product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
LC3B (D11) XP® Rabbit mAb
catalog :
3868
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D11
reactivity :
hamsters, human, mouse, rat, bovine, pigs , thale cress
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 165
Published Application/Species/Sample/DilutionReference
  • western blot; thale cress; fig 5c
Minton D, Elliehausen C, Javors M, Santangello K, Konopka A. Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis. Arthritis Res Ther. 2021;23:253 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 4a
Cao Y, Li Q, Yang Y, Ke Z, Chen S, Li M, et al. Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Front Cardiovasc Med. 2021;8:694219 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5f
Zeng H, Chen H, Li M, Zhuang J, Peng Y, Zhou H, et al. Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH. J Neuroinflammation. 2021;18:210 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Lee S, Chen Y, Chien C, Yan Y, Chen H, Chuang H, et al. Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model. PLoS ONE. 2021;16:e0254587 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4a
Liu M, Shan M, Zhang Y, Guo Z. Progranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma. J Inflamm Res. 2021;14:3891-3904 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Ding B, Bao C, Jin L, Xu L, Fan W, Lou W. CASK Silence Overcomes Sorafenib Resistance of Hepatocellular Carcinoma Through Activating Apoptosis and Autophagic Cell Death. Front Oncol. 2021;11:681683 pubmed publisher
  • western blot; human; loading ...; fig 1a, 1i
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000; loading ...; fig 4a
Wu Q, Tian A, Li B, Leduc M, Forveille S, Hamley P, et al. IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. J Immunother Cancer. 2021;9: pubmed publisher
  • western blot; mouse; loading ...; fig s2l
Basse A, Agerholm M, Farup J, Dalbram E, Nielsen J, Ørtenblad N, et al. Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity. Mol Metab. 2021;53:101271 pubmed publisher
  • western blot; human; 1:2000; fig 2e
Ray U, Roy D, Jin L, Thirusangu P, Staub J, Xiao Y, et al. Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. J Exp Clin Cancer Res. 2021;40:182 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Urdiciain A, Erausquin E, Zelaya M, Zazpe I, Lanciego J, Melendez B, et al. Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines. Biology (Basel). 2021;10: pubmed publisher
  • immunocytochemistry; human; 1:500; fig s3a
  • western blot; human; 1:1000; fig s3c
Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, et al. Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep. 2021;35:109024 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Dong W, Zhang H, Zhao C, Luo Y, Chen Y. Silencing of miR-150-5p Ameliorates Diabetic Nephropathy by Targeting SIRT1/p53/AMPK Pathway. Front Physiol. 2021;12:624989 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Shen S, Li B, Dai J, Wu Z, He Y, Wen L, et al. BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux. Front Pharmacol. 2020;11:618 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3a
Sozen E, Yazgan B, Tok O, Demirel T, Ercan F, Proto J, et al. Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue. Metabolism. 2020;106:154205 pubmed publisher
  • immunohistochemistry - paraffin section; rat; loading ...; fig 2a
  • western blot; rat; 1:1000; loading ...; fig 2e, 4e
Yan S, Ding H, Peng J, Wang X, Pang C, Wei J, et al. Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro. Biosci Rep. 2020;40: pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 6
Li J, Zhang W, Zhu S, Shi F. Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats. Animals (Basel). 2020;10: pubmed publisher
  • western blot; human; loading ...; fig 1j
Dai E, Han L, Liu J, Xie Y, Kroemer G, Klionsky D, et al. Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein. Autophagy. 2020;:1-15 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3e
Zhao X, Nedvetsky P, Stanchi F, Vion A, Popp O, Zühlke K, et al. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3f
  • western blot; human; loading ...; fig 3g
Li J, Shi K, Sabet Z, Fu W, Zhou H, Xu S, et al. New power of self-assembling carbonic anhydrase inhibitor: Short peptide-constructed nanofibers inspire hypoxic cancer therapy. Sci Adv. 2019;5:eaax0937 pubmed publisher
  • western blot; human; loading ...; fig 4b
Zhang B, Chen H, Ouyang J, Xie Y, Chen L, Tan Q, et al. SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect. Autophagy. 2019;:1-17 pubmed publisher
  • western blot; human; loading ...; fig 5a
Liu H, Feng X, Yang B, Tong R, Lu Y, Chen D, et al. Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway. Am J Transl Res. 2019;11:4713-4725 pubmed
  • western blot; human; loading ...; fig 2a
He R, Wang M, Zhao C, Shen M, Yu Y, He L, et al. TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. J Exp Clin Cancer Res. 2019;38:340 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3c
  • western blot; human; loading ...; fig 3a
Ni Z, Kuang L, Chen H, Xie Y, Zhang B, Ouyang J, et al. The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis. Cell Death Dis. 2019;10:522 pubmed publisher
  • western blot; human; loading ...; fig s8k
Xu D, Li X, Shao F, Lv G, Lv H, Lee J, et al. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Sci Adv. 2019;5:eaav4570 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 6f
  • western blot; mouse; 1:500; loading ...; fig 8a
Hass D, Barnstable C. Mitochondrial Uncoupling Protein 2 Knock-out Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in a Mouse Model of Glaucoma. J Neurosci. 2019;39:3582-3596 pubmed publisher
  • western blot; human; loading ...
