| Published Application/Species/Dilution | Reference |
|---|
- western blot; African green monkey; 1:1000
| Kren N, Zagon I, McLaughlin P. Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent. Exp Biol Med (Maywood). 2016;241:273-81 pubmed publisher |
- western blot; zebrafish ; 1:1000; fig 5
| Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci. 2016;17: pubmed publisher |
| Greenfeld H, Takasaki K, Walsh M, Ersing I, Bernhardt K, Ma Y, et al. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015;11:e1004890 pubmed publisher |
| Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher |
- immunocytochemistry; human
| Ehm P, Nalaskowski M, Wundenberg T, Jücker M. The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies. Nucleus. 2015;6:154-64 pubmed publisher |
- western blot; human; fig 5
| Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher |
- western blot; human
- western blot; mouse
| Fajardo V, Bombardier E, McMillan E, TRAN K, Wadsworth B, Gamu D, et al. Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype. Dis Model Mech. 2015;8:999-1009 pubmed publisher |
- western blot; human; 1:1000
| Martin S, Lovat P, Redfern C. Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells. J Cell Biochem. 2015;116:438-49 pubmed publisher |
| Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos M, Pardo V, Miquilena-Colina M, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5:e1179 pubmed publisher |
- immunocytochemistry; Caenorhabditis elegans; fig 4
| Guo B, Huang J, Wu W, Feng D, Wang X, Chen Y, et al. The nascent polypeptide-associated complex is essential for autophagic flux. Autophagy. 2014;10:1738-48 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Zhang L, Chen X, Sharma P, Moon M, Sheftel A, Dawood F, et al. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 2014;5:3430 pubmed publisher |
| Hauerslev S, Vissing J, Krag T. Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model. PLoS ONE. 2014;9:e100594 pubmed publisher |
- immunocytochemistry; human; fig 1
- western blot; human; fig 1
| Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher |
| Lemire B, Debigare R, Dubé A, Thériault M, Cote C, Maltais F. MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease. J Appl Physiol (1985). 2012;113:159-66 pubmed publisher |
| Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, et al. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells. Int J Oncol. 2015;46:474-86 pubmed publisher |
| Duggan S, Yan R, McCarthy J. A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains. FEBS Lett. 2015;589:1001-8 pubmed publisher |
| Shimokawa N, Koibuchi N. Downregulation of receptor tyrosine kinases through ubiquitination: analysis by immunodetection. Methods Mol Biol. 2015;1233:121-33 pubmed publisher |
| Shim H, Wei M, Brandhorst S, Longo V. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015;75:1056-67 pubmed publisher |
| Wada S, Matsushita Y, Tazawa H, Aoi W, Naito Y, Higashi A, et al. Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation. Free Radic Res. 2015;49:269-78 pubmed publisher |
| Bagheri-Yarmand R, Sinha K, Gururaj A, Ahmed Z, Rizvi Y, Huang S, et al. A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. J Biol Chem. 2015;290:11749-61 pubmed publisher |
| Lin Q, Wu F, Sheng P, Zhang Z, Zhang X, Guo X, et al. The SnRK2-APC/C(TE) regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways. Nat Commun. 2015;6:7981 pubmed publisher |
| Wade B, Wang C, Yan S, Bhat K, Huang B, Li S, et al. Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. J Neurosci. 2014;34:8411-22 pubmed publisher |
| Terada K, Horinouchi T, Fujioka Y, Higashi T, Nepal P, Horiguchi M, et al. Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors. J Biol Chem. 2014;289:35283-95 pubmed publisher |
| Huo L, Li C, Huang T, Lam Y, Xia W, Tu C, et al. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am J Transl Res. 2014;6:649-63 pubmed |
