product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
ROCK1 (C8F7) Rabbit mAb
catalog :
4035
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
C8F7
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 13
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 3d
Khalifeh Soltani A, Gupta D, Ha A, Podolsky M, Datta R, Atabai K. The Mfge8-α8β1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation. FASEB J. 2018;:fj201800109R pubmed publisher
  • western blot; mouse; 1:1000; fig s4
Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher
  • western blot; human; fig 7
Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher
  • western blot; mouse
Narayanan K, Chopra V, Rosas H, Malarick K, Hersch S. Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease. Mol Neurobiol. 2016;53:2132-40 pubmed publisher
  • western blot; mouse; 1:1000; fig 2a
Zhang X, Zhang T, Gao F, Li Q, Shen C, Li Y, et al. Fasudil, a Rho‑kinase inhibitor, prevents intima‑media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow‑induced vascular remodeling. Mol Med Rep. 2015;12:7317-25 pubmed publisher
  • western blot; human; fig s2c
Pelish H, Liau B, Nitulescu I, Tangpeerachaikul A, Poss Z, Da Silva D, et al. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 2015;526:273-276 pubmed publisher
  • western blot; human
Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher
Zandvakili I, Lin Y, Morris J, Zheng Y. Rho GTPases: Anti- or pro-neoplastic targets?. Oncogene. 2017;36:3213-3222 pubmed publisher
Lima V, Lobato N, Filgueira F, Webb R, Tostes R, Giachini F. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain. Braz J Med Biol Res. 2014;47:826-33 pubmed
Kobori T, Harada S, Nakamoto K, Tokuyama S. Time-dependent changes in the activation of RhoA/ROCK and ERM/p-ERM in the increased expression of intestinal P-glycoprotein by repeated oral treatment with etoposide. J Pharm Sci. 2013;102:1670-82 pubmed publisher
Kobori T, Harada S, Nakamoto K, Tokuyama S. Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia. J Pharm Sci. 2013;102:1095-105 pubmed publisher
Park J, Arakawa Takeuchi S, Jinno S, Okayama H. Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway. J Biol Chem. 2011;286:23132-41 pubmed publisher
Mayanagi T, Morita T, Hayashi K, Fukumoto K, Sobue K. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem. 2008;283:31183-96 pubmed publisher
product information
SKU :
4035S
Product-Name :
ROCK1 (C8F7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
160
Host :
Rabbit
Target :
ROCK1
Primary-Protein :
ROCK1
Alt-Names :
MGC131603,MGC43611,PRO0435,ROCK1,Renal carcinoma antigen NY-REN-35,Rho kinase,Rho-associated protein kinase 1,Rho-associated, coiled-coil containing protein kinase 1,Rho-associated, coiled-coil-containing protein kinase 1,p160 ROCK-1,p160-ROCK,p160ROCK
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.