Yambire K, Fernández Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, et al. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; loading ...; fig e3b
  • western blot; human; loading ...; fig 1b
Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1d
Cui Y, Carosi J, Yang Z, Ariotti N, Kerr M, Parton R, et al. Retromer has a selective function in cargo sorting via endosome transport carriers. J Cell Biol. 2019;218:615-631 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4c
  • western blot; human; loading ...; fig 1b
Nitta A, Hori K, Tanida I, Igarashi A, Deyama Y, Ueno T, et al. Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S. Biochem Biophys Res Commun. 2019;508:521-526 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s1a, s1b
Huang X, Wang X, Yuan X, Wu W, Lobie P, Wu Z. XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation. Oncogene. 2019;38:1448-1460 pubmed publisher
  • western blot; human; loading ...; fig 1c
Yang M, Li C, Zhu S, Cao L, Kroemer G, Zeh H, et al. TFAM is a novel mediator of immunogenic cancer cell death. Oncoimmunology. 2018;7:e1431086 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 1h
Leeman D, Hebestreit K, Ruetz T, Webb A, McKay A, Pollina E, et al. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science. 2018;359:1277-1283 pubmed publisher
  • western blot; mouse; 1:1000; fig 3a
Shroff A, Sequeira R, Patel V, Reddy K. Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans. Cell Immunol. 2018;324:59-73 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4d
  • western blot; human; loading ...; fig 4i
Smith M, Harley M, Kemp A, Wills J, Lee M, Arends M, et al. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 2018;44:217-232.e11 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 6d
Jimenez Orgaz A, Kvainickas A, Nägele H, Denner J, Eimer S, Dengjel J, et al. Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy. EMBO J. 2018;37:235-254 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
  • western blot; mouse; 1:1000; loading ...; fig 5d
Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
  • western blot; human; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 1a
Ruan H, Ma Y, Torres S, Zhang B, Feriod C, Heck R, et al. Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes Dev. 2017;31:1655-1665 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Dai S, Dulcey A, Hu X, Wassif C, Porter F, Austin C, et al. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 2017;13:1435-1451 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3e
Tan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 6c
  • western blot; human; 1:1000; fig 3b
Wang G, Zhou H, Strulovici Barel Y, Al Hijji M, Ou X, Salit J, et al. Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium. Autophagy. 2017;13:1205-1220 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1d
  • western blot; human; 1:1000; loading ...; fig 3h
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6
Xiao Z, Gaertner S, Morresi Hauf A, Genzel R, Duell T, Ullrich A, et al. Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients. Neoplasia. 2017;19:385-395 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s3a
  • western blot; human; loading ...; fig 2b
Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, et al. Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer. Cancer Immunol Res. 2017;5:363-375 pubmed publisher
  • western blot; human; loading ...; fig 5a
Xu Q, Zhu N, Chen S, Zhao P, Ren H, Zhu S, et al. E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells. Sci Rep. 2017;7:45375 pubmed publisher
  • western blot; human; loading ...; fig 8a
Marwaha R, Arya S, Jagga D, Kaur H, Tuli A, Sharma M. The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. J Cell Biol. 2017;216:1051-1070 pubmed publisher
  • immunocytochemistry; mouse; fig 2c
  • western blot; mouse; loading ...; fig 8a
Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
  • western blot; human; loading ...; fig 2a
Møller A, Kampmann U, Hedegaard J, Thorsen K, Nordentoft I, Vendelbo M, et al. Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes. Sci Rep. 2017;7:43775 pubmed publisher
  • western blot; human; loading ...; fig 4b
Datta S, Choudhury D, Das A, Das Mukherjee D, Das N, Roy S, et al. Paclitaxel resistance development is associated with biphasic changes in reactive oxygen species, mitochondrial membrane potential and autophagy with elevated energy production capacity in lung cancer cells: A chronological study. Tumour Biol. 2017;39:1010428317694314 pubmed publisher
