product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Akt (Ser473) (193H12) Rabbit mAb
catalog :
4058
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
193H12
reactivity :
human, mouse, rat, dogs, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 277
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5a
Rock S, Jiang K, Wu Y, Liu Y, Li J, Weiss H, et al. Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner. Cell Mol Gastroenterol Hepatol. 2022;13:501-516 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 6b
Berger C, Heyne H, Heiland T, Dommel S, Höfling C, Guiu Jurado E, et al. A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice. J Lipid Res. 2021;62:100105 pubmed publisher
  • western blot; human; loading ...
Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, et al. The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun. 2021;12:4928 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, et al. Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell Rep. 2021;36:109490 pubmed publisher
  • western blot; human; loading ...; fig 5d
Innamorati G, Wilkie T, Malpeli G, Paiella S, Grasso S, Rusev B, et al. Gα15 in early onset of pancreatic ductal adenocarcinoma. Sci Rep. 2021;11:14922 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4m
Watson A, Grant A, Parker S, Hill S, Whalen M, Chakrabarti J, et al. Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Cell Rep. 2021;35:109293 pubmed publisher
  • western blot; human; loading ...; fig s7
Bayoumi A, Elsayed A, Han S, Petta S, Adams L, Aller R, et al. Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus. Adv Sci (Weinh). 2021;8:2004168 pubmed publisher
  • flow cytometry; mouse; loading ...
Tichy E, Ma N, Sidibe D, Loro E, Kocan J, Chen D, et al. Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening. Cell Rep. 2021;35:109098 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3a
Correll E, Ramser B, Knott M, McCullumsmith R, McGuire J, Ngwenya L. Deficits in pattern separation and dentate gyrus proliferation after rodent lateral fluid percussion injury. IBRO Neurosci Rep. 2021;10:31-41 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Wang D, Zou J, Dai J, Cheng Z. Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway. Sci Rep. 2021;11:8235 pubmed publisher
  • western blot; mouse; loading ...; fig 6e
Tirronen A, Downes N, Huusko J, Laakkonen J, Tuomainen T, Tavi P, et al. The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death. Biomolecules. 2021;11: pubmed publisher
  • western blot; human; loading ...; fig 2d
Bao Y, Oguz G, Lee W, Lee P, Ghosh K, Li J, et al. EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Nat Commun. 2020;11:5878 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Wang B, Li Q, Wang J, Zhao S, Nashun B, Qin L, et al. Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model. Cell Commun Signal. 2020;18:157 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4c
Cook S, Comrie W, Poli M, Similuk M, Oler A, Faruqi A, et al. HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. Science. 2020;369:202-207 pubmed publisher
  • western blot; dogs; 1:2000; loading ...; fig 3b
Wu Q, Li G, Wen C, Zeng T, Fan Y, Liu C, et al. Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis. Sci Adv. 2020;6:eaay9819 pubmed publisher
  • western blot; human; loading ...; fig 3b
Liu Q, Borcherding N, Shao P, Maina P, Zhang W, Qi H. Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance. EBioMedicine. 2020;51:102612 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Xu C, Zhang M, Bian L, Li Y, Yao Y, Li D. N-glycosylated SGK196 suppresses the metastasis of basal-like breast cancer cells. Oncogenesis. 2020;9:4 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a, 3f, 3k
Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Cai Y, Xue F, Qin H, Chen X, Liu N, Fleming C, et al. Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation. Cell Rep. 2019;27:3034-3048.e5 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1s2b
Jewell J, Fu V, Hong A, Yu F, Meng D, Melick C, et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3i
Martins V, Dent J, Svensson K, Tahvilian S, Begur M, Lakkaraju S, et al. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 4f
Gioran A, Piazzesi A, Bertan F, Schroer J, Wischhof L, Nicotera P, et al. Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction. EMBO J. 2019;38: pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Sutherland L, Ruhe M, Gattegno Ho D, Mann K, Greaves J, Koscielniak M, et al. LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci. 2018;131: pubmed publisher