| Sisinni L, Maddalena F, Lettini G, Condelli V, Matassa D, Esposito F, et al. TRAP1 role in endoplasmic reticulum stress protection favors resistance to anthracyclins in breast carcinoma cells. Int J Oncol. 2014;44:573-82 pubmed publisher |
| Wecksler A, Hwang S, Wettersten H, Gilda J, Patton A, Leon L, et al. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014;25:433-46 pubmed publisher |
| Dong S, Zhao J, Wei J, Bowser R, Khoo A, Liu Z, et al. F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation. Mol Cancer. 2014;13:76 pubmed publisher |
| Nardon C, Schmitt S, Yang H, Zuo J, Fregona D, Dou Q. Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia. PLoS ONE. 2014;9:e84248 pubmed publisher |
| Chen X, Chinchilla P, Fombonne J, Ho L, Guix C, Keen J, et al. Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. Mol Cell Biol. 2014;34:3855-66 pubmed publisher |
| Bonacci T, Audebert S, Camoin L, Baudelet E, Bidaut G, Garcia M, et al. Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. J Proteome Res. 2014;13:2478-94 pubmed publisher |
| Zhang S, Tang W, Weng S, Liu X, Rao B, Gu J, et al. Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma. Oncotarget. 2014;5:7183-97 pubmed |
| Uren R, Turbic A, Wong A, Klein R, Murray S, Turnley A. A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology. J Neurochem. 2014;129:614-27 pubmed publisher |
| Homma T, Ishibashi D, Nakagaki T, Satoh K, Sano K, Atarashi R, et al. Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein. Sci Rep. 2014;4:4504 pubmed publisher |
| Joung H, Eom G, Choe N, Lee H, Ko J, Kwon D, et al. Ret finger protein mediates Pax7-induced ubiquitination of MyoD in skeletal muscle atrophy. Cell Signal. 2014;26:2240-8 pubmed publisher |
| Ribeiro-Rodrigues T, Catarino S, Marques C, Ferreira J, Martins-Marques T, Pereira P, et al. AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. FASEB J. 2014;28:4629-41 pubmed publisher |
| Kageyama S, Sou Y, Uemura T, Kametaka S, Saito T, Ishimura R, et al. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. J Biol Chem. 2014;289:24944-55 pubmed publisher |
| Steg A, Burke M, Amm H, Katre A, Dobbin Z, Jeong D, et al. Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer. Oncotarget. 2014;5:7065-80 pubmed |
| Li L, Yao Y, Gu X, Che D, Ma C, Dai Z, et al. Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J Biol Chem. 2014;289:32628-38 pubmed publisher |
| Yu T, Calvo L, Anta B, López-Benito S, López-Bellido R, Vicente-Garcia C, et al. In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J Neurosci. 2014;34:6098-106 pubmed publisher |
| Wilkie-Grantham R, Matsuzawa S, Reed J. Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein. J Biol Chem. 2013;288:12777-90 pubmed publisher |
| Peng C, Zhu F, Wen W, Yao K, Li S, Zykova T, et al. Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway. J Biol Chem. 2012;287:25881-92 pubmed publisher |
| Li X, Lu Y, Liang K, Hsu J, Albarracin C, Mills G, et al. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 2012;31:4372-83 pubmed publisher |
| Kuiken H, Egan D, Laman H, Bernards R, Beijersbergen R, Dirac A. Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling. J Cell Mol Med. 2012;16:2140-9 pubmed publisher |
| Downs C, Kumar A, KREINER L, Johnson N, Helms M. H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8. J Biol Chem. 2013;288:8136-45 pubmed publisher |
| Kashima L, Idogawa M, Mita H, Shitashige M, Yamada T, Ogi K, et al. CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation. J Biol Chem. 2012;287:12975-84 pubmed publisher |
| Lin A, Guttman J. Lack of Tir ubiquitylation contributes to enteropathogenic E. coli remaining extracellular during nonphagocytic cell infections. Anat Rec (Hoboken). 2012;295:1230-8 pubmed publisher |
| Grishina I, Debus K, García-Limones C, Schneider C, Shresta A, Garcia C, et al. SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation. Biochim Biophys Acta. 2012;1823:2287-96 pubmed publisher |
| Gui J, Yue Y, Chen R, Xu W, Xiong S. A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-κB signaling. PLoS ONE. 2012;7:e46515 pubmed publisher |
