Nat Commun. 2021;12:2038 pubmed publisher
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- western blot; mouse; loading ...; fig 6b
| Cao Z, Cheng Y, Wang J, Liu Y, Yang R, Jiang W, et al. HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression. J Exp Clin Cancer Res. 2021;40:118 pubmed publisher
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- western blot; mouse; loading ...; fig 1d
| Zhang X, Wang X, Yuan Z, Radford S, Liu C, Libutti S, et al. Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell Rep. 2021;34:108830 pubmed publisher
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- flow cytometry; mouse; 1:100; fig 6b
| Sun Z, Yao Y, You M, Liu J, Guo W, Qi Z, et al. The kinase PDK1 is critical for promoting T follicular helper cell differentiation. elife. 2021;10: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3a
- western blot; mouse; 1:1000; loading ...; fig 3a
| Chen X, Yao H, Kashif M, Revêchon G, Eriksson M, Hu J, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. elife. 2021;10: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4e
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- western blot; mouse; 1:500; loading ...; fig 3s1e
| Cuddy S, Schinlever A, Dochnal S, Seegren P, Suzich J, Kundu P, et al. Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. elife. 2020;9: pubmed publisher
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- western blot; human; loading ...; fig 4a
| Karnan S, Ota A, Murakami H, Rahman M, Hasan M, Wahiduzzaman M, et al. Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma. Cell Death Discov. 2020;6:127 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3b, 3c
| Jiang X, Xu Y, Ren H, Jiang J, Wudu M, Wang Q, et al. KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity. Cell Biosci. 2020;10:139 pubmed publisher
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- immunohistochemistry; mouse; 1:100; loading ...; fig 5a
- western blot; mouse; 1:1000; loading ...; fig 5e
| Li J, Zhang L, Zheng Y, Shao R, Liang Q, Yu W, et al. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. elife. 2020;9: pubmed publisher
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- western blot; human; loading ...; fig 4j
| Cai H, Yu Y, Ni X, Li C, Hu Y, Wang J, et al. LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis. Cell Death Dis. 2020;11:1032 pubmed publisher
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- western blot; bovine; loading ...; fig s2b
| Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed publisher
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- western blot; human; loading ...
| Wilson M, Reske J, Holladay J, Neupane S, Ngo J, Cuthrell N, et al. ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep. 2020;33:108366 pubmed publisher
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- western blot; human; loading ...; fig 3f
| Sünderhauf A, Raschdorf A, Hicken M, Schlichting H, Fetzer F, Brethack A, et al. GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells. Front Oncol. 2020;10:575854 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Dong X, Feng M, Yang H, Liu H, Guo H, Gao X, et al. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma. Int J Biol Sci. 2020;16:2835-2852 pubmed publisher
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- western blot; zebrafish ; 1:1000; loading ...; fig 3d
| Ganassi M, Badodi S, Wanders K, Zammit P, Hughes S. Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis. elife. 2020;9: pubmed publisher
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- western blot; human; loading ...; fig 6a
| Tan Y, Sementino E, Liu Z, Cai K, Testa J. Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis. Sci Rep. 2020;10:15837 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6e
| Zhu W, Liu C, Lu T, Zhang Y, Zhang S, Chen Q, et al. Knockout of EGFL6 by CRISPR/Cas9 Mediated Inhibition of Tumor Angiogenesis in Ovarian Cancer. Front Oncol. 2020;10:1451 pubmed publisher
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- western blot; mouse; loading ...; fig 6c
| Zhao L, Fan M, Zhao L, Yun H, Yang Y, Wang C, et al. Fibroblast growth factor 1 ameliorates adipose tissue inflammation and systemic insulin resistance via enhancing adipocyte mTORC2/Rictor signal. J Cell Mol Med. 2020;24:12813-12825 pubmed publisher
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- western blot; mouse; 1:500; fig s4-2b
| Tremblay M, Viala S, Shafer M, Graham Paquin A, Liu C, Bouchard M. Regulation of stem/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation. elife. 2020;9: pubmed publisher
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- western blot; human; fig 7g
| Liu C, Teo M, Pek S, Wu X, Leong M, Tay H, et al. A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions. Diabetes. 2020;69:2467-2480 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Zhou Y, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, et al. WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5. BMC Cancer. 2020;20:840 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 5s2a
| Rogerson C, Ogden S, Britton E, Ang Y, Sharrocks A. Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma. elife. 2020;9: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 6d
| Teramura Y, Tanaka M, Yamazaki Y, Yamashita K, Takazawa Y, Ae K, et al. Identification of Novel Fusion Genes in Bone and Soft Tissue Sarcoma and Their Implication in the Generation of a Mouse Model. Cancers (Basel). 2020;12: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 5g
| Eyler C, Matsunaga H, Hovestadt V, Vantine S, van Galen P, Bernstein B. Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance. Genome Biol. 2020;21:174 pubmed publisher
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- western blot; human; loading ...; fig 6c
| Brunner A, Suryo Rahmanto A, Johansson H, Franco M, Viiliäinen J, Gazi M, et al. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. elife. 2020;9: pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 5d
| Wang W, Wang H, Xiang L, Ni T, Jin F, Deng J, et al. DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer. Oncol Rep. 2020;44:77-90 pubmed publisher
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- western blot; mouse; loading ...; fig s6c
| Han C, Kang I, Harten I, Gebe J, Chan C, Omer M, et al. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020;31:107818 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 3a
| Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, et al. Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels. PLoS ONE. 2020;15:e0235573 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s7b
| Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
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- western blot; human; loading ...; fig 2a
| Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 5c
| Pattwell S, Arora S, Cimino P, Ozawa T, Szulzewsky F, Hoellerbauer P, et al. A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nat Commun. 2020;11:2977 pubmed publisher
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- western blot; zebrafish ; 1:1000; loading ...; fig 4a
| El Maï M, Marzullo M, de Castro I, Ferreira M. Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. elife. 2020;9: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig s6d
| Jiang H, Gallet S, Klemm P, Scholl P, Folz Donahue K, Altmuller J, et al. MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020;107:306-319.e9 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:150; loading ...; fig 3s3
| Zhang K, Yao E, Lin C, Chou Y, Wong J, Li J, et al. A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. elife. 2020;9: pubmed publisher
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- western blot; mouse; loading ...; fig 4e
- western blot; human; loading ...; fig 4a
| Feng Y, Mischler W, Gurung A, Kavanagh T, Androsov G, Sadow P, et al. Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. Cancer Res. 2020;80:2751-2763 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3e
| Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 3a
| Bozic M, Caus M, Rodrigues Díez R, Pedraza N, Ruiz Ortega M, Garí E, et al. Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis. Nat Commun. 2020;11:1943 pubmed publisher
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- western blot; human; loading ...; fig 3h
| Rigiracciolo D, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, et al. IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells. 2020;9: pubmed publisher
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- western blot; human; loading ...; fig 2e
| Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, et al. Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Theranostics. 2020;10:5137-5153 pubmed publisher
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- western blot; rhesus macaque; 1:1000; loading ...; fig 5a
| Du T, Zhu G, Chen Y, Shi L, Liu D, Liu Y, et al. Anterior thalamic nucleus stimulation protects hippocampal neurons by activating autophagy in epileptic monkeys. Aging (Albany NY). 2020;12:6324-6339 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3d
| Wu W, Jing D, Meng Z, Hu B, Zhong B, Deng X, et al. FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity. Theranostics. 2020;10:2859-2871 pubmed publisher
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- western blot; mouse; loading ...; fig s4a
| Li X, Wu Y, Zhao J, Wang H, Tan J, Yang M, et al. Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus. Theranostics. 2020;10:2675-2695 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 5
| Liang W, Gao R, Yang M, Wang X, Cheng K, Shi X, et al. MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. Oncol Lett. 2020;19:2272-2280 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 2e
| Xu M, Ge C, Qin Y, Lou D, Li Q, Feng J, et al. Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation. Mol Metab. 2020;34:112-123 pubmed publisher
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- western blot; human; 1:1000; fig 4f
| Steins A, van Mackelenbergh M, van der Zalm A, Klaassen R, Serrels B, Goris S, et al. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. EMBO Rep. 2020;21:e48780 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4b, 4d
| Dong C, Zhang J, Fang S, Liu F. IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells. Cell Div. 2020;15:4 pubmed publisher
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- western blot; mouse; loading ...; fig 5d
| Shi H, Wang Q, Zheng M, Hao S, Lum J, Chen X, et al. Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice. J Neuroinflammation. 2020;17:77 pubmed publisher
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- western blot; human; loading ...; fig 1f
| Howell M, Green R, Khalil R, Foran E, Quarni W, Nair R, et al. Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis. FASEB Bioadv. 2020;2:90-105 pubmed publisher
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- western blot; human; loading ...; fig 1, 2
| Leite M, Marques M, Melo J, Pinto M, Cavadas B, Aroso M, et al. Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions. Cells. 2020;9: pubmed publisher
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- western blot; human; loading ...; fig 4i
| Pothuraju R, Rachagani S, Krishn S, Chaudhary S, Nimmakayala R, Siddiqui J, et al. Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance. Mol Cancer. 2020;19:37 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4b
| Koren Iton A, Salomon Zimri S, Smolar A, Shavit Stein E, Dori A, Chapman J, et al. Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology. Int J Mol Sci. 2020;21: pubmed publisher
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- western blot; human; loading ...; fig 7a
| Zhang Y, Du P, Li Y, Zhu Q, Song X, Liu S, et al. TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway. Int J Biol Sci. 2020;16:739-751 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4g
| Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, Komori M, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Eneuro. 2020;7: pubmed publisher
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- western blot; human; 1:200; loading ...; fig 7
| Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
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- western blot; mouse; loading ...; fig 4b
| Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, et al. Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway. Pharmacol Res. 2020;153:104678 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1k
| Xhima K, Markham Coultes K, Nedev H, Heinen S, Saragovi H, Hynynen K, et al. Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease. Sci Adv. 2020;6:eaax6646 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s4
| Meng X, Zhao Y, Han B, Zha C, Zhang Y, Li Z, et al. Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways. Nat Commun. 2020;11:594 pubmed publisher
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- western blot; rat; loading ...; fig 7a
- western blot; human; loading ...; fig 10a
| Zhang Y, Mao X, Chen W, Guo X, Yu L, Jiang F, et al. A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation. Mol Ther Nucleic Acids. 2020;19:890-904 pubmed publisher
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- immunocytochemistry; human; 1:400; loading ...; fig 1s1
- western blot; human; 1:1000; loading ...; fig 1s3
| Lyashenko E, Niepel M, Dixit P, Lim S, Sorger P, Vitkup D. Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks. elife. 2020;9: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3i
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- western blot; mouse; loading ...
