product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-FRS2-α (Tyr436) Antibody
catalog :
3861
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 11
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig s3f
Frattini V, Pagnotta S, Tala -, Fan J, Russo M, Lee S, et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018;553:222-227 pubmed publisher
  • immunocytochemistry; human; 1:30; loading ...; fig 1
Feng S, Shao L, Castro P, Coleman I, Nelson P, Smith P, et al. Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors. Oncotarget. 2017;8:6179-6192 pubmed publisher
  • western blot; human; loading ...; fig 2a
Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, et al. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget. 2016;7:86011-86025 pubmed publisher
  • western blot; mouse; 1:1000; fig 9e
Chen Q, Arai D, Kawakami K, Sawada T, Jing X, Miyajima M, et al. EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling. PLoS ONE. 2015;10:e0126942 pubmed publisher
  • western blot; human
Wang J, Mikse O, Liao R, Li Y, Tan L, Jänne P, et al. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Oncogene. 2015;34:2167-77 pubmed publisher
  • western blot; human; fig 4
Tan L, Wang J, Tanizaki J, Huang Z, Aref A, Rusan M, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014;111:E4869-77 pubmed publisher
  • western blot; human
Czaplinska D, Turczyk L, Grudowska A, Mieszkowska M, Lipinska A, Skladanowski A, et al. Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration. Biochim Biophys Acta. 2014;1843:2461-70 pubmed publisher
  • western blot; mouse; 1:100
Lee S, Griep A. Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling. PLoS ONE. 2014;9:e97470 pubmed publisher
Farooqui M, Bohrer L, Brady N, Chuntova P, Kemp S, Wardwell C, et al. Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival. Mol Cancer. 2015;14:138 pubmed publisher
Wöhrle S, Weiss A, Ito M, Kauffmann A, Murakami M, Jagani Z, et al. Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. PLoS ONE. 2013;8:e77652 pubmed publisher
Veniant M, Hale C, Helmering J, Chen M, Stanislaus S, Busby J, et al. FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS ONE. 2012;7:e40164 pubmed publisher
product information
SKU :
3861S
Product-Name :
Phospho-FRS2-α (Tyr436) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, (R)
Applications :
Immunoprecipitation
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
80 to 85
Host :
Rabbit
Target :
FRS2 (Tyr435) phosphate
Primary-Protein :
FRS2
Alt-Names :
FGFR signalling adaptor,FGFR substrate 2,FGFR-signaling adaptor SNT,FRS2,FRS2A,FRS2alpha,Fibroblast growth factor receptor substrate 2,SNT,SNT-1,SNT1,Suc1-associated neurotrophic factor target 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.