| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; loading ...; fig 3d
| Escasany E, Lanzón B, García Carrasco A, Izquierdo Lahuerta A, Torres L, Corrales P, et al. Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney. Dis Model Mech. 2021;14: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6b
| Berger C, Heyne H, Heiland T, Dommel S, Höfling C, Guiu Jurado E, et al. A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice. J Lipid Res. 2021;62:100105 pubmed publisher |
- western blot; mouse; 1:1000; loading ...
| Kearney A, Norris D, Ghomlaghi M, Kin Lok Wong M, Humphrey S, Carroll L, et al. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. elife. 2021;10: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6c
| Zoma M, Curti L, Shinde D, Albino D, Mitra A, Sgrignani J, et al. EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer. Nat Commun. 2021;12:4147 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3h
| Han B, Sun Z, Yu T, Wang Y, Kuang L, Li T, et al. SPOP-PTEN-SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway. Cell Death Discov. 2021;7:120 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6d
| Zhang M, Ceyhan Y, Kaftanovskaya E, Vasquez J, Vacher J, Knop F, et al. INPP4B protects from metabolic syndrome and associated disorders. Commun Biol. 2021;4:416 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 4a
| Frazier H, Anderson K, Ghoweri A, Lin R, Hawkinson T, Popa G, et al. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Aging Cell. 2020;19:e13220 pubmed publisher |
- western blot; human; loading ...; fig 5g
| Zhao Z, Xiang S, Qi J, Wei Y, Zhang M, Yao J, et al. Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy. Cell Death Dis. 2020;11:387 pubmed publisher |
- western blot; mouse; loading ...; fig 2c
| Krycer J, Elkington S, Díaz Vegas A, Cooke K, Burchfield J, Fisher Wellman K, et al. Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. J Biol Chem. 2020;295:99-110 pubmed publisher |
- western blot; human; 1:500; loading ...; fig e7j
| Ramírez C, Hauser A, Vucic E, Bar Sagi D. Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis. Nature. 2019;576:477-481 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Ali R, Alabdullah M, Miligy I, Normatova M, Babaei Jadidi R, Nateri A, et al. ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity. Cells. 2019;8: pubmed publisher |
- western blot; mouse; fig s1a
| Sivaram N, McLaughlin P, Han H, Petrenko O, Jiang Y, Ballou L, et al. Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer. J Clin Invest. 2019;130: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s3
| Slocum E, Craig A, Villanueva A, Germain D. Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2. Breast Cancer Res. 2019;21:56 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Zhang M, Suarez E, Vasquez J, Nathanson L, Peterson L, Rajapakshe K, et al. Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity. Oncogene. 2019;38:1121-1135 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Roy N, MacKay J, Robertson T, Hammer D, Burkhardt J. Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Sci Signal. 2018;11: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2e
| Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher |
- western blot; human; fig 3a
| Liu S, Cheng C. Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop. Cancer Res. 2017;77:3791-3801 pubmed publisher |
- western blot; human; loading ...; fig 1d
- western blot; mouse; loading ...; fig 1j
| Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 2017;545:365-369 pubmed publisher |
- western blot; human; loading ...; fig 5f
| Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Chen Y, Li C, Xie H, Fan Y, Yang Z, Ma J, et al. Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K→︀AKT→︀GSK3β→︀AM signaling. Oncogene. 2017;36:2879-2888 pubmed publisher |
- western blot; rat; loading ...; fig 6a
| Pandini G, Satriano C, Pietropaolo A, Gianì F, Travaglia A, La Mendola D, et al. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor. Front Neurosci. 2016;10:569 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Ramos P, Guerra A, Guerreiro O, Santos S, Oliveira H, Freire C, et al. Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts. Int J Mol Sci. 2016;18: pubmed publisher |
- western blot; mouse; loading ...; fig 4b
| Kocsis T, Trencsenyi G, Szabó K, Baán J, Müller G, Mendler L, et al. Myostatin propeptide mutation of the hypermuscular Compact mice decreases the formation of myostatin and improves insulin sensitivity. Am J Physiol Endocrinol Metab. 2017;312:E150-E160 pubmed publisher |
- western blot; human; fig 4c
| Chu Q, Huang H, Huang T, Cao L, Peng L, Shi S, et al. Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis. Cell Death Dis. 2016;7:e2456 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s2
| Zavorka M, Connelly C, Grosely R, MacDonald R. Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor. Oncotarget. 2016;7:62386-62410 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 8a
- western blot; human; 1:1000; loading ...; fig s2b
- immunohistochemistry; mouse; loading ...; fig 6b
- western blot; rat; 1:1000; loading ...; fig 5a
| Wang S, Jiang L, Han Y, Chew S, Ohara Y, Akatsuka S, et al. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016;7:69565-69578 pubmed publisher |
- western blot; mouse; loading ...; fig 5d
| Hauck L, Grothe D, Billia F. p21(CIP1/WAF1)-dependent inhibition of cardiac hypertrophy in response to Angiotensin II involves Akt/Myc and pRb signaling. Peptides. 2016;83:38-48 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, et al. Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2016;2:15044 pubmed publisher |
- western blot; mouse; 1:1000; fig 7
| Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Stein S, Mack E, Rome K, Pajcini K, Ohtani T, Xu L, et al. Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PLoS ONE. 2016;11:e0155408 pubmed publisher |
- western blot; mouse; fig 3
- western blot; human; fig s3
| Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3g
| Hoefig C, Harder L, Oelkrug R, Meusel M, Vennstrom B, Brabant G, et al. Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice. Endocrinology. 2016;157:2957-67 pubmed publisher |
- western blot; human; 1:600; fig 6
| Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, et al. Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways. Autophagy. 2016;12:999-1014 pubmed publisher |
- western blot; mouse; 1:1000; fig s5
| Lee K, Lee H, Lin H, Tsay H, Tsai F, Shyue S, et al. Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease. J Neuroinflammation. 2016;13:92 pubmed publisher |
- western blot; human; loading ...