  • western blot; mouse; loading ...; fig 6i
Macdougall C, Wood E, Loschko J, Scagliotti V, Cassidy F, Robinson M, et al. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metab. 2018;27:588-601.e4 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8c
Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
  • western blot; human; loading ...; fig 4c
Vu L, Pickering B, Cheng Y, Zaccara S, Nguyen D, Minuesa G, et al. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017;23:1369-1376 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6a
Zaytouni T, Tsai P, Hitchcock D, DuBois C, Freinkman E, Lin L, et al. Critical role for arginase 2 in obesity-associated pancreatic cancer. Nat Commun. 2017;8:242 pubmed publisher
  • western blot; human; loading ...; fig 9e
Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5d
Reynolds L, D Amico G, Lechertier T, Papachristodoulou A, Muñoz Félix J, De Arcangelis A, et al. Dual role of pericyte ?6?1-integrin in tumour blood vessels. J Cell Sci. 2017;130:1583-1595 pubmed publisher
  • western blot; human; loading ...; fig 10a
Lopes F, Bálint Å, Valvo S, Felce J, Hessel E, Dustin M, et al. Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages. J Cell Biol. 2017;216:1123-1141 pubmed publisher
  • western blot; human; 1:500; loading ...; fig s5c
Bohnacker T, Prota A, Beaufils F, Burke J, Melone A, Inglis A, et al. Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun. 2017;8:14683 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Basu R, Wu S, Kopchick J. Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways. Oncotarget. 2017;8:21579-21598 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Chowdhury A, Hasselbach L, Echtermeyer F, Jyotsana N, Theilmeier G, Herzog C. Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts. Sci Rep. 2017;7:42725 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 4A
  • western blot; mouse; loading ...; fig 4B
Gao L, Zhou C, Zhang X, Liu P, Jin Z, Zhu G, et al. ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis. Sci Rep. 2017;7:41272 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 1d
Ebner M, Sinkovics B, Szczygieł M, Ribeiro D, Yudushkin I. Localization of mTORC2 activity inside cells. J Cell Biol. 2017;216:343-353 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Graziano A, Cardile V, Avola R, Vicario N, Parenti C, Salvatorelli L, et al. Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. Oncotarget. 2017;8:13917-13931 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Clotet S, Soler M, Riera M, Pascual J, Fang F, Zhou J, et al. Stable Isotope Labeling with Amino Acids (SILAC)-Based Proteomics of Primary Human Kidney Cells Reveals a Novel Link between Male Sex Hormones and Impaired Energy Metabolism in Diabetic Kidney Disease. Mol Cell Proteomics. 2017;16:368-385 pubmed publisher
  • western blot; mouse; loading ...; fig 1i
Pal M, Gupta S. Testosterone supplementation improves glucose homeostasis despite increasing hepatic insulin resistance in male mouse model of type 2 diabetes mellitus. Nutr Diabetes. 2016;6:e236 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 12
Nagahara Y, Shimazawa M, Ohuchi K, Ito J, Takahashi H, Tsuruma K, et al. GPNMB ameliorates mutant TDP-43-induced motor neuron cell death. J Neurosci Res. 2017;95:1647-1665 pubmed publisher
  • western blot; human; loading ...; fig 7b
Natarajan S, Muthukrishnan E, Khalimonchuk O, Mott J, Becker D. Evidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress. J Cell Biochem. 2017;118:1678-1688 pubmed publisher
  • western blot; rat; loading ...; fig 2e
Mandel E, Dunford E, Trifonova A, Abdifarkosh G, Teich T, Riddell M, et al. Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction. PLoS ONE. 2016;11:e0166899 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Park J, Kim S, Yoo J, Jang J, Lee A, Oh J, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017;54:7706-7721 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Gómez Salinero J, López Olañeta M, Ortiz Sánchez P, Larrasa Alonso J, Gatto A, Felkin L, et al. The Calcineurin Variant CnA?1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation. Cell Chem Biol. 2016;23:1372-1382 pubmed publisher
  • western blot; human; loading ...; fig 7b
Horn T, Ferretti S, Ebel N, Tam A, Ho S, Harbinski F, et al. High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. Cancer Res. 2016;76:6950-6963 pubmed
  • western blot; human; 1:1000; loading ...; fig 3g