  • western blot; mouse; fig 3D
Kemter E, Frohlich T, Arnold G, Wolf E, Wanke R. Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD). Sci Rep. 2017;7:42970 pubmed publisher
  • western blot; human; loading ...; fig 4a,4d,4H,4i,,5F
  • western blot; mouse; loading ...; fig 4c
Roy D, Mondal S, Khurana A, Jung D, Hoffmann R, He X, et al. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. Sci Rep. 2017;7:41977 pubmed publisher
  • western blot; human; fig 2g
Kim M, Deng H, Wong Y, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Hum Mol Genet. 2017;26:729-741 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4c
Coccia M, Rossi A, Riccio A, Trotta E, Santoro M. Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance. Proc Natl Acad Sci U S A. 2017;114:1045-1050 pubmed publisher
  • western blot; human; loading ...; fig 1c
Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed publisher
  • western blot; rat; fig 3d
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2e
  • western blot; mouse; loading ...; fig 2a
Li J, Chen T, Xiao M, Li N, Wang S, Su H, et al. Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1. Oncotarget. 2016;7:86648-86659 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 1b
Lim J, Kim H, Nguyen K, Cho K. The role of TLR9 in stress-dependent autophagy formation. Biochem Biophys Res Commun. 2016;481:219-226 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2a
Yang M, Wang B, Miao L, Xu X, He X. Autophagy is involved in aldosterone‑induced mesangial cell proliferation. Mol Med Rep. 2016;14:4638-4642 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6g
Mercado Pimentel M, Igarashi S, Dunn A, Behbahani M, Miller C, Read C, et al. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation. Austin J Med Oncol. 2016;3: pubmed
  • western blot; mouse; loading ...; fig 2d
Qin Y, Liu Y, Hao W, Decker Y, Tomic I, Menger M, et al. Stimulation of TLR4 Attenuates Alzheimer's Disease-Related Symptoms and Pathology in Tau-Transgenic Mice. J Immunol. 2016;197:3281-3292 pubmed
  • western blot; human; loading ...; fig 2a
Mirkheshti N, Park S, Jiang S, Cropper J, Werner S, Song C, et al. Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer. Oncotarget. 2016;7:62240-62254 pubmed publisher
  • western blot; human; fig 3
Ratovitski E. Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. Mar Drugs. 2016;14: pubmed publisher
  • western blot; human; fig 3
Weikel K, Cacicedo J, Ruderman N, Ido Y. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016;36: pubmed publisher
  • western blot; human; 1:1000; fig 3d,4b,7b
Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed publisher
  • western blot; human; 1:1000; fig 3
Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, et al. A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria. Mol Med Rep. 2016;14:1970-8 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Hewitt G, Carroll B, Sarallah R, Correia Melo C, Ogrodnik M, Nelson G, et al. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 2016;12:1917-1930 pubmed
  • western blot; human; 1:5000; fig 3
Andersson A, Andersson B, Lorell C, Raffetseder J, Larsson M, Blomgran R. Autophagy induction targeting mTORC1 enhances Mycobacterium tuberculosis replication in HIV co-infected human macrophages. Sci Rep. 2016;6:28171 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 6d
  • immunocytochemistry; human; 1:200; loading ...; fig 3b
  • western blot; human; loading ...; fig 3f
Ranjan A, Srivastava S. Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 2016;6:26165 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1b
Koskela A, Reinisalo M, Petrovski G, Sinha D, Olmiere C, Karjalainen R, et al. Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Nutrients. 2016;8: pubmed publisher
  • western blot; rat; 1:1000; fig 2
Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium?sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher
  • western blot; human; fig 1a
Xu J, Li J, Wang J, Chi Y, Zhang K, Cui R. Heme oxygenase?1 protects H2O2?insulted glomerular mesangial cells from excessive autophagy. Mol Med Rep. 2016;13:5269-75 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 4b
  • immunocytochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 1a