| Park J, Jung C, Seo M, Otto N, Grunwald D, Kim K, et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy. 2016;12:547-64 pubmed publisher |
- western blot; human; fig 5
| Huang J, Yao C, Chuang S, Yeh C, Lee L, Chen R, et al. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction. BMC Cancer. 2016;16:245 pubmed publisher |
- western blot; human; 1:1000; fig 7
| Joo M, Park J, Yoo H, Lee B, Chun H, Lee S, et al. The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer. J Gastroenterol Hepatol. 2016;31:1717-1726 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
- western blot; human; 1:1000; fig 3
| Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, et al. Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer. EMBO Mol Med. 2016;8:388-406 pubmed publisher |
- western blot; human; fig 3
| Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El Deiry W. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases. Sci Signal. 2016;9:ra18 pubmed publisher |
| Iorga A, Li J, Sharma S, Umar S, Bopassa J, Nadadur R, et al. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. J Am Heart Assoc. 2016;5: pubmed publisher |
- western blot; human; fig 3
| Zhang Q, Wan M, Shi J, Horita D, Miller L, Kute T, et al. Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 2016;8:232-43 pubmed publisher |
- western blot; human; fig 2c
| Vergani E, Di Guardo L, Dugo M, Rigoletto S, Tragni G, Ruggeri R, et al. Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. Oncotarget. 2016;7:4428-41 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Ramcharan R, Aleksic T, Kamdoum W, Gao S, Pfister S, Tanner J, et al. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. Oncotarget. 2015;6:39877-90 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 7a
| Guo W, Zhang Y, Ling Z, Liu X, Zhao X, Yuan Z, et al. Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner. Cell Death Dis. 2015;6:e1919 pubmed publisher |
- western blot; mouse; fig s3d
| Joly A, Deepti A, Seignez A, Goloudina A, Hebrard S, Schmitt E, et al. The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development. Oncogene. 2016;35:2842-51 pubmed publisher |
- western blot; mouse; fig 1c
| Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
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- immunohistochemistry; human; 1:800
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- western blot; human; fig 3
| Vishwamitra D, Curry C, Alkan S, Song Y, Gallick G, Kaseb A, et al. The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⺠T-cell lymphoma. Mol Cancer. 2015;14:53 pubmed publisher |
| Wu C, Niu L, Yan Z, Wang C, Liu N, Dai Y, et al. Pcdh11x Negatively Regulates Dendritic Branching. J Mol Neurosci. 2015;56:822-8 pubmed publisher |
- western blot; mouse; 1:1000
| Skarra D, Thackray V. FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol. 2015;405:14-24 pubmed publisher |
| Seeßle J, Liebisch G, Schmitz G, Stremmel W, Chamulitrat W. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochim Biophys Acta. 2015;1851:549-65 pubmed publisher |
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- western blot; rat; 1:1000
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| Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, et al. ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Nat Commun. 2015;6:5794 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1
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- immunohistochemistry - paraffin section; human; 1:300
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| George S, Vishwamitra D, Manshouri R, Shi P, Amin H. The ALK inhibitor ASP3026 eradicates NPM-ALK? T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014;5:5750-63 pubmed |
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- western blot; mouse; fig 5
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- western blot; rat
- immunohistochemistry - frozen section; mouse
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- western blot; human; fig 7
- western blot; mouse
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