Queisser A, Hagedorn S, Wang H, Schaefer T, Konantz M, Alavi S, et al. Ecotropic viral integration site 1, a novel oncogene in prostate cancer. Oncogene. 2017;36:1573-1584 pubmed publisher
  • western blot; rat; fig 5
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed publisher
  • western blot; human; 1:2000; fig 5
Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed publisher
  • western blot; mouse; fig 2
Di Siena S, Gimmelli R, Nori S, Barbagallo F, Campolo F, Dolci S, et al. Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury. Cell Death Dis. 2016;7:e2317 pubmed publisher
  • western blot; human; loading ...; fig 1a
Liu Y, Wang S, Long Y, Chen S, Li Y, Zhang J. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway. Oncotarget. 2016;7:53153-53164 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed publisher
  • western blot; rat; 1:800; loading ...; fig 7
Sun Z, Zhan L, Liang L, Sui H, Zheng L, Sun X, et al. ZiBu PiYin recipe prevents diabetes-associated cognitive decline in rats: possible involvement of ameliorating mitochondrial dysfunction, insulin resistance pathway and histopathological changes. BMC Complement Altern Med. 2016;16:200 pubmed publisher
  • western blot; human; fig 1c
Hatem R, El Botty R, Chateau Joubert S, Servely J, Labiod D, de Plater L, et al. Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers. Oncotarget. 2016;7:48206-48219 pubmed publisher
  • western blot; human; fig 4e
Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, et al. SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Cancer Sci. 2016;107:1270-80 pubmed publisher
  • western blot; human; fig 2
Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed publisher
  • western blot; mouse; fig 4
Nwadozi E, Roudier E, Rullman E, Tharmalingam S, Liu H, Gustafsson T, et al. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB J. 2016;30:3039-52 pubmed publisher
  • western blot; human; 1:500; fig 3a
Li B, Guo W, Hong L, Liu Y, Liu C, Hong S, et al. Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse. Mol Med Rep. 2016;14:243-53 pubmed publisher
  • western blot; mouse; fig 2
Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Liu L, Wang F, Lu H, Cao S, Du Z, Wang Y, et al. Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice. Environ Health Perspect. 2016;124:1390-8 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Hakim S, Dyson J, Feeney S, Davies E, Sriratana A, Koenig M, et al. Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 2016;25:2295-2313 pubmed
  • western blot; rat; 1:1000; fig 6
Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, et al. Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13:3755-62 pubmed publisher
  • western blot; rat; 1:1000; fig 2
Xing Y, Sun W, Wang Y, Gao F, Ma H. Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart. Aging (Albany NY). 2016;8:873-88 pubmed publisher
  • western blot; mouse; fig 4
Du L, Chen X, Cao Y, Lu L, Zhang F, Bornstein S, et al. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling. Oncogene. 2016;35:4641-52 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Ebbing E, Medema J, Damhofer H, Meijer S, Krishnadath K, van Berge Henegouwen M, et al. ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3. Oncotarget. 2016;7:10243-54 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 2
  • western blot; mouse; fig 2
Malanga D, Belmonte S, Colelli F, Scarfò M, De Marco C, Oliveira D, et al. AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer. PLoS ONE. 2016;11:e0147334 pubmed publisher
  • western blot; mouse; fig s3a
Llanos S, García Pedrero J, Morgado Palacin L, Rodrigo J, Serrano M. Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun. 2016;7:10438 pubmed publisher
  • western blot; mouse; fig 8a
Zhang C, Huang X, Lu H, Meng X, Liu D, Kim Y, et al. Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice. Mol Cell Endocrinol. 2016;423:77-86 pubmed publisher
  • western blot; mouse; 1:1000; fig 4a
Lee K, Hsieh Y, Yang Y, Chan C, Huang Y, Lin H. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. Sci Rep. 2016;6:18899 pubmed publisher
  • western blot; mouse; fig 3
Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, et al. Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice. Drug Des Devel Ther. 2015;9:6327-42 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s9i
Ulrich F, Carretero Ortega J, Menendez J, Narvaez C, Sun B, Lancaster E, et al. Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development. 2016;143:147-59 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2b