| Goswami D, Chen D, Yang Y, Gudla P, Columbus J, Worthy K, et al. Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior. elife. 2020;9: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 7c
| Zhou L, Shao C, Xie Y, Wang N, Xu S, Luo B, et al. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. elife. 2020;9: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig ev1c
| Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, et al. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020;12:e11021 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4f
| Chen M, Lu P, Ma Q, Cao Y, Chen N, Li W, et al. CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes. Sci Adv. 2020;6:eaax9605 pubmed publisher
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- western blot; human; loading ...; fig 2a, 2b
| Li H, Lan J, Wang G, Guo K, Han C, Li X, et al. KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation. J Exp Clin Cancer Res. 2020;39:12 pubmed publisher
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- immunohistochemistry - paraffin section; rat; 1:25; loading ...; fig s1a
| Inoue T, Kokubo T, Daino K, Yanagihara H, Watanabe F, Tsuruoka C, et al. Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation-associated renal tumors in Eker rats. Cancer Sci. 2020;111:840-848 pubmed publisher
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- immunohistochemistry - paraffin section; human; loading ...; fig 9a
- western blot; human; 1:400; loading ...; fig 4a
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- western blot; human; loading ...; fig 5d
| Xu Q, Ge Q, Zhou Y, Yang B, Yang Q, Jiang S, et al. MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway. EBioMedicine. 2020;51:102609 pubmed publisher
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- western blot; human; loading ...; fig 5b
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- western blot; human; loading ...; fig 3f
| Liu H, Mei F, Yang W, Wang H, Wong E, Cai J, et al. Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling. Sci Adv. 2020;6:eaay3566 pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig 1c
| Modi J, Menzie Suderam J, Xu H, Trujillo P, Medley K, Marshall M, et al. Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model. J Biomed Sci. 2020;27:19 pubmed publisher
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- immunohistochemistry - frozen section; zebrafish ; 1:200; loading ...; fig s6d
| Bhattarai P, Cosacak M, Mashkaryan V, Demir S, Popova S, Govindarajan N, et al. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS Biol. 2020;18:e3000585 pubmed publisher
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- western blot; mouse; loading ...; fig 7a
| Liu W, Yang L, Liu Y, Yuan D, Zhao Z, Wang Q, et al. Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice. Biosci Rep. 2020;40: pubmed publisher
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- western blot; human; loading ...; fig 4d, 5a
| Yin Y, Wang X, Li T, Ren Q, Li L, Sun X, et al. MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling. Cancer Med. 2020;9:1544-1552 pubmed publisher
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- western blot; human; loading ...; fig 5d
| Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, et al. LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer. Cancer Med. 2020;9:724-736 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4bd
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- western blot; human; loading ...; fig 4g
| Chen X, Xiong X, Cui D, Yang F, Wei D, Li H, et al. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020;39:1557-1571 pubmed publisher
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- western blot; human; fig 5a
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- western blot; human; loading ...; fig 1a
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- western blot; rat; loading ...; fig 6e
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- western blot; human; 1:1000; loading ...; fig 6b-c, 6b-g
| Perri A, Agosti V, Olivo E, Concolino A, Angelis M, Tammè L, et al. Histone proteomics reveals novel post-translational modifications in breast cancer. Aging (Albany NY). 2019;11:11722-11755 pubmed publisher
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- western blot; human; loading ...; fig 5d
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- western blot; human; 1:1000; loading ...; fig 4d
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- western blot; human; 1:1000; loading ...; fig 6a
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- western blot; mouse; loading ...; fig 4d
- western blot; human; loading ...; fig 5a
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- western blot; rat; loading ...; fig 5a
| Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, et al. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019;29:2028-2040.e8 pubmed publisher
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- western blot; fruit fly ; fig 2a
| Ahlers L, Trammell C, Carrell G, Mackinnon S, Torrevillas B, Chow C, et al. Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors. Cell Rep. 2019;29:1946-1960.e5 pubmed publisher
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- western blot; mouse; loading ...; fig 3a, 3c
| Thirugnanam K, Cossette S, Lu Q, Chowdhury S, Harmann L, Gupta A, et al. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. J Am Heart Assoc. 2019;8:e012792 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 2a
- western blot; mouse; 1:1000; loading ...; fig 2b
| VASAN N, Razavi P, Johnson J, Shao H, Shah H, Antoine A, et al. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Science. 2019;366:714-723 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig e2b
| Canon J, Rex K, Saiki A, Mohr C, Cooke K, Bagal D, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575:217-223 pubmed publisher
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- western blot; mouse; loading ...; fig e6d
| Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 2a
| Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, et al. Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway. EBioMedicine. 2019;48:386-404 pubmed publisher
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- western blot; human; loading ...; fig s6a
| Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed publisher
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- flow cytometry; mouse; loading ...; fig 1a
| Ortega Molina A, Deleyto Seldas N, Carreras J, Sanz A, Lebrero Fernández C, Menéndez C, et al. Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. Nat Metab. 2019;1:775-789 pubmed publisher
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- western blot; human; loading ...; fig e11-7d
| Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed publisher
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- western blot; human; loading ...; fig 5a
| Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, et al. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochem Pharmacol. 2019;170:113642 pubmed publisher
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- western blot; human; loading ...; fig 3e
| Nam S, Gupta V, Lee H, Lee J, Wisdom K, Varma S, et al. Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis. Sci Adv. 2019;5:eaaw6171 pubmed publisher
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- western blot; human; 1:1000; fig 1c
| Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett P, et al. Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. Stem Cells. 2019;37:1293-1306 pubmed publisher
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- western blot; mouse; loading ...; fig 3a
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- western blot; human; 1:3000; loading ...; fig 2a, 2i, 6d
| Bi J, Ichu T, Zanca C, Yang H, Zhang W, Gu Y, et al. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019;30:525-538.e8 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 2b
| Mao N, Gao D, Hu W, Hieronymus H, Wang S, Lee Y, et al. Aberrant Expression of ERG Promotes Resistance to Combined PI3K and AR Pathway Inhibition through Maintenance of AR Target Genes. Mol Cancer Ther. 2019;18:1577-1586 pubmed publisher
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- western blot; human; loading ...; fig 4d
| Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, et al. Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. Theranostics. 2019;9:3879-3902 pubmed publisher
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- immunohistochemistry; mouse; 1:1000; loading ...; fig 1g
| Du T, Li H, Fan Y, Yuan L, Guo X, Zhu Q, et al. The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis. Nat Commun. 2019;10:2914 pubmed publisher
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- western blot; rat; loading ...; fig 4c
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- western blot; human; 1:1000; loading ...; fig 6h
| Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher
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- western blot; bovine; loading ...; fig 1d
| Iring A, Jin Y, Albarrán Juárez J, Siragusa M, Wang S, Dancs P, et al. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019;129:2775-2791 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 2a
| Wang H, Huang F, Zhang Z, Wang P, Luo Y, Li H, et al. Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer. Int J Biol Sci. 2019;15:929-941 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6c
| Wang L, Shi H, Liu Y, Zhang W, Duan X, Li M, et al. Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway. Int J Oncol. 2019;55:473-487 pubmed publisher
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- western blot; human; loading ...; fig 6a
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- western blot; human; loading ...; fig 4a
| Sabol R, Bowles A, Côté A, Wise R, O Donnell B, Matossian M, et al. Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models. Breast Cancer Res. 2019;21:67 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4c
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- western blot; human; loading ...; fig 5a
| Coulombe P, Paliouras G, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, et al. Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep. 2019;27:1769-1780.e4 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3c
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- flow cytometry; human; loading ...; fig 1d
- western blot; human; loading ...; fig 1c
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- western blot; human; loading ...; fig 4a
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- western blot; human; 1:1000; loading ...; fig 5a
| Cheng Z, Lei Z, Yang P, Si A, Xiang D, Tang X, et al. Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways. Mol Carcinog. 2019;: pubmed publisher
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- western blot; human; 1:2000; loading ...; fig e2b
| Shi Y, Gao W, Lytle N, Huang P, Yuan X, Dann A, et al. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019;569:131-135 pubmed publisher
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- western blot; mouse; loading ...; fig s7
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- western blot; mouse; 1:1000; loading ...; fig 6s1c
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- western blot; mouse; loading ...; fig s2d
| Wu J, Ma S, Sandhoff R, Ming Y, Hotz Wagenblatt A, Timmerman V, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019;50:1218-1231.e5 pubmed publisher
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- western blot; human; 1:500; loading ...; fig 3f
| Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed publisher
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- western blot; mouse; 1:2000; loading ...; fig 2e
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- western blot; mouse; 1:1000; loading ...; fig 5a
| Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed publisher
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- western blot; human; loading ...; fig 1a
| Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed publisher
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- western blot; human; loading ...; fig 2b
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- western blot; mouse; 1:4000; loading ...; fig s1e
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- immunohistochemistry - paraffin section; rat; 1:1000; loading ...; fig 12a
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- flow cytometry; human; 1:100; loading ...; fig 3a
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- western blot; human; 1:1000; loading ...; fig s18a
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- western blot; human; loading ...; fig 6f
- western blot; mouse; loading ...; fig 6b
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- western blot; human; 1:2000; loading ...; fig s2a
- western blot; mouse; 1:2000; loading ...; fig s2b
| Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, et al. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019;: pubmed publisher
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- western blot; human; loading ...; fig 2l
| Cao J, Zhao M, Liu J, Zhang X, Pei Y, Wang J, et al. RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog. Theranostics. 2019;9:811-828 pubmed publisher
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- western blot; mouse; loading ...; fig 4c
| Kaya P, Lee S, Lee Y, Kwon S, Yang H, Lee H, et al. Curcumae Radix Extract Decreases Mammary Tumor-Derived Lung Metastasis via Suppression of C-C Chemokine Receptor Type 7 Expression. Nutrients. 2019;11: pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 4a
| Dong H, Ye X, Zhong L, Xu J, Qiu J, Wang J, et al. Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis. Front Neurosci. 2019;13:44 pubmed publisher
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- western blot; human; loading ...; fig 6b
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- western blot; hamsters; 1:2000; loading ...; fig 8a
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- western blot; human; 1:500; loading ...; fig 5d
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- immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 2e
- western blot; mouse; loading ...; fig 2d
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- western blot; human; 1:2000; loading ...; fig 5c
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- western blot; human; loading ...; fig 4a
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- western blot; mouse; 1:2000; loading ...; fig 3c
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- western blot; mouse; 1:1000; loading ...; fig 2d
- western blot; human; 1:1000; loading ...; fig 2d
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- western blot; mouse; loading ...; fig 3h
| Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
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- western blot; human; loading ...; fig s2
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- western blot; human; loading ...; fig 1c
| Turowec J, Lau E, Wang X, Brown K, Fellouse F, Jawanda K, et al. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. J Biol Chem. 2019;294:1396-1409 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4a
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- western blot; rat; 1:1000; loading ...; fig 3b, 4f, 5f
| Zhou X, Zhang R, Zou Z, Shen X, Xie T, Xu C, et al. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. Br J Pharmacol. 2019;176:478-490 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 6c
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- western blot; human; loading ...; fig 5a
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- western blot; human; loading ...; fig 3e
| Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher
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- western blot; human; loading ...; fig s1d
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- immunohistochemistry; mouse; loading ...; fig 6b
| Barros Silva J, Linn D, Steiner I, Guo G, Ali A, Pakula H, et al. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep. 2018;25:3504-3518.e6 pubmed publisher
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- western blot; rat; loading ...; fig 7h
| Bitar M, Nader J, Al Ali W, Al Madhoun A, Arefanian H, Al Mulla F. Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452 pubmed publisher
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- western blot; mouse; loading ...; fig s4c, s7c
| Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4a
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- western blot; human; loading ...; fig s7f
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- western blot; mouse; 1:2000; loading ...; fig 5a
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- western blot; human; loading ...; fig s10d, s10g
- western blot; mouse; loading ...; fig s10c
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- western blot; mouse; loading ...; fig 8a
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- western blot; mouse; loading ...; fig 5b
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- western blot; mouse; 1:1000; loading ...; fig 6c
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- western blot; mouse; loading ...; fig 3c
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- flow cytometry; mouse; 1:50; loading ...; fig 6a
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- western blot; mouse; loading ...; fig s3a
| Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher
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- western blot; human; loading ...; fig s1b
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- western blot; human; 1:1000; loading ...; fig 3b
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- western blot; human; loading ...; fig 2d
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- western blot; human; fig 3a
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- western blot; mouse; fig 3a
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- western blot; human; 1:1000; loading ...; fig 5a
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- western blot; rat; 1:2000; loading ...; fig 4b
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- western blot; mouse; 1:2000; loading ...; fig 3f
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- western blot; mouse; fig 3a
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- western blot; mouse; 1:2000; loading ...; fig 5c
| Chiang A, Fowler S, Savjani R, Hilsenbeck S, Wallace C, Cirrito J, et al. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018;215:1349-1364 pubmed publisher
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- western blot; human; loading ...; fig s2f
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- western blot; human; loading ...; fig 6f
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- immunohistochemistry - paraffin section; human; loading ...; fig 4d
- western blot; human; loading ...; fig 1d
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- western blot; mouse; loading ...; fig 3e
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- western blot; human; 1:1000; loading ...; fig 1e
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- western blot; human; loading ...; fig 9d
| Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher
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- immunohistochemistry - paraffin section; human; fig 7b
- western blot; human; fig 3b
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- western blot; mouse; fig s2d
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- western blot; human; loading ...; fig s7d
| Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, et al. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018;115:1298-1303 pubmed publisher
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- western blot; human; loading ...; fig 6e
| Shen L, Qu X, Li H, Xu C, Wei M, Wang Q, et al. NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis. Oncogene. 2018;37:1759-1774 pubmed publisher
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- western blot; mouse; fig 1c
| Ambrogio C, Köhler J, Zhou Z, Wang H, Paranal R, Li J, et al. KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS. Cell. 2018;172:857-868.e15 pubmed publisher
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- western blot; human; fig 3b
| Bekkering S, Arts R, Novakovic B, Kourtzelis I, van der Heijden C, Li Y, et al. Metabolic Induction of Trained Immunity through the Mevalonate Pathway. Cell. 2018;172:135-146.e9 pubmed publisher
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- western blot; human; 1:1000; fig s3f
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- western blot; human; loading ...; fig 3h, 3i
| Khalil S, Delehanty L, Grado S, Holy M, White Z, Freeman K, et al. Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor. J Exp Med. 2018;215:661-679 pubmed publisher
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- western blot; mouse; loading ...; fig 3a
| Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6d
| Wang J, Ye Q, Cao Y, Guo Y, Huang X, Mi W, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017;8:2207 pubmed publisher
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- western blot; mouse; fig s1j
| Rajbhandari P, Thomas B, Feng A, Hong C, Wang J, Vergnes L, et al. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018;172:218-233.e17 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 6b
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- western blot; human; loading ...; fig 7b
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- western blot; human; fig 6a
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- western blot; mouse; loading ...; fig 1d
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- flow cytometry; mouse; loading ...; fig 4a
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- western blot; mouse; 1:1000; loading ...; fig 4a
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- western blot; human; loading ...; fig 1f
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- western blot; human; loading ...; fig 2e
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- western blot; mouse; loading ...; fig 2a
| Urbanska M, Gozdz A, Macias M, Cymerman I, Liszewska E, Kondratiuk I, et al. GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. 2018;55:6050-6062 pubmed publisher
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- western blot; human; loading ...; fig 2c
| Bostner J, Alayev A, Berman A, Fornander T, Nordenskjold B, Holz M, et al. Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2018;168:17-27 pubmed publisher
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- western blot; mouse; 1:3000; loading ...; fig 4g
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- western blot; human; loading ...; fig 4
| Zhang R, Li J, Yan X, Jin K, Li W, Xu J, et al. SODD promotes glucose uptake of colorectal cancer cells via AKT pathway. Cell Biol Int. 2017;: pubmed publisher
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- western blot; mouse; loading ...; fig s10c
| Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4e
| Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, et al. ALK is a therapeutic target for lethal sepsis. Sci Transl Med. 2017;9: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s2a
| Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher
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- western blot; human; fig 5a
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- western blot; human; loading ...; fig 7b
| Zhao Z, Jia Q, Wu M, Xie X, Wang Y, Song G, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018;24:130-144 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6h
- western blot; mouse; 1:1000; loading ...; fig 6h
| Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
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- western blot; human; loading ...; fig 3d
- western blot; mouse; loading ...; fig 2b
| Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, et al. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017;9: pubmed publisher
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- western blot; human; loading ...; fig 4b
- western blot; mouse; loading ...; fig 4a, 4b
| Comiskey D, Jacob A, Sanford B, Montes M, Goodwin A, Steiner H, et al. A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene. 2018;37:95-106 pubmed publisher
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- immunohistochemistry; mouse; loading ...; fig s5c
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- western blot; human; fig 4a
| Liu X, Zhou X, Xu H, He Z, Shi X, Wu S. SLC34A2 Regulates the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells Through PTEN/PI3K/AKT Signaling. DNA Cell Biol. 2017;36:775-780 pubmed publisher
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- western blot; human; loading ...; fig 9c
| Peterson J, Lin B, Shin J, Phelan P, Tsichlis P, Schwob J, et al. Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt. J Virol. 2017;91: pubmed publisher
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- western blot; mouse; loading ...; fig s5g
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- western blot; mouse; loading ...; fig s10a
| Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher
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- western blot; mouse; loading ...; fig 3
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- western blot; human; loading ...; fig 1a
| Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
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- western blot; human; loading ...; fig 3a
| Guo J, Jayaprakash P, Dan J, Wise P, Jang G, Liang C, et al. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017;37: pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 6a
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- western blot; human; 1:1000; loading ...; fig 8a
| Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed publisher
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- western blot; mouse; loading ...; fig 3a
| Wei X, Guo L, Liu Y, Zhou S, Liu Y, Dou X, et al. Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. Biochem Biophys Res Commun. 2017;491:814-820 pubmed publisher
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- western blot; mouse; loading ...; fig 2f
| Akiel M, Guo C, Li X, Rajasekaran D, Mendoza R, Robertson C, et al. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer Res. 2017;77:4014-4025 pubmed publisher
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- western blot; human; loading ...; fig 5
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- western blot; human; 1:2000; loading ...; fig 6
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- western blot; human; 1:2000; loading ...; fig 4h
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- western blot; human; loading ...; fig s5f
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- western blot; human; fig 5c
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- western blot; mouse; loading ...; fig 3g
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- western blot; mouse; fig s10m
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- immunohistochemistry; mouse; loading ...; fig 6a
- western blot; mouse; loading ...; fig 1e
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- western blot; mouse; loading ...; fig 1j
- western blot; human; loading ...; fig 1d
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- immunohistochemistry; zebrafish ; loading ...; fig 3s1g
- western blot; zebrafish ; loading ...; fig 3s1e
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- western blot; human; loading ...; fig 7a
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- western blot; human; 1:500; loading ...; fig 5c
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- western blot; rat; 1:1000; loading ...; fig 5c
| Arcego D, Toniazzo A, Krolow R, Lampert C, Berlitz C, Dos Santos Garcia E, et al. Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats. Mol Neurobiol. 2018;55:2740-2753 pubmed publisher
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- western blot; fruit fly ; loading ...; fig 1j
- western blot; human; loading ...; fig 1k
| Tawo R, Pokrzywa W, Kevei E, Akyuz M, Balaji V, Adrian S, et al. The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. Cell. 2017;169:470-482.e13 pubmed publisher
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- western blot; human; loading ...; fig 1a
| Vaishnavi A, Schubert L, Rix U, Marek L, Le A, Keysar S, et al. EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases. Cancer Res. 2017;77:3551-3563 pubmed publisher
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- western blot; human; 1:1000; fig 4c
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- western blot; mouse; loading ...; fig 4b
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- immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
- western blot; mouse; loading ...; fig 4a
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- immunocytochemistry; mouse; 1:200; loading ...; fig s4a
- western blot; mouse; 1:1000; loading ...; fig 2d, 2h
| Ahmed S, Macara I. The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Nat Commun. 2017;8:14867 pubmed publisher
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- western blot; human; 1:500; loading ...; fig 3A
| Guo Q, He J, Shen F, Zhang W, Yang X, Zhang C, et al. TCN, an AKT inhibitor, exhibits potent antitumor activity and enhances radiosensitivity in hypoxic esophageal squamous cell carcinoma in vitro and in vivo. Oncol Lett. 2017;13:949-954 pubmed publisher
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- western blot; human; loading ...; fig 5a
| Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, et al. Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer. Cancer Immunol Res. 2017;5:363-375 pubmed publisher
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- western blot; mouse; loading ...; fig 6f
| He W, Wang C, Mu R, Liang P, Huang Z, Zhang J, et al. MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. Oncogene. 2017;36:4212-4223 pubmed publisher
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- western blot; mouse; 1:500; fig 7b
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- western blot; human; fig 6a
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- western blot; human; fig 3c
| Lei L, Chen C, Zhao J, Wang H, Guo M, Zhou Y, et al. Targeted Expression of miR-7 Operated by TTF-1 Promoter Inhibited the Growth of Human Lung Cancer through the NDUFA4 Pathway. Mol Ther Nucleic Acids. 2017;6:183-197 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; loading ...; fig 7g
- western blot; mouse; loading ...; fig 5a
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- western blot; mouse; loading ...; fig 3b
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- immunohistochemistry; mouse; loading ...; fig 7b
- immunohistochemistry; human; loading ...; fig 5l
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- immunohistochemistry - paraffin section; mouse; 1:50; fig s7f
- western blot; human; loading ...; fig 2a, 3b, 3c, 4a
| Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher
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- western blot; human; loading ...; fig 1b
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- immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4c
- western blot; mouse; loading ...; fig 4b
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- western blot; human; loading ...; fig 1b
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- western blot; mouse; fig 3b
- western blot; human; loading ...; fig 4c
| CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed publisher
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- western blot; human; loading ...; fig 5d
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- western blot; mouse; fig 1d
| Jacobs B, McNally R, Kim K, Blanco R, Privett R, You J, et al. Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling. J Biol Chem. 2017;292:6987-6997 pubmed publisher
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- western blot; mouse; loading ...; fig s6
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- western blot; mouse; fig 7a
| Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
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- western blot; human; loading ...; fig 4a
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- immunocytochemistry; human; loading ...; fig s1
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- western blot; human; loading ...; fig 4a
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- western blot; human; loading ...; fig 1f
| Li K, Mo C, Gong D, Chen Y, Huang Z, Li Y, et al. DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin. Cancer Lett. 2017;400:194-202 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 3c
| Deying W, Feng G, Shumei L, Hui Z, Ming L, Hongqing W. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Biosci Rep. 2017;37: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 6e
| Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, et al. miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury. Theranostics. 2017;7:664-676 pubmed publisher
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- western blot; human; loading ...; fig 6a
| Lal S, Cheung E, Zarei M, Preet R, Chand S, Mambelli Lisboa N, et al. CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol Cancer Res. 2017;15:696-707 pubmed publisher
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- flow cytometry; mouse; loading ...; fig 5e
- western blot; mouse; 1:2000; loading ...; fig 3f
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- western blot; mouse; loading ...; fig 4a
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- western blot; mouse; loading ...; fig 7a
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- western blot; rat; 1:2000; fig 4A
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- western blot; human; loading ...; fig 1a
- western blot; mouse; loading ...; fig s9e
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- western blot; mouse; loading ...; fig s9a
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- western blot; mouse; 1:2000; loading ...; fig 6g
| Qian Q, Liu Q, Zhou D, Pan H, Liu Z, He F, et al. Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway. FASEB J. 2017;31:2104-2113 pubmed publisher
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- western blot; mouse; loading ...; fig 3a
| Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
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- western blot; mouse; loading ...; fig 6e
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- western blot; human; 1:1000; loading ...; fig 6a
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- immunohistochemistry; rat; 1:40; loading ...; fig 7c
| Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, et al. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Sci Rep. 2017;7:41916 pubmed publisher
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- western blot; mouse; loading ...; fig 12A
| Shen C, Zhou J, Wang X, Yu X, Liang C, Liu B, et al. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway. EBioMedicine. 2017;16:238-250 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 7c
| Lim E, Nakanishi S, Hoghooghi V, Eaton S, Palmer A, Frederick A, et al. AlphaB-crystallin regulates remyelination after peripheral nerve injury. Proc Natl Acad Sci U S A. 2017;114:E1707-E1716 pubmed publisher
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- western blot; mouse; 1:2000; fig 9e
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- western blot; human; loading ...; fig 4a
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- western blot; mouse; loading ...; fig 1b
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- western blot; mouse; loading ...; fig 4a
| Kissing S, Rudnik S, Damme M, Lüllmann Rauch R, Ichihara A, Kornak U, et al. Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Autophagy. 2017;13:670-685 pubmed publisher
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- western blot; mouse; loading ...; fig 5a
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- western blot; human; 1:1000; loading ...; fig 5a
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- western blot; rat; 1:1000; loading ...; fig 2a
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- western blot; human; 1:1000; loading ...; fig 3d
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- western blot; mouse; loading ...; fig 5d, 5e,5f
| Kanuri B, Kanshana J, Rebello S, Pathak P, Gupta A, Gayen J, et al. Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance. Sci Rep. 2017;7:41009 pubmed publisher
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- flow cytometry; human; 1:200; loading ...; fig 3
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- immunocytochemistry; human; 1:500; loading ...; fig 4
- western blot; human; 1:2000; loading ...; fig 5a
| Yoo S, Latifkar A, Cerione R, Antonyak M. Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. J Biol Chem. 2017;292:3947-3957 pubmed publisher
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- western blot; mouse; loading ...; fig 3a
| Chaudhari A, Gupta R, Patel S, Velingkaar N, Kondratov R. Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. Mol Biol Cell. 2017;28:834-842 pubmed publisher
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- western blot; human; loading ...; fig 3c,3d
| Cao H, Yu S, Chen D, Jing C, Wang Z, Ma R, et al. Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment. FEBS Open Bio. 2017;7:35-43 pubmed publisher
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- western blot; mouse; loading ...; fig 2c
| Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, et al. The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. J Exp Med. 2017;214:339-358 pubmed publisher
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- western blot; mouse; 1:2000; fig s7a
| Kechele D, Blue R, Zwarycz B, Espenschied S, Mah A, Siegel M, et al. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017;127:593-607 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 2b
- western blot; mouse; 1:1000; loading ...; fig 2b
| Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed publisher
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- immunocytochemistry; mouse; 1:500; fig 5a
- western blot; mouse; 1:3000; loading ...; fig 7e
| Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed publisher
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- western blot; human; 1:100; loading ...; fig 3b
| Granato M, Rizzello C, Gilardini Montani M, Cuomo L, Vitillo M, Santarelli R, et al. Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways. J Nutr Biochem. 2017;41:124-136 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 7c
| Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;36:3274-3286 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 9d
| Hussain R, Macklin W. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017;37:397-412 pubmed publisher
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- western blot; mouse; fig 5c
| Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease. Stem Cell Reports. 2017;8:84-94 pubmed publisher
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- western blot; mouse; 1:2000; fig 5a
| Decourtye L, Mire E, Clemessy M, Heurtier V, Ledent T, Robinson I, et al. IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice. PLoS ONE. 2017;12:e0170083 pubmed publisher
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- western blot; mouse; loading ...; fig s4a
| Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 1b
| Muranen T, Iwanicki M, Curry N, Hwang J, DuBois C, Coloff J, et al. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017;8:13989 pubmed publisher
|
- western blot; mouse; loading ...; fig 6b
| Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed publisher
|
- western blot; human; loading ...; fig 4a
| Wu Q, Ma Y, Ruan C, Yang Y, Liu X, Ge Q, et al. Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway. Cardiovasc Res. 2017;113:70-80 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3c
| Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3a
| Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017;292:2411-2421 pubmed publisher
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- western blot; rat; 1:2000; loading ...; fig 7a
| Hu N, Chang H, Du B, Zhang Q, Arfat Y, Dang K, et al. Tetramethylpyrazine ameliorated disuse-induced gastrocnemius muscle atrophy in hindlimb unloading rats through suppression of Ca2+/ROS-mediated apoptosis. Appl Physiol Nutr Metab. 2017;42:117-127 pubmed publisher
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- western blot; human; fig s2b
| Babagana M, Johnson S, Slabodkin H, Bshara W, Morrison C, Kandel E. P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells. Mol Carcinog. 2017;56:1515-1525 pubmed publisher
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- western blot; human; loading ...; fig s2d
| Tam K, Dalal K, Hsing M, Cheng C, Khosravi S, Yenki P, et al. Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner. Oncotarget. 2017;8:9617-9633 pubmed publisher
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- western blot; Xenopus laevis; loading ...; fig 4a
| Krycer J, Fazakerley D, Cater R, C Thomas K, Naghiloo S, Burchfield J, et al. The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. FEBS Lett. 2017;591:322-330 pubmed publisher
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- western blot; rat; loading ...; fig 2f
- western blot; mouse; loading ...; fig 2e
| Jin F, Jiang K, Ji S, Wang L, Ni Z, Huang F, et al. Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex. Hum Mol Genet. 2017;26:407-419 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4a
| Fourneaux B, Chaire V, Lucchesi C, Karanian M, Pineau R, Laroche Clary A, et al. Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications. Oncotarget. 2017;8:7878-7890 pubmed publisher
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- western blot; human; fig 1c
| Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan X, et al. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017;8:9251-9266 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s6
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|
- western blot; mouse; loading ...
| Ganta V, Choi M, Kutateladze A, Annex B. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circ Res. 2017;120:282-295 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6d
| Yang J, Savvatis K, Kang J, Fan P, Zhong H, Schwartz K, et al. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. Nat Commun. 2016;7:13710 pubmed publisher
|
- western blot; mouse; loading ...; fig 2b
| Zhang H, Wang W, Ren L, Zhao X, Wang Z, Zhuang D, et al. The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis. Cell Physiol Biochem. 2016;40:1079-1093 pubmed
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- western blot; human; loading ...; fig 3a
| Hess N, Jiang S, Li X, Guan Y, Tapping R. TLR10 Is a B Cell Intrinsic Suppressor of Adaptive Immune Responses. J Immunol. 2017;198:699-707 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; loading ...; fig 3f
- immunocytochemistry; mouse; 1:200; loading ...; fig s7c
- western blot; mouse; 1:1000; loading ...; fig s5a
| Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher
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- western blot; mouse; loading ...; fig 3
| Mukhopadhyay C, Triplett A, Bargar T, HECKMAN C, Wagner K, Naramura M. Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation. Proc Natl Acad Sci U S A. 2016;113:E8228-E8237 pubmed publisher
|
- western blot; mouse; loading ...; fig s3b
| Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed publisher
|
- immunohistochemistry; mouse; loading ...; fig 3d
| Weyandt J, Carney J, Pavlisko E, Xu M, Counter C. Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice. PLoS ONE. 2016;11:e0167205 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 2c
| Yan H, Gao Y, Zhang Y. Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease. Mol Med Rep. 2017;15:180-186 pubmed publisher
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- western blot; human; loading ...; fig s5a
| Grabinski T, Kanaan N. Novel Non-phosphorylated Serine 9/21 GSK3?/? Antibodies: Expanding the Tools for Studying GSK3 Regulation. Front Mol Neurosci. 2016;9:123 pubmed
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- western blot; human; loading ...; fig 2b
| Battram A, Durrant T, Agbani E, Heesom K, Paul D, Piatt R, et al. The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling. J Biol Chem. 2017;292:1691-1704 pubmed publisher
|
- western blot; mouse; loading ...; fig 4d
| Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed publisher
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- western blot; rat; loading ...; fig 6d
| Pearson Leary J, McNay E. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. J Neurosci. 2016;36:11851-11864 pubmed
|
- western blot; human; loading ...; fig 7
| Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s4a,s4b
| Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Shi D, Liu Y, Xi R, Zou W, Wu L, Zhang Z, et al. Caveolin-1 contributes to realgar nanoparticle therapy in human chronic myelogenous leukemia K562 cells. Int J Nanomedicine. 2016;11:5823-5835 pubmed
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- western blot; mouse; 1:2000; fig 8h
| Moyle L, Blanc E, Jaka O, Prueller J, Banerji C, Tedesco F, et al. Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy. elife. 2016;5: pubmed publisher
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- western blot; mouse; loading ...; fig 7a
| Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher
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- western blot; human; fig 2a, 2b, 2c
| Park J, Lee C, Kim H, Kim D, Son J, Ko E, et al. Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling. Oncotarget. 2016;7:83308-83318 pubmed publisher
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- immunohistochemistry - paraffin section; human; fig 6d
- western blot; human; loading ...; fig 5a