Follo C, Barbone D, Richards W, Bueno R, Broaddus V. Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome. Autophagy. 2016;12:1180-94 pubmed publisher
  • western blot; human; fig s1c
Pryde K, Smith H, Chau K, Schapira A. PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. J Cell Biol. 2016;213:163-71 pubmed publisher
  • western blot; human; fig 2
Wang Q, Xue L, Zhang X, Bu S, Zhu X, Lai D. Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress. Cell Cycle. 2016;15:1376-85 pubmed publisher
  • immunocytochemistry; human; fig 4
Xiao L, Shi X, Zhang Y, Zhu Y, Zhu L, Tian W, et al. YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells. Onco Targets Ther. 2016;9:1105-14 pubmed publisher
  • western blot; mouse; fig 4
  • western blot; rat; fig 6
Ren J, Li J, Liu X, Feng Y, Gui Y, Yang J, et al. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling. Sci Rep. 2016;6:23968 pubmed publisher
  • immunocytochemistry; hamsters; 1:200; loading ...; fig 3d
  • immunocytochemistry; human; 1:200; loading ...; fig 3d
  • western blot; human; 1:1000; loading ...; fig 1d
Zhang W, Shi H, Zhang M, Liu B, Mao S, Li L, et al. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. Int J Biochem Cell Biol. 2016;73:127-136 pubmed publisher
  • western blot; human; fig 3
Kim M, Sandford E, Gatica D, Qiu Y, Liu X, Zheng Y, et al. Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. elife. 2016;5: pubmed publisher
  • western blot; human; fig 1
Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, et al. BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget. 2016;7:9188-221 pubmed publisher
  • immunoprecipitation; mouse; 1:1000; loading ...; fig 6a
  • western blot; mouse; 1:1000; loading ...; fig 3a
Wu B, Yu L, Wang Y, Wang H, Li C, Yin Y, et al. Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. Oncotarget. 2016;7:2175-88 pubmed publisher
  • western blot; mouse; fig 1
Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed publisher
  • western blot; human; fig s4
Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed publisher
  • western blot; human; fig 5
Martínez Zamora A, Meseguer S, Esteve J, Villarroya M, Aguado C, Enríquez J, et al. Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier. PLoS ONE. 2015;10:e0144273 pubmed publisher
  • western blot; mouse; fig 6
McIlroy G, Tammireddy S, Maskrey B, Grant L, Doherty M, Watson D, et al. Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue. Biochem Pharmacol. 2016;100:86-97 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 5a
  • western blot; human; loading ...; fig 5c
Pettersen K, Monsen V, Hakvåg Pettersen C, Overland H, Pettersen G, Samdal H, et al. DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy. Free Radic Biol Med. 2016;90:158-72 pubmed publisher
  • chromatin immunoprecipitation; human; fig 2
  • immunoprecipitation; human; fig 1
  • immunocytochemistry; human; fig 3
  • western blot; human; fig 1
Dou Z, Xu C, Donahue G, Shimi T, Pan J, Zhu J, et al. Autophagy mediates degradation of nuclear lamina. Nature. 2015;527:105-9 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 1
Johansson I, Monsen V, Pettersen K, Mildenberger J, Misund K, Kaarniranta K, et al. The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. Autophagy. 2015;11:1636-51 pubmed publisher
  • immunocytochemistry; human
Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed publisher
  • western blot; human; loading ...; fig 3c, 4a
Yang S, Lin H, Chang V, Chen C, Liu Y, Wang J, et al. Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo. Oncotarget. 2015;6:23857-73 pubmed
  • western blot; human; fig 3
Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, et al. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015;16:838-849 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:4000; loading ...; fig 1d
  • western blot; human; 1:1000; fig 1e
Metge B, Mitra A, Chen D, Shevde L, Samant R. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015;5:11995 pubmed publisher
  • immunocytochemistry; human; fig s16
  • western blot; human; 1:1000; fig s14
Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed publisher
  • immunocytochemistry; human; fig 4
Wang J, Ma L, Tang X, Zhang X, Qiao Y, Shi Y, et al. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. 2015;6:24075-91 pubmed
  • flow cytometry; human; loading ...; fig 3b
  • immunohistochemistry; human; loading ...; fig 2c