Chen X, Dong X, Gao H, Jiang Y, Jin Y, Chang Y, et al. Suppression of HSP27 increases the anti‑tumor effects of quercetin in human leukemia U937 cells. Mol Med Rep. 2016;13:689-96 pubmed publisher
  • western blot; human; fig 2
Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed publisher
  • western blot; mouse; fig 3
Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, Cecconi F, et al. Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy. 2015;11:2142-52 pubmed publisher
  • western blot; human; fig 4a
Chen K, Zeng J, Tang K, Xiao H, Hu J, Huang C, et al. miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA. Biol Cell. 2016;108:41-50 pubmed publisher
  • western blot; mouse; fig 4
Hukelmann J, Anderson K, Sinclair L, Grzes K, Murillo A, Hawkins P, et al. The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nat Immunol. 2016;17:104-12 pubmed publisher
  • western blot; mouse; fig 2
Freedman T, Tan Y, Skrzypczynska K, Manz B, Sjaastad F, Goodridge H, et al. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. elife. 2015;4: pubmed publisher
  • flow cytometry; human; fig 3
  • western blot; human; 1:750; fig 1
Vétillard A, Jonchère B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
  • western blot; mouse; fig 3
da Rocha A, Pereira B, Pauli J, Cintra D, De Souza C, Ropelle E, et al. Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. PLoS ONE. 2015;10:e0140020 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Darr J, Klochendler A, Isaac S, Geiger T, Geiger T, Eden A. Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells. Mol Cancer. 2015;14:167 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; fig 4
Zhang Y, Wei X, Liang Y, Chen W, Zhang F, Bai J, et al. Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation. PLoS ONE. 2015;10:e0135851 pubmed publisher
  • western blot; mouse; fig 3
Park E, Kim N, Ficarro S, Zhang Y, Lee B, Cho A, et al. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat Struct Mol Biol. 2015;22:703-711 pubmed publisher
  • western blot; rat; 1:1000
Triplett J, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, et al. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta. 2015;1852:2213-24 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Zhou W, Shao H, Zhang D, Dong J, Cheng W, Wang L, et al. PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1. Cell Biosci. 2015;5:42 pubmed publisher
  • western blot; mouse; 1:1000
Rodríguez Seoane C, Ramos A, Korth C, Requena J. DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway. J Neurochem. 2015;135:598-605 pubmed publisher
  • western blot; rat; 1:2000; fig 5
Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, et al. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model. PLoS ONE. 2015;10:e0132451 pubmed publisher
  • western blot; human; 1:200; fig 1
Blancafort A, Giró Perafita A, Oliveras G, Palomeras S, Turrado C, Campuzano Ã, et al. Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs. PLoS ONE. 2015;10:e0131241 pubmed publisher
  • western blot; human; fig 2b
  • western blot; mouse; fig 2a
Bresin A, Callegari E, D Abundo L, Cattani C, Bassi C, Zagatti B, et al. miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model. Oncotarget. 2015;6:19807-18 pubmed
  • western blot; human; loading ...; fig 4d
Chen M, Yen C, Cheng C, Wu R, Huang S, Yu C, et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. Oncotarget. 2015;6:23594-608 pubmed
  • western blot; human; fig 2a
Fedorenko I, Abel E, Koomen J, Fang B, Wood E, Chen Y, et al. Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells. Oncogene. 2016;35:1225-35 pubmed publisher
  • immunocytochemistry; human; fig 4b
  • western blot; human; fig 4
Urban B, Collard T, Eagle C, Southern S, Greenhough A, Hamdollah Zadeh M, et al. BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. Gut. 2016;65:1151-64 pubmed publisher
  • flow cytometry; human; 1:400
Hellesøy M, Lorens J. Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis. Mol Biol Cell. 2015;26:2698-711 pubmed publisher
  • western blot; human; fig s6
Palla A, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez López G, et al. The pluripotency factor NANOG promotes the formation of squamous cell carcinomas. Sci Rep. 2015;5:10205 pubmed publisher
  • immunohistochemistry; human; 1:50
Demicco E, Wani K, Fox P, Bassett R, Young E, Lev D, et al. Histologic variability in solitary fibrous tumors reflects angiogenic and growth factor signaling pathway alterations. Hum Pathol. 2015;46:1015-26 pubmed publisher
