| Published Application/Species/Dilution | Reference |
|---|
- western blot; mouse; fig 1
| Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed publisher |
- western blot; mouse; fig 4
- western blot; rat; fig 6
| Ren J, Li J, Liu X, Feng Y, Gui Y, Yang J, et al. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling. Sci Rep. 2016;6:23968 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, et al. A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria. Mol Med Rep. 2016;14:1970-8 pubmed publisher |
- western blot; human; fig 3
| Ratovitski E. Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. Mar Drugs. 2016;14: pubmed publisher |
- immunocytochemistry; human; fig 4
| Xiao L, Shi X, Zhang Y, Zhu Y, Zhu L, Tian W, et al. YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells. Onco Targets Ther. 2016;9:1105-14 pubmed publisher |
- western blot; human; fig 1
| Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, et al. BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget. 2016;7:9188-221 pubmed publisher |
- western blot; human; 1:5000; fig 3
| Andersson A, Andersson B, Lorell C, Raffetseder J, Larsson M, Blomgran R. Autophagy induction targeting mTORC1 enhances Mycobacterium tuberculosis replication in HIV co-infected human macrophages. Sci Rep. 2016;6:28171 pubmed publisher |
- western blot; rat; 1:1000; fig 2
| Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher |
- western blot; human; fig 3
| Yi Y, Kang H, Bae E, Oh S, Seong Y, Bae I. β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells. Exp Mol Med. 2015;47:e143 pubmed publisher |
- western blot; human; fig 6
| Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, et al. The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell. 2015;14:274-83 pubmed publisher |
- western blot; human; 1:1000
| Porter K, Hirt J, Stamer W, Liton P. Autophagic dysregulation in glaucomatous trabecular meshwork cells. Biochim Biophys Acta. 2015;1852:379-85 pubmed publisher |
| Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-52 pubmed publisher |
- immunocytochemistry; mouse
| Chen G, Meng C, Lin K, Tuan H, Yang H, Chen C, et al. Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials. 2015;40:12-22 pubmed publisher |
- western blot; human; 1:1000; fig s14
- immunocytochemistry; human; fig s16
| Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed publisher |
- immunocytochemistry; human
| Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed publisher |
- western blot; human; fig 1
- immunocytochemistry; human; fig 2
| Johansson I, Monsen V, Pettersen K, Mildenberger J, Misund K, Kaarniranta K, et al. The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. Autophagy. 2015;11:1636-51 pubmed publisher |
- immunocytochemistry; human; fig 4
| Wang J, Ma L, Tang X, Zhang X, Qiao Y, Shi Y, et al. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. 2015;6:24075-91 pubmed |
- western blot; rat; fig 4f
| Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher |
- western blot; pig; fig 7
- western blot; mouse; fig 8
- immunohistochemistry; mouse; fig 8
| Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Autophagy. 2015;11:1081-98 pubmed publisher |
- western blot; human; 1:1000
| Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher |
- western blot; human; 1:1000; fig 1,2,3,4,5,6,7
| Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher |
- western blot; mouse; fig 1
| Roe N, Xu X, Kandadi M, Hu N, Pang J, Weiser-Evans M, et al. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015;1852:290-8 pubmed publisher |
| Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher |
- western blot; human; fig 1
| Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher |
- immunocytochemistry; rat; 1:250
| Arel-Dubeau A, Longpre F, Bournival J, Tremblay C, Demers-Lamarche J, Haskova P, et al. Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. Oxid Med Cell Longev. 2014;2014:425496 pubmed publisher |
- immunocytochemistry; human; 1:200
| Mancias J, Wang X, Gygi S, Harper J, Kimmelman A. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105-9 pubmed publisher |
- immunocytochemistry; mouse
| Roost M, van Iperen L, De Melo Bernardo A, Mummery C, Carlotti F, de Koning E, et al. Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell. 2014;6:22 pubmed publisher |