Campbell G, Rawat P, Bruckman R, Spector S. Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration. PLoS Pathog. 2015;11:e1005018 pubmed publisher
  • western blot; mouse; loading ...; fig 2
Giordano C, Lemaire C, Li T, Kimoff R, Petrof B. Autophagy-associated atrophy and metabolic remodeling of the mouse diaphragm after short-term intermittent hypoxia. PLoS ONE. 2015;10:e0131068 pubmed publisher
  • immunohistochemistry; mouse; fig 8
  • western blot; mouse; fig 8
  • western blot; pigs ; fig 7
Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Autophagy. 2015;11:1081-98 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2d
Huang C, Lee C, Lin H, Chen M, Lin C, Chang J. Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells. PLoS ONE. 2015;10:e0128045 pubmed publisher
  • western blot; rat; fig 1
Li J, Ren J, Liu X, Jiang L, He W, Yuan W, et al. Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis. Kidney Int. 2015;88:515-27 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 5
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
  • western blot; human; loading ...; fig 2a
Zhao J, Molitor T, Langston J, Nichols R. LRRK2 dephosphorylation increases its ubiquitination. Biochem J. 2015;469:107-20 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:1000
Meidhof S, Brabletz S, Lehmann W, Preca B, Mock K, Ruh M, et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol Med. 2015;7:831-47 pubmed publisher
  • immunocytochemistry; mouse
Roost M, van Iperen L, De Melo Bernardo A, Mummery C, Carlotti F, de Koning E, et al. Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell. 2014;6:22 pubmed publisher
  • western blot; human; 1:1000; fig 1,2,3,4,5,6,7
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher
  • western blot; human; fig 3
Yi Y, Kang H, Bae E, Oh S, Seong Y, Bae I. β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells. Exp Mol Med. 2015;47:e143 pubmed publisher
  • western blot; human; loading ...; fig 4c
Greenall S, Donoghue J, van Sinderen M, Dubljevic V, Budiman S, Devlin M, et al. EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications. Oncogene. 2015;34:5277-87 pubmed publisher
  • western blot; human; fig 6
Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, et al. The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell. 2015;14:274-83 pubmed publisher
  • western blot; human; fig 2
Rohatgi R, Janusis J, Leonard D, Bellvé K, Fogarty K, Baehrecke E, et al. Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene. 2015;34:5352-62 pubmed publisher
  • immunocytochemistry; rat; 1:250
Arel Dubeau A, Longpré F, Bournival J, Tremblay C, Demers Lamarche J, Haskova P, et al. Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. Oxid Med Cell Longev. 2014;2014:425496 pubmed publisher
  • western blot; rat; fig 4
Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher
  • western blot; human; fig 6
Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, et al. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle. 2014;13:3878-91 pubmed publisher
  • western blot; rat; fig 4f
Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Bifsha P, Yang J, Fisher R, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10:e1004863 pubmed publisher
  • immunocytochemistry; mouse
Chen G, Meng C, Lin K, Tuan H, Yang H, Chen C, et al. Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials. 2015;40:12-22 pubmed publisher
  • western blot; human; loading ...; fig 3a
Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher
  • western blot; human; 1:1000
Porter K, Hirt J, Stamer W, Liton P. Autophagic dysregulation in glaucomatous trabecular meshwork cells. Biochim Biophys Acta. 2015;1852:379-85 pubmed publisher
  • western blot; human; 1:1000
Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher
  • western blot; mouse; fig 1
Roe N, Xu X, Kandadi M, Hu N, Pang J, Weiser Evans M, et al. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015;1852:290-8 pubmed publisher
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:500
Nitta T, Sato Y, Ren X, Harada K, Sasaki M, Hirano S, et al. Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma. Int J Clin Exp Pathol. 2014;7:4913-21 pubmed
  • immunohistochemistry - paraffin section; human; 1:75
Liu Y, Wan S, Zhang P, Zhang W, Zheng J, Lin J, et al. Expression levels of autophagy related proteins and their prognostic significance in retinocytoma and retinoblastoma. Int J Ophthalmol. 2014;7:594-601 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • western blot; human