  • western blot; human; 1:1000; fig 4
Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey M, et al. The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Front Microbiol. 2015;6:280 pubmed publisher
  • western blot; human; 1:1000
Gassen N, Hartmann J, Zannas A, Kretzschmar A, Zschocke J, Maccarrone G, et al. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Mol Psychiatry. 2016;21:277-89 pubmed publisher
  • western blot; human; fig 1
Hausmann S, Brandt E, Köchel C, Einsele H, Bargou R, Seggewiss Bernhardt R, et al. Loss of serum and glucocorticoid-regulated kinase 3 (SGK3) does not affect proliferation and survival of multiple myeloma cell lines. PLoS ONE. 2015;10:e0122689 pubmed publisher
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Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed publisher
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Albers J, Danzer C, Rechsteiner M, Lehmann H, Brandt L, Hejhal T, et al. A versatile modular vector system for rapid combinatorial mammalian genetics. J Clin Invest. 2015;125:1603-19 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2
  • western blot; mouse; 1:1000; loading ...; fig 6
Yang Y, Deng Q, Feng X, Sun J. Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice. Mol Med Rep. 2015;12:746-52 pubmed publisher
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Wu H, Hwang Verslues W, Lee W, Huang C, Wei P, Chen C, et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015;212:333-49 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2a
Benzler J, Ganjam G, Pretz D, Oelkrug R, Koch C, Legler K, et al. Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance. Diabetes. 2015;64:2015-27 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Tontonoz P, Cortez Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed publisher
  • western blot; mouse
Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu Y, Fischman A, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS ONE. 2015;10:e0116633 pubmed publisher
  • immunohistochemistry - paraffin section; rat; loading ...; fig 6B
  • western blot; rat; 1:1000; loading ...; fig 6A
Padrão A, Moreira Gonçalves D, Oliveira P, Teixeira C, Faustino Rocha A, Helguero L, et al. Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia. Arch Biochem Biophys. 2015;567:13-21 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Zhou L, Park S, Xu L, Xia X, Ye J, Su L, et al. Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. Nat Commun. 2015;6:5949 pubmed publisher
  • western blot; mouse
  • western blot; rat
Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher
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Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford R, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med. 2015;21:166-72 pubmed publisher
  • western blot; human
Isoyama S, Kajiwara G, Tamaki N, Okamura M, Yoshimi H, Nakamura N, et al. Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474. Cancer Sci. 2015;106:171-8 pubmed publisher
  • western blot; human
Yang R, Chen Y, Tang C, Li H, Wang B, Yan Q, et al. MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b. BMC Cancer. 2014;14:917 pubmed publisher
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Parenti R, Cardile V, Graziano A, Parenti C, Venuti A, Bertuccio M, et al. Wilms' tumor gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line. PLoS ONE. 2014;9:e114333 pubmed publisher
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Manley S, Ni H, Williams J, Kong B, DiTacchio L, Guo G, et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol. 2014;2:991-1002 pubmed publisher
  • western blot; human; fig 3
Sun J, Lu F, He H, Shen J, Messina J, Mathew R, et al. STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion. J Cell Biol. 2014;207:535-48 pubmed publisher
  • western blot; human; fig 1
  • western blot; mouse; fig 1
Badolia R, Manne B, Dangelmaier C, Chernoff J, Kunapuli S. Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood. 2015;125:175-84 pubmed publisher
  • western blot; human; fig 3
Cai X, Dai Z, Reeves R, Caballero Benítez A, Duran K, Delrow J, et al. Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells. PLoS ONE. 2014;9:e108942 pubmed publisher
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Ozek C, Kanoski S, Zhang Z, Grill H, Bence K. Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. J Biol Chem. 2014;289:31682-92 pubmed publisher
  • western blot; human; fig 2
