product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PKM2 (D78A4) XP® Rabbit mAb
catalog :
4053P
quantity :
40 ul
price :
135 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 11
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig 3
  • immunoprecipitation; human; fig 2
Altuntas S, Rossin F, Marsella C, D'Eletto M, Díaz-Hidalgo L, Farrace M, et al. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation. Oncotarget. 2015;6:44941-54 pubmed publisher
  • western blot; human; fig 3
Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed publisher
  • western blot; mouse; fig 3
Ledee D, Smith L, Bruce M, Kajimoto M, Isern N, Portman M, et al. c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction. PLoS ONE. 2015;10:e0135262 pubmed publisher
  • immunohistochemistry; human; fig 4
Kim D, Fiske B, Birsoy K, Freinkman E, Kami K, Possemato R, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015;520:363-7 pubmed publisher
  • western blot; mouse; fig 4
Gao X, Krokowski D, Guan B, Bederman I, Majumder M, Parisien M, et al. Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response. elife. 2015;4:e10067 pubmed publisher
  • western blot; mouse; 1:1000; fig s9
Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed publisher
  • immunoprecipitation; human; fig 1c
  • western blot; human; fig 2d
Xie X, Wang M, Mei J, Hu F, Ding F, Lv L. Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation. Biochem Biophys Res Commun. 2015;467:427-33 pubmed publisher
  • ELISA; human; 1:1000
  • immunoprecipitation; human
  • western blot; human
Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2015;: pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig 8
Venkatesh A, Ma S, Le Y, Hall M, Ruegg M, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015;125:1446-58 pubmed publisher
Li J, Liu T, Zhao L, Chen W, Hou H, Ye Z, et al. Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells. Int J Oncol. 2015;46:775-81 pubmed publisher
Anastasiou D, Poulogiannis G, Asara J, Boxer M, Jiang J, Shen M, et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science. 2011;334:1278-83 pubmed publisher
product information
SKU :
4053P
Product-Name :
PKM2 (D78A4) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
60
Host :
Rabbit
Target :
PKM2
Primary-Protein :
PKM2
Alt-Names :
CTHBP,Cytosolic thyroid hormone-binding protein,KPYM,MGC3932,OIP-3,OIP3,Opa-interacting protein 3,PK, muscle type,PK2,PK3,PKM,PKM2,Pyruvate kinase 2/3,Pyruvate kinase isozymes M1/M2,Pyruvate kinase muscle isozyme,TCB,THBP1,Thyroid hormone-binding protein 1,Tumor M2-PK,p58,pyruvate kinase, muscle,thyroid hormone-binding protein, cytosolic
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.