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher
  • western blot; mouse
Brown D, LASSEGUE B, Lee M, Zafari R, Long J, Saavedra H, et al. Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. PLoS ONE. 2014;9:e96657 pubmed publisher
  • immunocytochemistry; human; 1:200
Mancias J, Wang X, Gygi S, Harper J, Kimmelman A. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105-9 pubmed publisher
  • western blot; human; 1:1000
Porter K, Jeyabalan N, Liton P. MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. Biochim Biophys Acta. 2014;1843:1054-62 pubmed publisher
  • western blot; rat
  • immunohistochemistry - frozen section; mouse
Li J, Xu Z, Jiang L, Mao J, Zeng Z, Fang L, et al. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int. 2014;86:86-102 pubmed publisher
  • western blot; human; fig 1
Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 3
  • western blot; human; 1:1000; fig 1
Gurkar A, Chu K, Raj L, Bouley R, Lee S, Kim Y, et al. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun. 2013;4:2189 pubmed publisher
  • western blot; human; 1:1000
Yuan Y, Tang A, Castoreno A, Kuo S, Wang Q, Kuballa P, et al. Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis. 2013;4:e690 pubmed publisher
  • western blot; mouse; 1:2000
Willis M, Min J, Wang S, McDonough H, Lockyer P, Wadosky K, et al. Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise. Cell Biochem Funct. 2013;31:724-35 pubmed publisher
  • western blot; human
Newman A, Scholefield C, Kemp A, Newman M, McIver E, Kamal A, et al. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE. 2012;7:e50672 pubmed publisher
Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, et al. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Sci Rep. 2018;8:106 pubmed publisher
Kang Y, Hsu W, Wu C, Hsin I, Wu P, Yeh K, et al. Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells. Oncotarget. 2017;8:105536-105552 pubmed publisher
Huang T, Kim C, Alvarez A, Pangeni R, Wan X, Song X, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017;32:840-855.e8 pubmed publisher
Kim J, Kim Y, Stinski M, Ahn J, Song Y. Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction. Front Microbiol. 2017;8:1854 pubmed publisher
Ding L, Wang Q, Shen M, Sun Y, Zhang X, Huang C, et al. Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy. Autophagy. 2017;13:1176-1190 pubmed publisher
Zhang P, Zheng Z, Ling L, Yang X, Zhang N, Wang X, et al. w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway. Autophagy. 2017;13:1093-1112 pubmed publisher
Tang F, Hu P, Yang Z, Xue C, Gong J, Sun S, et al. SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways. Oncol Rep. 2017;37:3449-3458 pubmed publisher
Liu X, Wang A, Liang X, Liu J, Zou F, Chen C, et al. Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies. Oncotarget. 2016;7:53515-53525 pubmed publisher
He M, Wang G, Han S, Jin Y, Li H, Wu X, et al. Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta. Open Biol. 2016;6: pubmed publisher
Zhao Y, Wang W, Guo S, Wang Y, Miao L, Xiong Y, et al. PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery. Nat Commun. 2016;7:11822 pubmed publisher
Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher
Corcelle Termeau E, Vindeløv S, Hämälistö S, Mograbi B, Keldsbo A, Bräsen J, et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy. 2016;12:833-49 pubmed publisher
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Roseno S, Davis P, Bollinger L, Powell J, Witczak C, Brault J. Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice. Nutr Metab (Lond). 2015;12:39 pubmed publisher
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product information
SKU :
3868S
Product-Name :
LC3B (D11) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M, R, (Mk, B, Pg)
Applications :
Flow cytometry
Product-Category :
Autophagy
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
14, 16
Host :
Rabbit
Target :
LC3B
Primary-Protein :
LC3B
Alt-Names :
Autophagy-related protein LC3 B,Autophagy-related ubiquitin-like modifier LC3 B,LC3B,MAP1 light chain 3-like protein 2,MAP1A/1BLC3,MAP1A/MAP1B LC3 B,MAP1A/MAP1B light chain 3 B,MAP1ALC3,MAP1LC3B,MLP3B,Microtubule-associated protein 1 light chain 3 beta,Microtubule-associated proteins 1A/1B light chain 3B,microtubule-associated proteins 1A/1B light chain 3
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.