Goldshmit Y, Trangle S, Kloog Y, Pinkas Kramarski R. Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma. Oncotarget. 2014;5:8602-13 pubmed
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De Santis R, Rosi A, Anastasi A, Chiapparino C, Albertoni C, Leoni B, et al. Efficacy of aerosol therapy of lung cancer correlates with EGFR paralysis induced by AvidinOX-anchored biotinylated Cetuximab. Oncotarget. 2014;5:9239-55 pubmed
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Tang J, Shen L, Yang Q, Zhang C. Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition. Cell Prolif. 2014;47:427-34 pubmed publisher
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Biswas C, Shah N, Muthu M, La P, Fernando A, Sengupta S, et al. Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses. J Biol Chem. 2014;289:26882-94 pubmed publisher
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Zhang S, Ren M, Zeng X, He P, Ma X, Qiao S. Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino Acids. 2014;46:2633-42 pubmed publisher
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Samartzis E, Gutsche K, Dedes K, Fink D, Stucki M, Imesch P. Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition. Oncotarget. 2014;5:5295-303 pubmed
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Celis Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, et al. Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014;33:1928-40 pubmed publisher
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Ramos A, Rodríguez Seoane C, Rosa I, Trossbach S, Ortega Alonso A, Tomppo L, et al. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet. 2014;23:5859-65 pubmed publisher
  • western blot; rat; fig 7
Morgan K, Black L. Investigation into the effects of varying frequency of mechanical stimulation in a cycle-by-cycle manner on engineered cardiac construct function. J Tissue Eng Regen Med. 2017;11:342-353 pubmed publisher
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Chen H, Mester T, Raychaudhuri N, Kauh C, Gupta S, Smith T, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014;99:E1635-40 pubmed publisher
  • western blot; human; fig 3
Elliott V, Rychahou P, Zaytseva Y, Evers B. Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model. PLoS ONE. 2014;9:e97432 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Billon C, Canaple L, Fleury S, Deloire A, Beylot M, Dombrowicz D, et al. TR? protects against atherosclerosis in male mice: identification of a novel anti-inflammatory property for TR? in mice. Endocrinology. 2014;155:2735-45 pubmed publisher
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Cen B, Xiong Y, Song J, Mahajan S, DuPont R, McEachern K, et al. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. 2014;34:2517-32 pubmed publisher
  • western blot; human
Asp N, Pust S, Sandvig K. Flotillin depletion affects ErbB protein levels in different human breast cancer cells. Biochim Biophys Acta. 2014;1843:1987-96 pubmed publisher
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Ota K, Liu R, Voleti B, Maldonado Avilés J, Duric V, Iwata M, et al. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nat Med. 2014;20:531-5 pubmed publisher
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Pérez Quintero L, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A. EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C?, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014;211:727-42 pubmed publisher
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Pourreyron C, Chen M, McGrath J, Salas Alanis J, South A, Leigh I. High levels of type VII collagen expression in recessive dystrophic epidermolysis bullosa cutaneous squamous cell carcinoma keratinocytes increases PI3K and MAPK signalling, cell migration and invasion. Br J Dermatol. 2014;170:1256-65 pubmed publisher
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Bokobza S, Jiang Y, Weber A, Devery A, Ryan A. Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;88:947-54 pubmed publisher
  • western blot; human
Feng C, Zhang Y, Yin J, Li J, Abounader R, Zuo Z. Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma. Neuro Oncol. 2014;16:1078-85 pubmed publisher
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Dorn C, Engelmann J, Saugspier M, Koch A, Hartmann A, Müller M, et al. Increased expression of c-Jun in nonalcoholic fatty liver disease. Lab Invest. 2014;94:394-408 pubmed publisher