| Sikander M, Hafeez B, Malik S, Alsayari A, Halaweish F, Yallapu M, et al. Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer. Sci Rep. 2016;6:36594 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 2
| Chruvattil R, Banerjee S, Nath S, Machhi J, Kharkwal G, Yadav M, et al. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Mol Neurobiol. 2017;54:7483-7496 pubmed publisher
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- western blot; hamsters; fig 1b
| Han C, Juncadella I, Kinchen J, Buckley M, Klibanov A, Dryden K, et al. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016;539:570-574 pubmed publisher
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- western blot; human; loading ...; fig 6a
| Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed publisher
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- western blot; mouse; loading ...; fig 1c
| Sheen M, Marotti J, Allegrezza M, Rutkowski M, Conejo Garcia J, Fiering S. Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis. 2016;5:e267 pubmed publisher
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- western blot; human; loading ...; fig 1b
| Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016;126:4527-4536 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, et al. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2017;13:41-56 pubmed publisher
|
- immunohistochemistry - paraffin section; human; loading ...; fig 6d
- western blot; human; 1:1000; loading ...; fig 3b
| Hau A, Leivo M, Gilder A, Hu J, Gonias S, Hansel D. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 2017;29:96-106 pubmed publisher
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- immunocytochemistry; mouse; 1:1000; loading ...; fig 1c
| Goebbels S, Wieser G, Pieper A, Spitzer S, Weege B, Yan K, et al. A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 2017;20:10-15 pubmed publisher
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- western blot; mouse; loading ...; fig 5a
| Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
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- western blot; mouse; loading ...; fig 2g
| Di Cataldo V, Geloen A, Langlois J, Chauveau F, Thézé B, Hubert V, et al. Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE-/- Mice. Front Physiol. 2016;7:453 pubmed
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- western blot; human; fig 5a
| Che D, Zhou T, Lan Y, Xie J, Gong H, Li C, et al. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016;38:1815-1822 pubmed publisher
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- western blot; mouse; fig 2
| Hinds T, Burns K, Hosick P, McBeth L, Nestor Kalinoski A, Drummond H, et al. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. J Biol Chem. 2016;291:25179-25191 pubmed
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- western blot; mouse; 1:2000; loading ...; fig 3d
| Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun. 2016;7:13130 pubmed publisher
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- western blot; rat; loading ...; fig 4c
| Beauvais G, Bode N, Watson J, Wen H, Glenn K, Kawano H, et al. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. J Neurosci. 2016;36:10245-10256 pubmed
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- western blot; human; loading ...; fig 5a
| Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed publisher
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- western blot; mouse; loading ...; fig 3b
| Gerriets V, Kishton R, Johnson M, Cohen S, Siska P, Nichols A, et al. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol. 2016;17:1459-1466 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 5b
| Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton Smith J, et al. Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia. Nat Genet. 2016;48:1349-1358 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s1b
| Little A, Sham D, Hristova M, Danyal K, Heppner D, Bauer R, et al. DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties. Oncogenesis. 2016;5:e261 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4a
| Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
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- western blot; human; fig 3
| Yuzugullu H, Von T, Thorpe L, Walker S, Roberts T, Frank D, et al. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discov. 2016;2:16030 pubmed publisher
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- western blot; human; fig 4
| Ang Z, Er J, Tan N, Lu J, Liou Y, Grosse J, et al. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci Rep. 2016;6:34145 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s23
- western blot; human; 1:1000; loading ...; fig 2b
| Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4f
| Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed publisher
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- western blot; human; 1:1000; fig 3
| Shamblott M, O Driscoll M, Gomez D, McGuire D. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Commun Signal. 2016;14:23 pubmed
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- western blot; human; 1:1000; loading ...; fig 1d
| Krepler C, Xiao M, Samanta M, Vultur A, Chen H, Brafford P, et al. Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget. 2016;7:71211-71222 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 5e
| Mercado Pimentel M, Igarashi S, Dunn A, Behbahani M, Miller C, Read C, et al. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation. Austin J Med Oncol. 2016;3: pubmed
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- western blot; Chinese hamsters; fig 2
| Hang Q, Isaji T, Hou S, Zhou Y, Fukuda T, Gu J. N-Glycosylation of integrin ?5 acts as a switch for EGFR-mediated complex formation of integrin ?5?1 to ?6?4. Sci Rep. 2016;6:33507 pubmed publisher
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- western blot; human; fig 6i
| Nip H, Dar A, Saini S, Colden M, Varahram S, Chowdhary H, et al. Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. Oncotarget. 2016;7:68371-68384 pubmed publisher
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- western blot; zebrafish ; 1:2000; loading ...; fig 1f
| Shin M, Male I, Beane T, Villefranc J, Kok F, Zhu L, et al. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016;143:3785-3795 pubmed
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- flow cytometry; mouse; loading ...; fig 7c
| Wu Y, Ren D, Chen G. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol. 2016;197:3336-3347 pubmed
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- western blot; human; loading ...; fig 4d
| Fan L, Liu M, Guo M, Hu C, Yan Z, Chen J, et al. FAM122A, a new endogenous inhibitor of protein phosphatase 2A. Oncotarget. 2016;7:63887-63900 pubmed publisher
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- western blot; human; 1:2000; fig s5b
| Josowitz R, Mulero Navarro S, Rodriguez N, Falce C, Cohen N, Ullian E, et al. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016;7:355-369 pubmed publisher
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- western blot; human; fig s2
| Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed
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- western blot; human; 1:1000; fig 2a
| Padhan N, Nordling T, Sundstrom M, Akerud P, Birgisson H, Nygren P, et al. High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer. BMC Cancer. 2016;16:683 pubmed publisher
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- western blot; human; loading ...; fig 1a
| Sun M, Cai J, Anderson R, Sun Y. Type I ? Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6. J Biol Chem. 2016;291:21461-21473 pubmed
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- western blot; dogs; loading ...; fig 6a
- western blot; human; loading ...; fig 4a
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- western blot; human; loading ...; fig 3, s3
| Beale G, Haagensen E, Thomas H, Wang L, Revill C, Payne S, et al. Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer. Br J Cancer. 2016;115:682-90 pubmed publisher
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- western blot; mouse; loading ...; fig 7h
| Ratsimandresy R, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017;14:127-142 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4.a, b, c
| Maynard J, Emmas S, Blé F, Barjat H, Lawrie E, Hancox U, et al. The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3K?/? inhibitor. EJNMMI Res. 2016;6:62 pubmed publisher
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- western blot; human; loading ...; fig 6a, 6d
| Buta C, Benabou E, Lequoy M, Régnault H, Wendum D, Meratbene F, et al. Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin. J Exp Clin Cancer Res. 2016;35:126 pubmed publisher
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- western blot; mouse; loading ...; fig 3f
| Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed publisher
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- western blot; human; loading ...; fig 2a
| Oh B, Kim S, Lee Y, Hong H, Kim T, Kim S, et al. Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. Oncotarget. 2016;7:57066-57076 pubmed publisher
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- western blot; human; loading ...; fig 5A
| Di Franco S, Turdo A, Benfante A, Colorito M, Gaggianesi M, Apuzzo T, et al. ?Np63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis. Oncotarget. 2016;7:54157-54173 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 7e
- immunocytochemistry; human; loading ...; fig 4c,4d
- western blot; human; 1:1000; loading ...; fig 5,6
| Xi R, Pan S, Chen X, Hui B, Zhang L, Fu S, et al. HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo. Oncotarget. 2016;7:57050-57065 pubmed publisher
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- immunohistochemistry; mouse; 1:50; fig s2
| Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher
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- western blot; human; fig 5c
| Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed publisher
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- western blot; human; fig 7a
| Wang Y, Wang Y, Li G. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. 2016;7:50937-50951 pubmed publisher
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- western blot; human; fig 2
| Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher
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- western blot; mouse; 1:2000; fig 6
| Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, et al. Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet. PLoS ONE. 2016;11:e0159568 pubmed publisher
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- western blot; human; 1:1000; fig 2
| Fang F, Qin Y, Hao F, Li Q, Zhang W, Zhao C, et al. CD147 modulates androgen receptor activity through the Akt/Gsk-3?/?-catenin/AR pathway in prostate cancer cells. Oncol Lett. 2016;12:1124-1128 pubmed
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- western blot; human; fig 4e
| Lazzarini E, Balbi C, Altieri P, Pfeffer U, Gambini E, Canepa M, et al. The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity. Sci Rep. 2016;6:29994 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 4a
- western blot; human; loading ...; fig 2a
| Saisana M, Griffin S, May F. Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation. Oncotarget. 2016;7:54445-54462 pubmed publisher
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- western blot; human; fig 6
| Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed publisher
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- western blot; mouse; fig 4
| McClelland Descalzo D, Satoorian T, Walker L, Sparks N, Pulyanina P, zur Nieden N. Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/?-Catenin-Dependent Transcription of p21(cip1). Stem Cell Reports. 2016;7:55-68 pubmed publisher
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- western blot; human; fig 4b
| Warner M, Bridge K, Hewitson J, Hodgkinson M, Heyam A, Massa B, et al. S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells. Nucleic Acids Res. 2016;44:9942-9955 pubmed
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- western blot; human; 1:2000; fig 5e
| Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Grassi M, Palma C, Thomé C, Lanfredi G, Poersch A, Faça V. Proteomic analysis of ovarian cancer cells during epithelial-mesenchymal transition (EMT) induced by epidermal growth factor (EGF) reveals mechanisms of cell cycle control. J Proteomics. 2017;151:2-11 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 3
| Alver T, Lavelle T, Longva A, Øy G, Hovig E, Bøe S. MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma. Oncotarget. 2016;7:55128-55140 pubmed publisher
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- western blot; human; loading ...; fig 2b
| Wang C, Guo S, Wang J, Yan X, Farrelly M, Zhang Y, et al. Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. Oncotarget. 2016;7:49597-49610 pubmed publisher
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- western blot; human; loading ...; fig 6a
| Shen P, Chen M, He M, Chen L, Song Y, Xiao P, et al. Inhibition of ER?/ERK/P62 cascades induces "autophagic switch" in the estrogen receptor-positive breast cancer cells exposed to gemcitabine. Oncotarget. 2016;7:48501-48516 pubmed publisher
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- western blot; rat; 1:500; fig 3
| Li X, Chen Y, Wang L, Shang G, Zhang C, Zhao Z, et al. Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Braz J Med Biol Res. 2016;49: pubmed publisher
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- western blot; mouse; 1:1000; fig 3c
| Rozo M, Li L, Fan C. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nat Med. 2016;22:889-96 pubmed publisher
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- immunohistochemistry; human; fig s1
| Hatem R, El Botty R, Chateau Joubert S, Servely J, Labiod D, de Plater L, et al. Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers. Oncotarget. 2016;7:48206-48219 pubmed publisher
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- western blot; human; loading ...; fig s3
| Xiao B, Chen D, Luo S, Hao W, Jing F, Liu T, et al. Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling. Oncotarget. 2016;7:50057-50073 pubmed publisher
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- western blot; mouse; fig 7
| Petrova L, Gran C, Bjoras M, Doetsch P. Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells. PLoS ONE. 2016;11:e0158581 pubmed publisher
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- western blot; human; fig s4a
| Chen Y, LaMarche M, Chan H, Fekkes P, García Fortanet J, Acker M, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016;535:148-52 pubmed
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- immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4f
| Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, et al. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017;36:618-627 pubmed publisher
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- immunocytochemistry; mouse; 1:200; fig 14
- western blot; mouse; 1:4000; fig 13
| Schmitt D, Funk N, Blum R, Asan E, Andersen L, Rülicke T, et al. Initial characterization of a Syap1 knock-out mouse and distribution of Syap1 in mouse brain and cultured motoneurons. Histochem Cell Biol. 2016;146:489-512 pubmed publisher
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- western blot; mouse; 1:2000; fig S11
| Gautheron J, Vucur M, Schneider A, Severi I, Roderburg C, Roy S, et al. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nat Commun. 2016;7:11869 pubmed publisher
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- western blot; human; fig 2a
| Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed publisher
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- western blot; human; 1:3000; loading ...; fig 1e
- immunohistochemistry; mouse; 1:100; loading ...; fig 5c
| Wang Y, Hersheson J, López D, Hammer M, Liu Y, Lee K, et al. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell Rep. 2016;16:79-91 pubmed publisher
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- western blot; human; 1:1000; fig 4
| Meinhardt G, Saleh L, Otti G, Haider S, Velicky P, Fiala C, et al. Wingless ligand 5a is a critical regulator of placental growth and survival. Sci Rep. 2016;6:28127 pubmed publisher
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- western blot; human; 1:1000; fig 6A
| Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed publisher
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- western blot; mouse; fig s4
| Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
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- western blot; mouse; loading ...; fig 7
| Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed publisher
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- western blot; mouse; loading ...; fig 1a
| Krag T, Pinós T, Nielsen T, Duran J, GarcÃa Rocha M, Andreu A, et al. Differential glucose metabolism in mice and humans affected by McArdle disease. Am J Physiol Regul Integr Comp Physiol. 2016;311:R307-14 pubmed publisher
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- western blot; human; fig 1
| Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
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- western blot; mouse; fig 6
| Tejada T, Tan L, Torres R, Calvert J, Lambert J, Zaidi M, et al. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A. 2016;113:6949-54 pubmed publisher
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- western blot; human; 1:1000; fig s4
| Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher
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- western blot; mouse; fig 1
| Foltz S, Luan J, Call J, Patel A, Peissig K, Fortunato M, et al. Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy. Skelet Muscle. 2016;6:20 pubmed publisher
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- immunohistochemistry; rat; fig 7a
| Fernandez Monreal M, Sánchez Castillo C, Esteban J. APPL1 gates long-term potentiation through its plekstrin homology domain. J Cell Sci. 2016;129:2793-803 pubmed publisher
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- western blot; human; fig 4
| Tzani I, Ivanov I, Andreev D, Dmitriev R, Dean K, Baranov P, et al. Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform. Open Biol. 2016;6: pubmed publisher
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- western blot; human; loading ...; fig 5c
| Sun F, Zhang Z, Tan E, Lim Z, Li Y, Wang X, et al. Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice. Carcinogenesis. 2016;37:701-711 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6a
| He F, Wei L, Luo W, Liao Z, Li B, Zhou X, et al. Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS. Oncotarget. 2016;7:37000-37012 pubmed publisher
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- western blot; mouse; 1:1000; fig 5
| Kessler S, Laggai S, Van Wonterg E, Gemperlein K, Muller R, Haybaeck J, et al. Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation. Front Physiol. 2016;7:147 pubmed publisher
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- western blot; mouse; fig 3
| Chan E, Shetty M, Sajikumar S, Chen C, Soong T, Wong B. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep. 2016;6:26119 pubmed publisher
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- western blot; human; fig 7
| Huang D, Zhao C, Ju R, Kumar A, Tian G, Huang L, et al. VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis. Sci Rep. 2016;6:26059 pubmed publisher
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- western blot; mouse; 1:1000; fig 4
| Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher
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- western blot; mouse; loading ...; fig 6a
| Song X, Yao Z, Yang J, Zhang Z, Deng Y, Li M, et al. HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways. Oncotarget. 2016;7:33796-808 pubmed publisher
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- western blot; human; fig 3
| Hein A, Post C, Sheinin Y, Lakshmanan I, Natarajan A, Enke C, et al. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016;35:6319-6329 pubmed publisher
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- western blot; mouse; loading ...; fig 6a
| Rao E, Zhang Y, Li Q, Hao J, Egilmez N, Suttles J, et al. AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Oncotarget. 2016;7:33783-95 pubmed publisher
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- western blot; mouse; fig 5
| Wang N, Dong B, Quan Y, Chen Q, Chu M, Xu J, et al. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016;6:668-678 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig s10b
| Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, et al. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun. 2016;7:11471 pubmed publisher
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- western blot; human; fig 5
| Cieniewicz A, Cooper P, MCGEHEE J, Lingham R, Kihm A. Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation. Cell Signal. 2016;28:1037-47 pubmed publisher
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- western blot; human; fig 2
| Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher
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- western blot; human; fig 6e
| Vorvis C, Hatziapostolou M, Mahurkar Joshi S, Koutsioumpa M, Williams J, Donahue T, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1124-37 pubmed publisher
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- western blot; human; fig 6
| Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, et al. Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer. Sci Rep. 2016;6:25447 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 7a
| Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed publisher
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- western blot; mouse; 1:1000; fig 4
| Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield P, et al. Neuronal human BACE1 knockin induces systemic diabetes in mice. Diabetologia. 2016;59:1513-1523 pubmed publisher
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- immunohistochemistry - paraffin section; zebrafish ; fig 6
| He S, Mansour M, Zimmerman M, Ki D, Layden H, Akahane K, et al. Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. elife. 2016;5: pubmed publisher
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- western blot; human; 1:500; fig 4
| Du R, Liu Z, Hou X, Fu G, An N, Wang L. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. Mol Med Rep. 2016;13:5045-52 pubmed publisher
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- immunocytochemistry; mouse; fig 4
- western blot; mouse; fig 1
| Qiu X, Wei R, Li Y, Zhu Q, Xiong C, Chen Y, et al. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016;7:31440-53 pubmed publisher
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- western blot; mouse; fig 2
| Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y. Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A. 2016;113:E2589-97 pubmed publisher
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- western blot; mouse; loading ...