| Tseng S, Huang Y, Chen H, Chiu H, Huang Y, Wo T, et al. Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel. Biochem Pharmacol. 2013;85:583-94 pubmed publisher |
| Oh Y, Franck W, Han S, Shows A, Gokce E, Muddiman D, et al. Polyubiquitin is required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae. PLoS ONE. 2012;7:e42868 pubmed publisher |
| George J, Shukla Y. Early changes in proteome levels upon acute deltamethrin exposure in mammalian skin system associated with its neoplastic transformation potential. J Toxicol Sci. 2013;38:629-42 pubmed |
| Paterson A, Mockridge C, Adams J, Krysov S, Potter K, Duncombe A, et al. Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia. Blood. 2012;119:1726-36 pubmed publisher |
| Somborac-Bačura A, van der Toorn M, Franciosi L, Slebos D, Zanić-Grubisić T, Bischoff R, et al. Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells. Exp Physiol. 2013;98:316-25 pubmed publisher |
| Zhang Y, Gong J, Xing T, Zheng S, Ding W. Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells. Cell Death Dis. 2013;4:e550 pubmed publisher |
| Tschan S, Brouwer A, Werkhoven P, Jonker A, Wagner L, Knittel S, et al. Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrob Agents Chemother. 2013;57:3576-84 pubmed publisher |
| Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, et al. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep. 2013;3:1832 pubmed publisher |
| Shelly M, Cancedda L, Lim B, Popescu A, Cheng P, Gao H, et al. Semaphorin3A regulates neuronal polarization by suppressing axon formation and promoting dendrite growth. Neuron. 2011;71:433-46 pubmed publisher |
| Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, et al. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ. 2012;19:1482-94 pubmed publisher |
| Gabriel N, Hareendran S, Sen D, Gadkari R, Sudha G, Selot R, et al. Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. Hum Gene Ther Methods. 2013;24:80-93 pubmed publisher |
| Sen D, Gadkari R, Sudha G, Gabriel N, Kumar Y, Selot R, et al. Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods. 2013;24:104-16 pubmed publisher |
| Wei J, Mialki R, Dong S, Khoo A, Mallampalli R, Zhao Y, et al. A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2. Biochim Biophys Acta. 2013;1833:2757-64 pubmed publisher |
| Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, et al. BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis. Blood. 2012;119:2688-98 pubmed publisher |
| Wobst H, Forster S, Laurini C, Sekulla A, Dreiseidler M, Hohfeld J, et al. UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM. FEBS J. 2012;279:4398-409 pubmed publisher |
| Li W, Peng C, Lee M, Lim D, Zhu F, Fu Y, et al. TRAF4 is a critical molecule for Akt activation in lung cancer. Cancer Res. 2013;73:6938-50 pubmed publisher |
| Marangoudakis S, Andrade A, Helton T, Denome S, Castiglioni A, Lipscombe D. Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms. J Neurosci. 2012;32:10365-9 pubmed publisher |
| Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, et al. Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes. J Biol Chem. 2011;286:44057-66 pubmed publisher |
| Busch D, Morgan J. Synuclein accumulation is associated with cell-specific neuronal death after spinal cord injury. J Comp Neurol. 2012;520:1751-71 pubmed publisher |
| Jarzylo L, Man H. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci. 2012;32:2552-63 pubmed publisher |
| Blonska M, Joo D, Zweidler-McKay P, Zhao Q, Lin X. CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors. J Immunol. 2012;188:3160-8 pubmed publisher |
| Obitsu S, Sakata K, Teshima R, Kondo K. Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell Death Dis. 2013;4:e674 pubmed publisher |
| Thelen M, Damme M, Daμμe M, Schweizer M, Hagel C, Wong A, et al. Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis. PLoS ONE. 2012;7:e35493 pubmed publisher |
| Shen S, Lee W, Yang L, Tsai H, Yang L, Chen Y. Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes. Exp Dermatol. 2012;21:370-5 pubmed publisher |