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Morgan K, Black L. Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs. Tissue Eng Part A. 2014;20:1654-67 pubmed publisher
  • western blot; human; loading ...; fig 5e
Xia Q, Cai Y, Peng R, Wu G, Shi Y, Jiang W. The CDK1 inhibitor RO3306 improves the response of BRCA-pro?cient breast cancer cells to PARP inhibition. Int J Oncol. 2014;44:735-44 pubmed publisher
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Chen Y, Thang M, Chan Y, Huang Y, Ma N, Yu A, et al. Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. PLoS ONE. 2013;8:e82751 pubmed publisher
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Du Y, Teng X, Wang N, Zhang X, Chen J, Ding P, et al. NF-?B and enhancer-binding CREB protein scaffolded by CREB-binding protein (CBP)/p300 proteins regulate CD59 protein expression to protect cells from complement attack. J Biol Chem. 2014;289:2711-24 pubmed publisher
  • flow cytometry; human; loading ...; fig 5a
Shi L, Wang J, Ren J, Cheng Y, Ying R, Wu X, et al. KLRG1 impairs CD4+ T cell responses via p16ink4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection. J Immunol. 2014;192:649-57 pubmed publisher
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Zhu J, Lin F, Brown D, Clark R. A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals. J Invest Dermatol. 2014;134:921-929 pubmed publisher
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Segatto M, Manduca A, Lecis C, Rosso P, Jozwiak A, Swiezewska E, et al. Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats. Neuropsychopharmacology. 2014;39:841-54 pubmed publisher
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Smith M, Tippetts T, Brassfield E, Tucker B, Ockey A, Swensen A, et al. Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle. Biochem J. 2013;456:427-39 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
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Thompson W, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, et al. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013;31:2528-37 pubmed publisher
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Geissler A, Haun F, Frank D, Wieland K, Simon M, Idzko M, et al. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ. 2013;20:1317-29 pubmed publisher
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Hori T, Gardner L, Hata T, Chen F, Baine A, Uemoto S, et al. Pretreatment of liver grafts in vivo by ?-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Ann Transplant. 2013;18:299-313 pubmed publisher
  • western blot; human; fig 2
Imesch P, Samartzis E, Dedes K, Fink D, Fedier A. Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells. Fertil Steril. 2013;100:770-6 pubmed publisher
  • western blot; human; fig 5
Garcia Murillas I, Sharpe R, Pearson A, Campbell J, Natrajan R, Ashworth A, et al. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene. 2014;33:2478-86 pubmed publisher
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Jacobo S, DeAngelis M, Kim I, Kazlauskas A. Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol. 2013;33:1976-90 pubmed publisher
  • western blot; rat
Kim J, Hwang I, Choi S, Lee H, Lee Y, Goo J, et al. Aqueous extract of Liriope platyphylla, a traditional Chinese medicine, significantly inhibits abdominal fat accumulation and improves glucose regulation in OLETF type II diabetes model rats. Lab Anim Res. 2012;28:181-91 pubmed publisher
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Ambacher K, Pitzul K, Karajgikar M, Hamilton A, Ferguson S, Cregan S. The JNK- and AKT/GSK3?- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PLoS ONE. 2012;7:e46885 pubmed publisher
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Gardner L, Hori T, Chen F, Baine A, Hata T, Uemoto S, et al. Effect of specific activation of ?-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy. Hepatol Res. 2012;42:1131-40 pubmed publisher
  • flow cytometry; human; fig 3
Lamottke B, Kaiser M, Mieth M, Heider U, Gao Z, Nikolova Z, et al. The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases. Eur J Haematol. 2012;88:406-15 pubmed publisher
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product information
SKU :
4058S
Product-Name :
Phospho-Akt (Ser473) (193H12) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R
Applications :
Flow cytometry
Product-Category :
PI3K / Akt Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
60
Host :
Rabbit
Target :
Akt1 (Ser473) phosphate/Akt2 (Ser474) phosphate/Akt3 (Ser472) phosphate
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.