| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; pigs ; loading ...; fig 3a
| Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, et al. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathog. 2021;17:e1009940 pubmed publisher |
- western blot; mouse; 1:5000; loading ...; fig s3a
| Cui M, Atmanli A, Morales M, Tan W, Chen K, Xiao X, et al. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nat Commun. 2021;12:5270 pubmed publisher |
- western blot; human; loading ...; fig 1d
| Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed publisher |
- western blot; human; loading ...; fig 10b
| Sun M, Li J, Mao L, Wu J, Deng Z, He M, et al. p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy. Front Immunol. 2021;12:685523 pubmed publisher |
- western blot; human; loading ...; fig 5a, 5c
| Xia X, Huang C, Liao Y, Liu Y, He J, Shao Z, et al. The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression. Cell Death Dis. 2021;12:329 pubmed publisher |
- western blot; human; loading ...; fig 3k
| Cai H, Yu Y, Ni X, Li C, Hu Y, Wang J, et al. LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis. Cell Death Dis. 2020;11:1032 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5g
| Vatapalli R, Sagar V, Rodriguez Y, Zhao J, Unno K, Pamarthy S, et al. Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer. Nat Commun. 2020;11:4153 pubmed publisher |
- western blot; human; loading ...; fig 2f
| Osei Amponsa V, Sridharan V, Tandon M, Evans C, Klarmann K, Cheng K, et al. Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity. Mol Cell Biol. 2020;: pubmed publisher |
- western blot; mouse; loading ...; fig 6f, 6g, 6h, 6i
| Wang W, Hu D, Wu C, Feng Y, Li A, Liu W, et al. STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection. PLoS Pathog. 2020;16:e1008335 pubmed publisher |
- western blot; human; loading ...; fig 3a, s5b
| Park J, Burckhardt C, Lazcano R, Solis L, Isogai T, Li L, et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020;578:621-626 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Kwan S, Au Yeung C, Yeung T, Rynne Vidal A, Wong K, Risinger J, et al. Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression. Cancers (Basel). 2020;12: pubmed publisher |
- western blot; human; loading ...; fig 2d
| Zhou H, Zeng H, Yuan D, Ren J, Cheng S, Yu H, et al. NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma. Cell Commun Signal. 2019;17:168 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s1e
| Zhang Y, Thery F, Wu N, Luhmann E, Dussurget O, Foecke M, et al. The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Nat Commun. 2019;10:5383 pubmed publisher |
- western blot; human; loading ...; fig 7a
| Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, et al. Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via the inhibition of Smurf1 expression. Br J Pharmacol. 2019;: pubmed publisher |
- western blot; human; 1:500; loading ...; fig 7d, 7e
| Yang Y, Willis T, Button R, Strang C, Fu Y, Wen X, et al. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat Commun. 2019;10:3759 pubmed publisher |
- western blot; human; loading ...; fig 4s1b
| Kabir S, Cidado J, Andersen C, Dick C, Lin P, Mitros T, et al. The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells. elife. 2019;8: pubmed publisher |
- western blot; mouse; loading ...; fig 4e
| Lim J, Park H, Heisler J, Maculins T, Roose Girma M, Xu M, et al. Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins. elife. 2019;8: pubmed publisher |
- western blot; mouse; 1:5000; loading ...; fig 5b
| An D, Fujiki R, Iannitelli D, Smerdon J, Maity S, Rose M, et al. Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. elife. 2019;8: pubmed publisher |
- western blot; mouse; loading ...; fig s6c
| Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 2a
| Lee L, Seager R, Nakamura Y, Wilkinson K, Henley J. Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). PLoS ONE. 2019;14:e0213116 pubmed publisher |
- western blot; human; loading ...; fig s2g
| Lee Y, Chen M, Lee J, Zhang J, Lin S, Fu T, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019;364: pubmed publisher |
- western blot; human; loading ...; fig 4e
| Sandstrom A, Mitchell P, Goers L, Mu E, Lesser C, Vance R. Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019;364: pubmed publisher |
- western blot; human; loading ...; fig 5b
| Zhao Y, Yu Y, Li H, Zhang Z, Guo S, Zhu S, et al. FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma. Mol Oncol. 2019;13:1150-1165 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Turowec J, Lau E, Wang X, Brown K, Fellouse F, Jawanda K, et al. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. J Biol Chem. 2019;294:1396-1409 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Lingel H, Wissing J, Arra A, Schanze D, Lienenklaus S, Klawonn F, et al. CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation. Cell Death Differ. 2017;24:1739-1749 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Liu H, Wang K, Chen S, Sun Q, Zhang Y, Chen L, et al. NFATc1 phosphorylation by DYRK1A increases its protein stability. PLoS ONE. 2017;12:e0172985 pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 4g