| Brown D, LASSEGUE B, Lee M, Zafari R, Long J, Saavedra H, et al. Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. PLoS ONE. 2014;9:e96657 pubmed publisher |
- western blot; human; fig 6
| Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, et al. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle. 2014;13:3878-91 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:50
| Bifsha P, Yang J, Fisher R, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10:e1004863 pubmed publisher |
- immunohistochemistry - frozen section; mouse
- western blot; rat
| Li J, Xu Z, Jiang L, Mao J, Zeng Z, Fang L, et al. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int. 2014;86:86-102 pubmed publisher |
- immunohistochemistry - paraffin section; human
- western blot; human
| Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher |
- western blot; human; 1:1000
| Porter K, Jeyabalan N, Liton P. MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. Biochim Biophys Acta. 2014;1843:1054-62 pubmed publisher |
- immunocytochemistry; human; 1:200
- western blot; human; 1:500
| Nitta T, Sato Y, Ren X, Harada K, Sasaki M, Hirano S, et al. Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma. Int J Clin Exp Pathol. 2014;7:4913-21 pubmed |
- immunohistochemistry - paraffin section; human; 1:75
| Liu Y, Wan S, Zhang P, Zhang W, Zheng J, Lin J, et al. Expression levels of autophagy related proteins and their prognostic significance in retinocytoma and retinoblastoma. Int J Ophthalmol. 2014;7:594-601 pubmed publisher |
- western blot; human; 1:1000
| Yuan Y, Tang A, Castoreno A, Kuo S, Wang Q, Kuballa P, et al. Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis. 2013;4:e690 pubmed publisher |
| Newman A, Scholefield C, Kemp A, Newman M, McIver E, Kamal A, et al. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE. 2012;7:e50672 pubmed publisher |
- western blot; mouse; 1:2000
| Willis M, Min J, Wang S, McDonough H, Lockyer P, Wadosky K, et al. Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise. Cell Biochem Funct. 2013;31:724-35 pubmed publisher |
| Ranjan A, Srivastava S. Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 2016;6:26165 pubmed publisher |
| Shen C, Wang C, Fan F, Yang Z, Cao Q, Liu X, et al. Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway. Biochim Biophys Acta. 2015;1852:310-8 pubmed publisher |
| Ali J, Lagasse B, Minuk A, Love A, Moraya A, Lam L, et al. Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells. Int J Cancer. 2015;136:E455-69 pubmed publisher |
| Chen X, Wu J, You X, Zhu H, Wei J, Xu M. Cold ischemia-induced autophagy in rat lung tissue. Mol Med Rep. 2015;11:2513-9 pubmed publisher |
| Zhong W, Zhu H, Sheng F, Tian Y, Zhou J, Chen Y, et al. Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy. 2014;10:1285-300 pubmed publisher |
| Ye L, Yu J, Liang Y, Zeng J, Huang R, Liao S. Beclin 1 knockdown retards re-endothelialization and exacerbates neointimal formation via a crosstalk between autophagy and apoptosis. Atherosclerosis. 2014;237:146-54 pubmed publisher |
| Ringer L, Sirajuddin P, Tricoli L, Waye S, Choudhry M, Parasido E, et al. The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells. Oncotarget. 2014;5:10678-91 pubmed |
| Coffey E, Beckel J, Laties A, Mitchell C. Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP. Neuroscience. 2014;263:111-24 pubmed publisher |
| Lee H, Lee J, Park M, Hong Y, Marti H, Kim H, et al. Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. Nat Commun. 2014;5:5514 pubmed publisher |
| Wei M, Chen M, Chen K, Lou P, Lin S, Hung S, et al. Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Autophagy. 2014;10:1179-92 pubmed publisher |
| Porter K, Nallathambi J, Lin Y, Liton P. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013;9:581-94 pubmed publisher |
| Chertov A, Holzhausen L, Kuok I, Couron D, Parker E, Linton J, et al. Roles of glucose in photoreceptor survival. J Biol Chem. 2011;286:34700-11 pubmed publisher |
| Gao D, Inuzuka H, Tan M, Fukushima H, Locasale J, Liu P, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011;44:290-303 pubmed publisher |
| Xu X, Bucala R, Ren J. Macrophage migration inhibitory factor deficiency augments doxorubicin-induced cardiomyopathy. J Am Heart Assoc. 2013;2:e000439 pubmed publisher |