| Stephenson E, Ragauskas A, Jaligama S, Redd J, Parvathareddy J, Peloquin M, et al. Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in adult mice. Am J Physiol Endocrinol Metab. 2016;310:E1003-15 pubmed publisher
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- western blot; mouse; 1:1000; fig s1
| Seo J, Singh N, Ottesen E, Sivanesan S, Shishimorova M, Singh R. Oxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy Gene. PLoS ONE. 2016;11:e0154390 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3d
| Yard B, Adams D, Chie E, Tamayo P, Battaglia J, Gopal P, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nat Commun. 2016;7:11428 pubmed publisher
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- western blot; human; fig 5
| Chowdhury B, Porter E, Stewart J, Ferreira C, Schipma M, Dykhuizen E. PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. PLoS ONE. 2016;11:e0153718 pubmed publisher
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- immunohistochemistry; fruit fly ; 1:800; loading ...; fig s3c
| Monyak R, Emerson D, Schoenfeld B, Zheng X, Chambers D, Rosenfelt C, et al. Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model. Mol Psychiatry. 2017;22:1140-1148 pubmed publisher
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- western blot; human; loading ...; fig 2a
| von Mässenhausen A, SANDERS C, Thewes B, Deng M, Queisser A, Vogel W, et al. MERTK as a novel therapeutic target in head and neck cancer. Oncotarget. 2016;7:32678-94 pubmed publisher
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- western blot; human; fig 1
| Kumar A, Abbas W, Colin L, Khan K, Bouchat S, Varin A, et al. Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line. Sci Rep. 2016;6:24090 pubmed publisher
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- western blot; mouse; loading ...; fig 5c
| Gao Y, Bai X, Zhang D, Han C, Yuan J, Liu W, et al. Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis. Nat Struct Mol Biol. 2016;23:441-9 pubmed publisher
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- western blot; mouse; 1:1000; fig 5
| Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/?-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed publisher
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- western blot; African green monkey; fig 3
| Wen M, Wang J, Chiu Y, Wang M, Lee S, Tai C. N-Cadherin Regulates Cell Migration Through a Rab5-Dependent Temporal Control of Macropinocytosis. Traffic. 2016;17:769-85 pubmed publisher
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- western blot; fruit fly ; 1:1000; fig 2a
| Palu R, Thummel C. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. PLoS Genet. 2016;12:e1005978 pubmed publisher
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- western blot; human; loading ...; fig 7
| Rorsman C, Tsioumpekou M, Heldin C, Lennartsson J. The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem. 2016;291:11608-18 pubmed publisher
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- western blot; human; fig 4
| Phelps Polirer K, Abt M, Smith D, Yeh E. Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer. PLoS ONE. 2016;11:e0153025 pubmed publisher
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- western blot; human; fig 2
| Fearnley G, Smith G, Abdul Zani I, Yuldasheva N, Mughal N, Homer Vanniasinkam S, et al. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open. 2016;5:571-83 pubmed publisher
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- western blot; human; fig 5
| Papadakis E, Barker C, Syed H, Reeves T, Schwaiger S, Stuppner H, et al. The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ. Oncogenesis. 2016;5:e215 pubmed publisher
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- western blot; mouse; 1:1000; fig 3
| Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151 pubmed publisher
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- western blot; human; fig 7
| Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed publisher
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- western blot; mouse; fig 2
| Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li J, et al. Activation of mTORC1 is essential for ?-adrenergic stimulation of adipose browning. J Clin Invest. 2016;126:1704-16 pubmed publisher
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- western blot; human; 1:1000; fig 5
| Maugeri G, D Amico A, Rasà D, Reitano R, Saccone S, Federico C, et al. Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells. Genes Cancer. 2016;7:47-58 pubmed
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- western blot; hamsters; loading ...; fig 3a
| Gao Z, Zhang H, Hu F, Yang L, Yang X, Zhu Y, et al. Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan. Cell Signal. 2016;28:652-62 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; fig 4
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- western blot; human; fig 1
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- western blot; human; fig 4
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- western blot; human; fig 6
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- western blot; human; fig 5
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- western blot; human; fig 4
| Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, et al. Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat Commun. 2016;7:11030 pubmed publisher
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- western blot; mouse; 1:1000; fig s4
| Giannogonas P, Apostolou A, Manousopoulou A, Theocharis S, Macari S, Psarras S, et al. Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy. Sci Rep. 2016;6:23342 pubmed publisher
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- flow cytometry; mouse; fig 5
| Apostolidis S, RodrÃguez RodrÃguez N, Suárez Fueyo A, Dioufa N, Ozcan E, CrispÃn J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed publisher
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- western blot; mouse; fig 5
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- western blot; mouse; fig 3
| Kral J, Kuttke M, Schrottmaier W, Birnecker B, Warszawska J, Wernig C, et al. Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways. Sci Rep. 2016;6:23034 pubmed publisher
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- western blot; human; loading ...; fig 3c
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- immunohistochemistry - paraffin section; human; 1:50; fig 4
| Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, et al. Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer. EMBO Mol Med. 2016;8:388-406 pubmed publisher
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- western blot; human; 1:1000; fig 2
- immunohistochemistry - paraffin section; mouse; 1:50; fig 6
- western blot; mouse; 1:1000; fig 6
| Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed publisher
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- western blot; human; fig 5
| Du Z, Li L, Huang X, Jin J, Huang S, Zhang Q, et al. The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation. Oncotarget. 2016;7:21618-30 pubmed publisher
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- western blot; human; 1:2000; fig 4
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- western blot; mouse; 1:1000; fig 8
| Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, et al. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol. 2016;131:753-73 pubmed publisher
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- western blot; human; loading ...; fig 3g
| Lee D, Wang Y, Kalaitzidis D, Ramachandran J, Eda H, Sykes D, et al. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016;126:1300-10 pubmed publisher
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- western blot; human; fig 1d
| Mason J, Davison Versagli C, Leliaert A, Pape D, McCallister C, Zuo J, et al. Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death Differ. 2016;23:1271-82 pubmed publisher
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| Schwarzer M, Makki K, Storelli G, Machuca Gayet I, Srůtková D, Hermanova P, et al. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science. 2016;351:854-7 pubmed publisher
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- western blot; human; fig 6
| Wu G, Zeng G. METCAM/MUC18 is a novel tumor and metastasis suppressor for the human ovarian cancer SKOV3 cells. BMC Cancer. 2016;16:136 pubmed publisher
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- western blot; mouse; fig 4
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- western blot; human
- western blot; mouse; fig 5
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- western blot; human; fig 7
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- immunohistochemistry; human; 1:100; fig 4
- western blot; human; 1:100; fig 4
| Tobita T, Guzman Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, et al. SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. PLoS ONE. 2016;11:e0149344 pubmed publisher
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- western blot; mouse; 1:1000; fig 6
| Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
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- western blot; rat; 1:1000; fig 4b
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- western blot; human; 1:1000; fig 7
| Senol Cosar O, Flach R, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, et al. Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion. Nat Commun. 2016;7:10686 pubmed publisher
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- western blot; human; fig 4
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- western blot; human; fig 5f
| Minna E, Romeo P, Dugo M, De Cecco L, Todoerti K, Pilotti S, et al. miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma. Oncotarget. 2016;7:12731-47 pubmed publisher
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- western blot; mouse; fig s5
| Krause C, Popp O, Thirunarayanan N, Dittmar G, Lipp M, Müller G. MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR. Oncotarget. 2016;7:10414-32 pubmed publisher
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- western blot; human; 1:1000; fig 2
| Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed
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- western blot; mouse; loading ...; fig 7e
| Lakshmipathi J, Alvarez Perez J, Rosselot C, Casinelli G, Stamateris R, Rausell Palamos F, et al. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016;65:1283-96 pubmed publisher
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- western blot; human; loading ...; fig 3c
| Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, et al. Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation. Biochim Biophys Acta. 2016;1863:1106-18 pubmed publisher
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- western blot; human; fig 3
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- western blot; human; 1:1000; fig 3
- western blot; mouse; 1:1000; fig 1
| Ding M, Bruick R, Yu Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Nat Cell Biol. 2016;18:319-27 pubmed publisher
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- western blot; mouse; 1:2500; fig 4
| White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, et al. KRAS insertion mutations are oncogenic and exhibit distinct functional properties. Nat Commun. 2016;7:10647 pubmed publisher
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- western blot; human; fig 6
| Coke C, Scarlett K, Chetram M, Jones K, Sandifer B, Davis A, et al. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression. J Biol Chem. 2016;291:9991-10005 pubmed publisher
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- western blot; human; 1:1000; fig 4
| Egawa H, Jingushi K, Hirono T, Ueda Y, Kitae K, Nakata W, et al. The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN. Sci Rep. 2016;6:20574 pubmed publisher
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- immunocytochemistry; mouse; fig 6
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- western blot; mouse; 1:1000; fig 5
| Theodosiou M, Widmaier M, Böttcher R, Rognoni E, Veelders M, Bharadwaj M, et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. elife. 2016;5:e10130 pubmed publisher
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- western blot; human; 1:1000; fig 1
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- western blot; human; fig 4
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- western blot; mouse; fig 5
- western blot; human; fig 1
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- western blot; human; fig 5
| Heynen G, Nevedomskaya E, Palit S, Jagalur Basheer N, Lieftink C, Schlicker A, et al. Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma. Mol Cancer Res. 2016;14:411-22 pubmed publisher
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- western blot; rat; 1:1000; fig 4
| Chen X, Yang Q, Zheng T, Bian J, Sun X, Shi Y, et al. Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury. Stem Cells Int. 2016;2016:5161248 pubmed publisher
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- western blot; mouse; 1:1000; fig 2
| Watari K, Shibata T, Nabeshima H, Shinoda A, Fukunaga Y, Kawahara A, et al. Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice. Sci Rep. 2016;6:19470 pubmed publisher
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- western blot; mouse; fig 1
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- western blot; mouse; fig 1
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- western blot; human; 1:1000; fig 5
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- western blot; mouse; 1:1000; fig 3
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- western blot; human; fig 5d
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- immunocytochemistry; human; fig 1
- western blot; human; fig 1
| Jeong J, VanHouten J, Dann P, Kim W, Sullivan C, Yu H, et al. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A. 2016;113:E282-90 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:50; fig 5
| Creedon H, Balderstone L, Muir M, Balla J, Gómez Cuadrado L, Tracey N, et al. Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer. Dis Model Mech. 2016;9:131-40 pubmed publisher
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- western blot; mouse; 1:1000; fig 2
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- western blot; rat; 1:2000; fig 4
| Zhang H, Xiong Z, Wang J, Zhang S, Lei L, Yang L, et al. Glucagon-like peptide-1 protects cardiomyocytes from advanced oxidation protein product-induced apoptosis via the PI3K/Akt/Bad signaling pathway. Mol Med Rep. 2016;13:1593-601 pubmed publisher
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- immunohistochemistry; mouse; fig st1
- western blot; mouse; fig st1
| Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed publisher
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- western blot; human; fig 6e
| Hamada D, Maynard R, Schott E, Drinkwater C, Ketz J, Kates S, et al. Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus. Arthritis Rheumatol. 2016;68:1392-402 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:500; fig 6
| Benedykcinska A, Ferreira A, Lau J, Broni J, Richard Loendt A, Henriquez N, et al. Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen. Dis Model Mech. 2016;9:211-20 pubmed publisher
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- western blot; hamsters; loading ...; fig 3a
| Schmieg N, Rocchi C, Romeo S, Maggio R, Millan M, Mannoury La Cour C. Dysbindin-1 modifies signaling and cellular localization of recombinant, human D₃ and D₂ receptors. J Neurochem. 2016;136:1037-51 pubmed publisher
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- western blot; mouse; 1:1000; fig 6
| Zhang Y, Fan J, Ho J, Hu T, Kneeland S, Fan X, et al. Crim1 regulates integrin signaling in murine lens development. Development. 2016;143:356-66 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 3c
| Yan L, Liu Y, Xiang J, Wu Q, Xu L, Luo X, et al. PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer. Int J Oncol. 2016;48:471-84 pubmed publisher
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- western blot; mouse; 1:1000; fig 3
| Drilon A, Somwar R, Wagner J, Vellore N, Eide C, Zabriskie M, et al. A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer. Clin Cancer Res. 2016;22:2351-8 pubmed publisher
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- western blot; human; loading ...; fig 6e
| Hu Y, Guo R, Wei J, Zhou Y, Ji W, Liu J, et al. Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells. Cell Death Dis. 2015;6:e2020 pubmed publisher
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- western blot; human; fig 5
- western blot; mouse; fig 5
| Vural A, Al Khodor S, Cheung G, Shi C, Srinivasan L, McQuiston T, et al. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. J Immunol. 2016;196:846-56 pubmed publisher
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- western blot; mouse; fig 5
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- western blot; mouse; loading ...; fig s2
| Kiermaier E, Moussion C, Veldkamp C, Gerardy Schahn R, de Vries I, Williams L, et al. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 2016;351:186-90 pubmed publisher
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- western blot; human; fig 4
| Adam M, Matt S, Christian S, Hess Stumpp H, Haegebarth A, Hofmann T, et al. SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status. Cell Cycle. 2015;14:3734-47 pubmed publisher
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- western blot; human; fig 1