| Xiang J, Yang S, Xin N, Gaertig M, Reeves R, Li S, et al. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proc Natl Acad Sci U S A. 2017;114:E1224-E1233 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, et al. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog. 2017;13:e1006162 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2b
| Myöhänen T, Norrbacka S, Savolainen M. Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture. Neurosci Lett. 2017;636:83-89 pubmed publisher |
| McKelvey A, Lear T, Dunn S, Evankovich J, Londino J, Bednash J, et al. RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. elife. 2016;5: pubmed publisher |
- western blot; human; loading ...; fig 5b
| Ding S, Mooney N, Li B, Kelly M, Feng N, Loktev A, et al. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016;12:e1005929 pubmed publisher |
- immunohistochemistry; mouse; 1:300; loading ...; fig 6j
| Wu Q, Yang X, Zhang Y, Zhang L, Feng L. Chronic mild stress accelerates the progression of Parkinson's disease in A53T ?-synuclein transgenic mice. Exp Neurol. 2016;285:61-71 pubmed publisher |
- western blot; mouse; loading ...; fig 10c
| Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed publisher |
- western blot; human; loading ...; fig 1h
| Mo Z, Zhang Q, Liu Z, Lauer J, Shi Y, Sun L, et al. Neddylation requires glycyl-tRNA synthetase to protect activated E2. Nat Struct Mol Biol. 2016;23:730-7 pubmed publisher |
- western blot; human; 1:1000; fig 8
| Bento C, Ashkenazi A, Jimenez Sanchez M, Rubinsztein D. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016;7:11803 pubmed publisher |
- western blot; human; loading ...; fig 3c
| Trousil S, Kaliszczak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. 2016;7:37103-37120 pubmed publisher |
- western blot; human; loading ...; fig 2e
| Swiader A, Nahapetyan H, Faccini J, D Angelo R, Mucher E, Elbaz M, et al. Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Oncotarget. 2016;7:28821-35 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Jo S, Lee Y, Kim S, Lee H, Chung H. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Biochim Biophys Acta. 2016;1863:1499-509 pubmed publisher |
- western blot; human; 1:1000; fig 8
| Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher |
- immunohistochemistry - frozen section; mouse; fig 4
| Li M, Lu G, Hu J, Shen X, Ju J, Gao Y, et al. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports. 2016;6:396-410 pubmed publisher |
- western blot; human; loading ...; fig ev1d
| Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed publisher |
- western blot; human; fig 4
| Lei Y, Kansy B, Li J, Cong L, Liu Y, Trivedi S, et al. EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex. Oncogene. 2016;35:4698-707 pubmed publisher |
- western blot; mouse; 1:3000; fig s11
| Tai D, Liu Y, Hsu W, Ma Y, Cheng S, Liu S, et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016;7:10552 pubmed publisher |
- western blot; zebrafish ; 1:1000; fig 5
| Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci. 2016;17: pubmed publisher |
- immunoprecipitation; rat; 1:1000; fig 5
| Kwon D, Eom G, Ko J, Shin S, Joung H, Choe N, et al. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun. 2016;7:10492 pubmed publisher |
| Asano S, Arvapalli R, Manne N, Maheshwari M, Ma B, Rice K, et al. Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction. Int J Nanomedicine. 2015;10:6215-25 pubmed publisher |
- western blot; African green monkey; 1:1000
| Kren N, Zagon I, McLaughlin P. Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent. Exp Biol Med (Maywood). 2016;241:273-81 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher |
- other; mouse; 1:500; fig s1
| Chiang C, Uzoma I, Lane D, Memišević V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher |
- western blot; human
- western blot; mouse
| Fajardo V, Bombardier E, McMillan E, TRAN K, Wadsworth B, Gamu D, et al. Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype. Dis Model Mech. 2015;8:999-1009 pubmed publisher |
| Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher |
| Greenfeld H, Takasaki K, Walsh M, Ersing I, Bernhardt K, Ma Y, et al. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015;11:e1004890 pubmed publisher |
- western blot; human; fig s5
| Cheng J, Yang H, Fang J, Ma L, Gong R, Wang P, et al. Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 2015;6:7023 pubmed publisher |
- immunocytochemistry; human
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- immunohistochemistry; mouse; fig 7
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- immunohistochemistry - frozen section; mouse; 1:200; fig s9
- western blot; mouse; 1:1000; fig 3
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| Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Nakashima H, Nguyen T, Goins W, Chiocca E. Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015;290:1485-95 pubmed publisher |
- western blot; human; 1:1000
| Martin S, Lovat P, Redfern C. Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells. J Cell Biochem. 2015;116:438-49 pubmed publisher |
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