product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Tau (Tau46) Mouse mAb
catalog :
4019
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Tau46
reactivity :
human, mouse, brown rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 26
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1a
Faraco G, Hochrainer K, Segarra S, Schaeffer S, Santisteban M, Menon A, et al. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019;: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2a
zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, et al. Protein kinase N1 critically regulates cerebellar development and long-term function. J Clin Invest. 2018;128:2076-2088 pubmed publisher
  • western blot; brown rat; loading ...; fig 3b
Gasparotto J, Girardi C, Somensi N, Ribeiro C, Moreira J, Michels M, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018;293:226-244 pubmed publisher
  • western blot; brown rat; 1:1000; fig 2
Zhao Y, Song J, Ma X, Zhang B, Li D, Pang H. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res. 2016;11:944-50 pubmed publisher
  • western blot; mouse; fig 6
Wang H, Wang R, Carrera I, Xu S, Lakshmana M. TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. Eneuro. 2016;3: pubmed publisher
  • western blot; human
Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher
  • western blot; mouse; fig 1
Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed publisher
  • western blot; human; 1:1000; fig 5
Hossini A, Megges M, Prigione A, Lichtner B, Toliat M, Wruck W, et al. Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. BMC Genomics. 2015;16:84 pubmed publisher
  • western blot; brown rat; 1:1000
Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, et al. Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 2019;10:2479 pubmed publisher
Yu W, Shi X, Cui X, Niu Y, Zhang W, Bai X, et al. Jian-Pi-Zhi-Dong-Decoction regulates the expression of glutamate transporters to attenuate glutamate excitotoxicity and exerts anti-tics effects in Tourette syndrome model rats. Neuropsychiatr Dis Treat. 2018;14:3381-3392 pubmed publisher
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, et al. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018;136:537-555 pubmed publisher
Rao C, Farooqui M, Zhang Y, Asch A, Yamada H. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018;:e12797 pubmed publisher
Huang W, Chen Y, Page D. Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome. Nat Commun. 2016;7:13421 pubmed publisher
Zhou L, Gao Q, Nie M, Gu J, Hao W, Wang L, et al. Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE-/- mice: implications for Alzheimer's disease. Sci Rep. 2016;6:36335 pubmed publisher
Gomes J, Nogueira R, Vieira M, Santos S, Ferraz Nogueira J, Relvas J, et al. Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia. Cell Death Differ. 2016;23:1749-1764 pubmed publisher
Wright D, Trezise J, Kamnaksh A, Bekdash R, Johnston L, Ordidge R, et al. Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury. Sci Rep. 2016;6:28713 pubmed publisher
Kim Y, Choi S, D Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, et al. A 3D human neural cell culture system for modeling Alzheimer's disease. Nat Protoc. 2015;10:985-1006 pubmed publisher
Whittington R, Virág L, Gratuze M, Petry F, Noël A, Poitras I, et al. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiol Aging. 2015;36:2414-28 pubmed publisher
Zigdon H, Savidor A, Levin Y, Meshcheriakova A, Schiffmann R, Futerman A. Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease. PLoS ONE. 2015;10:e0120194 pubmed publisher
Liu H, Lu S, Ho P, Tse H, Pang S, Kung M, et al. LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity. Ann Clin Transl Neurol. 2014;1:199-208 pubmed publisher
Whittington R, Virag L, Marcouiller F, Papon M, El Khoury N, Julien C, et al. Propofol directly increases tau phosphorylation. PLoS ONE. 2011;6:e16648 pubmed publisher
Bottley A, Phillips N, Webb T, Willis A, Spriggs K. eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease. PLoS ONE. 2010;5: pubmed publisher
Saiz Sanchez D, Ubeda Banon I, de la Rosa Prieto C, Argandoña Palacios L, Garcia Muñozguren S, Insausti R, et al. Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Exp Neurol. 2010;223:347-50 pubmed publisher
Wu G, Huang H, Garcia Abreu J, He X. Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS ONE. 2009;4:e4926 pubmed publisher
product information
SKU :
4019P
Product-Name :
Tau (Tau46) Mouse mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, (B)
Applications :
Immunofluorescence (Frozen)
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
50 to 80
Host :
Mouse
Target :
tau
Primary-Protein :
tau iso8
Alt-Names :
DDPAC,FLJ31424,FTDP-17,G protein beta1/gamma2 subunit-interacting factor 1,MAPT,MAPTL,MGC138549,MSTD,MTBT1,MTBT2,Microtubule-associated protein tau,Neurofibrillary tangle protein,PHF-tau,PPND,Paired helical filament-tau,TAU
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.