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- western blot; human; 1:500; fig 5
| Bo Q, Sun X, Liu J, Sui X, Li G. Antitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinoma. Oncol Lett. 2015;10:1979-1984 pubmed
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- western blot; human; 1:1000; tbl 1
| Oudart J, Doué M, Vautrin A, Brassart B, Sellier C, Dupont Deshorgue A, et al. The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction. Oncotarget. 2016;7:1516-28 pubmed publisher
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- western blot; human; fig 5
| O Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis C, Drummond R, et al. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene. 2016;35:3771-80 pubmed publisher
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- western blot; human; fig 5
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- western blot; human; fig 2
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- western blot; human; 1:1000; fig 9
| E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
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- western blot; mouse; 1:100; fig 5
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- western blot; mouse; loading ...; fig 3h
| Skeldon A, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, et al. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. 2016;196:437-47 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 1a
| Momcilovic M, McMickle R, Abt E, Seki A, Simko S, Magyar C, et al. Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Cancer Res. 2015;75:4910-22 pubmed publisher
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- immunohistochemistry; mouse; fig 5
- western blot; mouse; fig 5
| Hu X, Garcia C, Fazli L, Gleave M, Vitek M, Jansen M, et al. Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. Sci Rep. 2015;5:15182 pubmed publisher
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- immunocytochemistry; human; 1:1000; fig 6
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- western blot; dogs; 1:2000; fig 5
| Clemente Vicario F, Alvarez C, ROWELL J, Roy S, London C, Kisseberth W, et al. Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines. PLoS ONE. 2015;10:e0142007 pubmed publisher
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- flow cytometry; human; fig 2
- western blot; human; fig 2
| Ksionda O, Melton A, Bache J, Tenhagen M, Bakker J, Harvey R, et al. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene. 2016;35:3658-68 pubmed publisher
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- western blot; human; 1:1000; fig 7e
| Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Shankaraiah R, Seano G, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. J Natl Cancer Inst. 2016;108: pubmed publisher
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- western blot; human; 1:1000; fig 2
| Jackson E, Rendina Ruedy E, Smith B, Lacombe V. Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet. PLoS ONE. 2015;10:e0142077 pubmed publisher
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- western blot; mouse; fig 5
| Nikonova A, Deneka A, Eckman L, Kopp M, Hensley H, Egleston B, et al. Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease. Front Oncol. 2015;5:228 pubmed publisher
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- western blot; mouse; fig 6
| Lin C, Chen Y, Lin C, Chen Y, Lo G, Lee P, et al. Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy. Sci Rep. 2015;5:15807 pubmed publisher
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- western blot; mouse; fig 2
- western blot; human; fig 4b
| Hirano T, Yasuda H, Tani T, Hamamoto J, Oashi A, Ishioka K, et al. In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer. Oncotarget. 2015;6:38789-803 pubmed publisher
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| Rizvi F, Mathur A, Krishna S, Siddiqi M, Kakkar P. Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes. Redox Biol. 2015;6:587-598 pubmed publisher
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- western blot; human; 1:1000; fig 6
| Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, et al. Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 2016;107:84-94 pubmed publisher
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- western blot; human; 1:1000
| Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-776 pubmed
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- western blot; human; fig 2
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| Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100-104 pubmed publisher
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- immunohistochemistry; mouse; 1:100; fig 8e-h
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- western blot; human; 1:500; fig s14b
| Lin K, Kao S, Lai C, Chen C, Wu C, Hsu H, et al. Tumor Suppressor Lzap Suppresses Wnt/β-Catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of Glycogen Synthase Kinase 3. J Biol Chem. 2015;290:29808-19 pubmed publisher
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- western blot; human; 1:1000; fig s5
| Lu R, Herrera B, Eshleman H, Fu Y, Bloom A, Li Z, et al. Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation. PLoS Pathog. 2015;11:e1005200 pubmed publisher
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- western blot; mouse; fig 5
- western blot; rat; fig 3
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- western blot; mouse; fig 3
| Arriola Apelo S, Neuman J, Baar E, Syed F, Cummings N, Brar H, et al. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system. Aging Cell. 2016;15:28-38 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 11
| Sugiyama S, Yoshino Y, Kuriyama S, Inoue M, Komine K, Otsuka K, et al. A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization. Anticancer Agents Med Chem. 2016;16:633-47 pubmed
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- western blot; human; 1:2000; fig 4b
| MartÃnez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher
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- western blot; human; fig 1
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| Luehders K, Sasai N, Davaapil H, Kurosawa Yoshida M, Hiura H, Brah T, et al. The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway. Development. 2015;142:3351-61 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 2a
- western blot; mouse; loading ...; fig 2b
| Payne S, Maher M, Tran N, Van De Hey D, Foley T, Yueh A, et al. PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors. Oncogenesis. 2015;4:e169 pubmed publisher
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- western blot; human; loading ...; fig 4c
| Fan S, Snell C, Turley H, Li J, McCormick R, Perera S, et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. 2016;35:3004-15 pubmed publisher
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- western blot; rat; 1:1000; fig 8
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- western blot; human; 1:500; fig 4
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| Kimball S, Ravi S, Gordon B, Dennis M, Jefferson L. Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. J Nutr. 2015;145:2496-502 pubmed publisher
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- western blot; human; 1:2000; fig 4
| Shnitsar I, Bashkurov M, Masson G, Ogunjimi A, Mosessian S, Cabeza E, et al. PTEN regulates cilia through Dishevelled. Nat Commun. 2015;6:8388 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 7b
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- western blot; mouse; 1:1000; fig s5
| Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen P, Viero G, et al. eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. Nat Commun. 2015;6:8261 pubmed publisher
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- western blot; mouse; 1:4000; fig s3
| Liu R, Yang Y, Shen J, Chen H, Zhang Q, Ba R, et al. Fstl1 is involved in the regulation of radial glial scaffold development. Mol Brain. 2015;8:53 pubmed publisher
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- western blot; human; 1:1000
| Davare M, Vellore N, Wagner J, Eide C, Goodman J, Drilon A, et al. Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2015;112:E5381-90 pubmed publisher
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- western blot; human; fig 4a
| Vennin C, Spruyt N, Dahmani F, Julien S, Bertucci F, Finetti P, et al. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. Oncotarget. 2015;6:29209-23 pubmed publisher
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- western blot; rat; 1:1000
| Li M, Yang S, Xing B, Ferguson B, Gulchina Y, Li Y, et al. LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. Exp Neurol. 2015;273:190-201 pubmed publisher
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- western blot; rat; loading ...; fig 3a
| Yao K, Wu J, Zhang J, Bo J, Hong Z, Zu H. Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines. Cell Mol Neurobiol. 2016;36:801-9 pubmed publisher
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- western blot; human; loading ...; fig 3a
| Sasaki N, Itakura Y, Toyoda M. Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. J Biol Chem. 2015;290:25475-86 pubmed publisher
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- western blot; mouse; 1:2000; fig 4
| Ebert S, Dyle M, Bullard S, Dierdorff J, Murry D, Fox D, et al. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015;290:25497-511 pubmed publisher
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- western blot; human; loading ...; fig 1a
| Reuther C, Heinzle V, Spampatti M, Vlotides G, de Toni E, Spöttl G, et al. Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition. Neuroendocrinology. 2016;103:383-401 pubmed publisher
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- western blot; human; fig 1a
| Thijssen R, Ter Burg J, van Bochove G, de Rooij M, Kuil A, Jansen M, et al. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells. Leukemia. 2016;30:337-45 pubmed publisher
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- western blot; human; fig 6
| Gong Y, Qiu W, Ning X, Yang X, Liu L, Wang Z, et al. CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration. Oncotarget. 2015;6:25856-67 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6a
| Feng R, Ye J, Zhou C, Qi L, Fu Z, Yan B, et al. Calreticulin down-regulation inhibits the cell growth, invasion and cell cycle progression of human hepatocellular carcinoma cells. Diagn Pathol. 2015;10:149 pubmed publisher
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- western blot; dogs; 1:1000; fig 6a
| Tuncay H, Brinkmann B, Steinbacher T, Schürmann A, Gerke V, Iden S, et al. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015;6:8128 pubmed publisher
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- western blot; mouse; 1:1000; fig 3f
| Chang C, Lin W, Pai L, Lee H, Wu S, Ding S, et al. Cytoophidium assembly reflects upregulation of IMPDH activity. J Cell Sci. 2015;128:3550-5 pubmed publisher
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- western blot; mouse; fig 3
| Zhao C, Su Y, Zhang J, Feng Q, Qu L, Wang L, et al. Fibrinogen-derived fibrinostatin inhibits tumor growth through anti-angiogenesis. Cancer Sci. 2015;106:1596-606 pubmed publisher
|
- immunohistochemistry - paraffin section; human; loading ...; fig 5
- western blot; human; loading ...; fig 4a
| Chang L, Zhao D, Liu H, Wang Q, Zhang P, Li C, et al. Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma. Mol Med Rep. 2015;12:6702-10 pubmed publisher
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- western blot; human; 1:2000
| Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez Villaseñor I, et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain. 2015;8:51 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:100; fig 3
- western blot; human; fig 3
| Barbone D, Follo C, Echeverry N, Gerbaudo V, Klabatsa A, Bueno R, et al. Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models. PLoS ONE. 2015;10:e0134825 pubmed publisher
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| Sivaraj K, Li R, Albarrán Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher
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- western blot; human; loading ...; fig e7a
| Saeed M, Andreo U, Chung H, Espiritu C, Branch A, Silva J, et al. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature. 2015;524:471-5 pubmed publisher
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- western blot; mouse; fig 3
| Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, et al. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015;5:12982 pubmed publisher
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- western blot; mouse; 1:1000; fig 1
| Morley T, Xia J, Scherer P. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun. 2015;6:7906 pubmed publisher
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- immunocytochemistry; human; fig s6
| Ahn J, Li J, Chen E, Kent D, Park H, Green A. JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation. Oncogene. 2016;35:2235-46 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:80; fig s1a
| Pencik J, Schlederer M, Gruber W, Unger C, Walker S, Chalaris A, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 2015;6:7736 pubmed publisher
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- western blot; mouse; 1:2000
| Dahlhoff M, Schäfer M, Muzumdar S, Rose C, Schneider M. ERBB3 is required for tumor promotion in a mouse model of skin carcinogenesis. Mol Oncol. 2015;9:1825-33 pubmed publisher
|
- western blot; human; loading ...; fig 4a
| Luo J, Wu N, Jiang B, Wang L, Wang S, Li X, et al. Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition. Mar Drugs. 2015;13:4452-69 pubmed publisher
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- western blot; human; 1:500; fig 3
| Sarma P, Bag I, Ramaiah M, Kamal A, Bhadra U, Pal Bhadra M. Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis. Cancer Biol Ther. 2015;16:1486-501 pubmed publisher
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- western blot; rat; 1:1000; fig 1
| Geletu M, Guy S, Greer S, Raptis L. Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication. Exp Cell Res. 2015;336:223-31 pubmed publisher
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| Zhou J, Joshi B, Duan X, Pant A, Qiu Z, Kuick R, et al. EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging. Clin Transl Gastroenterol. 2015;6:e101 pubmed publisher
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- western blot; human; fig 3
| Jiang S, Zou Z, Nie P, Wen R, Xiao Y, Tang J. Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells. PLoS ONE. 2015;10:e0132880 pubmed publisher
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- western blot; human; fig 4d
| Schipany K, Rosner M, Ionce L, Hengstschläger M, Kovacic B. eIF3 controls cell size independently of S6K1-activity. Oncotarget. 2015;6:24361-75 pubmed
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- western blot; rat; 1:2000
| GarcÃa Pérez D, Laorden M, Milanés M. Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration. Int J Neuropsychopharmacol. 2015;19: pubmed publisher
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- flow cytometry; mouse; loading ...; fig 3h
| Li Y, Shen C, Zhu B, Shi F, Eisen H, Chen J. Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells. J Immunol. 2015;195:1591-8 pubmed publisher
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- western blot; human; fig 5
| Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, et al. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015;16:838-849 pubmed publisher
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- western blot; human; 1:1000; fig 2.e
| Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61 pubmed publisher
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- western blot; human; fig 3
| Reis C, Chen P, Srinivasan S, Aguet F, Mettlen M, Schmid S. Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis. EMBO J. 2015;34:2132-46 pubmed publisher
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| Andersson L, Scharin Täng M, Lundqvist A, Lindbom M, Mardani I, Fogelstrand P, et al. Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia. Cardiovasc Res. 2015;107:478-86 pubmed publisher
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- western blot; human; 1:1000; fig 1e
| Ding B, Gomi K, Rafii S, Crystal R, Walters M. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci. 2015;128:2983-8 pubmed publisher
|
- immunohistochemistry; human; loading ...; fig 2c
- western blot; mouse; loading ...; fig 1d
| Zidek L, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, et al. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO Rep. 2015;16:1022-36 pubmed publisher
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- immunohistochemistry - frozen section; zebrafish ; 1:50; fig 9
| Westcot S, Hatzold J, Urban M, Richetti S, Skuster K, Harm R, et al. Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS ONE. 2015;10:e0130688 pubmed publisher
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- western blot; human; 1:2000; fig 7
| Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher
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- western blot; mouse; 1:1000; fig s4
| Chang C, Lin C, Lu C, Martel J, Ko Y, Ojcius D, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. 2015;6:7489 pubmed publisher
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- western blot; mouse; 1:1000; fig s9
| Braccini L, Ciraolo E, Campa C, Perino A, Longo D, Tibolla G, et al. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nat Commun. 2015;6:7400 pubmed publisher
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- western blot; human; fig 1
| Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed
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- western blot; human; fig 2
| Hutchinson K, Johnson D, Johnson A, Sanchez V, Kuba M, Lu P, et al. ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma. Oncotarget. 2015;6:22348-60 pubmed
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- western blot; human; fig 3
| Shen Y, Zeng L, Novosyadlyy R, Forest A, Zhu A, Korytko A, et al. A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation. MAbs. 2015;7:931-45 pubmed publisher
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- immunocytochemistry; human; 1:50; fig 4
| Koos B, Cane G, Grannas K, Löf L, Arngården L, Heldin J, et al. Proximity-dependent initiation of hybridization chain reaction. Nat Commun. 2015;6:7294 pubmed publisher
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- western blot; human; 1:1000; fig 4
| Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt A, et al. Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies. Oncotarget. 2015;6:21522-32 pubmed
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- western blot; mouse; fig 5
| Subathra M, Korrapati M, Howell L, Arthur J, Shayman J, Schnellmann R, et al. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015;309:F204-15 pubmed publisher
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- western blot; human; 1:500
| Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed publisher
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| Zhang F, Cui J, Lv B, Yu B. Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis. Int J Mol Med. 2015;36:415-23 pubmed publisher
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- western blot; mouse; fig 1b
| DiPilato L, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum M. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Mol Cell Biol. 2015;35:2752-60 pubmed publisher
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- immunohistochemistry; dogs; fig 4
| Liu D, Xiong H, Ellis A, Northrup N, Dobbin K, Shin D, et al. Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level. PLoS Genet. 2015;11:e1005277 pubmed publisher
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- western blot; mouse; fig 5
| Sawada T, Arai D, Jing X, Furushima K, Chen Q, Kawakami K, et al. Trans-Activation between EphA and FGFR Regulates Self-Renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2α. PLoS ONE. 2015;10:e0128826 pubmed publisher
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- western blot; mouse; 1:200; fig 2
| Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, et al. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS ONE. 2015;10:e0127942 pubmed publisher
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- western blot; human; fig 1
| Li L, Qi L, Liang Z, Song W, Liu Y, Wang Y, et al. Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells. Int J Mol Med. 2015;36:113-22 pubmed publisher
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- western blot; mouse; fig 4
| Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed publisher
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- western blot; human; 1:2000; fig 1b
| Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher
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| Li P, Sheu M, Ma W, Pan C, Sheu J, Wu C. Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells. Mar Drugs. 2015;13:3046-60 pubmed publisher
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- western blot; mouse; 1:2000; fig 4
| Revuelta López E, Cal R, Herraiz Martínez A, De Gonzalo Calvo D, Nasarre L, Roura S, et al. Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes. J Mol Cell Cardiol. 2015;85:25-36 pubmed publisher
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- western blot; rat; 1:1000
| Heinen A, Beyer F, Tzekova N, Hartung H, Küry P. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Exp Neurol. 2015;271:25-35 pubmed publisher
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- western blot; human; 1:1000; fig 3
| Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
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| Rios Doria J, Sabol D, Chesebrough J, Stewart D, Xu L, Tammali R, et al. A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways. Mol Cancer Ther. 2015;14:1637-49 pubmed publisher
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- western blot; human; 1:1500; fig 6
| Liu X, Wang J, Li S, Li L, Huang M, Zhang Y, et al. Histone deacetylase 3 expression correlates with vasculogenic mimicry through the phosphoinositide3-kinase / ERK-MMP-laminin5γ2 signaling pathway. Cancer Sci. 2015;106:857-66 pubmed publisher
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- western blot; mouse; fig 5
| Buonora J, Mousseau M, Jacobowitz D, Lazarus R, Yarnell A, Olsen C, et al. Autoimmune Profiling Reveals Peroxiredoxin 6 as a Candidate Traumatic Brain Injury Biomarker. J Neurotrauma. 2015;32:1805-14 pubmed publisher
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- western blot; mouse; fig 1
| Lee E, Park E, Mun H, Chang E, Ko J, Kim D, et al. Soluble receptor for advanced glycation end products inhibits disease progression in autosomal dominant polycystic kidney disease by down-regulating cell proliferation. FASEB J. 2015;29:3506-14 pubmed publisher
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| Dungan C, Li Z, Wright D, Williamson D. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle. Muscle Nerve. 2016;53:107-17 pubmed publisher
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- western blot; human; 1:1000; fig 3
- western blot; mouse; 1:1000; fig 5
| Mendonsa A, Chalfant M, Gorden L, VanSaun M. Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells. PLoS ONE. 2015;10:e0126686 pubmed publisher
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| Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, et al. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. Cell Mol Life Sci. 2015;72:3783-801 pubmed publisher
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- immunohistochemistry - paraffin section; human; loading ...; fig 5
- western blot; human; loading ...; fig 2d
| Chen H, Huang W, Yang L, Lin C. The PTEN-AKT-mTOR/RICTOR Pathway in Nasal Natural Killer Cell Lymphoma Is Activated by miR-494-3p via PTEN But Inhibited by miR-142-3p via RICTOR. Am J Pathol. 2015;185:1487-99 pubmed publisher
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- western blot; mouse; 1:1000
| Kim H, Kim I, Dong Y, Lee I, Kim J, Kim J, et al. Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci. 2015;16:8772-88 pubmed publisher
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- western blot; human; 1:2000; fig 3
| Bugaj L, Spelke D, Mesuda C, Varedi M, Kane R, Schaffer D. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun. 2015;6:6898 pubmed publisher
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| Moreira J, Wohlwend M, Alves M, Wisløff U, Bye A. A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med. 2015;13:76 pubmed publisher
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- western blot; mouse; fig 7
| Bettaieb A, Jiang J, Sasaki Y, Chao T, Kiss Z, Chen X, et al. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015;149:468-80.e10 pubmed publisher
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- western blot; human; 0.071 ug/ml; fig 4
| Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed publisher
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- western blot; mouse; fig f5
| Ip L, Poulogiannis G, Viciano F, Sasaki J, Kofuji S, Spanswick V, et al. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015;6:10548-62 pubmed
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| Navis A, van Lith S, van Duijnhoven S, de Pooter M, Yetkin Arik B, Wesseling P, et al. Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein. Acta Neuropathol. 2015;130:131-44 pubmed publisher
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- western blot; human; fig s8
| Ohashi M, Holthaus A, Calderwood M, Lai C, Krastins B, Sarracino D, et al. The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. PLoS Pathog. 2015;11:e1004822 pubmed publisher
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- western blot; human; 1:1000; fig 3b
| Janes K. An analysis of critical factors for quantitative immunoblotting. Sci Signal. 2015;8:rs2 pubmed publisher
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- immunocytochemistry; mouse; fig 4
| Ota A, Kovary K, Wu O, Ahrends R, Shen W, Costa M, et al. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. J Lipid Res. 2015;56:1068-78 pubmed publisher
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- western blot; mouse; fig 1a
| Sadok A, McCarthy A, Caldwell J, Collins I, Garrett M, Yeo M, et al. Rho kinase inhibitors block melanoma cell migration and inhibit metastasis. Cancer Res. 2015;75:2272-84 pubmed publisher
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- western blot; mouse; fig 2
| Yamakoshi K, Katano S, Iida M, Kimura H, Okuma A, Ikemoto Uezumi M, et al. Dysregulation of the Bmi-1/p16(Inkâ´a) pathway provokes an aging-associated decline of submandibular gland function. Aging Cell. 2015;14:616-24 pubmed publisher
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- western blot; mouse; 1:1000
| Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015;22:1775-84 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:150
| Ye R, Wang M, Wang Q, Scherer P. Adiponectin-mediated antilipotoxic effects in regenerating pancreatic islets. Endocrinology. 2015;156:2019-28 pubmed publisher
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- immunocytochemistry; human; 1:400
| Fallahi Sichani M, Moerke N, Niepel M, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015;11:797 pubmed publisher
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- western blot; mouse; 1:1000; fig 8
| Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015;142:1254-66 pubmed publisher
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- immunohistochemistry; mouse; 1:1000; fig 2
- western blot; mouse; 1:1000; fig s2
| Venkatesh A, Ma S, Le Y, Hall M, Rüegg M, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015;125:1446-58 pubmed publisher
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- western blot; human; 1:2000
| Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, et al. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochem Pharmacol. 2015;95:16-27 pubmed publisher
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- western blot; mouse; 1:1000
| Tapia O, Fong L, Huber M, Young S, Gerace L. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS ONE. 2015;10:e0116196 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 5c
- western blot; human; 1:1000; loading ...; fig 3c
| Ma W, Na M, Tang C, Wang H, Lin Z. Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways. Mol Med Rep. 2015;12:1050-8 pubmed publisher
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- western blot; human; 1:1000
| Panneerselvam J, Jin J, Shanker M, Lauderdale J, BATES J, Wang Q, et al. IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. PLoS ONE. 2015;10:e0122439 pubmed publisher
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- immunocytochemistry; mouse; 1:50; fig 6c
- immunocytochemistry; human; 1:50; loading ...; fig 6d, 6e
- western blot; human
| Maione F, Oliaro Bosso S, Meda C, Di Nicolantonio F, Bussolino F, Balliano G, et al. The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination. Sci Rep. 2015;5:9054 pubmed publisher
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- western blot; mouse; fig 6a
| Rao E, Zhang Y, Zhu G, Hao J, Persson X, Egilmez N, et al. Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death. Oncotarget. 2015;6:7944-58 pubmed
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- western blot; human; fig 5
| Wilson F, Johannessen C, Piccioni F, Tamayo P, Kim J, Van Allen E, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015;27:397-408 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1
| Geurts L, Everard A, Van Hul M, Essaghir A, Duparc T, Matamoros S, et al. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nat Commun. 2015;6:6495 pubmed publisher
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| Münzberg C, Höhn K, Krndija D, Maaß U, Bartsch D, Slater E, et al. IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells. J Cell Mol Med. 2015;19:948-59 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4a
| Wu J, Pipathsouk A, Keizer Gunnink A, Fusetti F, Alkema W, Liu S, et al. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015;26:1629-39 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Sanjurjo L, Amézaga N, Aran G, Naranjo Gómez M, Arias L, Armengol C, et al. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses. Autophagy. 2015;11:487-502 pubmed publisher
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- western blot; human; loading ...; fig 4a,b
| Fumagalli I, Dugue D, Bibault J, Clémenson C, Vozenin M, Mondini M, et al. Cytotoxic effect of lapatinib is restricted to human papillomavirus-positive head and neck squamous cell carcinoma cell lines. Onco Targets Ther. 2015;8:335-45 pubmed publisher
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- western blot; human; fig 7
| Okita N, Honda Y, Kishimoto N, Liao W, Azumi E, Hashimoto Y, et al. Supplementation of strontium to a chondrogenic medium promotes chondrogenic differentiation of human dedifferentiated fat cells. Tissue Eng Part A. 2015;21:1695-704 pubmed publisher
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- western blot; human; fig 2
| Momeny M, Saunus J, Marturana F, McCart Reed A, Black D, Sala G, et al. Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget. 2015;6:3932-46 pubmed
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- western blot; zebrafish ; fig 4a
| Jeffery J, Neyt C, Moore W, Paterson S, Bower N, Chenevix Trench G, et al. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. FASEB J. 2015;29:1999-2009 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 1
| Kodigepalli K, Nanjundan M. Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells. PLoS ONE. 2015;10:e0117464 pubmed publisher
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- western blot; mouse; 1:1000; fig s7a
| Dametto P, Lakkaraju A, Bridel C, Villiger L, O CONNOR T, Herrmann U, et al. Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP. PLoS ONE. 2015;10:e0117412 pubmed publisher
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- western blot; rat; 1:1000
| Castorina A, Waschek J, Marzagalli R, Cardile V, Drago F. PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. PLoS ONE. 2015;10:e0117799 pubmed publisher
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- western blot; human; fig 2
| Papadakis A, Sun C, Knijnenburg T, Xue Y, Grernrum W, Hölzel M, et al. SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer. Cell Res. 2015;25:445-58 pubmed publisher
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- western blot; mouse
- western blot; human
| Schreiber K, Ortiz D, Academia E, Anies A, Liao C, Kennedy B. Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins. Aging Cell. 2015;14:265-73 pubmed publisher
|
- immunohistochemistry - paraffin section; zebrafish ; 1:200
| Ju B, Chen W, Orr B, Spitsbergen J, Jia S, Eden C, et al. Oncogenic KRAS promotes malignant brain tumors in zebrafish. Mol Cancer. 2015;14:18 pubmed publisher
|
- western blot; mouse
- western blot; human
| Li S, Bhave D, Chow J, Riera T, Schlee S, Rauch S, et al. Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels. J Biol Chem. 2015;290:10018-36 pubmed publisher
|
- western blot; mouse; loading ...; fig 4a
| Chen Z, Shen H, Sun C, Yin L, Tang F, Zheng P, et al. Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. Am J Physiol Endocrinol Metab. 2015;308:E460-9 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:50
- western blot; mouse; 1:1000
| Chandler R, Damrauer J, Raab J, Schisler J, Wilkerson M, Didion J, et al. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun. 2015;6:6118 pubmed publisher
|
- immunohistochemistry - paraffin section; rat
| Ammar A, Esmat A, Hassona M, Tadros M, Abdel Naim A, Guns E. The effect of pomegranate fruit extract on testosterone-induced BPH in rats. Prostate. 2015;75:679-92 pubmed publisher
|
- western blot; human; 1:2000
| López de Figueroa P, Lotz M, Blanco F, Caramés B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67:966-76 pubmed publisher
|
- western blot; human; 1:500; fig 1
| Niemeyer B, Parrish J, Spoelstra N, Joyal T, Richer J, Jedlicka P. Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes. PLoS ONE. 2015;10:e0116895 pubmed publisher
|
| Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed publisher
|
- western blot; human; fig 1
| Blanchard Z, Paul B, Craft B, ElShamy W. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. Breast Cancer Res. 2015;17:5 pubmed publisher
|
- western blot; mouse; fig 2
- western blot; human; fig 9
| Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, et al. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol Cell Biol. 2015;35:1299-313 pubmed publisher
|
- immunohistochemistry; human; 1:100
- western blot; human; fig 1
| Cheng Y, Chen P, Chiang H, Suen C, Hwang M, Lin T, et al. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death Dis. 2015;6:e1584 pubmed publisher
|
- western blot; mouse; fig 7
| Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed publisher
|
- western blot; mouse; fig 2
| Boj S, Hwang C, Baker L, Chio I, Engle D, Corbo V, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160:324-38 pubmed publisher
|
- immunocytochemistry; human; 1:100
| Lee S, Lee K, Lee J, Kang S, Kim H, Asahara T, et al. Selective Interference Targeting of Lnk in Umbilical Cord-Derived Late Endothelial Progenitor Cells Improves Vascular Repair, Following Hind Limb Ischemic Injury, via Regulation of JAK2/STAT3 Signaling. Stem Cells. 2015;33:1490-500 pubmed publisher
|
- western blot; human; 1:1000
| Zhang X, Cheng S, Bian K, Wang L, Zhang X, Yan B, et al. MicroRNA-26a promotes anoikis in human hepatocellular carcinoma cells by targeting alpha5 integrin. Oncotarget. 2015;6:2277-89 pubmed
|
- immunohistochemistry - frozen section; mouse; 1:200
- western blot; mouse
| Ni H, Bhakta A, Wang S, Li Z, Manley S, Huang H, et al. Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice. PLoS ONE. 2014;9:e115849 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:250; fig 2
- western blot; human; fig 2
| Cebulla J, Huuse E, Pettersen K, van der Veen A, Kim E, Andersen S, et al. MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity. Br J Cancer. 2015;112:504-13 pubmed publisher
|
- western blot; rat; 1:500; fig 12
| Pino M, Verstraeten S. Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression. J Appl Toxicol. 2015;35:952-69 pubmed publisher
|
| Fiorini C, Cordani M, Gotte G, Picone D, Donadelli M. Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner. Biochim Biophys Acta. 2015;1853:549-60 pubmed publisher
|
| Inaba J, McConnell E, Davis K. Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation. Int J Mol Sci. 2014;15:23705-24 pubmed publisher
|
| Shao C, Ahmad N, Hodges K, Kuang S, Ratliff T, Liu X. Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer. J Biol Chem. 2015;290:2024-33 pubmed publisher
|
- western blot; human; loading ...; fig 2g
- western blot; mouse; loading ...; fig 3d
| Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med. 2015;21:71-5 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse
- western blot; mouse
| Bisson J, Mills B, Paul Helt J, Zwaka T, Cohen E. Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Dev Biol. 2015;398:80-96 pubmed publisher
|
| Ozmen A, Unek G, Kipmen Korgun D, Cetinkaya B, Avcil Z, Korgun E. Glucocorticoid exposure altered angiogenic factor expression via Akt/mTOR pathway in rat placenta. Ann Anat. 2015;198:34-40 pubmed publisher
|
- western blot; mouse; 1:1000
| Smithline Z, Nikonova A, Hensley H, Cai K, Egleston B, Proia D, et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS ONE. 2014;9:e114403 pubmed publisher
|
- western blot; human; fig s4
| Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher
|
- western blot; rhesus macaque; fig s1
| O Connell K, Guo W, Serra C, Beck M, Wachtman L, Hoggatt A, et al. The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques. FASEB J. 2015;29:1165-75 pubmed publisher
|
| Galinato M, Orio L, Mandyam C. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. 2015;286:97-108 pubmed publisher
|
| Carter E, Miron Buchacra G, Goldoni S, Danahay H, Westwick J, Watson M, et al. Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7. PLoS ONE. 2014;9:e113555 pubmed publisher
|
- western blot; human; fig s1
| Gasser J, Inuzuka H, Lau A, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014;56:595-607 pubmed publisher
|
| Kapodistria K, Tsilibary E, Politis P, Moustardas P, Charonis A, Kitsiou P. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol. 2015;400:112-28 pubmed publisher
|
- western blot; mouse; fig 8a
| Olayanju A, Copple I, Bryan H, Edge G, Sison R, Wong M, et al. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. Free Radic Biol Med. 2015;78:202-12 pubmed publisher
|
- western blot; human; fig 1
| Heynen G, Fonfara A, Bernards R. Resistance to targeted cancer drugs through hepatocyte growth factor signaling. Cell Cycle. 2014;13:3808-17 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; fig s4
| Huang L, Carney J, Cardona D, Counter C. Decreased tumorigenesis in mice with a Kras point mutation at C118. Nat Commun. 2014;5:5410 pubmed publisher
|
| Soga M, Ohashi A, Taniguchi M, Matsui T, Tsuda T. The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes. FEBS Open Bio. 2014;4:898-904 pubmed publisher
|
- western blot; human; fig 5
| Qin J, Rajaratnam R, Feng L, Salami J, Barber Rotenberg J, Domsic J, et al. Development of organometallic S6K1 inhibitors. J Med Chem. 2015;58:305-14 pubmed publisher
|
| Hong Y, Kim J, Pectasides E, Fox C, Hong S, Ma Q, et al. Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models. PLoS ONE. 2014;9:e109440 pubmed publisher
|
- western blot; human; fig 4
| Tan L, Wang J, Tanizaki J, Huang Z, Aref A, Rusan M, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014;111:E4869-77 pubmed publisher
|
- western blot; rat; 1:3000
| Bing L, Wu J, Zhang J, Chen Y, Hong Z, Zu H. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochem Res. 2015;40:41-8 pubmed publisher
|
| Souza R, Piedade W, Soares L, Souza P, Aguiar A, Vechetti Júnior I, et al. Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions. PLoS ONE. 2014;9:e110020 pubmed publisher
|
| Holland W, Chinn D, Lara P, Gandara D, Mack P. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines. J Cancer Res Clin Oncol. 2015;141:615-26 pubmed publisher
|
- immunohistochemistry; human; 1:50
| Guerrouahen B, Pasquier J, Kaoud N, Maleki M, Beauchamp M, Yasmeen A, et al. Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer. Mol Cancer Ther. 2014;13:3123-36 pubmed publisher
|
- western blot; human; fig 3, 4
| Puig M, Lugo R, Gabasa M, Giménez A, Velásquez A, Galgoczy R, et al. Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer. Mol Cancer Res. 2015;13:161-73 pubmed publisher
|
| Portella A, Silveira P, Laureano D, Cardoso S, Bittencourt V, Noschang C, et al. Litter size reduction alters insulin signaling in the ventral tegmental area and influences dopamine-related behaviors in adult rats. Behav Brain Res. 2015;278:66-73 pubmed publisher
|
| Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, et al. An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 2014;52:897-906 pubmed publisher
|
- western blot; mouse; fig 1
| Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-133 pubmed publisher
|
| Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, et al. Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging. 2015;36:188-200 pubmed publisher
|
| Ritchie I, Wright D, Dyck D. Adiponectin is not required for exercise training-induced improvements in glucose and insulin tolerance in mice. Physiol Rep. 2014;2: pubmed publisher
|
| Niu H, Nie L, Liu M, Chi Y, Zhang T, Li Y. Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells. BMC Nephrol. 2014;15:135 pubmed publisher
|
- western blot; mouse; fig 6
| Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, et al. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun. 2014;5:4657 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:1000
| Selfridge J, Wilkins H, E L, Carl S, Koppel S, Funk E, et al. Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure. J Bioenerg Biomembr. 2015;47:1-11 pubmed publisher
|
- western blot; human; loading ...; fig 6a
| Wang F, Cai M, Mai S, Chen J, Bai H, Li Y, et al. Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression. Oncotarget. 2014;5:6716-33 pubmed
|
- western blot; human; fig 2
| Patel A, Burton D, Halvorsen K, Balkan W, Reiner T, Perez Stable C, et al. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015;34:2586-96 pubmed publisher
|
| Martin V, Corso S, Comoglio P, Giordano S. Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence. Mol Oncol. 2014;8:1561-74 pubmed publisher
|
- western blot; human; fig s3b
| Zaganjor E, Weil L, Gonzales J, Minna J, Cobb M. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proc Natl Acad Sci U S A. 2014;111:10568-73 pubmed publisher
|
- western blot; mouse; 1:1000
| E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-2583 pubmed publisher
|
- western blot; human; fig 5
| Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, et al. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS ONE. 2014;9:e101526 pubmed publisher
|
| Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, et al. CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE. 2014;9:e101137 pubmed publisher
|
- flow cytometry; human; 1:100
| Hellesøy M, Blois A, Tiron C, Mannelqvist M, Akslen L, Lorens J. Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis. Tissue Eng Part A. 2014;20:2590-603 pubmed publisher
|
- western blot; human; 1:1000
| Tanaka T, Iino M. Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. Cell Signal. 2014;26:2071-85 pubmed publisher
|
| Wang J, Mikse O, Liao R, Li Y, Tan L, Jänne P, et al. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Oncogene. 2015;34:2167-77 pubmed publisher
|
- western blot; mouse; 1:1000
| Johnston Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS ONE. 2014;9:e98775 pubmed publisher
|
| Wan Y, Yang Y, Leng Q, Lan B, Jia H, Liu Y, et al. Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells. Cell Signal. 2014;26:2202-9 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse
| Godde N, Sheridan J, Smith L, Pearson H, Britt K, Galea R, et al. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet. 2014;10:e1004323 pubmed publisher
|
- western blot; human; loading ...; fig 1a
| Chen K, Yang T, Wu C, Cheng C, Hsu S, Hung H, et al. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway. PLoS ONE. 2014;9:e97888 pubmed publisher
|
- western blot; human; fig 4
| Chin R, Fu X, Pai M, Vergnes L, Hwang H, Deng G, et al. The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397-401 pubmed publisher
|
| Stevenson C, de la Rosa G, Anderson C, Murphy P, Capece T, Kim M, et al. Essential role of Elmo1 in Dock2-dependent lymphocyte migration. J Immunol. 2014;192:6062-70 pubmed publisher
|
- western blot; domestic rabbit; 1:2,000
| Jiang Y, Kou Z, Wu T, An W, Zhou R, Wang H, et al. Xist deficiency and disorders of X-inactivation in rabbit embryonic stem cells can be rescued by transcription-factor-mediated conversion. Stem Cells Dev. 2014;23:2283-96 pubmed publisher
|
- western blot; rat; 1:2000
| Hardman S, Hall D, Cabrera A, Hancock C, Thomson D. The effects of age and muscle contraction on AMPK activity and heterotrimer composition. Exp Gerontol. 2014;55:120-8 pubmed publisher
|
| Liu B, Cao Y, Huizinga T, Hafler D, Toes R. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014;44:2121-9 pubmed publisher
|
| Tobin G, Zhang J, Goodwin D, Stewart S, Xu L, Knapton A, et al. The role of eNOS phosphorylation in causing drug-induced vascular injury. Toxicol Pathol. 2014;42:709-24 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:50
| Flavin R, Pettersson A, Hendrickson W, Fiorentino M, Finn S, Kunz L, et al. SPINK1 protein expression and prostate cancer progression. Clin Cancer Res. 2014;20:4904-11 pubmed publisher
|
- western blot; mouse; 1:1000
| Wahl S, McLane L, Bercury K, Macklin W, Wood T. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014;34:4453-65 pubmed publisher
|
- western blot; human; 1:1000
| Chen W, Ho C, Chang Y, Chen H, Lin C, Ling T, et al. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat Commun. 2014;5:3472 pubmed publisher
|
| Knubel K, Pernu B, Sufit A, Nelson S, Pierce A, Keating A. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme. Oncotarget. 2014;5:1338-51 pubmed
|
| Wang H, Sun W, Ma J, Pan Y, Wang L, Zhang W. Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/?-catenin pathway. PLoS ONE. 2014;9:e91730 pubmed publisher
|
- immunohistochemistry - paraffin section; human
| Boin A, Couvelard A, Couderc C, Brito I, Filipescu D, Kalamarides M, et al. Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas. Neuro Oncol. 2014;16:1196-209 pubmed publisher
|
- immunohistochemistry; mouse
- western blot; mouse
| Hu J, Lu J, Lian G, Zhang J, Hecht J, Sheen V. Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS ONE. 2014;9:e89352 pubmed publisher
|
| Yoon H, Choi Y, Song J, Do I, Kang S, Ko Y, et al. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PLoS ONE. 2014;9:e88587 pubmed publisher
|
| Park E, Kim B, Lee E, Chang E, Kim D, Choi S, et al. Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease. J Biol Chem. 2014;289:9254-62 pubmed publisher
|
| Solan J, Lampe P. Specific Cx43 phosphorylation events regulate gap junction turnover in vivo. FEBS Lett. 2014;588:1423-9 pubmed publisher
|
| Tchetchelnitski V, Van Den Eijnden M, Schmidt F, Stoker A. Developmental co-expression and functional redundancy of tyrosine phosphatases with neurotrophin receptors in developing sensory neurons. Int J Dev Neurosci. 2014;34:48-59 pubmed publisher
|
- western blot; rat; 1:1000
| Zhang Q, Pan Y, Wang R, Kang L, Xue Q, Wang X, et al. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. J Nutr Biochem. 2014;25:420-8 pubmed publisher
|
- western blot; human; 1:1000; fig 7
| Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, et al. SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nat Commun. 2014;5:3159 pubmed publisher
|
- immunohistochemistry; human; 1:2000
| Jespersen J, Mikkelsen U, Nedergaard A, Thorlund J, Schjerling P, Suetta C, et al. Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission. Scand J Med Sci Sports. 2015;25:175-83 pubmed publisher
|
- western blot; mouse; 1:1000
| Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher
|
- immunohistochemistry; mouse; 1:50
| Maire C, Ramkissoon S, Hayashi M, Haidar S, Ramkissoon L, diTomaso E, et al. Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells. 2014;32:313-26 pubmed publisher
|
- western blot; mouse; 1:2500
| Wheeler S, Hammond C, Jornayvaz F, Samuel V, Shulman G, Soroka C, et al. Ost?-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. 2014;306:G425-38 pubmed publisher
|
| Borghgraef P, Menuet C, Theunis C, Louis J, Devijver H, Maurin H, et al. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS ONE. 2013;8:e84442 pubmed publisher
|
| McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-? response and ROR?t localization. Eur J Immunol. 2014;44:1137-42 pubmed publisher
|
| Wang W, Chen Y, Wang S, Hu N, Cao Z, Wang W, et al. PIASx? ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase. J Biol Chem. 2014;289:3217-30 pubmed publisher
|
- flow cytometry; human; loading ...; fig 5a
| Shi L, Wang J, Ren J, Cheng Y, Ying R, Wu X, et al. KLRG1 impairs CD4+ T cell responses via p16ink4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection. J Immunol. 2014;192:649-57 pubmed publisher
|
- western blot; rat; 1:1000
| Yue X, Hariri D, Caballero B, Zhang S, Bartlett M, Kaut O, et al. Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson's disease. Neuroscience. 2014;258:385-400 pubmed publisher
|
| Wang Y, Briz V, Chishti A, Bi X, Baudry M. Distinct roles for ?-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 2013;33:18880-92 pubmed publisher
|
- western blot; mouse; 1:1000
| Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed publisher
|
- immunohistochemistry - free floating section; mouse; 1:200
| Haws M, JARAMILLO T, Espinosa F, Widman A, Stuber G, Sparta D, et al. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol. 2014;522:1171-90 pubmed publisher
|
- immunohistochemistry; human
| Wang J, Chen J, Miller D, Li W. Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Mol Cancer Ther. 2014;13:16-26 pubmed publisher
|
- western blot; rat; 1:1000
| Castorina A, Scuderi S, D Amico A, Drago F, D Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Exp Cell Res. 2014;322:108-21 pubmed publisher
|
- western blot; African green monkey
| Dunn C, Lampe P. Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size. J Cell Sci. 2014;127:455-64 pubmed publisher
|
- western blot; mouse; 1:10000
| Chen Z, Morris D, Jiang L, Liu Y, Rui L. SH2B1 in ?-cells regulates glucose metabolism by promoting ?-cell survival and islet expansion. Diabetes. 2014;63:585-95 pubmed publisher
|
| Ni H, Du K, You M, Ding W. Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol. 2013;183:1815-1825 pubmed publisher
|
- western blot; human; 1:2000
| Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, et al. Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J. 2014;28:131-42 pubmed publisher
|
- western blot; human; fig 1g
| Sáinz Jaspeado M, Huertas Martínez J, Lagares Tena L, Martín Liberal J, Mateo Lozano S, de Alava E, et al. EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1. PLoS ONE. 2013;8:e71449 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:50
- western blot; human
| Kucherlapati M, Esfahani S, Habibollahi P, Wang J, Still E, Bronson R, et al. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS ONE. 2013;8:e68817 pubmed publisher
|
| Hauerslev S, Sveen M, Vissing J, Krag T. Protein turnover and cellular stress in mildly and severely affected muscles from patients with limb girdle muscular dystrophy type 2I. PLoS ONE. 2013;8:e66929 pubmed publisher
|
- western blot; mouse; fig 2b
| Chang A, Huang J, Battiprolu P, Hill J, Kamm K, Stull J. The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. PLoS ONE. 2013;8:e66720 pubmed publisher
|
- western blot; human; fig 4
| Brouxhon S, Kyrkanides S, Teng X, O Banion M, Clarke R, Byers S, et al. Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers. Mol Carcinog. 2014;53:893-906 pubmed publisher
|
- western blot; mouse; 1:1,000
| Mietzsch U, McKenna J, Reith R, Way S, Gambello M. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013;521:3817-31 pubmed publisher
|
- western blot; mouse; 1:1000
| Griffeth R, Carretero J, Burks D. Insulin receptor substrate 2 is required for testicular development. PLoS ONE. 2013;8:e62103 pubmed publisher
|
- western blot; human
- western blot; mouse
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